Article
Plant Sciences
Violeta Popovici, Laura Bucur, Cerasela Elena Gird, Dan Rambu, Suzana Ioana Calcan, Elena Iulia Cucolea, Teodor Costache, Madalina Ungureanu-Iuga, Mircea Oroian, Silvia Mironeasa, Verginica Schroder, Emma-Adriana Ozon, Dumitru Lupuliasa, Aureliana Caraiane, Victoria Badea
Summary: This study investigated the antioxidant, cytotoxic, and rheological properties of Usnea barbata extract in canola oil. The results showed that the extract had high radical scavenging activity and cytotoxicity, making it suitable for potential pharmaceutical formulations. Additionally, the study suggested a possible synergism between lichen secondary metabolites, minerals, and canola oil phytoconstituents.
Article
Plant Sciences
Violeta Popovici, Laura Bucur, Antoanela Popescu, Verginica Schroder, Teodor Costache, Dan Rambu, Iulia Elena Cucolea, Cerasela Elena Gird, Aureliana Caraiane, Daniela Gherghel, Gabriela Vochita, Victoria Badea
Summary: Lichens, specifically Usnea barbata, are significant sources of antioxidants with high levels of usnic acid, polyphenols, and tannins contributing to their antioxidant properties. Different solvent extracts of Usnea barbata displayed varying levels of usnic acid, polyphenols, tannins, antioxidant activity, and cytotoxicity, with ethyl acetate and methanol extracts showing promising antioxidant effects but also high levels of cytotoxicity. Additionally, a moderate correlation was observed between the content of usnic acid, polyphenols, tannins, antioxidant activity, and cytotoxicity.
Article
Biochemistry & Molecular Biology
Virginia Casas-Arrojo, Juan Decara, Maria de los Angeles Arrojo-Agudo, Claudia Perez-Manriquez, Roberto T. Abdala-Diaz
Summary: Porphyridium cruentum's sulfated polysaccharides exhibit strong immunomodulatory and cytotoxic effects, inducing IL-6 cytokines and TNF-alpha. They show potential as a valuable ingredient in nutraceutical products.
Article
Biochemistry & Molecular Biology
Violeta Popovici, Laura Bucur, Gabriela Vochita, Daniela Gherghel, Cosmin Teodor Mihai, Dan Rambu, Suzana Ioana Calcan, Teodor Costache, Iulia Elena Cucolea, Elena Matei, Florin Ciprian Badea, Aureliana Caraiane, Victoria Badea
Summary: Lichens are a valuable resource for traditional medicine due to their diverse metabolites, with the study finding that acetone and ethyl acetate extracts of U. barbata showed the most potent anticancer effects against CAL-27 oral squamous carcinoma cells and V79 lung fibroblasts. The research suggests that the anticancer activity of U. barbata extracts may be partially due to an imbalance in antioxidant defense mechanisms leading to oxidative stress.
Article
Biochemistry & Molecular Biology
Andrea Di Credico, Giulia Gaggi, Pascal Izzicupo, Ines Bucci, Angela Di Baldassarre
Summary: Nutraceuticals and functional foods, such as resveratrol, play a significant role in enhancing immune surveillance in menopausal women through increasing cytotoxic activity of lymphocytes. The study analyzed the effects of resveratrol on lymphocyte cytotoxicity in menopausal women, revealing increased cytokine production, immune synapse formation, and target cell lysis with resveratrol treatment, without affecting total antioxidant capacity of lymphocytes.
Article
Microbiology
Lina Rocio Davila Giraldo, Claudia Cristina Perez Jaramillo, Jonh Jairo Mendez Arteaga, Walter Murillo-Arango
Summary: This study evaluated the nutritional value of nine species of wild macrofungi from Ibague-Tolima, Colombia, as well as their antioxidant, antimicrobial, and cytotoxic activities. The results showed that Pleurotus and Lentinus genus had the highest protein percentages. The extracts from Phellinus gilvus and Ganoderma australe exhibited lower IC50 values and showed effective antimicrobial and antifungal activities.
