Journal
FLY
Volume 5, Issue 4, Pages 369-370Publisher
LANDES BIOSCIENCE
DOI: 10.4161/fly.5.4.17283
Keywords
balancer chromosomes; Tubby; Drosophila melanogaster
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We generated FM7a and CyO balancer chromosomes bearing a Tubby(1) (Tb(1)) dominant transgene. Flies heterozygous for these FM7a and CyO derivatives exhibit a phenotype undistinguishable from that elicited by the Tb1 mutation associated with the TM6B balancer. We tested two of these Tb-bearing balancers (FM7-TbA and CyO-TbA) for more than 30 generations and found that the Tb1 transgene they carry is stable. Thus, these new Tb-tagged balancers are particularly useful for balancing lethal mutations and distinguish homozygous mutant larvae from their heterozygous siblings.
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