Article
Biochemistry & Molecular Biology
Manal F. El-Khadragy, Wafa A. AL-Megrin, Suliman Alomar, Afrah F. Alkhuriji, Dina M. Metwally, Shahenda Mahgoub, Hatem K. Amin, Ola A. Habotta, Ahmed E. Abdel Moneim, Rasha S. Albeltagy
Summary: Arsenic is a major global environmental pollutant with reproductive toxicity. This study found that chlorogenic acid (CGA) protects against arsenic-induced testicular damage through its antioxidant, anti-inflammatory, and anti-apoptotic properties.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Pharmacology & Pharmacy
Aghogho Oyibo, Amos O. Abolaji, Damilola A. Omoboyowa, Oyeronke A. Odunola
Summary: The Ethyl Acetate Fraction (EACF) of Ethanol Leaf Extract of Vitellaria paradoxa (ELVp) was found to increase the longevity of Drosophila melanogaster and mitigate Sodium Arsenite (SA)-induced toxicity. The GC-MS analysis of EACF revealed compounds that exhibited varying degrees of binding affinity against the fly's glutathione-S-transferase-2 (GST-2). By augmenting the fly's antioxidant system and possessing high antioxidant properties, EACF prevented SA-induced oxidative stress.
Article
Biochemistry & Molecular Biology
Ana Claudia Ferreira Souza, Mariana Machado-Neves, Daniel Silva Sena Bastos, Felipe Couto Santos, Luiz Otavio Guimaraes Ervilha, John Lennon de Paiva Coimbra, Larissa de Sales Araujo, Leandro Licursi de Oliveira, Simone Eliza Facioni Guimaraes
Summary: Exposure to arsenic during pregnancy has negative effects on the reproductive development of male rats, leading to reduced body weight, inhibited testicular development, and decreased hormone levels. Additionally, signs of oxidative stress were observed in the prepubertal male rats exposed to arsenic.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Polymer Science
Songmin Oh, Do-Yeong Kim
Summary: This study extracted and characterized the mucilage from Corchorus olitorius L. and investigated its potential applications in various fields. The mucilage showed good solubility, swelling index, water-holding capacity, and oil-binding capacity, as well as antioxidant activity. It can be utilized as a new hydrocolloid source with potential applications in foods, cosmetics, and pharmaceuticals.
Article
Pharmacology & Pharmacy
Yi-Xin Cui, Lu Dong, Meng Zhang, Yi-Nan Liu, Yong -Hui Chen, Ming -Zhao Jia, Kun-Pan Chen, Hui Wang, Ya-Wen Shi, Tian -You Ma, Jing-Hong Chen
Summary: Chronic exposure to arsenic in drinking water can lead to myocardial injury and cardiomyocyte apoptosis through oxidative stress and a reduction in NO content. Rats exposed to different doses of sodium arsenite showed localized inflammatory foci and necrotic myocardial tissues with increasing concentrations of sodium arsenite. The activities and gene expression of antioxidant enzymes decreased, as well as NO content, NOS activity, and NOS mRNA expression in the myocardial tissue of exposed rats.
Article
Agronomy
Susmita Dey, Ashok Biswas, Siqi Huang, Defang Li, Liangliang Liu, Yong Deng, Aiping Xiao, Ziggiju Mesenbet Birhanie, Jiangjiang Zhang, Jianjun Li, Youcai Gong
Summary: The study revealed that varieties Y49 and M33 showed high chlorophyll and carotenoid content and could withstand low-temperature stress by accumulating different antioxidants. Osmolytes compounds significantly increased in Y49 and M33, serving as a defense mechanism for osmotic readjustment to reduce oxidative damage induced by low temperature. PCA and hierarchical cluster analysis identified three groups, with Y49 and M33 being low-temperature tolerant, M18 and W57 being intermediate, and Y38, T8, and Y1 being low temperature susceptible.
