Journal
FITOTERAPIA
Volume 81, Issue 2, Pages 97-103Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2009.08.022
Keywords
Euphorbia peplis L.; Euphorbiaceae; Cerebrosides; Glycosphingolipid
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Two new cerebrosides have been isolated from the whole plants of Euphorbia peplis L. The structures were established by FT-IR spectroscopy, FAB MS, EI-MS, ESI-MS, 1D and 2D NMR spectroscopy. The structures of the cerebrosides were characterized as 1-O-beta-D-glycosides of phytosphingosines, which comprised a common long-chain base, (2S, 3S, 4R, 8Z)-2-amino-8 (Z)-octadecene-1,3,4-triol with 2-hydroxy fatty acids of varying chain lengths (C25, C22) linked to the amino group. The isolated compounds were shown to possess significant antiproliferative properties against cultured human tumor cell lines KB and IMR-32. (C) 2009 Elsevier B.V. All rights reserved.
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