Article
Medicine, Research & Experimental
Kenneth S. Plante, Varun Dwivedi, Jessica A. Plante, Diana Fernandez, Divya Mirchandani, Nathen Bopp, Patricia V. Aguilar, Jun-Gyu Park, Paula Pino Tamayo, Jennifer Delgado, Vinay Shivanna, Jordi B. Torrelles, Luis Martinez-Sobrido, Rick Matos, Scott C. Weaver, K. Jagannadha Sastry, Robert A. Newman
Summary: The study demonstrates the significant inhibitory effects of oleandrin and N. oleander extract PBI-06150 on SARS-CoV-2, showing potent antiviral activity both prophylactically and therapeutically. These findings support the further development of oleandrin and its extracts for potential treatments against COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Rajat Sharma, Swati Singh, Nisha Tewari, Priyankar Dey
Summary: Nerium oleander is a medicinal plant used for the treatment of cancers and hyperglycemia, but its toxic effects can be fatal. The presence of cardiac glycosides causes apoptosis in cancer cells and leads to oleander poisoning. This review analyzes the factors contributing to the dual pharmacological and toxicological role of oleander, with a focus on gut microbial diversity and other factors such as dose, mode of treatment, plant genotypic variations, and environmental effects.
Article
Agriculture, Dairy & Animal Science
Chelsea A. Sykes, Francisco A. Uzal, Asli Mete, Jennine Ochoa, Michael Filigenzi, Robert H. Poppenga, Javier Asin
Summary: Oleander poisoning in horses can be diagnosed postmortem based on changes in the heart and the presence of oleandrin. Kidney lesions have also been observed in multiple mammalian species, but have only been briefly mentioned in horses. This study reviewed cases of spontaneous oleander poisoning in horses and found microscopic kidney lesions, although less severe and frequent compared to other species. However, these lesions were also found in horses with different causes of death. Therefore, microscopic renal lesions cannot be used as a specific diagnostic marker for oleander poisoning in horses.
Article
Biochemical Research Methods
Yatendra Singh, Renu Nimoriya, Priyanka Rawat, Dipak K. Mishra, Sanjeev Kanojiya
Summary: In this study, UHPLC-ESI-MS/MS techniques were used to quantitatively determine cardiac glycosides (CGs) and their seasonal variation in leaf and stem samples of Nerium oleander. A total of 21 CGs were quantitatively determined, including three chemical markers: odoroside H (244.8 μg/g), odoroside A (231.4 μg/g), and oleandrin (703.9 μg/g). The season-specific accumulation of these chemical markers was observed. Additionally, the remaining 18 CGs were relatively quantified in the same samples. The developed method is simple and reliable for the identification and quantification of multiple CGs in N. oleander.
PHYTOCHEMICAL ANALYSIS
(2022)
Article
Allergy
H. Daflaoui, H. Ragragui, H. Aburabie, S. Dikhaye, N. Zizi
Summary: Nerium Oleander is a plant known for its systemic toxicity, with limited literature on its cutaneous effects. This case report describes a patient who developed acute eczema following local application of Nerium oleander leaves, which was successfully treated with topical corticosteroids and barrier cream. The plant is commonly used in alternative medicine, but can cause severe skin reactions along with systemic effects such as cardiac, neurological, and digestive issues.
REVUE FRANCAISE D ALLERGOLOGIE
(2021)
Article
Chemistry, Applied
Giuseppina Sanna, Silvia Madeddu, Alessandra Serra, David Collu, Thomas Efferth, F. Lukmanul Hakkim, Luay Rashan
Summary: The study found that extracts from Nerium oleander have antiviral activity against polio virus type 1, with the mechanism of action identified to be within the first two hours post infection.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Petroula Seridou, Sofia Monogyiou, Evdokia Syranidou, Nicolas Kalogerakis
Summary: This study found that Nerium oleander plants can accumulate antimony (Sb) in the roots and demonstrated that the addition of organic acids (OAs) and oxygen nanobubbles (O(2)NBs) can help the plants maintain water content and antioxidant enzyme activity. However, the translocation of Sb from the roots to the shoots was low.
