Journal
FITOTERAPIA
Volume 82, Issue 6, Pages 834-840Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2011.04.009
Keywords
Ginkgo biloba; Polyprenols; Essentiale; Hepatoprotective; Antioxidant
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Funding
- National Natural Science Foundation of China [30871986]
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The hepatoprotective effects of polyprenols from Ginkgo biloba L leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague-Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl4-diminished activity of the antioxidant enzymes and reduced CCl4-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale. (C) 2011 Elsevier B.V. All rights reserved.
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