Article
Chemistry, Applied
Alice Cariola, Madeleine El Chami, Jonathan Granatieri, Luca Valgimigli
Summary: Bakuchiol is a potent tyrosinase inhibitor for treating skin photoaging. It exhibits competitive inhibition against mushroom tyrosinase with average K-i constants of 6.71 +/- 1.23 jiM and 1.15 +/- 0.34 jiM for monophenolase and diphenolase reactions respectively. It also shows good antioxidant activity, making it a potential natural food preservative against oxidation and food-browning.
Article
Plant Sciences
Neha Mahajan, Bhupendra Koul, Pankaj Gupta, Bhahwal Ali Shah, Joginder Singh
Summary: Psoralea corylifolia is a medicinal plant used in traditional herbal medicine for treating various skin disorders. It contains numerous bioactive compounds with anti-vitiligo, anti-microbial, anti-tumor, and anti-depression properties. Further research is needed to explore the extraction methods and dosage optimization of its bioactive constituents.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Hu-Tong-Yue Gao, Guang-Zhen Lang, Ying-Da Zang, Jie Ma, Jing-Zhi Yang, Fei Ye, Jin-Ying Tian, Pan-Pan Gao, Chuang-Jun Li, Dong-Ming Zhang
Summary: Nine new compounds were isolated from Psoralea corylifolia fruits, showing varying degrees of PTP1B inhibitory activity. Compounds 5 and 9 exhibited significant inhibition, with molecular docking simulations indicating low binding affinities to PTP1B.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Nan Li, Tao Liu, Shan Zhu, Yi Yang, Zijing Wang, Zhiyue Zhao, Xiang Wang, Wenxiao Qin, Yiqi Yan, Yang Liu, Qingmei Xia, Han Zhang
Summary: This study found that corylin can prevent skin aging by inhibiting oxidative stress through the Keap1-Nrf2 signaling pathway. These findings provide evidence for the discovery of novel therapies targeting skin aging.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xiao-Wei Chen, Zi-Chao Hou, Chi Chen, Ling-Hui Zhang, Meng-En Chen, Fu-Min Zhang
Summary: The first enantioselective total syntheses of six natural and two proposed meroterpenoids from Psoralea corylifolia have been achieved in 7-9 steps from 2-methylcyclohexanone. These synthetic approaches offer a high level of flexibility, stereodivergent fashion, and short route, providing a potential platform for the preparation of various this-type meroterpenoids and their pseudo-natural products.
Article
Chemistry, Medicinal
Zi-Chao He, Qing-Xia Xu, Xiu-Wei Yang, Zhao-Jing Wang, Wei Xu
Summary: The study isolated various compounds from Psoralia corylifolia fruits and found that non-glycoside compounds showed stronger inhibition of NO production compared to glycoside compounds. The structure-activity relationships of non-glycoside compounds were also discussed.
Article
Biochemistry & Molecular Biology
Hye-Ock Jang, Tea-Young Ahn, Ji-Min Ju, Soo-Kyung Bae, Hyung-Ryong Kim, Da-Sol Kim
Summary: This study found that Psoralea corylifolia extracts and bakuchiol can promote odontogenic differentiation in human dental pulp stem cells. These findings may contribute to future research on dentin regeneration.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Agricultural Engineering
Yuanyue Wang, Yanjiao Luo, Yixin Zhang, Chaoqun Xu, Yu Yao, Jiajun Gu, Yude Peng, Yongzhen Pang, Gang Ding, Fengmei Suo, Guoan Shen, Shangang Jia, Baolin Guo
Summary: In this study, researchers identified PcPT11 as a prenyltransferase in Psoralea corylifolia capable of utilizing 23 substrates for the biosynthesis of prenylated polyphenols. PcPT11 exhibited highly regio-specific prenyltransferase activity at the C-6 position of flavonoids, leading to the production of compounds with important pharmacological effects. The study also demonstrated the strong expression of PcPT11 in fruits and leaves, as well as its localization in chloroplasts when expressed in Nicotiana benthamiana.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Chemistry, Analytical
Barbora Legerska, Daniela Chmelova, Miroslav Ondrejovic, Stanislav Miertus
Summary: Microorganisms and plants are important sources of compounds with potential pharmaceutical applications. TLC-Bioautography combines separation and biological analysis to screen extracts for enzyme inhibitors. This review summarizes the methods and applications of TLC-Bioautography and discusses its potential future developments.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Oncology
Bhawna Chopra, Ashwani Kumar Dhingra, Ajmer Singh Grewal, Akash Jain, Jasmine Chaudhary, Parul Grover
Summary: The present study aims to explore the anticancer potential of bakuchiol and provide insights for the design and development of novel molecular entities for various disorders. Relevant literature and patents emphasizing the anticancer potential of bakuchiol were identified and reviewed. The findings suggest that bakuchiol has promising anticancer potential against various types of cancer, and it also shows synergistic or potentiating effects when used in combination with other anticancer drugs or natural compounds. Therefore, bakuchiol holds great potential as a therapeutic option for tumors.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Ami Lee, Hyun Yang, Taesoo Kim, Hyunil Ha, Youn-Hwan Hwang
Summary: This study utilized a pharmacokinetic approach to identify bioavailable components in Psoralea corylifolia extracts and found that certain constituents of PC could benefit bone health.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Qing-Xia Xu, Zhao-Jing Wang, Zi-Chao He, Jing Xu, Wei Xu, Xiu-Wei Yang
Summary: Nine new flavonoid dimers, named psocorylins R-Z (1-9), were isolated from the fruits of Psoralea corylifolia L. These compounds exhibited diverse structures, including rare cyclobutane-containing chalcone dimers and flavonoid monomer-linked dimers. Cytotoxicity assays showed that some of the compounds demonstrated cytotoxic activities against MCF-7 cells, and further experiments revealed their potential mechanism of action involving the Bcl-2/Bax/Cleaved caspase-3 pathway.
