The effect of safranal on histamine (H1) receptors of guinea pig tracheal chains

The effect of three concentrations of safranal on histamine (H-1) receptors was tested on two groups of tracheal chains incubated with: 1) indomethacin, and 2) indomethacin, propranolol and atropine (n = 6). The EC50 (effective concentration of histamine causing 50% of maximum response) obtained in the presence of chlorpheniramine and all concentrations of safranal in both groups were significantly greater than those of saline (p<0.05 to p<0.001). The EC50 obtained in the presence of all concentrations of safranal and maximum response of its two higher concentrations (1.25 and 2.5 mu g/mL) in group 2 were greater than in group 1 (p<0.05 to p<0.001). (C) 2010 Elsevier B.V. All rights reserved.