Modeling Huntington disease inDrosophila

Huntingtin Aggregation Kinetics and Their Pathological Role in a Drosophila Huntington’s Disease Model

(2011) Kurt R. Weiss et al.   GENETICS

Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation

(2011) L. S. Havel et al.   HUMAN MOLECULAR GENETICS

Kinase inhibitors modulate huntingtin cell localization and toxicity

(2011) Randy Singh Atwal et al.   Nature Chemical Biology

High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model

(2011) Joost Schulte et al.   PLoS One

Towards the Treatment of Polyglutamine Diseases: The Modulatory Role of Protein Context

(2010) A. L. Robertson et al.   CURRENT MEDICINAL CHEMISTRY

PolyQ Disease: Too Many Qs, Too Much Function?

(2010) Ian H. Kratter et al.   NEURON

Formation and Toxicity of Soluble Polyglutamine Oligomers in Living Cells

(2010) Patrick Lajoie et al.   PLoS One

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons

(2009) C. Sinadinos et al.   NEUROBIOLOGY OF DISEASE

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments

(2008) Simon C. Warby et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Suppression of Neurodegeneration and Increased Neurotransmission Caused by Expanded Full-Length Huntingtin Accumulating in the Cytoplasm

(2008) Eliana Romero et al.   NEURON

Atrophy and degeneration in sciatic nerve of presymptomatic mice carrying the Huntington's disease mutation

(2007) Anna Wade et al.   BRAIN RESEARCH