BIOORGANIC CHEMISTRY
(2023)
Article
Biophysics
Yusheng Feng, Zhifen Han, Chong Chen, Xuchen Wang, Jing Liu, Yousef Khan, Maobin Xie, Yufeng Chen, Yue Zhang, Gang Li
Summary: A study has developed an intestinal stent loaded with a combination of traditional Chinese medicines for the treatment of intestinal tumors. The stent, made using emulsion electrospinning technology, has a core-shell structure and sustained drug release properties. In vitro tests have shown that the drug-loaded membrane effectively inhibits tumor cell growth.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biochemistry & Molecular Biology
Qingxia Xu, Youbo Zhang, Zichao He, Zhenyu Liu, Yingtao Zhang, Wei Xu, XiuWei Yang
Summary: This study systematically investigated the chemical constituents of Psoralea corylifolia and identified coumarins, isoflavones, flavonones, and meroterpenoids as the active compounds for treating osteoporosis. The study also corrected the structures of four known coumarins and reported 37 undescribed compounds.
Article
Plant Sciences
Yan Qin, Quan Wen, Jie Cao, Chengle Yin, Daofeng Chen, Zhihong Cheng
PHARMACEUTICAL BIOLOGY
(2016)
Article
Biochemical Research Methods
Jihe Tang, Jinge Zhou, Qingjiu Tang, Tao Wu, Zhihong Cheng
PHYTOCHEMICAL ANALYSIS
(2016)
Article
Plant Sciences
Dongsheng Du, Yan Lu, Zhihong Cheng, Daofeng Chen
JOURNAL OF ETHNOPHARMACOLOGY
(2016)
Article
Biochemical Research Methods
Jinge Zhou, Qingjiu Tang, Tao Wu, Zhihong Cheng
PHYTOCHEMICAL ANALYSIS
(2017)
Article
Biochemical Research Methods
Yan Qin, Yingming Pang, Zhihong Cheng
PHYTOCHEMICAL ANALYSIS
(2016)
Article
Chemistry, Analytical
Yan Qin, Boyan Gao, Haiming Shi, Jie Cao, Chengle Yin, Weiying Lu, Liangli Yu, Zhihong Cheng
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2017)
Article
Biochemical Research Methods
Qihui Guo, Yanzhi Sun, Qingjiu Tang, Hongchao Zhang, Zhihong Cheng
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
(2020)
Article
Biochemical Research Methods
Na Zhang, Meng Wang, Yue Li, Mingzhe Zhou, Tao Wu, Zhihong Cheng
Summary: A new alkaloid derivatisation reagent with improved sensitivity and specificity has been developed and optimised, making it a universal and effective staining reagent for structurally diverse natural alkaloids.
PHYTOCHEMICAL ANALYSIS
(2021)
Article
Chemistry, Analytical
Yanzhi Sun, Hongchao Zhang, Zhihong Cheng
Summary: A 96-well plates-based UV spectrophotometric method was developed for determination of total GLS in Isatis indigotica roots. The method showed acceptable accuracy, precision, reproducibility, and stability, making it suitable for high-throughput determination of total GLS.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Xin Liu, Zhihong Cheng
Summary: This study prepared several derivatives of EFL1 through chemical and microbial transformations and evaluated their ability to inhibit P-gp activity. The results showed that the substrate 1 and its biotransformed product 9 exhibited the highest P-gp inhibitory activity by down-regulating P-gp expression at the protein level.
NATURAL PRODUCT RESEARCH
(2023)
Article
Food Science & Technology
Yanzhi Sun, Yingjie Fu, Rirong Chen, Yipeng Zhang, Tougen Liao, Hui Xi, Shihao Sun, Zhihong Cheng
Summary: The identification and evaluation of volatile and non-volatile compounds in Dianhong tea can provide insights into its aroma and bioactive constituents. Samples from four main producing areas showed similar profiles of VOCs and non-VOCs under optimized GC-MS and LC-MS conditions.
CYTA-JOURNAL OF FOOD
(2022)
Article
Biochemical Research Methods
Xiaofan Fan, Yingzhe Li, Tao Wu, Zhihong Cheng
Summary: A simple and efficient affinity ultrafiltration (AUF) combined with HPLC-MS/MS method was developed in this study for screening neuraminidase (NA) inhibitors from Baphicacanthus cusia stems and leaves. Five active alkaloids were identified and evaluated for their NA inhibitory activity using a fluorescence-based assay. Molecular docking analysis revealed hydrogen bond and pi-cation interactions between these compounds and NA.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Biochemical Research Methods
Qihui Guo, Zeyun Li, Lulu Shen, Ying Xiao, Zhihong Cheng
Summary: The study aimed to develop and validate quantitative proton (H-1) nuclear magnetic resonance (qHNMR) methods for purity assessments of aliphatic and indole glucosinolates (1-5). Three qHNMR methods were successfully applied for purity assessments of four aliphatic glucosinolates and one indole glucosinolate. The qHNMR method provides a reliable and superior means to determine the purity of glucosinolates.
PHYTOCHEMICAL ANALYSIS
(2021)
Article
Integrative & Complementary Medicine
Xin-Xin Xie, Ze-Jing Jiang, Zhi-Hong Cheng, Dao-Feng Chen
CHINESE JOURNAL OF NATURAL MEDICINES
(2017)
Article
Chemistry, Analytical
Lei Zhang, Jiyao Shi, Jihe Tang, Zhihong Cheng, Xiaohui Lu, Yao Kong, Tao Wu
ANALYTICA CHIMICA ACTA
(2017)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
