Article
Oncology
Feng Li, Syeda Qasim, Dapeng Li, Q. Ping Dou
Summary: In-depth insights on cancer biology have highlighted the important roles of epigenetic mechanisms in tumorigenesis. Targeting the cancer epigenome with epi-drugs, including phytochemicals like EGCG, offers promising strategies for cancer chemoprevention and therapy. However, there are limitations to using EGCG as an epigenetic modulator in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Review
Biochemistry & Molecular Biology
Daniela Mokra, Jana Adamcakova, Juraj Mokry
Summary: This article reviews the biological effects of (-)-Epigallocatechin-3-gallate (EGCG) in respiratory diseases, including antioxidant, anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic effects. EGCG may be beneficial in respiratory diseases through modulation of various intracellular signaling cascades.
Review
Food Science & Technology
Chunpeng Wan, Jian Ouyang, Mingxi Li, Kannan R. R. Rengasamy, Zhonghua Liu
Summary: Diabetes mellitus is a major non-communicable disease with high mortality rates and economic burden. Green tea extract (GTE) and epigallocatechin-3-O-gallate (EGCG) found in green tea have shown promising results in managing diabetes by acting as potent antioxidants. The beneficial effects of green tea and its catechins, particularly EGCG, make it an attractive pharmacological agent for treating diabetes and its complications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Andrade, Joana Angelica Loureiro, Maria Carmo Pereira
Summary: The study evaluated the interaction of green tea extract (GTE) with liposomes as in vitro biomembrane models. Results showed that GTE has high affinity to the membrane by establishing hydrophobic interactions with non-polar region of phospholipids and electrostatic interactions with polar phospholipid heads, impacting the structure of the biomembrane by increasing its fluidity. Moreover, the findings suggest a direct contribution of EGCG and EGC on the GTE-membrane interaction.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Review
Neurosciences
Luiza Fernandes, Thyago R. Cardim-Pires, Debora Foguel, Fernando L. Palhano
Summary: The accumulation of protein aggregates in human tissues is a hallmark of more than 40 diseases called amyloidoses, with seven of them being associated with neurodegenerative processes. EGCG, a natural compound found in green tea, has shown potential in inhibiting protein aggregation, reducing toxicity, and remodeling fibril structures in neurodegenerative diseases such as AD, PD, and HD.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Sze Wan Hung, Yiran Li, Xiaoyan Chen, Kai On Chu, Yiwei Zhao, Yingyu Liu, Xi Guo, Gene Chi-Wai Man, Chi Chiu Wang
Summary: Green tea, with its main component EGCG, shows potential in suppressing reproductive cancers by regulating autophagy and other cellular processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Pawel Bakun, Dariusz T. Mlynarczyk, Tomasz Koczorowski, Magdalena Cerbin-Koczorowska, Ludwika Piwowarczyk, Emil Kolasinski, Maciej Stawny, Joanna Kuzminska, Anna Jelinska, Tomasz Goslinski
Summary: Epigallocatechin gallate (EGCG), a polyphenol found in green tea, has potential anticancer and neurodegenerative disease protective effects. However, its bioavailability is limited due to chemical instability and poor absorption, resulting in its current use as a dietary supplement rather than medication.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Food Science & Technology
Klaus W. Lange, Katharina M. Lange, Yukiko Nakamura
Summary: Alzheimer's disease is a global public health challenge with no effective treatment available. Research suggests that bioactive components in green tea may have preventive effects against AD, but clinical evidence is insufficient to support this claim.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Medicine, Research & Experimental
Atala B. Jena, Umesh C. Dash, Asim K. Duttaroy
Summary: This study investigated the interaction between curcumin and EGCG, plant-derived compounds, with NLRP3 complex using in silico approach. The results showed that curcumin and EGCG had higher binding affinity for NLRP3 protein compared to other complex proteins, suggesting their potential impact on the complex's function. Protein-protein interaction studies further confirmed the efficacy of these compounds in hindering the formation of NLRP3 complex. The therapeutic effect of curcumin and EGCG may be mediated by preventing the development of the NLRP3 complex.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
John M. Starbuck, Sergi Llambrich, Ruben Gonzalez, Julia Albaiges, Anna Sarle, Jens Wouters, Alejandro Gonzalez, Xavier Sevillano, James Sharpe, Rafael De La Torre, Mara Dierssen, Greetje Vande Velde, Neus Martinez-Abadias
Summary: The study found that in the DS mouse model, low doses of GTE-EGCG were beneficial for improving facial skeletal morphology, while early supplementation of EGCG in DS children was associated with reduced facial dysmorphology. However, high doses of GTE-EGCG usage led to increased facial dysmorphology, indicating dose-dependent effects of GTE-EGCG on modulating facial development.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Priscila Baltazar Goncalves, Ana Carolina Renno Sodero, Yraima Cordeiro
Summary: The major bioactive compound EGCG in green tea shows potential for treating neurodegenerative diseases by targeting protein misfolding and aggregation. There is an urgent need to develop effective drugs for these incurable ailments, and EGCG may offer opportunities in drug discovery for NDs.
Article
Biochemistry & Molecular Biology
Paulina Aguilera, Camilo Berrios-Pasten, Marcelo Veloso, Matias Galvez-Silva, Florian Turbant, Rosalba Lagos, Frank Wien, Veronique Arluison, Andres E. Marcoleta
Summary: Epigallocatechin gallate (EGCG), a green tea flavonoid, can interfere with the formation of MccE492 amyloid fibers, resulting in the formation of amorphous aggregates and small oligomers. Although the aggregation process is not completely prevented, EGCG is still an interesting inhibitor of MccE492 and other bacterial amyloids.
Article
Food Science & Technology
Wen-Ting Chen, Meei-Ju Yang, Yi-Wei Tsuei, Tsung-Chen Su, An-Ci Siao, Yow-Chii Kuo, Ling-Ru Huang, Yi Chen, Sy-Jou Chen, Po-Chuan Chen, Ching-Feng Cheng, Hui-Chen Ku, Yung-Hsi Kao
Summary: This study investigates the effect of epigallocatechin gallate (EGCG) on the growth of white and beige preadipocytes by modulating the miR-let-7a and HMGA2 pathways. The results show that EGCG inhibits the growth of 3T3-L1 and D12 preadipocytes, upregulates miR-let-7a expression, and downregulates HMGA2 mRNA and protein levels. Overexpression of miR-let-7a and HMGA2 antagonizes the inhibitory effects of EGCG on cell growth. Therefore, EGCG acts on preadipocytes through the miR-let-7a/HMGA2 pathway to inhibit their growth.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
