Article
Chemistry, Applied
Rifaldi, Edwin Sukandar, Arif Fadlan, Sri S. Fatmawati, Adi Purnomo, Johanis Wairata, Taslim Ersam
Summary: In our study on antidiabetic agents from Garcinia species, we found that the methanolic extract of G. macrantha A.C.Sm. exhibited significant inhibition of alpha-glucosidase, with 58.20% inhibition in sucrose substrate and 39.86% inhibition in maltose substrate at 100 μg/mL. Further phytochemical investigation led to the discovery of a new biphenyl compound, macrabiphenyl A, which showed weak activity against the enzyme.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biology
Nabil Abdulhafiz Alhakamy, Gamal Abdallah Mohamed, Usama Ahmed Fahmy, Basma Ghazi Eid, Osama Abdelhakim Aly Ahmed, Mohammed Wanees Al-Rabia, Amgad Ibrahim Mansour Khedr, Mohammed Zahid Nasrullah, Sabrin Ragab Mohamed Ibrahim
Summary: Two new benzophenones were purified from the pericarps fraction of Garcinia mangostana and showed significant alpha-amylase inhibitory activity. Docking studies and molecular dynamics simulations further confirmed their potential as alpha-amylase inhibitors.
Review
Environmental Sciences
Muhammad Shahid, Douglas Law, Ahmad Azfaralariff, Mukram M. Mackeen, Teek Foh Chong, Shazrul Fazry
Summary: This paper critically reviews the role of Garcinia atriviridis and its bioactive constituents in the prevention and treatment of different diseases, providing new insights for further research.
Article
Food Science & Technology
Kai Lin Yap, Ianne Kong, Lejaniya Abdul Kalam Saleena, Liew Phing Pui
Summary: The study developed a 3D printed gelatin edible film using glycerol and Garcinia atroviridis extract (GAE), and evaluated its physical, mechanical, and antimicrobial properties.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Article
Food Science & Technology
Lavinia de C. Brito, Andre Mesquita Marques, Flavia da Cunha Camillo, Maria Raquel Figueiredo
Summary: The Garcinia genus, belonging to the Clusiaceae family, has edible fruits with high dietary and economic values. By-products from Garcinia fruits, such as peel and seed, are rich in fibers, proteins, and bioactive metabolites, and can be used to produce flour with similar nutritional value to wheat flour and antioxidant properties. Peel waste from Garcinia mangostana has been utilized as a green absorbent to recover precious metals from electronic waste. Extracts and isolated compounds from Garcinia species, including polyphenols, bioflavonoids, anthocyanins, benzophenones, and xanthones, have shown potential in the treatment of various illnesses, emphasizing adipogenesis, diabetes, cardiovascular illness, and cancer.
Article
Biochemistry & Molecular Biology
Sutin Kaennakam, Edwin R. Sukandar, Pattama Phasuthan, Jantana Yahuafai, Prayumat Onsrisawat, Fadjar Mulya, Vudhichai Parasuk, Preecha Phuwapraisirisan, Santi Tip-pyang
Summary: Ten undescribed polyprenylated benzoylphloroglucinol derivatives named garcowacinols A-J (1-10) and four known analogues (11-14) were isolated from the twigs of Garcinia cowa. Their structures were determined by spectroscopic data analysis, and their absolute configurations were established based on NOESY and ECD data. The isolated compounds were evaluated for their cytotoxicity against human cancer cells, and Garcowacinol C showed significant activity against all five cancer cell lines.
Article
Chemistry, Applied
Nguyen Thi Thu Ha, Nguyen Van Tuyen, Nguyen Thanh Tra, Le Thi Tu Anh, Ninh The Son, Mac Litaudon, Pham Van Cuong, Bui Huu Tai, Phan Van Kiem
Summary: Three new xanthones were isolated from Garcinia mckeaniana stems, and they exhibited weak cytotoxic activity against several cell lines.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Jiri Kos, Tomas Strharsky, Sarka Stepankova, Katarina Svrckova, Michal Oravec, Jan Hosek, Ales Imramovsky, Josef Jampilek
Summary: A series of nature-inspired 3,4,5-trimethoxycinnamates were synthesized and characterized, with some compounds showing inhibitory activity against AChE and BChE, indicating potential pharmaceutical value.
