Review
Geriatrics & Gerontology
Dibyadeep Datta
Summary: Aging rhesus macaques serve as an invaluable model for studying the etiological mechanisms of sporadic Alzheimer's disease (AD) and exploring novel therapeutic strategies. These macaques naturally exhibit amyloid and tau pathology, synaptic dysfunction, and cognitive impairments similar to human AD. Unique molecular mechanisms in the newly evolved primate dorsolateral prefrontal cortex, involving feedforward cyclic adenosine monophosphate (cAMP)-Protein kinase A (PKA)-calcium signaling, play a critical role in higher-order cognition. However, genetic predispositions and age-related insults can exacerbate these signaling pathways and lead to downstream effects, increasing susceptibility to atrophy.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Danton H. O'Day
Summary: Calmodulin and various calmodulin-binding proteins play a role in the onset and progression of Alzheimer's disease. Calcium-dependent proteins such as A beta PP1, BACE1, PSEN-1, BIN1, and TREM2 are involved, along with classic calmodulin-binding proteins like CaMKII and CaN. The binding of A beta and A beta o to calmodulin and A beta receptors adds complexity to our understanding of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Pierandrea Mirino, Anna Pecchinenda, Maddalena Boccia, Adriano Capirchio, Fabrizia D'Antonio, Cecilia Guariglia
Summary: The cerebellum, despite its homogeneous structure and general association with motor functions, also contributes to various cognitive functions such as spatial navigation. Degeneration of the brainstem and reduction of neurons connected to the inferior olivary nucleus in early Alzheimer's disease may impact the modulatory functions of the cerebellum, leading to subtle alterations in spatial navigation abilities of patients.
Article
Psychiatry
Samuel J. Dienel, Kenneth N. Fish, David A. Lewis
Summary: A study found that mRNA levels of somatostatin (SST) and parvalbumin (PV) are lower in the dorsolateral prefrontal cortex (DLPFC) in schizophrenia. It is unclear whether this is due to lower transcript levels per neuron or fewer neurons. Distinguishing between these possibilities is crucial for understanding DLPFC dysfunction in schizophrenia and developing new treatments.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Manon Callens, Nina Kraskovskaya, Kristina Derevtsova, Wim Annaert, Geert Bultynck, Ilya Bezprozvanny, Tim Vervliet
Summary: The Bcl-2 protein family plays crucial roles in cellular health and neuronal function, with involvement in regulating apoptosis and Ca2+ signaling. Dysregulation of Bcl-2 proteins may contribute to the progression of neurodegenerative diseases like Alzheimer's, suggesting a potential therapeutic target in the treatment of AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Neurosciences
Ivan Fernandez Bessone, Jordi Navarro, Emanuel Martinez, Karina Karmirian, Mariana Holubiec, Matias Alloatti, Livia Goto-Silva, Cayetana Arnaiz Yepez, Daniel Martins-de-Souza, Juliana Minardi Nascimento, Luciana Bruno, Trinidad M. Saez, Stevens K. Rehen, Tomas L. . Falzone
Summary: Increased activity of DYRK1A may play a role in the abnormal metabolism of APP, and it regulates the intracellular distribution of APP in neurons by affecting axonal transport. These findings provide insights into the potential therapeutic intervention of using DYRK1A inhibitors to restore APP axonal transport in Down's syndrome and Alzheimer's disease.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Huiling Gao, Wei Zheng, Cheng Li, He Xu
Summary: Studies have shown that ApoE2 and ApoE3 can significantly attenuate H2O2-induced neuronal apoptosis, while ApoE4 has no neuroprotective effect and may even have a toxic effect. ApoE2 and ApoE3 regulate the Akt/FoxO3a/Bim signaling pathway in the presence of H2O2 to exert their effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Liang Wang, Wenjuan Zhou, Hongru Yang, Feng Liu, Ying Kong, Wenhan Wang, Hang Zhao, Wenjun Ma, Yuanhua Sang, Fan Yi, Hong Liu, Chao Liu, Aijun Hao, Jichuan Qiu
