Article
Biochemistry & Molecular Biology
Shigeru Murakami, Kohei Funahashi, Natsuki Tamagawa, Ma Ning, Takashi Ito
Summary: Taurine ameliorated diabetes and its complications by improving hepatic glucose metabolism and reducing oxidative stress.
Article
Medicine, Research & Experimental
Ankit P. Laddha, Yogesh A. Kulkarni
Summary: The study focused on the effect of daidzein in an experimental model of diabetic cardiomyopathy in rats. Daidzein treatment improved cardiac function, restored ECG and hemodynamic parameters, prevented the loss of cardiac marker enzymes, and reduced cardiac tissue necrosis and fibrosis in diabetic rats, suggesting its potential in mitigating the progression of diabetic cardiomyopathy.
Article
Pharmacology & Pharmacy
Sajed Amjadi, Fatemeh Shahnaz, Behrooz Shokouhi, Yadollah Azarmi, Mohammadreza Siahi-Shadbad, Saeed Ghanbarzadeh, Maryam Kouhsoltani, Alireza Ebrahimi, Hamed Hamishehkar
Summary: Encapsulation of rutin into nanophytosomes showed enhanced therapeutic effects in diabetic rats by controlling hyperglycemia and hyperlipidemia, regulating liver marker enzymes, improving antioxidant defenses, and alleviating diabetic complications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Kaveri M. Adki, Yogesh A. Kulkarni
Summary: This study demonstrates the effectiveness of paeonol in the management of diabetic retinopathy. Paeonol treatment significantly improved retinal physiology, reduced blood glucose levels and oxidative stress, and alleviated histopathological changes in the retina.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hassan Rakhshandeh, Hamed Rajabi Khasevan, Anella Saviano, Mohammad Reza Mahdinezhad, Vafa Baradaran Rahimi, Sajjad Ehtiati, Leila Etemad, Alireza Ebrahimzadeh-bideskan, Francesco Maione, Vahid Reza Askari
Summary: The study found that Portulaca oleracea extract has a protective effect on streptozotocin-induced type-I-diabetes-associated reproductive system dysfunction and inflammation in rats. It ameliorated various parameters and histopathological indexes' damage, indicating its potential use in managing diabetic-associated clinical complications.
Article
Pharmacology & Pharmacy
Ying Liu, Jiake Mo, Fang Liang, Siwei Jiang, Jing Xiong, Xubiao Meng, Zhaohui Mo
Summary: The Chinese traditional medicine Pien-Tze-Huang (PZH) has been found to be effective in treating diabetic foot ulcers. It promotes wound healing, vasculature, and upregulates the expression of growth factors. PZH also activates the Nrf2/ARE pathway and reduces inflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Qianxia Lin, Yueping Guo, Jie Li, Shuqi He, Yan Chen, Huoxi Jin
Summary: In this study, peptides with a molecular weight of less than 1 kD (HNCP) derived from Harpadon nehereus bone collagen were found to attenuate oxidative stress, reduce blood glucose, and improve glycolipid metabolism in streptozocin-induced type 1 diabetes mice.
Review
Physiology
Qi Chen, Zheng Li, Ricardo A. Pinho, Ramesh C. Gupta, Ukadike C. Ugbolue, Anand Thirupathi, Yaodong Gu
Summary: Taurine supplementation has been shown to reduce DNA damage, lactate levels, and muscular fatigue in exercise. High doses of taurine can increase glycerol levels, making it an effective agent for prolonged activities with higher intensities. Further research is needed to elucidate the role of taurine in fat metabolism during exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Neurosciences
Vanessa Castelli, Antonella Paladini, Michele d'Angelo, Marcello Allegretti, Flavio Mantelli, Laura Brandolini, Pasquale Cocchiaro, Annamaria Cimini, Giustino Varrassi
Summary: This review discusses the impact of oxidative stress in retinal neurodegenerative diseases and potential strategies for avoiding or counteracting oxidative damage in retinal tissues, with a specific focus on taurine. Increasing data suggest that taurine may effectively slow down the progression of degenerative retinal diseases, making it a promising candidate for prevention or adjuvant treatment of these diseases. The mechanism of taurine supplementation primarily involves reducing oxidative stress and improving antioxidant enzyme activities in the retina, with further research needed to fully understand its protective effects against retinal damage.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Environmental Sciences
Atef Abdel-Moneem Ali, Ehab Abdel-Raouf Essawy, Noha Sayed Mohamed, Ahmed E. Abdel Moneim, Fawzy Ali Attaby
Summary: Physalis juice (PJ) attenuates testicular impairments associated with diabetes through its antioxidative, anti-inflammatory, and antiapoptotic actions in streptozotocin (STZ)-induced diabetic rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Lilesh Kumar Pradhan, Pradyumna Kumar Sahoo, Sai Aparna, Meghana Sargam, Amit Kumar Biswal, Omkar Polai, Nishant Ranjan Chauhan, Saroj Kumar Das
Summary: The study demonstrates that taurine has a neuroprotective effect against BPA-induced neurotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Camila Moreno Rosa, Dijon Henrique Salome Campos, David Rafael Abreu Reyes, Felipe Cesar Damatto, Lucas Yamada Kurosaki, Luana Urbano Pagan, Mariana Janini Gomes, Camila Renata Correa, Ana Angelica Henrique Fernandes, Marina Politi Okoshi, Katashi Okoshi
Summary: Clinical trials have shown that SGLT2 inhibitors improve clinical outcomes in patients with diabetes mellitus. This study aimed to analyze the effects of the SGLT2 inhibitor dapagliflozin on cardiac remodeling in a rat model of Type 1 diabetes mellitus. The results demonstrated that dapagliflozin improved blood pressure, glycemia, and cardiac function, and attenuated cardiac changes in the experimental rat model.