APPLIED SCIENCES-BASEL
(2021)
Article
Plant Sciences
Lei Yang, Dan Zhang, Jia-Bao Li, Xi Zhang, Nan Zhou, Wen-Yue Zhang, Hui Lu
Summary: Two new prenylated xanthones, mangoxanthones A-B (1-2), were isolated from Garcinia mangostana, along with four known compounds. Compound 1 showed moderate inhibitory activities against alpha-glucosidase and alpha-amylase, and molecular docking predicted its binding sites. Initial structure-activity relationship discussions were conducted.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Edwin R. Sukandar, Sutin Kaennakam, Pia Raab, Xuehong Noest, Kitiya Rassamee, Rudolf Bauer, Pongpun Siripong, Taslim Ersam, Santi Tip-pyang, Warinthorn Chavasiri
Summary: Garcinia picrorhiza, a woody plant native to Indonesia, was found to contain 15 phenolic compounds in its stem bark, including newly discovered bioactive molecules with cytotoxic and anti-inflammatory properties. These findings suggest the potential for furanxanthone derivatives as cytotoxic and anti-inflammatory agents for further pharmacological studies.
Article
Biochemistry & Molecular Biology
Edwin R. Sukandar, Sutin Kaennakam, Sutthida Wongsuwan, Jaruwan Chatwichien, Sucheewin Krobthong, Yodying Yingchutrakul, Thanisorn Mahatnirunkul, Fadjar Mulya, Vudhichai Parasuk, David J. Harding, Preeyaporn Poldorn, Thanyada Rungrotmongkol, Santi Tip-pyang, Chanat Aonbangkhen, Warinthorn Chavasiri
Summary: Ten undescribed benzophenones, schomburginones A-J, were isolated from Garcinia schomburgkiana leaves. Their structures were determined using spectroscopic techniques, and their cytotoxic and anti-inflammatory activities were evaluated. These compounds showed promising cytotoxicity against HeLa cells and significant NO inhibitory activity in RAW 264.7 macrophage cells, making them potential candidates for anticancer drug development.
Article
Food Science & Technology
Muhammad Shahid, Shazrul Fazry, Ahmad Azfaralariff, Ahmed Abdul Kareem Najm, Douglas Law, Mukram M. Mackeen
Summary: This study aimed to identify the bioactive compounds and evaluate the antidiabetic and cytotoxic potential of G. atroviridis fruit extract. The extract showed promising inhibitory potential against α-amylase and α-glucosidase enzymes and low cytotoxicity on L6 cells. Furthermore, 18 potent antidiabetic bioactive compounds were identified.
Article
Chemistry, Medicinal
Darwati Darwati, Ayu Nadila Safitri, Nurul Ambardhani, Tri Mayanti, Nurlelasari Nurlelasari, Dikdik Kurnia
Summary: The study identified benzophenone extracted from Garcinia porrecta bark as a potential anticancer agent, displaying potency through blocking ER-α.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Muchtaridi Muchtaridi, Rina Fajri Nuwarda, Emmy Hainida Khairul Ikram, Aisyah Saad Abdul Rahim, Amirah Mohd Gazzali, Habibah A. Wahab
Summary: This study identified a potential neuraminidase inhibitor, garcinia acid, from Garcinia atroviridis. Garicinia acid showed high inhibitory activity against viral neuraminidase and interacted with its associated amino acid residues, suggesting its potential as an anti-influenza drug.
