Article
Medicine, Research & Experimental
Camille Keisha Mahendra, Hooi-Leng Ser, Syafiq Asnawi Zainal Abidin, Shafi Ullah Khan, Priyia Pusparajah, Thet Thet Htar, Lay-Hong Chuah, Siah Ying Tang, Long Chiau Ming, Khang Wen Goh, Yatinesh Kumari, Bey Hing Goh
Summary: This research focuses on the anti-pigmentation properties of Swietenia macrophylla seeds. Ethanol extraction and fractionation based on polarity were performed, followed by testing on zebrafish embryos. The ethanolic extract showed significant inhibition of tyrosinase activity and melanin production. Proteomic studies confirmed the downregulation of cathepsin LB and cytoskeletal proteins related to melanogenic pathway. Limonoids in the seed demonstrated stronger binding affinity to TYRP-1 than kojic acid, suggesting their potential in inhibiting pigmentation. Further studies and assays are needed for development of these phytocompounds into a skin whitening agent.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Camille Keisha Mahendra, Khang Wen Goh, Long Chiau Ming, Gokhan Zengin, Liang Ee Low, Hooi-Leng Ser, Bey Hing Goh
Summary: Cosmetics play an immeasurable role in our lives, from personal hygiene to skincare. Given the rise in demand for natural products, cosmetic companies are constantly searching for innovative ingredients and formulations. Swietenia macrophylla seeds have been found to possess potential cosmetic properties, such as skin whitening and protection against environmental damage, making them important in the pursuit of ageless beauty.
Article
Food Science & Technology
Chong Ning, Yuhan Jiao, Jiaqi Wang, Weiwei Li, Jingqiu Zhou, Yi-Chieh Lee, Dik-Lung Ma, Chung-Hang Leung, Rugang Zhu, Hui-Min David Wang
Summary: Diabetes is a global concern, with type 2 diabetes accounting for the majority of cases. Diet plays a crucial role in the development and control of diabetes. Natural substances may hold the key to diabetic health products and preventive treatments.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Guo-Kai Wang, Yun-Peng Sun, Wen-Fang Jin, Yang Yu, Jian-Yong Zhu, Jin-Song Liu
Summary: Sixteen new limonoids and 18 known limonoids were isolated from Swietenia macrophylla, and their structures were determined. Limonoid 19 exhibited significant cytotoxic effects against A375 cells and induced apoptosis.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Camille Keisha Mahendra, Syafiq Asnawi Zainal Abidin, Thet Thet Htar, Lay-Hong Chuah, Shafi Ullah Khan, Long Chiau Ming, Siah Ying Tang, Priyia Pusparajah, Bey Hing Goh
Summary: UVB radiation has detrimental effects on skin, but Swietenia macrophylla extract can reverse these effects, showing potential photoprotective properties by suppressing inflammation, collagen degradation, and cell apoptosis.
Review
Food Science & Technology
Meng Xiao, Xing Jia, Nifei Wang, Ji Kang, Xinzhong Hu, H. Douglas Goff, Steve W. Cui, Huihuang Ding, Qingbin Guo
Summary: Non-starch polysaccharides (NSPs) have therapeutic potential in managing type 2 diabetes mellitus (T2DM). However, more human clinical trials are needed to verify their actual efficacy. This article reviews the mechanisms of NSPs in treating T2DM and highlights the relationship between their structure and anti-T2DM activity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Food Science & Technology
Imrana Jazuli, Goh Bey Hing, Lakshmi Selvaratnam, Deepa Alex, Lee Learn Han, Yatinesh Kumari
Summary: Alzheimer's disease is a significant challenge to healthcare systems and economies worldwide, characterized by progressive memory dysfunction. Neuroinflammation plays a critical role in its progression. Available drugs primarily focus on symptomatic treatment, highlighting the need for safe adjunctive agents with specific targets and mechanisms of action. Swietenia macrophylla has shown potential neuroprotective properties, including anti-inflammatory, antioxidant, anti-acetylcholinesterase, and anti-mitochondrial dysfunction effects.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Materials Science, Paper & Wood
Masendra, Brandon Aristo Verick Purba, Ganis Lukmandaru
Summary: This study found significant differences in antioxidant activity between the outer and inner bark of Swietenia macrophylla, with the outer bark showing higher levels of total phenolic and flavonoid content as well as stronger antioxidant activity. GC-MS analysis revealed varying compositions of fatty acids, alcohols, and phenolic compounds in the inner and outer bark. A strong correlation was demonstrated between total phenolic content and antioxidant activity.