Article
Multidisciplinary Sciences
Subashini Thirukkalukundram Singarapriyavardhanan, Prakash Srinivasan Timiri Shanmugam, Sunil Kumar Koppala Narayana, Aiman A. Ammari, Ramzi A. Amran, Ahmad R. Alhimaidi
Summary: The study validated the protective role of Mimosa pudica plant extracts in diabetic rats, showing effects such as reducing blood glucose levels, improving liver and renal function, and antioxidant properties.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Natsumi Saito, Risako Mikami, Koji Mizutani, Kohei Takeda, Hiromi Kominato, Daisuke Kido, Yuichi Ikeda, Prima Buranasin, Keita Nakagawa, Shu Takemura, Takeshi Ueno, Keiichi Hosaka, Takao Hanawa, Tamayuki Shinomura, Takanori Iwata
Summary: In patients with diabetes, high-glucose-induced oxidative stress suppresses the proliferation and calcification of BMMSCs, impairing osseointegration and leading to implant failure.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Environmental Sciences
Fatima El Zahra M. Fathi, Kadry M. Sadek, Asmaa F. Khafaga, Abdel Wahab Al Senosy, Hanan A. Ghoniem, Sahar Fayez, Mohamed F. Zeweil
Summary: This study demonstrates that vitamin D can improve the harmful effects of type 2 diabetes by increasing insulin secretion and sensitivity, improving beta-cell function, reducing cortisol levels, and exerting anti-inflammatory and antioxidant effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Ching-chun Huang, Shih-chun Pan, Wei-shan Chin, Yu-cheng Chen, Chin-yu Hsu, Pinpin Lin, Yue Leon Guo
Summary: This population-based study found that living within a 3-km radius of petrochemical industrial parks (PIPs) during pregnancy, or having high petrochemical exposure opportunity, increased the risk of premature rupture of membranes (PROM). Additional research is needed to confirm these findings.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chia-Chi Ho, Yu-Cheng Chen, Ming-Hsien Tsai, Hui-Ti Tsai, Chen-Yi Weng, Shaw-Fang Yet, Pinpin Lin
Summary: Epidemiological studies have shown a link between ambient particulate matter exposure and vascular diseases. The research revealed that exposure to ambient PM led to increased cell migration ability in vascular smooth muscle cells and pulmonary arterial smooth muscle cells. Additionally, the study demonstrated that PM induced intracellular reactive oxygen species, activated the NF-kappa B signaling pathway, and increased expression of proinflammatory cytokines in VSMCs. Polyphenolic compounds like curcumin, resveratrol, and gallic acid were found to prevent PM-induced migration by blocking the ROS-dependent NF-kappa B signaling pathway in VSMCs.
Article
Biochemical Research Methods
Hao-Hsiang Ku, Pinpin Lin, Min-Pei Ling
Summary: This study proposes heavy metal hazard decision trees for aquatic products, categorizing them into seven groups and using risk assessment on seafood samples to analyze the relationships between different aquatic products and heavy metal concentrations. It provides a reference model for researchers and engineers by revealing the relationships among aquatic products, heavy metal concentrations, and potential human health risks.
