Article
Immunology
Sheikh F. Ahmad, Ahmed Nadeem, Mushtaq A. Ansari, Saleh A. Bakheet, Hatun A. Alomar, Haneen A. Al-Mazroua, Khalid E. Ibrahim, Ali A. Alshamrani, Mohammed A. Al-Hamamah, Ali S. Alfardan, Sabry M. Attia
Summary: In this study, the CXCR3-specific antagonist NBI-74330 was used to inhibit T-cell-mediated signaling in a mouse model of rheumatoid arthritis (RA). The results showed that NBI-74330 treatment significantly reduced arthritis symptoms and histopathological changes. Additionally, NBI-74330 treatment downregulated the percentages and gene expression levels of Th1, Th17, and Th22 cells. These findings suggest that NBI-74330 has potential as a treatment for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sabry M. Attia, Mohammed A. Al-Hamamah, Mohamed S. M. Attia, Abdulrazaq Alanazi, Sheikh F. Ahmad, Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Gamaleldin I. Harisa
Summary: Compared to the general population, arthritis patients have a higher risk of fertility abnormalities. Rituximab, a commonly used treatment, has not been fully studied in terms of its effect on germ cells. This study aimed to investigate the impact of rituximab on aneuploidy and redox imbalance in arthritic mouse sperm. Results showed that rituximab did not induce aneuploidy, while arthritis significantly increased the frequency of disomy. Rituximab treatment reduced the levels of disomic sperm and restored markers of oxidative stress. Furthermore, arthritis severity was reduced after rituximab treatment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Instruments & Instrumentation
Abhirami Thumsi, Srivatsan J. J. Swaminathan, Joslyn L. L. Mangal, Abhirami P. P. Suresh, Abhinav P. P. Acharya
Summary: The reprogramming of immune cells' metabolism can improve their function and reduce the severity of autoimmune diseases. In this study, a rheumatoid arthritis (RA) mouse model was developed to mimic immune flare-ups. The use of immune metabolic modulator paKG(PFK15 + bc2) microparticles (MPs) effectively reduced clinical symptoms of RA in mice.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yunji Heo, Mangeun Kim, Godagama Gamaarachchige Dinesh Suminda, Yunhui Min, Yaping Zhao, Mrinmoy Ghosh, Young-Ok Son
Summary: Holistic healthcare practitioners are exploring the use of Ganoderma lucidum (GL) mushroom, which has been used in traditional Chinese medicine for centuries, to treat rheumatoid arthritis (RA). A study found that GL spores (GLS) oil, rich in oleic and linoleic acids, significantly reduced clinical scores and inflammation in a RA mouse model. GLS oil also suppressed neutrophil infiltration and IL-6 expression, suggesting its potential use in the development of RA drugs. However, further clinical research is needed to support these findings.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Integrative & Complementary Medicine
Ju-Yeon Park, Young-Won Kwon, Sun-Ah Kim, Sun-Dong Park, Chang-Hyun Kim, Jin-Hee Kim, Ju-Hee Lee
Summary: The study demonstrated the anti-arthritic effects of SC-E3 in a mouse model of type-II collagen-induced arthritis, showing reduced paw swelling, bone erosion, inflammatory cell infiltration, and inflammation. SC-E3 was found to inhibit pro-inflammatory cytokines and osteoclastogenesis, indicating its potential therapeutic use for rheumatoid arthritis.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Review
Medicine, Research & Experimental
Jing Luan, Zhifang Hu, Jianghong Cheng, Ruisan Zhang, Peng Yang, Huifang Guo, Gang Nan, Na Guo, Xingchun Gou
Summary: Animal models are crucial for studying the pathogenesis of rheumatoid arthritis and evaluating the efficacy of anti-RA drugs, with the CIA mouse model being the most widely used due to its rapid and inexpensive generation and similarity to human RA. This review aims to introduce the CIA model to beginners and clarify important details for reliable results, summarizing information on model origin, pathogenesis, construction protocol, successful arthritis induction rate, and arthritis severity evaluation methods. With this knowledge, researchers can start quickly and avoid unnecessary errors.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Plant Sciences
Tae-Hyu Kim, Van-Long Truong, Woo-Sik Jeong
Summary: The root extract of Ligularia fischeri Turcz has higher antioxidant capacity and total flavonoid levels, enhancing cellular antioxidant defense and exhibiting anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Sabry M. Attia, Mudassar Shahid, Faris S. Alyousef, Mohammed A. Alswailem, Mohammed Alqinyah, Sheikh F. Ahmad
Summary: This study demonstrates that MVC has therapeutic potential in attenuating the severity of inflammatory arthritis in CIA mice by reducing pro-inflammatory responses and increasing anti-inflammatory responses.
