Journal
FITOTERAPIA
Volume 83, Issue 8, Pages 1693-1698Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2012.09.025
Keywords
Lichen; Stereocaulon halei; Photoprotection; Diphenyl ether; Pseudodepsidone; Antioxidant
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Funding
- French Ministry of Research and Education (Bio-Asia Program, DREIC [International Relations and Cooperation Department])
- French Embassy in Indonesia for a Ph.D. grant
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The diphenyl ether, lobarin (1) (syn. lobariol carboxylic acid) related to lobaric acid was isolated for the first time as a natural product along with five known compounds from Stereocaulon halei, a fruticose lichen collected in Indonesia. The structure of lobarin was elucidated by spectroscopic data analysis and its most stable conformers were determined by molecular mechanic dynamic calculations. A marked superoxide anion scavenging was found for compound 1 while no cytotoxicity on the B16 murine melanoma and HaCaT human keratinocyte cell lines was observed. (C) 2012 Elsevier B.V. All rights reserved.
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