Article
Medicine, Research & Experimental
Laine C. Pinto, Felipe P. Mesquita, Leilane H. Barreto, Pedro F. N. Souza, Ingryd N. F. Ramos, Adrielly V. U. Pinto, Bruno M. Soares, Milton N. da Silva, Rommel M. R. Burbano, Raquel C. Montenegro
Summary: The study demonstrated the anticancer activity of S. macrophylla leaf extract and its isolated compound L1 against human colorectal cancer cells. L1 showed potent cytotoxicity and induced DNA damage and apoptosis in cancer cells, suggesting its potential as a promising anticancer agent for managing colorectal cancer.
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Biotechnology & Applied Microbiology
Xiaoyu He, Chang'e Wang, Yuxian Zhu, Xiaoqin Jiang, Yuyang Qiu, Fei Yin, Wenyu Xiong, Bin Liu, Ying Huang
Summary: The study found that Spirulina compounds can improve the symptoms of type 2 diabetes mellitus by regulating the intestinal flora and increasing the content of short-chain fatty acids (SCFAs).
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Chemistry, Medicinal
Rochmah Kurnijasanti, Giftania Wardani, Mohd. Rais Mustafa, Sri Agus Sudjarwo
Summary: Hyperglycemia causes cardiac cell damage by increasing ROS production. This study proves the antioxidant activity of Swietenia macrophylla extract nanoparticles as a protector against STZ-induced cardiac cell damage. The nanoparticles were created using high-energy ball milling and analyzed for their chemical compounds and size.
Article
Chemistry, Physical
Phan Thi Thuy, Tran Trung Hieu, Dau Xuan Duc, Hoang Van Trung, Nguyen Huy Hung, William N. Setzer, Tran Dinh Thang, Ninh The Son
Summary: Phytochemical investigation of the methanol extract of Swietenia macrophylla fruit resulted in the isolation of four limonoids. Compound 3 exhibited better antioxidant activity than the positive control. Compound 1 showed strong larvicidal activity against Aedes aegypti mosquitoes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Nutrition & Dietetics
Qingyu Ma, Ruohan Zhai, Xiaoqing Xie, Tao Chen, Ziqi Zhang, Huicui Liu, Chenxi Nie, Xiaojin Yuan, Aobai Tu, Baoming Tian, Min Zhang, Zhifei Chen, Juxiu Li
Summary: This study demonstrates that Lycium barbarum polysaccharide (LBP) effectively alleviates the symptoms of hyperglycemia and hyperlipidemia in type 2 diabetic mice by modulating intestinal flora. LBP improves the activities of antioxidative enzymes, reduces inflammation, and enhances the production of beneficial short-chain fatty acids in the gut. Moreover, LBP reverses the dysregulation of certain hormones and the insulin signaling pathway, further improving glucose metabolism in diabetic mice.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Yunfeng Zhao, Peilin Song, Shuai Yin, Tianyong Fan, Fengwei Li, Xiaodong Ge, Tingting Liu, Wei Xu, Su Xu, Ligen Chen
Summary: This study evaluated the anti-diabetic activity of Onchidium struma polysaccharides (OsPs) in diabetic mice. The results showed that OsPs significantly improved the features of type 2 diabetes mellitus (T2DM) by reducing fasting blood glucose levels, improving oral glucose tolerance test results, and decreasing pro-inflammatory factors. OsPs also improved insulin resistance and biochemical indicators, reduced lipid accumulation in the liver, and regulated the dysbiosis of gut microbiota. Moreover, OsPs increased the concentration of short-chain fatty acids (SCFAs). OsPs can be used as a novel food supplement for the prevention and treatment of T2DM.
Article
Biochemistry & Molecular Biology
Tarun K. Dua, Swarnalata Joardar, Pratik Chakraborty, Shovonlal Bhowmick, Achintya Saha, Vincenzo De Feo, Saikat Dewanjee
Summary: The study demonstrated that Myricitrin has therapeutic potential in diabetic nephropathy by improving glucose uptake, alleviating toxicity induced by high glucose, attenuating oxidative stress and inflammation, and inhibiting apoptosis and fibrosis in renal cells. Additionally, in silico analysis predicted the drug-likeness of Myricitrin, suggesting it as a potential therapeutic agent for diabetic nephropathy.