BMC BIOINFORMATICS
(2022)
Article
Food Science & Technology
Chia-Chi Wang, Yu-Chih Liang, Shan-Shan Wang, Pinpin Lin, Chun-Wei Tung
Summary: This study proposes a machine learning-based weight-of-evidence (WoE) model for prioritizing chemicals of carcinogenic concern. The model integrates complementary computational methods and achieves better performance compared to single methods, providing a fast and comprehensive approach for prioritizing chemicals of carcinogenic concern.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tzu-Yin Chen, Chia-Hao Liu, Tsung-Hsien Chen, Mei-Ru Chen, Shan-Wen Liu, Pinpin Lin, Kurt Ming-Chao Lin
Summary: The role of epithelial-mesenchymal transition in lung diseases and cancer related to cigarette smoking is significant. Adipose-derived stem cell-conditioned medium shows protective effects against cigarette smoke-induced cell death and EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Wei-shan Chin, Shih-chun Pan, Ching-chun Huang, Yu-cheng Chen, Chin-yu Hsu, Pinpin Lin, Pau-chung Chen, Yue Leon Guo
Summary: This study found that individuals residing near petrochemical industrial parks (PIPs) have a higher risk of chronic glomerulonephritis (CGN), particularly those living within 10 kilometers of the PIPs. These findings highlight the importance of monitoring environmental nephrotoxic substances and the renal health of residents living near PIPs.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Chin-Yu Hsu, Pei-Yu Wu, Yu-Cheng Chen, Pau-Chung Chen, Yue Leon Guo, Yi-Jun Lin, Pinpin Lin
Summary: This study analyzed comprehensive measurement data of 109 VOCs collected from 17 monitoring stations around petrochemical industrial parks in Taiwan from 2015 to 2018. The results identified six VOCs, including 1,3-butadiene, benzene, 1,2-dichloroethane, chloroform, vinyl chloride, and acrylonitrile, with more than 50% of their emissions attributed to petrochemical industrial parks. This integrated approach can assist regulatory agencies in proposing effective control strategies to reduce the health risk associated with high-concern VOC emissions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Toxicology
Chia-Chi Ho, Wei-Te Wu, Yi-Jun Lin, Chen-Yi Weng, Ming-Hsien Tsai, Hui-Ti Tsai, Yu-Cheng Chen, Shaw-Fang Yet, Pinpin Lin
Summary: The present study provides in vitro, animal, and human evidence supporting the importance of AhR activation for PM2.5-induced vascular toxicities and that BkF was the major contributor of AhR activation. OPN is an AhR-dependent biomarker of PM2.5-induced vascular toxicity. The AhR activation potency may be applied in the risk assessment of vascular toxicity in PAH mixtures.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Biochemical Research Methods
Che-Yu Chou, Pinpin Lin, Jongwoon Kim, Shan-Shan Wang, Chia-Chi Wang, Chun-Wei Tung
Summary: In this study, a valid prediction model for ex vivo human placental barrier permeability was developed, which can be used for assessing the toxic effects of chemicals on the fetus.
BMC BIOINFORMATICS
(2022)
Article
Environmental Sciences
Ching-chun Huang, Shih-chun Pan, Wei-shan Chin, Yu-cheng Chen, Chih-da Wu, Chin-yu Hsu, Pinpin Lin, Pau-chung Chen, Yue Leon Guo
Summary: This study aimed to evaluate the association between exposure to petrochemical facilities and emissions and the risk of ADHD development in children. The results indicated that residents of townships near petrochemical plants, highly affected by petrochemical-containing prevailing winds, and with high benzene concentrations had an increased risk of ADHD development. This study provides clear evidence that living near petrochemical plants increases the risk of ADHD in children.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Salim Arrokhman, Yueh-Hsia Luo, Pinpin Lin
Summary: Bisphenol A (BPA) and its analogs, such as bisphenol F (BPF), bisphenol AF (BPAF), and bisphenol B (BPB), were found to increase the mortality of zebrafish embryos (ZFEs) and induce bradycardia. BPAF was the most potent, followed by BPB, BPA, and BPF.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Mu-Jean Chen, Yue Leon Guo, Pinpin Lin, Hung-Che Chiang, Pau-Chung Chen, Yu-Cheng Chen
Summary: The currently used air quality index (AQI) is criticized for its inability to capture the additive effects of air pollution on health risks and reflect non-threshold concentration-response relationships. In this study, we propose the air quality health index (AQHI) based on daily air pollution-mortality associations and compare its validity in predicting daily mortality and morbidity risks with the existing AQI.
ENVIRONMENTAL RESEARCH
(2023)
Article
Food Science & Technology
Shan -Shan Wang, Pinpin Lin, Chia-Chi Wang, Ying-Chi Lin, Chun-Wei Tung
Summary: This study developed a nonlinear machine learning method to predict the migration of chemicals from packaging materials to food, taking into account chemical properties, material type, food type, and temperature. The ensemble model leveraging multiple algorithms provides better performance compared to previous linear regression models. These prediction models can accelerate the assessment of migration of food contact chemicals from package to foods.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Pinpin Lin, Pei- Lee, Min-Pei Ling
Summary: This study quantifies the benefit-risk analysis of omega-3 polyunsaturated fatty acid and methylmercury for people consuming mercury-contaminated fish in Taiwan using a probabilistic approach. The results suggest that Taiwan residents do not need to reduce intake rate based on benefit considerations, despite the higher risks associated with cod and scad.
MARINE POLLUTION BULLETIN
(2023)
Article
Environmental Sciences
Kuan-Yu Kuo, Yu Chen, Yi Chuang, Pinpin Lin, Yi-Jun Lin
Summary: This study investigated the health risks of perfluoroalkyl substances (PFASs) on pregnant women, infants, and children, with a focus on the mixture risks of the four main PFASs. The findings revealed that PFOS was the most dominant PFAS in the serum of pregnant women and children globally, with potential immune effects exceeding 1. The cumulative hazard quotients (HQs) for developmental and immune effects in infants could also be greater than 1, suggesting concerns for infant development and immunity. The national and global serum database and risk assessment provide additional insights into PFAS exposure and mixture risks in vulnerable populations, serving as a reference for evaluating regulatory mitigation measures.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