Article
Plant Sciences
Sutin Kaennakam, Edwin Risky Sukandar, Kitiya Rassamee, Pongpun Siripong, Santi Tip-pyang
Summary: Five undescribed polyprenylated benzoylphloroglucinol derivatives (1-5) and five known analogues (6-10) were isolated from Garcinia schomburgkiana branches. Their structures were determined using NMR and HRESIMS analysis. Compound 6 exhibited potent cytotoxicity against five cancer cell lines with IC (50) values ranging from 5.05 to 7.03 μM.
Review
Food Science & Technology
Ting Yi Heung, Jessica Yue Shuen Huong, Wan Yeng Chen, Yi Wen Loh, Kooi Yeong Khaw, Bey-Hing Goh, Yong Sze Ong
Summary: Papaya extracts or their bioactive compounds may serve as a potential broad-spectrum therapy for cancer by targeting multiple characteristics of cancer development.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Maadh Jumaah, Melati Khairuddean, Sohaib Jumaah Owaid
Summary: Acid-responsive fluorescent compounds were prepared by introducing an ortho-hydroxyphenyl to pyrazoline with a benzothiazole backbone. These compounds demonstrated normal fluorescence photoinduced electron transfer (PET) under neutral conditions but showed fluorescence quenching under strongly acidic conditions. The method was also successfully applied to detect trifluoroacetic acid in water samples.
JOURNAL OF FLUORESCENCE
(2022)
Article
Microbiology
Kashvintha Nagarajan, Baharudin Ibrahim, Abdulkader Ahmad Bawadikji, Jun-Wei Lim, Woei-Yenn Tong, Chean-Ring Leong, Kooi Yeong Khaw, Wen-Nee Tan
Summary: Endophytic fungi are microorganisms that colonize living plants' tissues without causing harm. They are a natural source of bioactive metabolites with diverse pharmacological functions. Metabolomics studies of endophytic fungi are relatively unexplored.
Article
Biology
Shereen Lai Shi Min, Sook Yee Liew, Nelson Jeng Yeou Chear, Bey Hing Goh, Wen-Nee Tan, Kooi Yeong Khaw
Summary: Plant-derived terpenes have shown potential as cholinesterase inhibitors, making them a promising target for the treatment of Alzheimer's disease. Various terpenoids have been found to inhibit cholinesterase activity, with their chemical structures playing a role in this inhibition. This research encourages further exploration of terpenes for drug discovery and development in treating Alzheimer's disease.
Review
Fisheries
Joanna Xuan Hui Goh, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Hooi-Leng Ser, Kooi-Yeong Khaw, Vengadesh Letchumanan, Learn-Han Lee, Bey-Hing Goh
Summary: The shrimp farming industry faces challenges of disease and compromised shrimp quality due to high stocking density. Bacterial-derived additives have been widely adopted, particularly in Asia, for disease control. These additives, such as probiotics, synbiotics, paraprobiotics, and postbiotics, modulate the gut microbiota composition and show potential as alternatives to antibiotics. They not only help in disease control but also improve survival rate, enhance immunity, and promote growth. This review consolidates available data and provides a comprehensive overview of the research on bacterial derivatives in the shrimp industry, discussing challenges and future research niches.
REVIEWS IN AQUACULTURE
(2022)
Article
Environmental Sciences
Wei-Yao Chen, Yi Jing Chan, Jun Wei Lim, Chin Seng Liew, Mardawani Mohamad, Chii-Dong Ho, Anwar Usman, Grzegorz Lisak, Hirofumi Hara, Wen-Nee Tan
Summary: This study used artificial neural network (ANN) to predict the output parameters of anaerobic digestion and aerobic process in a commercialized integrated anaerobic-aerobic bioreactor (IAAB) system. The trained ANN models showed high accuracy and good consistency with industrial data. By optimizing the operating conditions, the COD removal and methane yield can be improved. The ANN model can serve as a decision support system for operators to predict the behavior of the IAAB system and address the issue of inconsistent biogas production.
