Journal
FITOTERAPIA
Volume 80, Issue 8, Pages 514-516Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2009.06.014
Keywords
Euphorbia pekinensis; Casbane diterpene; Pekinenal; 5 alpha-hydroxy-1 beta H,2 alpha H-casba-3Z,7E,11E-triene-18-al; Cytotoxic; X-ray
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Funding
- National Natural Science Foundation of China [30500066, 30672678]
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A new cytotoxic casbane diterpene, named pekinenal, was isolated from the roots of Euphorbia pekinensis. Its structure was elucidated as 5 alpha-hydroxy-1 beta H,2 alpha H-casba-3Z,7E,11E-triene-18-al by a combination of 1D- and 2D-NMR techniques and confirmed by X-ray crystallography. Pekinenal showed cytotoxic activity against all four human cancer cell lines tested. (C) 2009 Elsevier B.V. All rights reserved.
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