Summary: Alzheimer's disease (AD) is characterized by the loss of cholinergic neurons in the mesopontine area, and there is currently no effective method to repair these damaged neurons. Neural stem cell (NSC)-based therapy is a promising approach for AD treatment, but directing NSCs to differentiate into cholinergic neurons is challenging. This study synthesized calcium folate (CaFO) nanoparticles to promote the differentiation of NSCs into functional cholinergic neurons. The experiments demonstrated that under the stimulation of CaFO nanoparticles, NSCs differentiated into cholinergic neurons within 5 days. Animal experiments also showed that CaFO nanoparticles improved the cognitive memory ability of AD mice by promoting neuronal differentiation of NSCs. This study provides a new strategy for the treatment of AD by inducing the quick differentiation of NSCs into functional cholinergic neurons.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yanxing Yang, Sharareh Jalali, Bradley L. Nilsson, Cristiano L. Dias
Summary: The study found that electrostatic and hydrophobic interactions play important roles in the peptide-bilayer binding process. Peptides are strongly attracted to anionic lipid bilayers due to electrostatic interactions between positive residues and negative phosphate moieties. However, the presence of calcium ions significantly reduces the binding of peptides to the bilayer.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Mathematical & Computational Biology
Devanshi D. Dave, Brajesh Kumar Jha
Summary: This study focuses on the problem of higher calcium concentration in neurons which may lead to Alzheimer's Disease. A three-dimensional mathematical model is formulated to depict the changes in calcium levels within cells. Results show that replenishing buffers can balance cell calcium levels and have a positive effect on Alzheimer's affected cells.
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
(2021)
Article
Clinical Neurology
Qun Yao, Fanyu Tang, Yingying Wang, Yixin Yan, Lin Dong, Tong Wang, Donglin Zhu, Minjie Tian, Xingjian Lin, Jingping Shi
Summary: This study investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive processing in patients with Alzheimer's disease. The results show that rTMS applied to the cerebellum improves cognitive functions and modulates cerebello-cerebral functional connectivity. The findings suggest that bilateral cerebellum rTMS may be a promising non-invasive treatment for cognitive dysfunction in AD patients.
Review
Biochemistry & Molecular Biology
Joana Poejo, Jairo Salazar, Ana M. Mata, Carlos Gutierrez-Merino
Summary: This study addresses the implications of Aβ-CaM complexation in the formation of neurotoxic Aβ oligomers, the alteration of intracellular calcium homeostasis induced by Aβ, and the dysregulation of calcium-dependent neuronal activity and excitability induced by Aβ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Jinli Geng, Yingjun Tang, Zhen Yu, Yunming Gao, Wenxiang Li, Yitong Lu, Bo Wang, Huiming Zhou, Ping Li, Nan Liu, Ping Wang, Yubo Fan, Yaxiong Yang, Zengcai Guo, Xiaodong Liu
Summary: GCaMP-X performs well in chronic calcium imaging, causing less damage to neurons compared to traditional GCaMP. Its expression allows researchers to observe spontaneous and global calcium oscillations, with less impact on neural development and neuronal health.
Article
Clinical Neurology
Hang Yu, Manli Wang, Qiu Yang, Xiaojiao Xu, Rong Zhang, Xi Chen, Weidong Le
Summary: We propose that there may be alterations in the cerebellar electrophysiology and sleep-wake cycles at the early stage of Alzheimer's disease (AD), before the appearance of amyloid-beta neuropathological hallmarks. The characteristics of cerebellar electrophysiology could potentially serve as a biomarker for the prepathological detection of AD. Sleep disturbances are common in preclinical AD patients, and the structure and function of the cerebellum may be altered early on in the disease, suggesting its possible involvement in the progression of AD.