Article
Chemistry, Medicinal
Saly Gheda, Eman H. F. Abd El-Zaher, Alaa M. Abou-Zeid, Nesma A. Bedair, Leonel Pereira
Summary: This research evaluated the antifungal effectiveness of Arthrospira platensis extracts against pathogenic fungi and assessed their antioxidant and cytotoxicity effects. The methanol extract showed the highest inhibition zones against Candida albicans. In vivo, the extract cream successfully removed Candida spherical plastopores. The extract also exhibited strong cytotoxic activity against the HepG2 cell line and moderate cytotoxic activity against MCF7 and Hela cells.
Article
Biochemistry & Molecular Biology
Liubov Skrypnik, Olga Babich, Stanislav Sukhikh, Olga Shishko, Svetlana Ivanova, Oleg Mozhei, Ivan Kochish, Ilia Nikonov
Summary: The study shows that fossil shungite samples have antioxidant properties and can be used as an alternative to activated carbon in water purification. Further research is needed to optimize the extraction conditions and analyze the composition of the extracts.
Article
Biochemistry & Molecular Biology
Jana Hricoviniova, Zuzana Hricoviniova, Katarina Kozics
Summary: This study examined a series of 2,3-substituted quinazolinone derivatives for their biological properties, revealing that derivatives with electron-donating moieties exhibited the most potent antioxidant and DNA-protective effects without genotoxicity. Additionally, these compounds showed higher cytotoxicity in renal carcinoma cells compared to renal epithelial cells. The findings suggest that these quinazolinones may serve as potential model structures for the development of pharmacologically active agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Manish Rana, Imran Ansari, Charmy Twala, Sumbul Khan, Anupam Mandal, Rahisuddin Rahisuddin
Summary: In this study, a series of Pyrazoline derivatives were designed and synthesized, and their molecular structures were characterized using various techniques. The compounds showed promising anticancer activity against MCF-7 cancer cells with low toxicity towards HepG2 normal cells. The study also investigated the DNA binding interactions, antioxidant capacity, and ADMET properties of the derivatives.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Sang-Cheol Lee, Na-Hyun Lee, Kapil D. Patel, Soo-Kyung Jun, Jeong-Hui Park, Jonathan Campbell Knowles, Hae-Won Kim, Hae-Hyoung Lee, Jung-Hwan Lee
Summary: In this study, nano-sized antioxidative biomaterials using selenium were developed to protect and accelerate the differentiation of C2C12 myoblasts in an oxidative stress environment. The selenium nanoparticles showed antioxidant effects, reduced apoptosis and intracellular ROS levels, and up-regulated genes associated with myoblast differentiation. These results suggest that SeNPs can be used for the treatment of skeletal muscle in a cellular redox environment.
Article
Food Science & Technology
Maria Julia Martinez, Adriana Balbina Andreu, Luciana Barbini
Summary: Hepatocellular carcinoma (HCC) is a common and deadly tumor. Late diagnosis and treatment delay contribute to poor prognosis. Polyphenols from potatoes have antioxidant properties and cytotoxic effects on HCC cells, making them a potential treatment option.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
ShuTing Li, Dan Xu, Jing Jia, Wenbo Zou, JieYing Liu, Yao Wang, Kun Zhang, Xi Zheng, Yan-Yan Ma, Xuejian Zhang, Deng-Gao Zhao
Summary: In this study, 13 previously undescribed neo-clerodane diterpenoids and 27 known analogs were isolated from Scutellaria barbata. The absolute configurations of the undescribed compounds were determined, and their inhibitory effects on nitric oxide generation in macrophages were evaluated. Compound 36 showed the highest activity and suppressed nitric oxide synthase expression and NF-kappa B signaling.
Review
Biochemistry & Molecular Biology
Alejandra Vanessa Lopez-Corona, Illeen Valencia-Espinosa, Fabio Antonio Gonzalez-Sanchez, Angelica Lizeth Sanchez-Lopez, Luis Eduardo Garcia-Amezquita, Rebeca Garcia-Varela
Summary: Raspberries contain a wide range of phenolic compounds that have antioxidant and anti-inflammatory activities, which may be beneficial for the treatment of chronic degenerative diseases and cancer.
