Article
Biochemistry & Molecular Biology
Mustafa Genco Erdem, Ozge Unlu, Fatma Ates, Denizhan Karis, Mehmet Demirci
Summary: The study found that the oral microbiota of male patients with treated and untreated hyperthyroidism differ, while the treatment method has no impact on the oral microbiota. By conducting extensive multicenter studies to identify the core oral microbiota and long-term monitoring of hyperthyroidism, important data for understanding the pathogenesis of the disease may be obtained.
Article
Endocrinology & Metabolism
Xiao Jiang, Xinyu Zhao, Xiaotong Gu, Tao Luo, Pengqian Li, Chuchu Wan, Haixia Liu
Summary: Hashimoto's thyroiditis, an autoimmune disease, is associated with an increased risk of hypothyroidism. Metabolomics was applied to analyze 21 metabolites in Hashimoto's thyroiditis, revealing the impact of phospholipids and different metabolic pathways in the pathogenesis of the disease. The study suggests the potential of SM, LPC, and PC as biomarkers for identifying patients with Hashimoto's thyroiditis in different clinical stages.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Jiaojiao Yuan, Shuo Qi, Xufan Zhang, Hezheng Lai, Xinyi Li, Xiaoheng Chen, Zhe Li, Simiao Yao, Zhiguo Ding
Summary: This study aimed to investigate the local symptoms of Hashimoto's thyroiditis (HT) and their prevalence. The common local symptoms in HT patients include neck pain, voice changes, throat discomfort, shortness of breath, dysphagia, and goiter-related symptoms. These symptoms should be identified in the clinic and included in the early diagnosis and management of HT.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nikola Ralchev Ralchev, Aleksandar Mishel Markovski, Inna Angelova Yankova, Iliyan Konstantinov Manoylov, Irini Atanas Doytchinova, Nikolina Mihaylova Mihaylova, Alexander Dimitrov Shinkov, Andrey Ivanov Tchorbanov
Summary: This study aims to selectively suppress anti-thyroglobulin IgG antibody-producing B lymphocytes in Hashimoto's thyroiditis patients using a chimeric protein molecule. The results show that this treatment method can reduce B-cell autoreactivity and promote apoptosis in targeted cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Maja Cvek, Dean Kalicanin, Ana Baric, Marko Vuletic, Ivana Gunjaca, Vesela Torlak Lovric, Veselin Skrabic, Ante Punda, Vesna Boraska Perica
Summary: Our study found no significant association between vitamin D and HT, but there may be a slight decrease in vitamin D levels associated with overt hypothyroidism. A significant correlation was identified between vitamin D and TSH in all HT patients, as well as a correlation between vitamin D and systolic blood pressure in OVERT HT patients.
Review
Nutrition & Dietetics
Filip Lebiedzinski, Katarzyna Aleksandra Lisowska
Summary: Hashimoto's thyroiditis (HT) is an autoimmune disease affecting the thyroid gland and often requires lifelong treatment. Vitamin D deficiency is associated with a higher prevalence of thyroid autoimmunity, and vitamin D supplementation shows promise in reducing antibody levels and improving thyroid function in HT patients. Studies suggest that vitamin D may impact various immune mechanisms and improve clinical outcomes, but further research is needed.