ALZHEIMERS & DEMENTIA
(2022)
Review
Biochemistry & Molecular Biology
Alexander V. Blagov, Andrey V. Grechko, Nikita G. Nikiforov, Evgeny E. Borisov, Nikolay K. Sadykhov, Alexander N. Orekhov
Summary: Mitochondrial dysfunction is recognized as a contributor to neurodegenerative diseases, including Alzheimer's disease. The accurate dynamics of mitochondria are crucial for their complex functions, and disruption of these dynamics may play a key role in the pathogenesis of AD. Improving mitochondrial dynamics and function could provide an alternative treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Legal
Mieszko Olczak, Lukasz A. Poniatowski, Justyna Niderla-Bielinska, Magdalena Kwiatkowska, Dominik Chutoranski, Sylwia Tarka, Teresa Wierzba-Bobrowicz
FORENSIC SCIENCE INTERNATIONAL
(2019)
Review
Medicine, General & Internal
M. Prokopienko, T. Wierzba-Bobrowicz, W. Grajkowska, T. Stepien, M. Sobstyl
Summary: Chordoid meningioma is a rare histopathological type of meningioma, often associated with Castleman's syndrome. Due to its high proliferative index, it exhibits aggressive biological behavior and a high risk of postoperative recurrence. Meticulous histopathological examination is crucial for determining an adequate postoperative treatment plan.
NIGERIAN JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Stepien, Janusz Heitzman, Teresa Wierzba-Bobrowicz, Pawel Gosek, Pawel Krajewski, Agnieszka Chrzczonowicz-Stepien, Jaroslaw Berent, Tomasz Jurek, Filip Bolechala
Summary: This study discussed the neuropathological characteristics of murder-suicides, revealing neurodegenerative changes in the brains of these suicide killers. The presence of these neurodegenerative changes at such a young age in some murderers may indicate preclinical lesions affecting cognitive functions and associated with depressed moods.
Article
Cell Biology
Monika Bijata, Ewa Baczynska, Franziska E. Mueller, Krystian Bijata, Julia Masternak, Adam Krzystyniak, Bernadeta Szewczyk, Marcin Siwiec, Svitlana Antoniuk, Matylda Roszkowska, Izabela Figiel, Marta Magnowska, Krzysztof H. Olszynski, Agnieszka D. Wardak, Adam Hogendorf, Blazej Ruszczycki, Nataliya Gorinski, Josephine Labus, Tomasz Stepien, Sylwia Tarka, Andrzej J. Bojarski, Krzysztof Tokarski, Robert K. Filipkowski, Evgeni Ponimaskin, Jakub Wlodarczyk
Summary: This study investigates the impact of 5-HT7R/MMP-9 signaling and dendritic spine plasticity on major depressive disorder. The results show that activation of 5-HT7R and chronic stress both negatively affect dendritic spine elongation and density in the hippocampus, which are associated with depressive-like behavior.
Article
Cell Biology
Tomasz Stepien, Sylwia Tarka, Natalia Chmura, Michal Grzegorczyk, Albert Acewicz, Paulina Felczak, Teresa Wierzba-Bobrowicz
Summary: Infection with SARS-CoV-2 leads to neurological and psychiatric symptoms due to inflammation and hypoxia in key brain regions. The mechanisms behind these symptoms are largely unknown. A study comparing COVID-19 patients with a control group found a decrease in neuronal progenitor cells and newborn neurons in the infected group. The COVID-19 patients also showed increased microglial activation. The inflammatory response caused by COVID-19 negatively affects adult neurogenesis through increased cytokine concentration.
Article
Neurosciences
Leszek Lombarski, Przemyslaw Kunert, Sylwia Tarka, Tomasz Stepien, Dominik Chutoranski, Slawomir Kujawski, Andrzej Marchel
Summary: This study aimed to identify the morphological and histological determinants for low wall strength in unruptured saccular intracranial aneurysms (sIAs). The results showed that larger sIAs may be at a higher risk of rupture. Histological analysis revealed that hyalinization corresponds to the weakened regions of the sIA wall.
