Journal
FLUID PHASE EQUILIBRIA
Volume 320, Issue -, Pages 49-55Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fluid.2012.02.009
Keywords
Naproxen; Solubility; Ethyl acetate plus ethanol mixtures; Solution thermodynamics; Jouyban-Acree model
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By using the van't Hoff and Gibbs equations the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution and of mixing of naproxen (NAP) in some ethyl acetate + ethanol mixtures were evaluated from solubility data determined at several temperatures. By means of enthalpy-entropy compensation analysis, a non linear Delta H-soIn degrees vs. Delta(soIn)G degrees compensation plot with negative and positive slopes was obtained if all the composition intervals are considered. Finally, the Jouyban-Acree model has been applied to correlate the drug solubilities as well as the respective thermodynamic quantities of solution in these solvent mixtures. (C) 2012 Elsevier B.V. All rights reserved.
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