Journal
FITOTERAPIA
Volume 82, Issue 6, Pages 868-877Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2011.04.016
Keywords
Cyclovirobuxine D; Heart failure; Cardiac function; Myocardial infarction
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Funding
- Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica [P09010]
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The effect of Cyclovirobuxine D, an active ingredient from Buxus microphylla, was investigated in the potential prevention of cardiac dysfunction in rats with congestive heart failure. Heart failure was induced by left coronary artery occlusion and verified using echocardiography. Cyclovirobuxine D was administered for 30 days (0.5, 1.0 and 2.0 mg/kg, ig) and mortality, cardiac function, hemodynamics, microcirculation, histology and ultrastructure assessments were observed. Results from the present study suggest that Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction and supports the potential for Cyclovirobuxine D as a new therapy for heart failure. (C) 2011 Elsevier B.V. All rights reserved.
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