Journal
FITOTERAPIA
Volume 81, Issue 6, Pages 644-648Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.03.010
Keywords
Rosmarinic acid; Prolyl oligopeptidase; Cognitive performance; Morris water maze
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Funding
- Seoul Research and Business Development Program [10524]
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It is well known that inhibition of prolyl oligopeptidase (POP) is involved in memory-related function. In this study, we observed that rosmarinic acid (RA) inhibits POP activity with an IC50 of 63.7 mu M. Subsequently, we investigated the cognitive-enhancing effects of RA employing the Morris water maze paradigm. The results demonstrated that RA is non-competitive POP inhibitor and that acute and subchronic RA treatments showed an inverted U-shaped dose-response curve in the platform crossings. Furthermore, chronic RA treatment significantly increased the platform crossings. These results suggest that RA has a cognitive-enhancing effect which may be mediated by inhibition of POP. (C) 2010 Elsevier B.V. All rights reserved.
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