Journal
FITOTERAPIA
Volume 82, Issue 2, Pages 219-224Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.10.002
Keywords
Amentotaxus formosana; Cytotoxicity; Anti-inflammatory activity
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Funding
- National Science Council of the Republic of China [NSC 93-2320-B-037-007]
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Two new abietane diterpenoids, ramentoxide (1) and ramentoxidone (2) and a new icetexane diterpenoid, amentonone (3) were isolated from the barks of Amentotaxus formosana. The structures of 1-3 were determined by spectroscopic methods. Known compounds brevitaxin (4), and (+)-ferruginol (5) and ent-kaur-16-en-15-one (6) isolated from this plant revealed potent cytotoxic activity against human breast adenocarcinoma cells, MCF-7 cells with an IC50 value of 0.08 +/- 0.05 mu g/mL, and significant anti-inflammatory activities, respectively. (C) 2010 Elsevier B.V. All rights reserved.
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