Review
Chemistry, Multidisciplinary
Smith B. Babiaka, Aurelien F. A. Moumbock, Stefan Gunther, Fidele Ntie-Kang
Summary: Cyperus rotundus L., commonly known as Nutgrass, is a notorious weed found in temperate tropical and subtropical regions worldwide. Efforts to identify its bioactive constituents have resulted in the characterization of about 192 compounds, including terpenoids, flavonoids, stilbenes, aromatics, and aliphatic fatty acids. This review summarizes the bioactivities and mechanism of action of some of these compounds.
Article
Genetics & Heredity
Renjie Wu, Cong Yu, Yang Wu
Summary: Cyperus rotundus, a sedge plant, has a chloroplast genome with 133 genes and an overall GC content of 33.26%, showing a close relationship with Eleocharis celluosa and Eleocharis dulcis in phylogenetic analysis.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Review
Plant Sciences
Jose Jailson Lima Bezerra, Anderson Angel Vieira Pinheiro
Summary: Cyperus rotundus is widely used in traditional medicine in Asian countries and has shown potential anticancer effects against various tumor cell lines, with its chemical compounds playing a key role.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Domenic Mittas, Monizi Mawunu, Giorgia Magliocca, Thea Lautenschlaeger, Stefan Schwaiger, Hermann Stuppner, Stefania Marzocco
Summary: This study analyzed the chemical composition of the rhizomes and roots extract of Cyperus articulatus and evaluated their anti-inflammatory potential through in vitro experiments, revealing multiple compounds with inhibitory effects on the production of inflammatory mediators, supporting the traditional medicinal use of Cyperus articulatus for treating inflammation-related disorders.
Article
Multidisciplinary Sciences
Yilong Chen, Na Li, Dan Wang, Jiuyu Fan, Rui Chu, Shengrong Li
Summary: In this study, the UPLC-MS/MS technique was used to examine the changes in blood levels of exogenous constituents and metabolites in rats with dysmenorrhea treated with Cyperi rhizoma (CR) and Cyperi rhizoma processed with vinegar (CRV). The results showed that certain constituents and metabolites in the blood of the CRV-treated rats were significantly higher compared to the CR-treated rats. CRV reduced the levels of proinflammatory, platelet aggregation, and vasoconstriction substances, and provided analgesic effects by modulating fatty acid metabolism.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Plant Sciences
Bian-Xia Xue, Ru-Shang He, Jia-Xin Lai, Nana Ama Mireku-Gyimah, Li-Hua Zhang, Hong-Hua Wu
Summary: Cyperus rotundus L. is a widely used plant in traditional medicine systems around the world, including traditional Chinese medicine (TCM). It has various medicinal properties, including treating liver disease, stomach pain, breast tenderness, dysmenorrhea, and menstrual irregularities. This review provides a comprehensive summary of its vernacular names, distribution, phytochemistry, pharmacology, toxicology, and analytical methods. It also includes data mining on TCM prescriptions containing C. rotundus and the effects of its compounds on different biological activities.
PHYTOCHEMISTRY REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Rahul V. Khandare, Anuprita D. Watharkar, Pankaj K. Pawar, Anil A. Jagtap, Neetin S. Desai
Summary: The study found that hydrophytes, including Canna indica, Epipremnum aureum, Cyperus alternifolius, and Cyperus rotundus, can effectively remove fluoride from water, with removal rates of 95%, 52%, 65%, and 56% respectively. Factors such as increased fluoride concentration and biomass can affect the removal efficiency of these plants, as well as the fluoride content and antioxidant enzyme activities in their roots and leaves.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Biochemistry & Molecular Biology
Hui-Juan Qu, Kai-Wen Lin, Xiao-Liang Li, Hong-Ya Ou, Yin-Feng Tan, Mei Wang, Na Wei
Summary: The study analyzed the composition of the essential oil from Alpinia officinarum-Cyperus rotundus and its individual herbs, demonstrating their protective effects against gastric ulcers and confirming their anti-inflammatory and analgesic properties in both in vivo and in vitro experiments.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Environmental Sciences
Shu-Yu Liu, Chen-Yang Wei, Yao Tong, Wang Chen, Zong-Yun Han, Dong-Qiang Zeng, Wen-Wei Tang
Summary: Rhizosphere microorganisms, especially plant growth-promoting rhizobacteria (PGPR), have a significant impact on plant growth. This study found that the presence of Cyperus rotundus L. increased the abundance of PGPR and soil enzyme activity. However, the growth of C. rotundus also led to a decrease in soil nutrients.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Reham M. Samra, Amal F. Soliman, Ahmed A. Zaki, Ahmed Ashour, Ahmed A. Al-Karmalawy, Madiha A. Hassan, Ahmed M. Zaghloul
Summary: Eight methanolic extracts were tested for cytotoxic activity against cancer cell lines, with the rhizomes of Cyperus rotundus extract showing the highest activity. Nine compounds were identified, including one new compound and eight known compounds, some of which demonstrated promising anticancer activity. Further research is needed to explore the potential of these compounds as new anticancer agents in the future.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Plant Sciences
Zhi Zou, Yujiao Zheng, Zhongtian Zhang, Yanhua Xiao, Zhengnan Xie, Lili Chang, Li Zhang, Yongguo Zhao
Summary: This study provides the first genome-wide characterization of the oleosin family in tigernut and reveals their important roles in oil accumulation.