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Yun Ji Park, Do Yeon Kwon, Song Yi Koo, To Quyen Truong, Sung-Chul Hong, Jaeyoung Choi, Jinyoung Moon, Sang Min Kim
Summary: In this study, we investigated the physiological and transcriptomic changes induced by severe drought stress in L. fischeri plants. We identified two anthocyanins and two flavones upregulated by drought stress for the first time. RNA sequencing revealed 24 meaningful differentially expressed genes associated with phenylpropanoid biosynthesis, providing insights into the regulation of key phenylpropanoid biosynthetic genes in L. fischeri under drought stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Immunology
Junnan Zhou, Yuhang Mao, Xiaotian Shi, Yudie Zhang, Xiaolu Yu, Xuan Liu, Li Diao, Xue Yang, Changze Liu, Dan Liu, Xin Tan, Mei Liu
Summary: This study demonstrates the potential therapeutic effect of peimine on rheumatoid arthritis (RA), including the inhibition of destructive behaviors and over-expression of pro-inflammatory cytokines. It also provides insights into the molecular mechanism of action of peimine on RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Biochemistry & Molecular Biology
Ju-Eun Hong, Chang-Gun Lee, Soonjae Hwang, Junyoung Kim, Minjeong Jo, Da-Hye Kang, Sang-Hyeon Yoo, Woo-Seung Kim, Yongheum Lee, Ki-Jong Rhee
Summary: This study found that pulsed electromagnetic field (PEMF) can alleviate inflammation in rheumatoid arthritis (RA), particularly at a frequency of 10 Hz. The treated mice had lower levels of joint inflammation and IL-1 beta. The results suggest that PEMF treatment can preserve joint morphology and delay the occurrence of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yezan M. Salamoun, Kishore Polireddy, Yu Kyoung Cho, Matthew R. Medcalf, Ryan S. Funk
Summary: This study found that treatment with MTX led to significant reductions in arthritis activity, affecting levels of 5mTHF, NMI, and quinolone in the blood, which may serve as potential biomarkers for therapeutic response and disease activity.
Article
Immunology
Pablo A. Silveira, Fiona Kupresanin, Adelina Romano, Wei-Hsun Hsu, Tsun-Ho Lo, Xinsheng Ju, Hsiao-Ting Chen, Helen Roberts, Daniel G. Baker, Georgina J. Clark
Summary: This study investigated the immunosuppressive mechanisms of anti-CD83 antibody treatment and found that it can achieve immune suppression and reduce the symptoms of autoimmune rheumatoid arthritis. The treatment selectively depleted mature dendritic cells and induced regulatory dendritic cells and regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Le Ba Vinh, Se Jin Jo, Phong Nguyen Viet, Dan Gao, Kyoung Won Cho, Eun-Jeong Koh, Sung Sun Park, Young Ho Kim, Seo Young Yang
Summary: S. hexaphylla is an important medicinal plant with analgesic, sedative, and diuretic effects. This study identified seven compounds with anti-inflammatory properties, indicating that they may be useful candidates for treating inflammatory and other diseases.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Viet Cuong Le Canh, Vinh Le Ba, Pham Thi Hai Yen, Lien Le Thi, Pham Thi Thuy Hoai, Ton That Huu Dat, Do Thi Thao, Long Giang Bach, Young Ho Kim, Hoang Le Tuan Anh
Summary: A phytochemical investigation of Physalis minima isolated six withanolides, with compounds 1 and 3 exhibiting the strongest cytotoxicity against HepG2, SK-LU-1, and MCF7 cancer cell lines.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Le Canh Viet Cuong, Le Tuan Anh, Ton That Huu Dat, Tran Thi Phuong Anh, Le Quynh Lien, Young Ho Kim, Hoang Le Tuan Anh
Summary: A new ursane-type triterpene and eight known compounds were isolated from the aerial parts of Ophiorrhiza baviensis, with some compounds being reported for the first time in this plant species. The structures of these compounds were elucidated through analysis of HR-ESI-MS and NMR spectra, and their biological activities were evaluated. This study represents the first report on the chemical constituents and biological activities of O. baviensis.
