Double vision Pigment genes do more than just color

The use of P element collections led to the discovery of unanticipated effects from common genetic background mutants white, brown and rosy in our previously reported model of tauopathy that expresses full-length human tau in the fly eye, in which mutant rosy suppresses mutant white and brown worsening of tau-induced toxicity.(1) Here we discuss further possible effects of mini-white and evidence for autophagy as a mediator of white enhancement of tau toxicity.