PLANT CELL REPORTS
(2023)
Article
Biology
S. Birendra Kumar, Swati Krishna, Sneha Pradeep, Divya Elsa Mathews, Ramya Pattabiraman, Manikanta Murahari, T. P. Krishna Murthy
Summary: The study utilized a computational approach to screen potential SARS-CoV-2 M-pro inhibitors from Cyperus rotundus Linn, identifying beta-amyrin and stigmasta-5,22-dien-3-ol as promising candidates. By evaluating binding free energy and conducting molecular dynamics simulations, the study showed the strong binding interactions and stability of these compounds. Additionally, ADMET studies were performed to assess the pharmacokinetic properties and safety profile of the compounds.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Fares Fenanir, Abderrahmane Semmeq, Yacine Benguerba, Michael Badawi, Marie-Antoinette Dziurla, Smain Amira, Hocine Laouer
Summary: This study identified the essential oil of Algerian Cyperus rotundus L. and investigated the interaction of certain anti-inflammatory molecules with 5-Lypoxygenase (5-LO) and leukotriene A4 hydrolase (LTA4H). The results showed that oxygenated terpenes in the essential oil exhibited anti-inflammatory activities and formed strong interactions with the enzymes. Molecular dynamics simulations confirmed the stability of the natural product-enzyme interactions.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Plant Sciences
Zhi Zou, Yanhua Xiao, Li Zhang, Yongguo Zhao
Summary: The study characterizes the Lhc family genes in tigernut and reveals their development regulation and diurnal fluctuation expression patterns in leaves. This provides valuable information for further understanding the evolution and functional analysis of Lhc genes in Cyperaceae family.
Article
Green & Sustainable Science & Technology
Rouzbeh Zangoueinejad, Behnaz Sirooeinejad, Mohammad Taghi Alebrahim, Ali Ahsan Bajwa
Summary: The combination of herbicides and mulches is an effective integrated weed management option for controlling purple nutsedge in tomato crops. The combination of fomesafen + S-metolachlor and natural mulch provides the most effective weed control and highest tomato yield.