Review
Chemistry, Multidisciplinary
Marwa A. M. Abdel-Razek, Miada F. Abdelwahab, Usama Ramadan Abdelmohsen, Ashraf N. E. Hamed
Summary: Corchorus olitorius L. is a nutritious leafy vegetable with potential nutraceutical benefits. Its leaves are rich in minerals, vitamins, and various bioactive compounds, which have shown multiple health-promoting effects.
Article
Biochemistry & Molecular Biology
Maryam Dehdashti Moghadam, Hasan Baghshani, Hamideh Ghodrati Azadi, Zahra Moosavi
Summary: Caffeic acid has an ameliorative role against arsenic-induced testicular damage in mice, increasing antioxidant capacity and hormone levels, attenuating oxidative damage and histopathological alterations.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Environmental Sciences
Cihan Gur, Serkan Ali Akarsu, Nurhan Akaras, Sibel Cigdem Tuncer, Fatih Mehmet Kandemir
Summary: This study investigated the protective effects of carvacrol against testicular toxicity induced by sodium arsenite. The results showed that carvacrol improved sperm motility and reduced abnormal and dead sperm. It also reduced oxidative stress, inflammation, autophagy, and apoptosis induced by sodium arsenite.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Jingyu Ren, Shubin Li, Chunyu Wang, Yuchun Hao, Zhanpeng Liu, Yuzhen Ma, Gang Liu, Yanfeng Dai
Summary: Accumulating evidence shows the connection between arsenic exposure and mitochondrial dysfunction-induced reproductive toxicology. This study found that GSH supplementation effectively ameliorated meiotic defects of ovine oocytes exposed to NaAsO2, showcasing improved reproductive capacities and inhibited cellular damage. Further exploration into GSH applications in livestock affected by arsenic exposure is warranted based on these findings.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Jason A. Coral, Samuel Heaps, Stephen P. Glaholt, Jonathan A. Karty, Stephen C. Jacobson, Joseph R. Shaw, Maria Bondesson
Summary: This study investigated the bimodal response of arsenic on zebrafish embryos and found distinct bimodal phenotypic effects. Exposure to arsenic at different concentrations led to varying physiological and morphological abnormalities in the embryos. Tests with dechorionated embryos supported the idea that the bimodal toxicity response was not caused by the chorion limiting arsenic availability.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Mirza Hasanuzzaman, Md. Rakib Hossain Raihan, Ebtihal Khojah, Bassem N. Samra, Masayuki Fujita, Kamrun Nahar
Summary: The supplementation of biochar and chitosan significantly alleviated the oxidative damage caused by salt stress in jute plants by enhancing antioxidant systems and glyoxalase enzyme activities, improving stress tolerance, reducing Na+ accumulation and ionic toxicity, and decreasing the Na+/K+ ratio.
Article
Environmental Sciences
Rajesh Koley, Debojyoti Mishra, Naba Kumar Mondal
Summary: In this study, magnesium oxide nanoparticles (MgO NPs) synthesized through a green route were evaluated for their efficacy in reducing arsenic (As) accumulation and phytotoxicity in rice plants. The results showed that the application of MgO NPs significantly reduced As accumulation in the roots and shoots of rice seedlings, and improved their growth and antioxidant defense system activity. These findings suggest the potential use of MgO NPs for mitigating As contamination and improving rice yield.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Iman Fatemi, Hamidreza Khalili, Saeed Mehrzadi, Zahra Basir, Alireza Malayeri, Mehdi Goudarzi
Summary: This study evaluated the effect of chrysin on sodium arsenite-induced hepatotoxicity, showing that chrysin significantly mitigated liver toxicity and had a hepatoprotective effect. Chrysin was most effective at a dose of 100 mg/kg/day.
