Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 48, Issue -, Pages S69-S74Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2009.10.017
Keywords
Furan; Margin of exposure; MoE
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Furan is commonly found in foods such as coffee, canned and jarred foods, including baby food containing meat, and various vegetables. It is thought to be formed by the thermal decomposition of carbohydrates. Furan is carcinogenic in rodents, although the detailed mechanism of action has not been completely established. for all the turnout types induced. Dose-response modelling of the data for hepatocellular tumours gives a BMDL10 of 1.23 mg/kg/day, and MOEs of between 750 and 4300 for exposures of infants and adults. (C) 2009 ILSI Europe. Published by Elsevier Ltd. All rights reserved.
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