Article
Biotechnology & Applied Microbiology
Petroula Seridou, Konstantinos Fyntrilakis, Evdokia Syranidou, Nicolas Kalogerakis
Summary: This study found that Tamarix smyrnensis and Nerium oleander, two salt-tolerant plants, have a strong ability to accumulate Sb(III), thus they can effectively remove Sb from aqueous solutions. Although the higher concentration of Sb (10 ppm) significantly affected the chlorophyll content in Nerium oleander, it didn't have a significant impact on plant growth and water content during the experimental period. Additionally, the study also found that the roots of both plants are more prone to accumulating Sb.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Vinay Kumar Mishra, Braj Kishore Rathour, Sunil K. Mishra, Ram Sagar
Summary: Cardenolide and pregnatriene compounds were isolated from the chloroform fraction of the 95% aqueous ethanolic extract of dried roots of Nerium oleander. The stereochemical structure of these compounds was determined using spectroscopic methods including IR, HRMS and NMR spectroscopy.
NATURAL PRODUCT RESEARCH
(2021)
Article
Environmental Sciences
Noreen Khalid, Ali Noman, Atia Nazir, Aasma Tufail, Naila Hadayat, Fahad Mohammed Alzuaibr, Sobia Ikram, Noreen Akhter, Mumtaz Hussain, Muhammad Aqeel
Summary: Metal pollutants released from motor vehicles are deposited in roadside environments, causing significant health hazards at all levels of the ecosystem. This study assessed the potential of Nerium oleander to accumulate heavy metals commonly released by automobiles along a busy road in Punjab, Pakistan. The plant showed the ability to absorb heavy metals, but these pollutants negatively affected its physiological attributes. However, antioxidant activity of N. oleander was found to be increased.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Claude Bragard, Katharina Dehnen-Schmutz, Francesco Di Serio, Marie-Agnes Jacques, Josep Anton Jaques Miret, Annemarie Fejer Justesen, Alan MacLeod, Christer Sven Magnusson, Panagiotis Milonas, Juan A. Navas-Cortes, Stephen Parnell, Roel Potting, Philippe Lucien Reignault, Hans-Hermann Thulke, Wopke van der Werf, Antonio Vicent Civera, Jonathan Yuen, Lucia Zappala, Andrea Battisti, Hugo Mas, Daniel Rigling, Olaf Mosbach-Schulz, Paolo Gonthier
Summary: The European Commission requested risk assessments for high-risk plants, including bare rooted and potted Nerium oleander from Turkey. A non-regulated pest Phenacoccus solenopsis was identified and risk mitigation measures were evaluated, with an expert judgement indicating a high likelihood of plants being free from the pest.
Article
Multidisciplinary Sciences
Nese Bakir Cilesizoglu, Emine Yalcin, Kueltigin Cavusoglu, Selin Sipahi Kuloglu
Summary: This study investigated the phytochemical analysis and toxicity profile of leaf and flower extracts of Nerium oleander in Giresun province, Turkey. The extracts showed significant effects on physiological parameters and antioxidant/oxidant balance. They also exhibited cytotoxic and genotoxic effects, which were associated with the phytochemical content of the extracts.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Xuanjiao Bai, Gang Wang, Ying Ren, Jianping Han
Summary: A specific and highly sensitive qPCR-based method was developed to identify oleander in this study. The method was validated in mixture systems and simulated forensic specimens, and demonstrated a detection limit of 0.1% in digested samples.
Article
Medicine, Legal
Anna Carfora, Raffaella Petrella, Renata Borriello, Lucia Aventaggiato, Roberto Gagliano-Candela, Carlo Pietro Campobasso
Summary: A 71-year-old male laboratory technician committed suicide by ingesting oleander leaves, resulting in fatal arrhythmia due to oleander intoxication. Toxicological investigations confirmed toxic levels of oleandrin in all biological samples, indicating the cause of death as being ingestion of the infusion.
FORENSIC SCIENCE MEDICINE AND PATHOLOGY
(2021)
Article
Environmental Sciences
Noureddine El Messaoudi, Mohammed El Khomri, El-Houssaine Ablouh, Amal Bouich, Abdellah Lacherai, Amane Jada, Eder C. Lima, Farooq Sher
Summary: Tetracycline was effectively removed from water using biosynthesized silicon dioxide nanoparticles from Nerium oleander leaves, showing high removal efficiency. The nanoparticles demonstrated good reusability in experimental conditions.