Article
Biochemistry & Molecular Biology
Shiv Rakesh Naik, Prashant Bharadwaj, Nadia Dingelstad, Subha Kalyaanamoorthy, Subhash C. Mandal, Aravindhan Ganesan, Debprasad Chattopadhyay, Partha Palit
Summary: COVID-19, caused by SARS-CoV-2 virus, has led to a global pandemic with significant impact. While safe and approved treatments are lacking, certain herbal compounds show potential efficacy and may be important in future COVID-19 treatment.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Cell Biology
Saikat Dewanjee, Jayalakshmi Vallamkondu, Rajkumar Singh Kalra, Albin John, P. Hemachandra Reddy, Ramesh Kandimalla
Summary: Diabetes is clinically associated with a higher risk of cardiac failure, with diabetic cardiomyopathy being a common complication that results from myocardial infarction. The dysfunction of autophagy plays a crucial role in the development of diabetic cardiomyopathy, leading to impaired cellular homeostasis and potential pathogenic effects. Current research focuses on understanding the molecular mechanisms of autophagy regulation in diabetic cardiomyopathy and exploring pharmacotherapeutic strategies to target autophagy.
AGEING RESEARCH REVIEWS
(2021)
Article
Neurosciences
Saikat Dewanjee, Jayalakshmi Vallamkondu, Rajkumar Singh Kalra, Nagaprasad Puvvada, Ramesh Kandimalla, P. Hemachandra Reddy
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to a year-long phase of public health adversaries and compromised healthcare globally. Understanding of neurological complications in COVID-19 patients is still limited, and factors such as age, sex, comorbidity, and disease severity play a role in exacerbating neurological manifestations in these patients.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Cell Biology
Saikat Dewanjee, Jayalakshmi Vallamkondu, Rajkumar Singh Kalra, Pratik Chakraborty, Moumita Gangopadhyay, Ranabir Sahu, Vijaykrishna Medala, Albin John, P. Hemachandra Reddy, Vincenzo De Feo, Ramesh Kandimalla
Summary: Diabetes mellitus is a major manifestation of metabolic syndrome with increasing prevalence. Chronic hyperglycemia can lead to various vascular complications, being the major cause of morbidity and mortality in diabetic patients. Histone deacetylase (HDAC) plays a crucial role in regulating molecular activities in diabetes and could serve as a potential therapeutic target for developing novel intervention strategies.
Article
Plant Sciences
Naibedya Dutta, Deepak Bharadwaj Pemmaraju, Suvranil Ghosh, Asif Ali, Ayan Mondal, Chirantan Majumder, Vinod K. Nelson, Subhash C. Mandal, Anup K. Misra, Aravind K. Rengan, Velyutham Ravichandiran, Chun-Tao Che, Katerina Gurova, Andrei Gudkov, Mahadeb Pal
Summary: The study showed that an alkaloid-rich fraction of Ervatamia coronaria leaf extracts (AFE) exhibited high toxicity to colorectal cancer cells by inducing cell cycle arrest and activating both apoptotic and autophagy pathways. It targeted key genes and signaling pathways involved in cancer cell survival and proliferation, offering a potential alternative therapy for colorectal cancer with minimal side effects on normal cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Cell Biology
Gilbert Ogunmokun, Saikat Dewanjee, Pratik Chakraborty, Chandrasekhar Valupadas, Anupama Chaudhary, Viswakalyan Kolli, Uttpal Anand, Jayalakshmi Vallamkondu, Parul Goel, Hari Prasad Reddy Paluru, Kiran Dip Gill, P. Hemachandra Reddy, Vincenzo De Feo, Ramesh Kandimalla
Summary: Alzheimer's disease is a prominent neurodegenerative disease that impairs cognitive function and is associated with neuroinflammation. Understanding factors such as cytokines and growth factors related to the development of AD can help us better understand and treat the disease.
Review
Cell Biology
Saikat Dewanjee, Ramesh Kandimalla, Rajkumar Singh Kalra, Chandrasekhar Valupadas, Jayalakshmi Vallamkondu, Viswakalyan Kolli, Sarbani Dey Ray, Arubala P. Reddy, P. Hemachandra Reddy
Summary: This article highlights the pathological crosstalk between COVID-19 and RA, emphasizing the importance of immune responses, particularly in the activation of cytokines. It also points out the relevance of the relationship between COVID-19 and RA for clinical monitoring and management.
Review
Biochemistry & Molecular Biology
Ramesh Kandimalla, Pratik Chakraborty, Jayalakshmi Vallamkondu, Anupama Chaudhary, Sonalinandini Samanta, P. Hemachandra Reddy, Vincenzo De Feo, Saikat Dewanjee
Summary: The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic, prompting rapid development of multiple vaccine candidates which have been commercialized in 2021. While these vaccines showed promising results, key insights into their epidemiology, protective mechanisms, and reinfection tendencies are lacking. This report provides insights into vaccination prospects, diverse strategies, approved vaccines, success rates, and potential challenges for the future.
