Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 48, Issue 6, Pages 1483-1487Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2010.03.015
Keywords
Pseudocereals; Phenolic compounds; Genotoxicity; Antimutagenicity
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Funding
- Slovak Grant Agencies Vega [1/0845/08]
- APVV [0310-06]
- AV [4/0013/07]
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Extracts of amaranth (Amaranthus L.), sorghum (Sorghum bicolor L.) and Japanese millet (Echinochloa frumentacea L.) were evaluated for mutagenicity in Salmonella typhimurium strains TA98, TA100 and TA102. All three pseudocereal extracts were also assessed for their antimutagenic properties against the direct mutagens 2-nitrofluorene (2NF) for strain TA98, 3-(5-nitro-2-furyl)acrylic acid (5NFAA) for TA100 and H2O2 for TA102 strain and against the indirect mutagen aflatoxin B-1 (AFB(1)). No mutagenicity was induced by any of the pseudocereal extracts when tested at concentrations as high as 50 mg/ml. All three extracts showed similar antimutagenicity against 5NFAA and no antimutagenicity against 2NF. The number of revertants induced by H2O2 extract was inhibited in order amaranth Japanese milet sorghum. All extracts were effective in the inhibition of mutagenic activity of aflatoxin B1. The total polyphenol content as well as the amount of the flavonoids and phenolic acids as main component of polyphenolics were also determined. (C) 2010 Elsevier Ltd. All rights reserved.
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