FOLIA NEUROPATHOLOGICA
(2022)
Review
Neurosciences
Albert Acewicz, Tomasz Stepien, Paulina Felczak, Sylwia Tarka, Teresa Wierzba-Bobrowicz
Summary: Transactive response DNA binding protein of 43 kDa (TDP-43) plays a crucial role in several neurodegenerative diseases and can be present in other neuropathologies as well. This article discusses the occurrence and morphology of TDP-43 pathology in common neurodegenerative diseases, while a follow-up article will focus on rare neurodegenerative diseases or neurological diseases with nondegenerative etiology.
FOLIA NEUROPATHOLOGICA
(2022)
Review
Psychiatry
Tomasz Stepien
Summary: Adult human brain neurogenesis involves the division, differentiation, and integration of new neurons, which are regulated by internal and external factors. Inflammation may stimulate neurogenesis, but chronic brain inflammation can hinder the process. Restoring the balance between dying and emerging neurons is crucial for treating neurodegenerative diseases.
POSTEPY PSYCHIATRII I NEUROLOGII
(2021)
Article
Pathology
Paulina Felczak, Agnieszka Cudna, Beata Blazejewska-Hyzorek, Julia Buczek, Iwona Kurkowska-Jastrzebska, Tomasz Stepien, Albert Acewicz, Teresa Wierzba-Bobrowicz
Summary: Our study found that patients with a mutation in the NOTCH3 gene, accompanied by type II diabetes/impaired glucose metabolism, may experience increased damage to small blood vessels, modifying the pathogenesis of CADASIL.
POLISH JOURNAL OF PATHOLOGY
(2021)
Article
Neurosciences
Albert Acewicz, Teresa Wierzba-Bobrowicz, Lukasz Michalowski, Mariola Pecak, Sylwia Tarka, Dominik Chutoranski, Tomasz Stepien, Paulina Felczak, Katarzyna Sklinda, Anna Nasierowska-Guttmejer, Malgorzata Dorobek
Summary: This case report presents an RA-associated encephalomyelitis confirmed by post-mortem neuropathological examination. Despite intensive treatment, the patient did not survive, and the neuropathological findings supported the diagnosis of encephalomyelitis.
FOLIA NEUROPATHOLOGICA
(2021)
Article
Neurosciences
Sylwia Tarka, Milena Laure-Kamionowska, Teresa Wierzba-Bobrowicz, Katarzyna Witulska, Elzbieta Ciara, Krystyna Szymanska, Pawel Krajewski, Tomasz Stepien, Albert Acewicz, Paulina Felczak
FOLIA NEUROPATHOLOGICA
(2020)
Letter
Pathology
Paulina Felczak, Iwona Stepniak, Pawel Kowalski, Tomasz Stepien, Teresa Wierzba-Bobrowicz
POLISH JOURNAL OF PATHOLOGY
(2019)
Article
Neurosciences
Mieszko Olczak, Lukasz Poniatowski, Magdalena Kwiatkowska, Dorota Samojlowicz, Sylwia Tarka, Teresa Wierzba-Bobrowicz
FOLIA NEUROPATHOLOGICA
(2019)
Article
Neurosciences
Tomasz Stepien, Sylwia Tarka, Dominik Chutoranski, Paulina Felczak, Albert Acewicz, Teresa Wierzba-Bobrowicz
FOLIA NEUROPATHOLOGICA
(2018)
Article
Neurosciences
Anna Pietrzak, Magdalena Badura-Stronka, Tiia Kangas-Kontio, Paulina Felczak, Wojciech Kozubski, Anna Latos-Bielenska, Teresa Wierzba-Bobrowicz, Jolanta Florczak-Wyspianska
FOLIA NEUROPATHOLOGICA
(2019)