Review
Immunology
Alessio Mazzieri, Pia Montanucci, Giuseppe Basta, Riccardo Calafiore
Summary: In Hashimoto's thyroiditis, the genetic basis, particularly the HLA genes, play a significant role in the development of the disease. Other genes and transcription factors, including BACH2, are also involved in the autoimmune background of HT. The interaction between these genes and environmental factors leads to autoimmunity and ultimately damage to the thyroid gland. The role of Th17 and Treg cells in HT is still not well-defined compared to Th1 cells and cytotoxic lymphocytes. imbalanced Th17/Treg ratio serves as a prognostic factor for gland damage. Genetic panels and immunotherapy may provide better targeted treatment and preventive interventions for individuals with potential or early stage HT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Shi Tang, Min Yang, Dan Zhang, Ya-fie Tong, Ying Xin
Summary: Analyzing the clinical characteristics of Hashimoto's thyroiditis in children below 3 years of age revealed that most patients presented with hypothyroidism or subclinical hypothyroidism at initial diagnosis. Children with global developmental delay require continuous screening to detect HT-induced hypothyroidism. Thyroxine replacement can partially alleviate hypothyroid clinical manifestations, emphasizing the importance of early diagnosis and treatment for improving patient prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
A. P. Weetman
Summary: Recent studies have provided new insights into the genetic, environmental, and pathogenic mechanisms of HT, including the identification of multiple cytokine networks, various defects in T regulatory cells, and possible disease associations. Additionally, there is growing evidence suggesting a direct role of the autoimmune process in causing persistent symptoms in a subset of patients with levothyroxine-treated HT.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
B. Sigman, D. F. Linder, J. L. Waller, W. B. Bollag, S. L. Baer, S. Tran, M. Kheda, L. Young, A. Mohammed, C. M. Isales, B. Siddiqui
Summary: The purpose of this study is to examine the association of Hashimoto's thyroiditis (HT) with the risk of renal transplant failure. The results showed that patients with HT had a significantly increased risk of renal transplant failure. These findings suggest that thyroid health and HT may play a significant role in the development of increased risk of renal transplant failure.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Aniceta A. Mikulska, Marta Karazniewicz-Lada, Dorota Filipowicz, Marek Ruchala, Franciszek K. Glowka
Summary: This article provides an overview of the metabolic profile, effectiveness of micronutrient supplementation, and impact of dietary management in patients with Hashimoto's thyroiditis (HT). The review includes recent literature such as randomized controlled trials, meta-analyses, and clinical trials. Many HT patients experience excess body weight, metabolic disorders, and reduced quality of life. The role of vitamin D, selenium, and other nutrients is still debated, and there is currently no specific recommended diet for HT patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Christian Zinck Jensen, Jeppe Lerche la Cour, Torquil Watt, Jorgen Kim Kanters, Henrik Enghusen Poulsen, Jens Faber, Christina Ellervik, Birte Nygaard
Summary: This study found that patients receiving LT4 treatment had an increased prevalence of antidepressant use, rather than those with TPOAb positivity. The results do not support thyroid autoimmunity as a significant factor for antidepressant use in patients receiving LT4 treatment.
Article
Endocrinology & Metabolism
Sara Csiha, Istvan Molnar, Sandor Halmi, David Hutkai, Hajnalka Lorincz, Sandor Somodi, Monika Katko, Mariann Harangi, Gyorgy Paragh, Endre V. Nagy, Eszter Berta, Miklos Bodor
Summary: The levels of advanced glycation end products (AGEs) in the serum of patients with Hashimoto thyroiditis (HT) are lower, and soluble RAGE (sRAGE) can reduce the interaction between AGEs and their receptor in a competitive manner, which is beneficial for thyroid function balance in patients. Further research is needed to confirm these results.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Psychiatry
Celeste Lipkes, Shanzay Haider, Ali Rashid, Gustavo A. Angarita, Sarah Riley
Summary: This case report highlights the importance of thorough medical workup for new onset psychosis, particularly in cases related to hypothyroidism. It also emphasizes the need for further consensus in the literature regarding choice of antipsychotic and duration of treatment for psychosis secondary to hypothyroidism.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Rosaria Maddalena Ruggeri, Salvatore Giovinazzo, Maria Cristina Barbalace, Mariateresa Cristani, Angela Alibrandi, Teresa M. Vicchio, Giuseppe Giuffrida, Mohamed H. Aguennouz, Marco Malaguti, Cristina Angeloni, Francesco Trimarchi, Silvana Hrelia, Alfredo Campenni, Salvatore Cannavo
Summary: The study found that individuals with Hashimoto's thyroiditis had higher intake frequencies of animal foods compared to controls, while controls reported higher intake frequencies of plant foods. Meat consumption was associated with increased odds of developing thyroid autoimmunity, while adherence to Mediterranean diet traits was protective. In Hashimoto's thyroiditis subjects, markers of oxidative stress were significantly higher and antioxidant activity was lower, indicating a condition of oxidative stress.