Article
Food Science & Technology
Prasenjit Manna, Saikat Dewanjee, Swarnalata Joardar, Pratik Chakraborty, Hiranmoy Bhattacharya, Shrestha Bhanja, Chiranjib Bhattacharyya, Manas Bhowmik, Shovonlal Bhowmick, Achintya Saha, Joydeep Das, Parames C. Sil
Summary: This study revealed that CA has a protective effect against Dox-induced cardiotoxicity by suppressing oxidative stress and interfering with pathological signaling events. CA can potentially be used as an effective agent to alleviate Dox-induced cardiotoxicity in the future.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Saikat Dewanjee, Tarun K. Dua, Paramita Paul, Abhijit Dey, Jayalakshmi Vallamkondu, Sonalinandini Samanta, Ramesh Kandimalla, Vincenzo De Feo
Summary: Acetaminophen is a commonly used prescription medicine for pain and fever, but overdose or frequent use can cause severe liver injury. This review explores the potential of using probiotics and postbiotics as dietary supplements to protect against and treat acetaminophen-induced liver damage. Different probiotic bacteria and postbiotics have shown promising results in preclinical models, highlighting their potential as a safe therapeutic option against oxidative liver injury.
Review
Virology
Pardeep Yadav, Pratik Chakraborty, Niraj Kumar Jha, Saikat Dewanjee, Abhimanyu Kumar Jha, Siva Prasad Panda, Prabhu Chandra Mishra, Abhijit Dey, Saurabh Kumar Jha
Summary: Japanese encephalitis virus (JEV) is the leading cause of neurodegenerative disease in Southeast Asia and the Western Pacific region, posing a risk to 1.15 billion people and causing thousands of deaths each year. JEV enters neurons by binding to specific receptors and forms complexes, which also play a role in carcinogenic activity. In addition, JEV can enter brain cells and macrophages through other pathways, leading to inflammation in the central nervous system.
Review
Chemistry, Medicinal
Bhuvi Sachdeva, Punya Sachdeva, Arvind Negi, Shampa Ghosh, Sungsoo Han, Saikat Dewanjee, Saurabh Kumar Jha, Rakesh Bhaskar, Jitendra Kumar Sinha, Ana Claudia Paiva-Santos, Niraj Kumar Jha, Kavindra Kumar Kesari
Summary: Chitin is a biopolymer derived from marine crustaceans and organisms like bacteria, fungi, and algae, which offers biodegradability and biocompatibility properties suitable for biomedical applications. Its deacetylated derivative, chitosan, also possesses similar properties and can be used as a support material in biomedical applications. Additionally, both chitin and chitosan have intrinsic material properties such as antioxidant, antibacterial, and antitumor activities. This paper focuses on the use of chitin and chitosan biopolymers in drug delivery strategies for cancer treatment.
Review
Biochemistry & Molecular Biology
Nilanjan Ghosh, Leena Chacko, Hiranmoy Bhattacharya, Jayalakshmi Vallamkondu, Sagnik Nag, Abhijit Dey, Tanushree Karmakar, P. Hemachandra Reddy, Ramesh Kandimalla, Saikat Dewanjee
Summary: Diabetes mellitus (DM) and cardiovascular complications often occur together, creating a challenging situation. The development of diabetic cardiomyopathy (DCM) involves complex pathophysiological pathways at the metabolic and molecular level, leading to structural and functional alterations of the heart. Glucagon-like peptide-1 (GLP-1) analogues and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have shown promising results in improving cardiovascular outcomes in diabetes. This article highlights the pathways contributing to DCM and discusses potential future therapies.
Review
Biochemistry & Molecular Biology
Hafiza Padinharayil, Jinsu Varghese, Mithun Chacko John, Golgodu Krishnamurthy Rajanikant, Cornelia M. Wilson, Minnatallah Al-Yozbaki, Kaviyarasi Renu, Saikat Dewanjee, Rupa Sanyal, Abhijit Dey, Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Alex George
Summary: Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) supports therapeutic advances and accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention and management. Global cancer mortality projections indicate that cancer will become the leading cause of death, particularly non-small cell lung cancer (NSCLC) which accounts for a significant portion of lung cancers. Early diagnosis and proper management play crucial roles in NSCLC therapies. Advanced techniques, such as immune checkpoint inhibitors (ICIs) and targeted molecular therapies, have improved the treatment of late-stage NSCLC. However, the improvement of cancer biomarkers and the development of prospective studies are needed for better therapeutic outcomes.
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
