Journal
FITOTERAPIA
Volume 83, Issue 4, Pages 690-698Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2012.02.006
Keywords
TWHF; Microemulsion; Transdermal delivery system; Pharmacodynamics; Toxicity
Categories
Funding
- Science and Technology Commission of Shanghai Municipality [09dZ1971101]
- Shanghai Rising-Star Program [10QA1400800]
- National Natural Science Foundation of China [30901862]
- Scientific Research Foundation for the Returned Overseas Chinese Scholar
Ask authors/readers for more resources
The present study is trying to produce a transdermal microemulsion drug delivery system (TMDDS) for Tripterygium Wilfordii Hook f. (TWHF) and attempting to solve male reproductive toxicity problem of TWHF. The formulation was optimized by the central composite design with response surface methodology and was decided as 12% oleic acid, 19.7% Labrasol S. 19.7% ethanol and 19.7% Pharmasolve, and 29% water. TMDDS for TWHF had stronger transdermal ability than free TWHF, and TWHF microemulsion significantly inhibited the adjuvant-induced arthritis and at the same time, had preferable anti-inflammatory effect with the long-time administration. Various pharmacodynamics parameters proved that TWHF microemulsion can reduce the male reproductive toxicity and hepatotoxicity of rats. All these suggested that TMDDS could be a suitable delivery system for TWHF. (C) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available