Journal
FITOTERAPIA
Volume 82, Issue 3, Pages 331-341Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2010.11.002
Keywords
Tithonia diversifolia; Tagitinin C; Survivin; G2/M arrest; Autophagic cell death
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We investigated the antitumour activity of Tithonia diversifolia (TD) on malignant glioblastoma cells. Our results suggested that tagitinin C was the main component in viability inhibition on malignant glioblastoma cells, and also accounted to be the most abundant component (> 65%) in TD extract. Both TD extract and tagitinin C exhibited vigorous potential to produce in vitro viability inhibition, autophagic cell death and G2/M arrest. Furthermore, the activity of survivin, a critical resistant-factor in cancer therapy, could be down regulated significantly by TD extract and tagitinin C. These findings suggested that TD extract and tagitinin C were effective for treating malignant glioblastoma. (c) 2010 Elsevier B.V. All rights reserved.
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