Journal
FITOTERAPIA
Volume 90, Issue -, Pages 240-246Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2013.07.024
Keywords
Tetrastigma obtectum; Flavonoid; HepG2 glucose consumption; AMPK
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Funding
- Tianjin Research Program of Applied Basic and Cutting-edge Technologies [12JCZDJC25900).]
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Four new flavonoids including three C-glycosidic flavonoids, named tetrastigma A-D (1-4) and five known flavones (5-9) were isolated from the herbs of Tetrastigma obtectum (Wall.) Planch. The structures of 1-4 were elucidated by 1D- and 2D-NMR and HR mass spectrometric methods. Compound 1 caused significant enhancement in glucose consumption by insulin-resistant HepG2 cells compared with control cells. In addition, compound I stimulated phosphorylation of AMPK, which plays an important role in glycometabolism. (C) 2013 Elsevier B.V. All rights reserved.
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