Article
Biochemistry & Molecular Biology
Kohei Taniguchi, Miku Sakai, Nobuhiko Sugito, Yuki Kuranaga, Minami Kumazaki, Haruka Shinohara, Hiroshi Ueda, Manabu Futamura, Kazuhiro Yoshida, Kazuhisa Uchiyama, Yukihiro Akao
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Oncology
Haruka Shinohara, Minami Kumazaki, Yosuke Minami, Yuko Ito, Nobuhiko Sugito, Yuki Kuranaga, Kohei Taniguchi, Nami Yamada, Yoshinori Otsuki, Tomoki Naoe, Yukihiro Akao
Article
Oncology
Minami Kumazaki, Haruka Shinohara, Kohei Taniguchi, Tomoaki Takai, Yuki Kuranaga, Nobuhiko Sugito, Yukihiro Akao
EXPERIMENTAL CELL RESEARCH
(2016)
Article
Chemistry, Medicinal
Ken-ichi Nakashima, Naohito Abe, Masayoshi Oyama, Makoto Inoue
Article
Chemistry, Medicinal
Ken-ichi Nakashima, Naohito Abe, Fang-Rong Chang, Makoto Inoue, Masayoshi Oyama
JOURNAL OF NATURAL MEDICINES
(2017)
Article
Oncology
Nami Yamada, Yuki Kuranaga, Minami Kumazaki, Haruka Shinohara, Kohei Taniguchi, Yukihiro Akao
Article
Biochemistry & Molecular Biology
Tomoaki Takai, Yuki Yoshikawa, Teruo Inamoto, Koichiro Minami, Kohei Taniguchi, Nobuhiko Sugito, Yuki Kuranaga, Haruka Shinohara, Minami Kumazaki, Takuya Tsujino, Kiyoshi Takahara, Yuko Ito, Yukihiro Akao, Haruhito Azuma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Chemistry, Organic
Koki Mori, Aiko Shimogomi, Naohito Abe, Manami Haba, Tomoaki Yoshimura, Joko Ridho Witono, Dedy Darnaedi, Toshiyuki Tanaka, Jin Murata, Masayoshi Oyama
Article
Oncology
Haruka Shinohara, Nobuhiko Sugito, Yuki Kuranaga, Kazuki Heishima, Yosuke Minami, Tomoki Naoe, Yukihiro Akao
Article
Oncology
Takuya Tsujino, Nobuhiko Sugito, Kohei Taniguchi, Ryo Honda, Kazumasa Komura, Yuki Yoshikawa, Tomoaki Takai, Koichiro Minami, Yuki Kuranaga, Haruka Shinohara, Yoshihisa Tokumaru, Kazuki Heishima, Teruo Inamoto, Haruhito Azuma, Yukihiro Akao
Article
Biochemistry & Molecular Biology
Yoshihisa Tokumaru, Toshihiro Tajirika, Nobuhiko Sugito, Yuki Kuranaga, Haruka Shinohara, Takuya Tsujino, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Multidisciplinary
Roza I. Jalmakhanbetova, Yerlan M. Suleimen, Masayoshi Oyama, Eslam B. Elkaeed, Ibrahim. H. Eissa, Raigul N. Suleimen, Ahmed M. Metwaly, Margarita Yu. Ishmuratova
Summary: The ethanol extract of Artemisia sublessingiana aerial parts yielded seven compounds, including six flavonoids and one sesquiterpenoid. In silico examination of these compounds against the COVID-19 main protease showed promising binding modes, with compound 2 exhibiting the best binding energy. These results provide hope for potential treatment of the COVID-19 pandemic.
JOURNAL OF CHEMISTRY
(2021)
Article
Oncology
Ayuna Hattori, Emi Takamatsu-Ichihara, Yoshiki Yamamoto, Shuhei Fujita, Kazutsune Yamagata, Takuo Katsumoto, Yukino Machida, Haruka Shinohara, Ryo Murakami, Issay Kitabayashi
Summary: The chromatin-associated AAA+ ATPases Tip48 and Tip49 are crucial for various nuclear events and frequently overexpressed in human cancers. Loss of Tip49 triggers p53-dependent apoptosis and inhibits leukemia development. The compound DS-4950, which inhibits the ATPase activity of Tip48/49, effectively reduces tumor burden and improves survival in leukemia models. These findings suggest that Tip48/49 ATPases are functionally necessary and therapeutically targetable for the treatment of human cancers.
Article
Chemistry, Multidisciplinary
R. Jalmakhanbetova, Ye M. Suleimen, N. Abe, M. Oyama, A. M. Metwaly, I. H. Eissa, M. Yu Ishmuratova, Zh A. Ibatayev
Summary: A flavonoid compound was isolated and identified from Chondrilla brevirostris, and its chemical structure was established. Molecular docking study against COVID-19 main protease was conducted to investigate its potential activity against SARS-CoV-2.
BULLETIN OF THE UNIVERSITY OF KARAGANDA-CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Naohito Abe, Yuta Nakano, Aiko Shimogomi, Toshiyuki Tanaka, Masayoshi Oyama
NATURAL PRODUCT COMMUNICATIONS
(2016)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.