Article
Plant Sciences
Abazar Ghorbani, Leila Pishkar, Nasim Roodbari, Necla Pehlivan, Chu Wu
Summary: The study investigated the role of sodium nitroprusside in alleviating arsenic toxicity in tomato plants, showing that sodium nitroprusside reduced arsenic accumulation in roots and decreased translocation to the shoots by up-regulating the transcriptional expression of certain genes.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Tarun Kumar Dua, Simran Giri, Gouranga Nandi, Ranabir Sahu, Tapan Kumar Shaw, Paramita Paul
Summary: The green synthesis of silver nanoparticles (AgNPs) using an aqueous Eupatorium adenophorum leaf extract as a bioreductant is reported in this article. The E. adenophorum extract not only served as a bioreductant but also acted as a capping agent to stabilize the nanoparticles. Various characterization techniques were adopted to analyze the biosynthesized AgNPs. The AgNPs showed improved antioxidant, antibacterial and photocatalytic activities, suggesting their potential applications in various fields.
Article
Biochemistry & Molecular Biology
Tania Baishya, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Malay Bhattacharya, Ranabir Sahu
Summary: Different parts of Camellia sinensis (L.) were extracted using solvents of varying polarity to examine their phytochemical profiling and biological activities. The highest levels of total phenolic and flavonoid contents were observed in polar solvents, which also showed increased antioxidant, anti-inflammatory, and antidiabetic activities. HPTLC analysis revealed that polar solvents like hydroalcohol, methanol, and water yielded the highest levels of phenolic acids, epigallocatechin gallate, gallocatechin, and theaflavin, particularly in tea leaves. The findings suggested that polar solvents and young tea leaves were beneficial for obtaining extracts and that phenolics exhibited potent antioxidant, anti-inflammatory, and antidiabetic properties.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ankita Mallick, Ranabir Sahu, Gouranga Nandi, Tarun Kumar Dua, Tapan Kumar Shaw, Ankita Dhar, Aditya Kanu, Paramita Paul
Summary: The purpose of this study was to prepare a suitable carrier system to enhance the bioavailability of valacyclovir (VCV) and reduce dose-related side effects for the treatment of herpes. Liposomes encapsulating VCV were synthesized using thin film hydration and reverse-phase evaporation methods. The liposomes showed nanosize range, good colloidal stability, and appreciable drug loading capability. In vitro release studies revealed a biphasic release pattern with initial burst release followed by continuous drug release. The findings suggest that VCV formulated as a liposome can effectively treat herpes with a lower dose and improved bioavailability.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Review
Chemistry, Medicinal
Bhuvi Sachdeva, Punya Sachdeva, Arvind Negi, Shampa Ghosh, Sungsoo Han, Saikat Dewanjee, Saurabh Kumar Jha, Rakesh Bhaskar, Jitendra Kumar Sinha, Ana Claudia Paiva-Santos, Niraj Kumar Jha, Kavindra Kumar Kesari
Summary: Chitin is a biopolymer derived from marine crustaceans and organisms like bacteria, fungi, and algae, which offers biodegradability and biocompatibility properties suitable for biomedical applications. Its deacetylated derivative, chitosan, also possesses similar properties and can be used as a support material in biomedical applications. Additionally, both chitin and chitosan have intrinsic material properties such as antioxidant, antibacterial, and antitumor activities. This paper focuses on the use of chitin and chitosan biopolymers in drug delivery strategies for cancer treatment.
Review
Biochemistry & Molecular Biology
Nilanjan Ghosh, Leena Chacko, Hiranmoy Bhattacharya, Jayalakshmi Vallamkondu, Sagnik Nag, Abhijit Dey, Tanushree Karmakar, P. Hemachandra Reddy, Ramesh Kandimalla, Saikat Dewanjee
Summary: Diabetes mellitus (DM) and cardiovascular complications often occur together, creating a challenging situation. The development of diabetic cardiomyopathy (DCM) involves complex pathophysiological pathways at the metabolic and molecular level, leading to structural and functional alterations of the heart. Glucagon-like peptide-1 (GLP-1) analogues and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have shown promising results in improving cardiovascular outcomes in diabetes. This article highlights the pathways contributing to DCM and discusses potential future therapies.
