Journal
FITOTERAPIA
Volume 81, Issue 6, Pages 627-631Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.03.008
Keywords
Purine alkaloid; Theacrine; Camellia kucha; Anti-inflammation; Analgesia
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Funding
- National Talented Person Foundation of China [J0730638]
- Study Abroad Returnee Foundation of the National Ministry of Personnel, China [J20070022]
- National Natural Science Foundation of China [30900970]
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The anti-inflammatory and analgesic effects of theacrine (1, 3, 7, 9-tetramethyluric acid), a purine alkaloid which is abundantly present in Camellia kucha, were investigated. Xylene-induced ear edema, acetic acid-induced vascular permeability and lambda-carrageenan-induced paw edema were used to investigate anti-inflammatory activity, and acetic acid-induced writhing and hot-plate tests were used to determine analgesic effect. Oral administration of theacrine (8-32 mg/kg) induced dose-related anti-inflammatory and analgesic effects. On the other hand, oral caffeine administration (8-32 mg/kg) did not show an inhibitory effect on the inhibition of inflammatory response or cause analgesia. Additionally, the result of the acute toxicity test showed that the LD50 of theacrine was 810.6 mg/kg (769.5-858.0 mg/kg). The data obtained suggest theacrine possessed analgesic and anti-inflammatory activities. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.
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