Article
Microbiology
Wen-Nee Tan, Kashvintha Nagarajan, Vuanghao Lim, Juzaili Azizi, Kooi-Yeong Khaw, Woei-Yenn Tong, Chean-Ring Leong, Nelson Jeng-Yeou Chear
Summary: Endophytic fungi Diaporthe fraxini can produce bioactive metabolites with potential pharmacological activities. This study used metabolomics to investigate the variations in metabolomes of D. fraxini grown in different culture media. The supplemented culture medium stimulated the production of metabolites not found in the normal culture medium, and the fungal extract showed antioxidant activity.
Article
Plant Sciences
Mohammad Al-Amin, Nagla Mustafa Eltayeb, Chowdhury Faiz Hossain, Siti Sarah Fazalul Rahiman, Melati Khairuddean, Salizawati Muhamad Salhimi
Summary: This study isolated new and known compounds from the rhizomes of C. aeruginosa and identified several bioactive compounds. Among them, comosone II showed significant inhibition of MDA-MB-231 cell migration and invasion through the inhibition of MMP-9 enzyme.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Joanna Xuan Hui Goh, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Kooi-Yeong Khaw, Nurul-Syakima Ab Mutalib, Ya-Wen He, Bey-Hing Goh, Kok-Gan Chan, Learn-Han Lee, Vengadesh Letchumanan
Summary: The increasing prevalence of carbapenem resistance is a growing concern, and it has been discovered that environmental microbial populations could be indirectly contributing to this resistance. This study aims to explore the carbapenem resistance profile of Vibrio species in various settings and identify the transmission pathways for carbapenem resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Sook Yee Liew, Wen Qi Mak, Hin Yee Thew, Kooi Yeong Khaw, Hazrina Hazni, Marc Litaudon, Khalijah Awang
Summary: Phytochemical investigation on the bark of Nauclea officinalis led to the discovery of a new monoterpenoid indole alkaloid, nauclediol. Its structure was identified through extensive spectroscopic analysis. Nauclediol showed cholinesterase-inhibitory activities against AChE and BChE, with IC50 values of 15.429 and 8.756 μM, respectively. Statistical analysis revealed that nauclediol acts as a non-competitive inhibitor for both AChE and BChE. Molecular docking studies showed that nauclediol interacts with the choline-binding site and the catalytic triad of TcAChE and hBChE. This study also demonstrated the neuroprotective potential of nauclediol against amyloid beta-induced cytotoxicity and LPS-induced neuroinflammation activity in a dose-dependent manner.
Article
Biochemistry & Molecular Biology
Nelson Jeng-Yeou Chear, Tan Ai Fein Ching-Ga, Kooi-Yeong Khaw, Francisco Leon, Wen-Nee Tan, Siti R. R. Yusof, Christopher R. R. McCurdy, Vikneswaran Murugaiyah, Surash Ramanathan
Summary: A new natural oxindole alkaloid, along with two known alkaloids, was discovered in the leaves of Malaysian Uncaria attenuata Korth. The new compound showed strong inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), while the other two compounds selectively inhibited BChE. Molecular docking studies revealed the interaction between the new compound and AChE through both hydrogen and hydrophobic bonding. This research suggests that Uncaria attenuata could be a potential source for bioactive alkaloids in treating age-related dementia.
Article
Biochemistry & Molecular Biology
Muhammad Hafiz Husna Hasnan, Yasodha Sivasothy, Kooi Yeong Khaw, Mohd Azlan Nafiah, Hazrina Hazni, Marc Litaudon, Wan Adriyani Wan Ruzali, Sook Yee Liew, Khalijah Awang
Summary: Studies have been conducted to explore the potential of plant alkaloids, especially those from the Alseodaphne genus, as new drugs for Alzheimer's disease. A new alkaloid, N-methyl costaricine, was isolated from the bark of A. pendulifolia Gamb. and showed promising inhibition of cholinesterase. This compound has the potential to be developed as a new drug for Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