Review
Biochemistry & Molecular Biology
Hafiza Padinharayil, Jinsu Varghese, Mithun Chacko John, Golgodu Krishnamurthy Rajanikant, Cornelia M. Wilson, Minnatallah Al-Yozbaki, Kaviyarasi Renu, Saikat Dewanjee, Rupa Sanyal, Abhijit Dey, Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Alex George
Summary: Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) supports therapeutic advances and accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention and management. Global cancer mortality projections indicate that cancer will become the leading cause of death, particularly non-small cell lung cancer (NSCLC) which accounts for a significant portion of lung cancers. Early diagnosis and proper management play crucial roles in NSCLC therapies. Advanced techniques, such as immune checkpoint inhibitors (ICIs) and targeted molecular therapies, have improved the treatment of late-stage NSCLC. However, the improvement of cancer biomarkers and the development of prospective studies are needed for better therapeutic outcomes.
Article
Biochemical Research Methods
Gouhar Jahan Ashraf, Priya Das, Ranabir Sahu, Gouranga Nandi, Paramita Paul, Tarun Kumar Dua
Summary: This study investigated and optimized the ultrasonic-assisted extraction and quantification of caffeine and polyphenols from green tea using 2(3)-full factorial design and high-performance thin-layer chromatography. The results showed that sonication can simplify the extraction process and achieve higher extractive yield and concentration of caffeine and polyphenols compared to traditional methods. Scanning electron microscopy images revealed physical alterations and cell wall disintegration in the matrix, which accelerated the extraction process.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Md. Latifur Rahman, Subhajit Mandal, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Ranabir Sahu
Summary: This study aimed to investigate the effects of different extraction methods on the antioxidant activity and phenolic profiling of black rice. The highest contents of various phenolic compounds and antioxidant activity were observed in microwave-assisted extraction (MAE). MAE also showed the most abundant phenolic compounds. The results suggest that extraction techniques have an impact on the bioactive compounds and their properties.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2023)
Review
Endocrinology & Metabolism
Paramita Paul, Leena Chacko, Tarun K. Dua, Pratik Chakraborty, Udita Paul, Vishwakarma Vishal Phulchand, Niraj K. Jha, Saurabh K. Jha, Ramesh Kandimalla, Saikat Dewanjee
Summary: Diabetic nephropathy is a serious complication of diabetes mellitus, and early detection and effective treatment are crucial. Nanosystems have shown promise in the diagnosis and treatment of diabetic nephropathy, offering advantages such as early and accurate diagnosis, site-specific delivery, and improved pharmacokinetic profile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Simran Giri, G. Dey, R. Sahu, Paramita Paul, G. Nandi, T. K. Dua
Summary: Woodfordia fruticosa is a traditional medicinal plant with numerous therapeutic properties. Phytochemical investigations have identified 61 compounds belonging to various classes, such as glycosides, terpenes, flavonoids, tannins, sterols, phenolics, and essential oils. Pharmacological studies have shown that the plant possesses antihyperglycemic, antioxidant, anti-inflammatory, analgesic, hepatoprotective, antibacterial, gastroprotective, and wound healing properties. However, further studies on the isolated compounds are needed to fully explore the plant's potential applications.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Food Science & Technology
Subhajit Mandal, Md. Latifur Rahman, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Ranabir Sahu
Summary: This study investigated the effects of maceration, ultrasonic, and microwave-assisted extraction on the phenolic compounds of Tulaipanji rice flour. It was found that microwave-assisted extraction showed the highest phenolic content and antioxidant activity, particularly in bound phenolics.
INTERNATIONAL JOURNAL OF FOOD ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Abhijit Changder, Sanat Kumar Mandal, Saurav Sarkar, Riyasree Paul, Ananya Ghosh, Paramita Paul, Tarun Kumar Dua, Ranabir Sahu, Gouranga Nandi, Lakshmi Kanta Ghosh
Summary: The present study evaluated the application of Cassia fistula seed galactomannan (CFSG) as a tablet binder for diclofenac sodium. The research confirmed the excellent binding capacity of CFSG and its potential as an alternative tablet binder.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)