Article
Biology
Shereen M. Korany, Hoda H. El-Hendawy, Hana Sonbol, Marwa A. Hamada
Summary: Microbial levan from Pseudomonas fluorescens strain ES was optimized for production with sucrose, potassium dihydrogen phosphate, yeast extract, and pH value identified as critical factors. The purified levan exhibited cytotoxic activity against skin carcinoma and hepatocellular carcinoma, as well as antioxidant activity with an IC50 of 24.42.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xianghui Zeng, Anne Marit de Groot, Alice J. A. M. Sijts, Femke Broere, Erik Oude Blenke, Stefano Colombo, Willem van Eden, Henrik Franzyk, Hanne Morck Nielsen, Camilla Foged
Article
Chemistry, Multidisciplinary
Chao Huang, Sheng-Jiao Yan, Xiang-Hui Zeng, Bo Sun, Min-Bo Lan, Jun Lin
Article
Pharmacology & Pharmacy
Monica Agnoletti, Adam Bohr, Kaushik Thanki, Feng Wan, Xianghui Zeng, Johan Peter Boetker, Mingshi Yang, Camilla Foged
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2017)
Article
Pharmacology & Pharmacy
Kaushik Thanki, Xianghui Zeng, Sarah Justesen, Sarah Tejlmann, Emily Falkenberg, Elize Van Driessche, Hanne Morck Nielsen, Henrik Franzyk, Camilla Foged
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2017)
Review
Pharmacology & Pharmacy
Zhaolu Xie, Xianghui Zeng
EXPERT OPINION ON DRUG DELIVERY
(2017)
Article
Pharmacology & Pharmacy
Nan Zhang, Chunyu Xu, Na Li, Shasha Zhang, Lingling Fu, Xiao Chu, Haiying Hua, Xianghui Zeng, Yongxing Zhao
Article
Chemistry, Medicinal
Hongjun Kang, Xingqing Xiao, Chao Huang, Yan Yuan, Dongyan Tang, Xiaochang Dai, Xianghui Zeng
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Medicine, Research & Experimental
Anne Marit de Groot, Kaushik Thanki, Monique Gangloff, Emily Falkenberg, Xianghui Zeng, Djai C. J. van Bijnen, Willem van Eden, Henrik Franzyk, Hanne M. Nielsen, Femke Broere, Nick J. Gay, Camilla Foged, Alice J. A. M. Sijts
MOLECULAR THERAPY-NUCLEIC ACIDS
(2018)
Article
Engineering, Biomedical
Xianghui Zeng, Ralf Morgenstern, Andreas M. Nystrom
Article
Chemistry, Organic
Jingbo Chen, Zhuxian Sun, Yanli Zhang, Jingchao Chen, Penghui Li, Xianghui Zeng, Benlin Yin, Yan Xie, Chen Qing, Hongbin Zhang
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2014)
Review
Pharmacology & Pharmacy
Stefano Colombo, Xianghui Zeng, Heloise Ragelle, Camilla Foged
EXPERT OPINION ON DRUG DELIVERY
(2014)
Article
Polymer Science
Yvonne Hed, Yuning Zhang, Oliver C. J. Andren, Xianghui Zeng, Andreas M. Nystroem, Michael Malkoch
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
(2013)
Article
Chemistry, Physical
Pontus Lundberg, Nathaniel A. Lynd, Yuning Zhang, Xianghui Zeng, Daniel V. Krogstad, Tim Paffen, Michael Malkoch, Andreas M. Nystrom, Craig J. Hawker
Article
Pharmacology & Pharmacy
Manon A. A. Jansen, Lasse H. Klausen, Kaushik Thanki, Jeppe Lyngso, Jan Skov Pedersen, Henrik Franzyk, Hanne M. Nielsen, Willem van Eden, Mingdong Dong, Femke Broere, Camilla Foged, Xianghui Zeng
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2019)
Article
Chemistry, Medicinal
Xianghui Zeng, Yanli Zhang, Chen Qing, Hongbin Zhang
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