Article
Multidisciplinary Sciences
Pramod N. Nehete, Kathryn A. Shelton, Bharti P. Nehete, Sriram Chitta, Lawrence E. Williams, Steven J. Schapiro, Christian R. Abee
Article
Pharmacology & Pharmacy
Jacob Couturier, Lee C. Winchester, James W. Suliburk, Gregory K. Wilkerson, Anthony T. Podany, Neeti Agarwal, Corrine Ying Xuan Chua, Pramod N. Nehete, Bharti P. Nehete, Alessandro Grattoni, K. Jagannadha Sastry, Courtney Fletcher, Jordan E. Lake, Ashok Balasubramanyam, Dorothy E. Lewis
ANTIVIRAL RESEARCH
(2018)
Article
Virology
Sunam Gurung, Alisha N. Preno, Jamie P. Dubaut, Hugh Nadeau, Kimberly Hyatt, Nicole Reuter, Bharti Nehete, Roman F. Wolf, Pramod Nehete, Dirk P. Dittmer, Dean A. Myers, James F. Papin
JOURNAL OF VIROLOGY
(2018)
Correction
Multidisciplinary Sciences
Stephanie Dorta-Estremera, Pramod N. Nehete, Guojun Yang, Hong He, Bharti P. Nehete, Kathryn A. Shelton, Michael A. Barry, K. Jagannadha Sastry
Article
Chemistry, Multidisciplinary
Corrine Ying Xuan Chua, Priya Jain, Andrea Ballerini, Giacomo Bruno, R. Lyle Hood, Manas Gupte, Song Gao, Nicola Di Trani, Antonia Susnjar, Kathryn Shelton, Lane R. Bushman, Marco Folci, Carly S. Filgueira, Mark A. Marzinke, Peter L. Anderson, Ming Hu, Pramod Nehete, Roberto C. Arduino, Jagannadha K. Sastry, Alessandro Grattoni
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Multidisciplinary Sciences
Stephanie Dorta-Estremera, Pramod N. Nehete, Guojun Yang, Hong He, Bharti P. Nehete, Kathryn K. Shelton, Michael A. Barry, K. Jagannadha Sastry
Article
Multidisciplinary Sciences
Pramod N. Nehete, Gregory Wilkerson, Bharti P. Nehete, Sriram Chitta, Julio C. Ruiz, Henrieta Scholtzova, Lawrence E. Williams, Christian R. Abee, John A. Vanchiere
Article
Multidisciplinary Sciences
Pramod N. Nehete, Bharti P. Nehete, Greg K. Wilkerson, Steve J. Schapiro, Lawrence E. Williams
Summary: This study quantified the effects of transport, relocation, and acclimation to new surroundings on female squirrel monkeys by analyzing blood samples. Significant changes were observed in T cells, NK cells, B cells, and cytokine levels during different time points of the relocation process. This data could help determine the optimal time for using newly arrived animals in research studies.
Article
Immunology
Pramod N. Nehete, Bharti P. Nehete, Akash G. Patel, Sriram Chitta, Henrieta Scholtzova, Lawrence E. Williams
Summary: The study found that nonhuman primates experience significant changes in hematological and immunological parameters, including lymphocytes, T cells, B cells, and natural killer cells, when subjected to stress factors such as relocation.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Nicola Di Trani, Fernanda P. Pons-Faudoa, Antons Sizovs, Kathryn A. Shelton, Mark A. Marzinke, Pramod N. Nehete, Alessandro Grattoni
Summary: Long-acting implantable drug delivery systems provide an effective approach for the management or prevention of chronic conditions by sustained parenteral therapeutic administration, improving adherence to treatment regimens. However, their clinical deployment is challenged by factors such as poor drug loading capacity, requiring repeated surgical replacement for continued therapy.
ADVANCED THERAPEUTICS
(2022)
Correction
Biotechnology & Applied Microbiology
Hong Qin, Pramod N. Nehete, Hong He, Bharti Nehete, Stephanie Buchl, Soung-chul Cha, Jagannadha K. Sastry, Larry W. Kwak
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Immunology
Arshad Khan, Shailbala Singh, Gloria Galvan, Chinnaswamy Jagannath, K. Jagannadha Sastry
Article
Veterinary Sciences
Pramod N. Nehete, Elizabeth R. Magden, Bharti P. Nehete, Lawrence E. Williams, Christian R. Abee, K. Jagannadha Sastry
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2017)
Article
Veterinary Sciences
Pramod N. Nehete, Bharti P. Nehete, Sriram Chitta, Lawrence E. Williams, Christian R. Abee
COMPARATIVE MEDICINE
(2017)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