Article
Endocrinology & Metabolism
Krzysztof Lewandowski, Monika Gluchowska, Karolina Garnysz, Wojciech Horzelski, Mariusz Grzesiak, Andrzej Lewinski
Summary: Healthy first-trimester pregnant women may demonstrate similar or greater insulin resistance than women with PCOS, and this is accompanied by a high prevalence of early gestational diabetes. Further research is needed to determine the importance of gestational diabetes screening in the first trimester.
ENDOKRYNOLOGIA POLSKA
(2022)
Article
Immunology
Magdalena Stasiak, Katarzyna Zawadzka-Starczewska, Andrzej Lewinski
Summary: This study presents two cases of subacute thyroiditis (SAT) triggered by mRNA-based COVID-19 vaccines, suggesting a possible association between HLA profiles and SAT susceptibility. The occurrence of SAT after vaccination may be HLA-dependent and related to the presence of specific HLA genes. This hypothesis aligns with the proposed mechanism of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and its association with HLA-based genetic susceptibility.
Article
Medicine, General & Internal
Paulina Cegla, Marta Wojewodzka, Izabela Gorczewska, Wioletta Chalewska, Grazyna Lapinska, Pawel Ochman, Agata Sackiewicz, Marek Dedecjus
Summary: This study aimed to identify the optimal PSA cut-off value for assessing disease extent in [Ga-68]Ga-PSMA-11 PET/CT study in patients after radical prostatectomy. Retrospective analysis on 215 patients revealed that PSA level plays a crucial role in determining disease extent, with specific cut-off values helpful in stratifying oligo- and polymetastatic diseases.
Article
Oncology
Alan L. Ho, Marek Dedecjus, Lori J. Wirth, R. Michael Tuttle, William B. Inabnet, Jan Tennvall, Fernanda Vaisman, Lars Bastholt, Andrew G. Gianoukakis, Patrice Rodien, Ralf Paschke, Rossella Elisei, David Viola, Karen So, Danielle Carroll, Tina Hovey, Bhavana Thakre, James A. Fagin
Summary: This study investigated whether adding Selumetinib to adjuvant RAI improves complete remission rates in patients with DTC at high risk of primary treatment failure. The results showed that Selumetinib did not significantly increase the CR rate 18 months after RAI, and treatment-related adverse events were minimal.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Genetics & Heredity
Lena Rutkowska, Kinga Salacinska, Dominik Salachna, Pawel Matusik, Iwona Pinkier, Lukasz Kepczynski, Malgorzata Piotrowicz, Ewa Starostecka, Andrzej Lewinski, Agnieszka Gach
Summary: This study used next generation sequencing to identify disease-causing mutations in FH-related and candidate genes. The researchers found pathogenic and possibly pathogenic variants in several genes, including a novel mutation in the LDLR gene. These findings expand our understanding of FH-related variants and are valuable for genetic counseling in patients with the disease.
Article
Oncology
Laura D. Locati, Elena Colombo, Marek Dedecjus, Christelle de la Fouchardiere, Ward Sents, Massimo Bongiovanni, Romana Netea-Maier
Summary: Anaplastic thyroid carcinoma (ATC) is a rare and deadly cancer, and there are challenges in prescribing novel treatments in Europe as they haven't been licensed for ATC yet. Patients manage to receive these drugs through alternative ways. An investigation showed disparities in access to new treatments, and it emphasized the urgent need for access to cutting-edge therapies and the feasibility of clinical trials.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Nutrition & Dietetics
Pawel Pludowski, Beata Kos-Kudla, Mieczyslaw Walczak, Andrzej Fal, Dorota Zozulinska-Ziolkiewicz, Piotr Sieroszewski, Jaroslaw Peregud-Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewinski, Robert Spaczynski, Miroslaw Wielgos, Jaroslaw Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchala, Arkadiusz Zygmunt, Mieczyslaw Szalecki, Artur Bossowski, Justyna Czech-Kowalska, Marek Wojcik, Beata Pyrzak, Michal A. Zmijewski, Pawel Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spirydon N. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski
Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.
