Journal
FITOTERAPIA
Volume 81, Issue 7, Pages 910-913Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.06.003
Keywords
Curculigosides F-H; Phenolic glycoside; Anti-HBV; Curculigo orchioides
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Funding
- Project of Yunnan Science and Technology Plan [2008IF011]
- Projects of new drugs development of China [2009ZX09102-126]
- Ministry of Sciences and Technology [2009CB941300]
- State key laboratory in KIB [0807E31211]
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Three new phenolic glycosides, curculigosides F-H (1-3), were isolated from rhizomes of Curculigo orchioides Gaertn. Their structures were elucidated based on comprehensive spectroscopic analyses including IR, MS, 1D- and 2D NMR (HSQC, COSY, and HMBC). Curculigosides F-H (1-3) were evaluated for their anti-HBV activity in vitro using the HBV transfected Hep G2.2.15 cell line. Compound 1 exhibited weak activity with an IC(50) value of 2.08 mM on hepatitis B virus (HBV) e antigen (HBeAg) secretion of the HepG2.2.15 cell line. (C) 2010 Elsevier B.V. All rights reserved.
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