Article
Pharmacology & Pharmacy
Ralitza Gueorguieva, Elizabeth K. C. Schwartz, R. Ross MacLean, Elise E. DeVito, Tore Eid, Ran Wu, Stephanie S. O'Malley, Mehmet Sofuoglu
Summary: This study aimed to determine if plasma menthol glucuronide (MG) concentrations can predict changes in subjective drug effects, urges to smoke, and heart rate following concurrent inhaled menthol and intravenous nicotine. The results showed that changes in plasma MG concentrations were proportional to menthol concentration in e-liquids, and were predictive of cooling effect in menthol smokers without active nicotine infusion.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Marharyta Cherniakova, Victoria Varchenko, Konstantin Belikov
Summary: The interest in deep eutectic solvents (DESs) as green solvents has increased in the last 10 years. DESs have been extensively studied for their applications in extraction technologies. Their properties, which can be finely tuned, make them suitable for the extraction of metal ions and organic substances. However, there is a lack of summarization on the extraction properties of DESs based on their chemical composition. This review covers the physicochemical properties and practical application of menthol-based eutectic solvents, and discusses the appropriateness of using the term DES for mixtures with lower melting points.
Article
Food Science & Technology
Laura Sofia Mora-Florez, Daniel Cabrera-Rodriguez, Maria Hernandez-Carrion
Summary: This study obtained menthol and luteolin encapsulates using different hydrocolloids to replace the conventional preparation of peppermint and chamomile beverages. The results showed that formulations using maltodextrin-sodium caseinate and maltodextrin-soy protein had the best combination of powder properties, making them suitable for easy-to-consume and eco-friendly aromatic beverages.
Article
Public, Environmental & Occupational Health
Michael Kotlyar, Ryan Shanley, Sheena R. Dufresne, Gretchen A. Corcoran, Dorothy K. Hatsukami
Summary: This pilot study examined the impact of restricting menthol cigarettes on current menthol smokers. It found that abstaining from menthol cigarettes led to lower smoking rates and levels of exhaled CO. Participants who abstained also reported higher motivation to quit and perceived effectiveness of quitting skills. The flavor of e-cigarettes provided did not significantly affect smoking behavior or CO levels. These findings suggest that banning menthol flavor in combustible cigarettes could enhance the harm reduction potential of e-cigarettes.
PREVENTIVE MEDICINE
(2022)
Review
Immunology
Haojin Cheng, Xuemei An
Summary: Menthol's protective effects against inflammatory damage are mainly attributed to the reduction in pro-inflammatory cytokines and related inflammatory markers, as well as pathway activation. Further research is needed to establish relationships between mechanisms of action and clarify clinical relevance of any anti-inflammatory effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mashima Naksawat, Chosita Norkaew, Kantorn Charoensedtasin, Sittiruk Roytrakul, Dalina Tanyong
Summary: This study revealed the anti-leukemic effects and underlying mechanisms of menthol in NB4 and Molt-4 leukemic cell lines, including induction of apoptosis and autophagy through activating the caspase cascade, regulating BAX and p53/MDM2, and modulating autophagy via the ATG3/mTOR signaling pathway.
Article
Substance Abuse
Joanne D'Silva, Erin O'Gara, Craig S. Fryer, Raymond G. Boyle
Summary: The study found that the majority of African American smokers smoke Newport menthol cigarettes and believe that menthol cigarettes are more harmful than non-menthol cigarettes, targeted towards African Americans. Some participants were receptive to policy changes, while others found the policy inconvenient and unfair. Overall, there was a lack of understanding of the policy's intended public health impact.