NATURAL PRODUCT RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Hyun Wook Huh, Young-Guk Na, Ki-Hyun Bang, Sung-Jin Kim, Minki Kim, Kyung-Tae Kim, Jong-Seong Kang, Young-Ho Kim, Jong-Suep Baek, Hong-Ki Lee, Cheong-Weon Cho
Article
Chemistry, Multidisciplinary
Nguyen Van Hiep, Ngo Minh Duc, Young Ho Kim
Article
Chemistry, Applied
Le Xuan Duy, Vinh Le Ba, Dan Gao, Vu Dinh Hoang, Tran Quoc Toan, Seo Young Yang, Dao Duy Quang, Young Ho Kim, Nguyen Manh Cuong
Summary: Nine bioactive compounds were isolated from the fruits of the Vietnamese medicinal plant Docynia indica, with one newly discovered compound. These compounds showed inhibitory effects on soluble epoxide hydrolase, suggesting their potential in preventing cardiovascular and other related diseases.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Hyunyong Lee, Jihyun Jeon, Joobyoung Yoon, Seung-Hwan Kim, Hyun Sik Choi, Jong Seung Kang, Yong Sup Lee, Mase Lee, Young Ho Kim, Hwan Bong Chang
Article
Plant Sciences
Hoang Le Tuan Anh, Vinh Le Ba, Thi Thao Do, Van Kiem Phan, Hai Yen Pham Thi, Long Giang Bach, Manh Hung Tran, Phuong Anh Tran Thi, Young Ho Kim
Summary: A new compound, physalucoside A, along with withanolides and flavonoids, were isolated from the medicinal plantPhysalis angulata. The withanolides were found to be primarily responsible for the anti-inflammatory activity of the plant. This study suggests that withanolides hold promise as candidates for the development of new anti-inflammatory drugs.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Gi Ho Lee, Ji Yeon Kim, Sun Woo Jin, Thi Hoa Pham, Jin Song Park, Chae Yeon Kim, Jae Ho Choi, Eun Hee Han, Young Ho Kim, Hye Gwang Jeong
Summary: Inflammatory diseases are caused by excessive inflammation triggered by pro-inflammatory mediators, while the Nrf2 signaling pathway plays a protective role through regulating antioxidant enzymes. Impressic acid (IPA) isolated from Acanthopanax koreanum showed anti-inflammatory effects by inhibiting LPS-induced cytokines and ROS production, and activating the Nrf2 pathway in macrophages. This suggests that IPA has potential for preventing inflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jae Ho Choi, Gi Ho Lee, Sun Woo Jin, Ji Yeon Kim, Yong Pil Hwang, Eun Hee Han, Young Ho Kim, Hye Gwang Jeong
Summary: The lupane-type triterpenoid Impressic acid (IPA) showed suppressive effects on AD-like skin symptoms induced by DNCB in mice, reducing serum IgE and TSLP concentrations, as well as mRNA levels of related genes. IPA also inhibited certain signaling pathways in cells and reduced inflammatory responses in ear tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Yoo Kyong Han, Ji Sun Lee, Seo Young Yang, Ki Yong Lee, Young Ho Kim
Summary: Compounds isolated from Lycopus lucidus, such as methyl rosmarinate, martynoside, dimethyl lithospermate, and 9 '' methyl lithospermate, showed significant inhibitory activity against sEH, making them potential candidates for further development in cardiovascular disease prevention and treatment.
Article
Biochemical Research Methods
Dan Gao, Jin Hyeok Kim, Le Ba Vinh, Eun-Young Seo, Seo Young Yang, Chong Woon Cho, Young Ho Kim, Kyung Tae Kim, Jaehoon Sim, Jong Seong Kang
Summary: The utilization of heat treatment and citric acid treatment to process ginseng flowers can convert polar ginsenosides into rare ginsenosides, improving their biological activities. Combining these two methods can significantly increase the content of less-polar ginsenosides, highlighting the potential for functional food applications.
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Dan Gao, Chong Woon Cho, Le Ba Vinh, Jin Hyeok Kim, Young Ho Kim, Jong Seong Kang
Summary: The chemical compositions of trifoliate orange changed greatly during the fermentation process. The HPLC-DAD-ESI-MS/MS technique was successfully applied to screen and identify the unknown constituents, providing a reliable method for quality control of fermented products. Multivariate statistical analysis helped classify the trifoliate oranges and Partial Least Square Discriminate Analysis was more suitable for accurate discrimination based on different chemical patterns in test samples.
ACTA CHROMATOGRAPHICA
(2021)
Article
Plant Sciences
Yu Juan Chai, Younghoon Go, Hai Qi Zhou, Hong Xu Li, Sun Joo Lee, Yeo Jin Park, Wahyu Widowatib, Rizal Rizal, Young Ho Kim, Seo Young Yang, Wei Li
Summary: Three undescribed bicyclo[3.2.1]octanoid neolignan glucosides, along with a known neolignan, were isolated from Piper crocatum leaves. Their chemical structures were elucidated through spectroscopic analyses and compared with previous data. Two compounds showed strong inhibitory effects against pyruvate dehydrogenase E1 alpha S300 phosphorylation in comparison to the positive control.
Article
Biochemistry & Molecular Biology
Jang Hoon Kim, Ji Su Park, Yun Ji Lee, Sena Choi, Young Ho Kim, Seo Young Yang
Summary: A novel compound and nine known compounds were isolated from the root bark of Ulmus davidiana, and tested for inhibitory activity on soluble epoxide hydrolase (sEH). Compound 2 was identified as a potential sEH inhibitor both in vitro and in silico, and further molecular dynamics study revealed detailed interaction signals with the enzyme. Compound 2 shows promise for development as a new sEH inhibitor from natural plants.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)