Journal
FITOTERAPIA
Volume 82, Issue 6, Pages 920-926Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2011.05.001
Keywords
Quercetin; TGF-beta 1; Smads; Cell cycles; Laminin and type IV collagen; Oxidative stress
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Funding
- National Natural Foundation of China [30973572]
- Xuzhou Natural Science Foundation of China [XX10A068]
- Xuzhou Medical College President Foundation of China [09KJZ22, 2010KJZ25]
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Quercetin's protective effects on the glomerulosclerosis of diabetic nephropathy (DN) in rat mesangial cells were investigated. The cell cycles, type IV collagen and laminin. TGF-beta(1) mRNA, Smad 2/3 and Smad 7, and activities of cell antioxidases were measured. Compared with the high glucose group, quercetin may decrease the cell percentages of G(0)/G(1) phase, Smad 2/3 expression, laminin and type IV collagen, and TGF-beta(1) mRNA level significantly. The antioxidant capacity, the cell percentages of S phase and Smad 7 expression was significantly increased by quercetin. These results suggest that quercetin is a protective agent against glomerulosclerosis in DN. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
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