NICOTINE & TOBACCO RESEARCH
(2021)
Article
Medicine, General & Internal
Amy M. Cohn, Rachel Cassidy, Rachel Denlinger-Apte, Eric Donny, Andrea C. Villanti, Dorothy Hatsukami, Delaney Dunn, Riley Wyatt, Taylor Niznik, Tamar Cohen-Davidyan, Michael Smith, Sarah J. Ehlke
Summary: This study aims to assess the appeal of menthol and non-menthol very low nicotine cigarettes (VLNCs) among young adult smokers, as well as the impact of proposed product standards on tobacco product purchasing behavior. The findings of this study will be disseminated through peer-reviewed journal articles and presentations at scientific conferences.
Article
Biochemistry & Molecular Biology
Tomasz Szostek, Daniel Szulczyk, Jolanta Szymanska-Majchrzak, Michal Kolinski, Sebastian Kmiecik, Dagmara Otto-Slusarczyk, Aleksandra Zawodnik, Eliza Rajkowska, Kinga Chaniewicz, Marta Struga, Piotr Roszkowski
Summary: Sixteen new Ciprofloxacin derivatives were designed and synthesized, and their antimicrobial and cytotoxic activities were evaluated. Derivative 12 exhibited the highest antimicrobial activity and showed good activity against cancer cells without cytotoxicity to normal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Substance Abuse
Sophia Mus, Inti Barrientos, Desiree Vidana-Perez, Jose Monzon, Joaquin Barnoya, Michelle K. Page, Ashleigh C. Block, Maciej L. Goniewicz, Richard J. O'Connor, James F. Thrasher
Summary: This study found that flavor capsule cigarettes commonly contain menthol and other compounds that may enhance addictiveness and pose health risks. Variability in chemical content among different brand varieties and countries emphasizes the importance of setting product standards.
NICOTINE & TOBACCO RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Yijia Zhao, Huafeng Pan, Wei Liu, E. Liu, Yaobin Pang, Hongjin Gao, Qingying He, Wenhao Liao, Yejing Yao, Jinhao Zeng, Jing Guo
Summary: This study reviewed the anticancer activity and underlying mechanism of menthol, highlighting its safety profile and multiple pathways of action. Due to its excellent anticancer activity, further research is needed to develop menthol as a novel anticancer agent.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Engineering, Environmental
Tasrin Shahnaz, Anjali Jayakumar, Das Bedadeep, Selvaraju Narayanasamy
Summary: Graphene-based composites have been shown to be important modern materials in the past few years, with graphene-based aerogels being widely explored for wastewater treatment. The exponential growth of scientific publications on graphene-based materials in the last five years has provided significant momentum for research and development.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Review
Engineering, Environmental
Ning Zhang, Xianwen Yang, Yalun Wang, Yunfei Qi, Yana Zhang, Jialiang Luo, Ping Cui, Wei Jiang
Summary: The continuous increase in oil spill accidents from industries and daily life has resulted in severe economic loss, destruction of the ecological environment, and threats to human health. Designing and fabricating efficient separation membrane materials is an effective approach to solve this problem, attracting tremendous attention. This article provides a comprehensive overview of separation membrane materials with controlled pore structure and tunable wettability for highly efficient oil/water emulsion separation. Different types of membrane materials and special functional membranes have also been summarized, focusing on their application in oil/water separation.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Agricultural Engineering
Ana Tinoco, Filipa Goncalves, Andre F. Costa, David S. Freitas, Artur Cavaco-Paulo, Artur Ribeiro
Summary: The study developed a system for controlled delivery of perfumes on hair based on zein, a protein derived from maize, and keratin. The Keratin:Zein particles showed high stability and improved hair's mechanical properties and hydration degree, with potential for personalized hair cosmetic products.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, M. A. Cancellieri, H. Chon, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: According to the evaluation conducted, d-8-p menthene-1,2-epoxide has been found to be non-genotoxic and low in repeated dose, reproductive, and local respiratory toxicity. It is also considered to have a low risk of skin sensitization and phototoxicity/photoallergenicity. Additionally, it meets the environmental safety standards and does not pose a persistent, bioaccumulative, and toxic (PBT) risk.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