Article
Biochemistry & Molecular Biology
Mariola Swiderek-Matysiak, Magdalena Oset, Malgorzata Domowicz, Grazyna Galazka, Magdalena Namiecinska, Mariusz Stasiolek
Summary: A study analyzed 242 cerebrospinal fluid samples from patients with T2-hyperintensive lesions on brain MRI. The levels of IL-6, osteopontin, and neurofilaments light chain were found to be significantly different among groups, but their diagnostic power for differentiating multiple sclerosis from other inflammatory CNS disorders was weak.
Article
Biochemistry & Molecular Biology
Katarzyna Malicka, Wojciech Horzelski, Andrzej Lewinski, Krzysztof C. C. Lewandowski
Summary: The study results indicate that AVP is not crucial in the stimulation of ACTH-cortisol, but it may play an important role in GH secretion.
Article
Nutrition & Dietetics
Magdalena Basinska-Lewandowska, Krzysztof Lewandowski, Wojciech Horzelski, Andrzej Lewinski, Elzbieta Skowronska-Jozwiak
Summary: The study found a correlation between 25OHD concentrations below 12 ng/mL and an increased risk of COVID-19 infection. However, no significant increase in infection risk was observed for individuals with 25OHD concentrations above 20 ng/mL.
Article
Genetics & Heredity
Magdalena Stasiak, Katarzyna Zawadzka-Starczewska, Boguslaw Tymoniuk, Bartlomiej Stasiak, Andrzej Lewinski
Summary: The risk of GO is higher in patients with elevated TC and/or LDL cholesterol, and this risk is associated with specific HLA alleles. The study investigated the relationship between TC/LDL levels and the presence of GO-related HLA alleles in GD patients. The results showed a correlation between the high-risk HLA alleles (HLA-B*37:01 and C*03:02) and higher TC/LDL levels, as well as lower TC levels in alleles associated with non-GO GD (HLA-C*17:01 and B*08:01).
Article
Medicine, General & Internal
Anna Lupinska, Sara Aszkielowicz, Grzegorz Zielinski, Renata Stawerska, Andrzej Lewinski
Summary: Cushing's disease is extremely rare in children and this report presents a case of a 16-year-old boy with CD who initially experienced spinal pain and vertebral fractures. After diagnostic tests, CD was confirmed based on cortisol profile results, dexamethasone suppression tests, and bilateral sampling during catheterization of the inferior petrosal sinuses.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Environmental Sciences
Katarzyna Wojciechowska-Durczynska, Arkadiusz Zygmunt, Marta Mikulak, Marta Ludwisiak, Andrzej Lewinski
Summary: Gorham-Stout disease is a rare and life-threatening condition characterized by lymphatic vessel proliferation and bone loss. No standard treatment has been determined and the available therapies have varying effectiveness and significant side effects. We report the first case of an adult Polish patient with Gorham-Stout disease and the use of combined treatment with sirolimus and zoledronic acid.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Endocrinology & Metabolism
Malgorzata Karbownik-Lewinska, Jan Stepniak, Paulina Iwan, Andrzej Lewinski
Summary: Excess iodine can interfere with thyroid hormone synthesis and act as a potential endocrine-disrupting chemical through oxidative stress. It is important to be cautious with iodine intake to avoid negative effects on thyroid physiology.
Article
Medicine, General & Internal
Ewa Placzkiewicz-Jankowska, Leszek Czupryniak, Grzegorz Gajos, Andrzej Lewinski, Marek Ruchala, Magdalena Stasiak, Krzysztof Strojek, Ewelina Szczepanek-Parulska, Mariusz Wylezol, Lucyna Ostrowska, Piotr Jankowski
Summary: Obesity is a chronic disease that has a significant impact on health. The goal of obesity treatment is to reduce the associated risks and achieve long-term weight reduction. However, medical treatment alone cannot solve the problem of obesity, and preventive measures at the population level are necessary.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2022)
