Article
Horticulture
Hairong Wu, Qian Ao, Huie Li, Fenfang Long
Summary: This study introduces a novel in vitro regeneration method for Rhododendron decorum using flower buds as explants. The optimal medium combinations and plant growth regulators for callus induction, adventitious shoot differentiation, proliferation, and rooting were determined. The developed regeneration system is simple, efficient, and minimally damages the mother plants, providing a foundation for plantlet propagation, genetic transformation, and new-variety breeding of R. decorum.
Article
Plant Sciences
Xingxing Mao, Ji Wang, Nawal Shrestha, Yazhen Ma, Jianquan Liu
Summary: This study aimed to delimit species boundaries within the Rhododendron species complex, resulting in the identification of two distinct species and one putative hybrid group. The findings were based on morphological analyses and population genetic data, indicating a potential introgression event that formed the hybrid group. Further investigations are needed to validate the existence and characteristics of this hybrid group.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yuanyuan Feng, Hanqi Zhang, Biao Gao, Guijuan Zheng, Suqin Zha, Guangmin Yao
Summary: Twenty-eight grayanane diterpenoids, including 13 new ones, were isolated from the flowers of Rhododendron dauricum L. Their structures were determined and their analgesic activities were evaluated, revealing the potential of these compounds as novel analgesics.
BIOORGANIC CHEMISTRY
(2023)
Article
Integrative & Complementary Medicine
He Yan-Chen, Yao Yu-Min, Xue Qiu-Wen, Fang Xin, Liang Shuang
Summary: In this study, a process for the preparation of diterpenoid fraction from Rhododendron molle fruits was established for potential arthritis therapy. The diterpenoid fraction was found to significantly alleviate rheumatoid arthritis symptoms in animal experiments, demonstrating potential as a safer and more effective alternative treatment option.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Chemistry, Multidisciplinary
Lang Huang, Guijuan Zheng, Yuanyuan Feng, Pengfei Jin, Biao Gao, Hanqi Zhang, Xiaomin Ma, Junfei Zhou, Guangmin Yao
Summary: Six highly oxygenated dimeric grayanane diterpenoids, including three new compounds, were isolated from the flowers of Rhododendron molle collected in Hubei, China. These compounds displayed significant analgesic activities and may have potential biosynthetic pathways.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Caroline G. Webster, Hyeri Park, Amanda F. Ennis, Jiyong Hong
Summary: Rhodojaponin III is a natural product with a novel chemical scaffold and potent antinociceptive activity, potentially representing a new class of natural non-opioid analgesics. Researchers synthesized the bicyclo[3.2.1]octane fragment of this compound through Au(I) and Mn(III)-mediated reactions, providing important experimental tools for future biological studies.
TETRAHEDRON LETTERS
(2021)
Article
Women's Studies
Catharine R. Stimpson
Summary: This essay provides a comprehensive history of the Title IX legislation in the United States and highlights the instability of the law. It emphasizes the need for a new code of ethics based on feminist principles to supplement the limitations of the legal system.
Article
Biochemistry & Molecular Biology
Ke Zeng, Shurong Ban, Zhiwei Cao, Pengkun Cao, Xujing Luo, Rong Wang, Zhengbao Zhao, Jinfang Xu
Summary: The phytochemical study of Rhododendron amesiae leaves led to the identification of 19 compounds, including diterpenoids, triterpenoids, and flavonoids. Some compounds were isolated and reported for the first time from the Rhododendron genus and the Ericaceae family. The chemotaxonomic significance of these compounds was also discussed.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Pharmacology & Pharmacy
JiaXu Qin, XiangWei Zheng, YanChen He, Yang Hong, Shuang Liang, Xin Fang
Summary: DF extracted from the fruit of Rhododendron molle has potential therapeutic effects on arthritis. It exhibits anti-inflammatory properties by inhibiting the secretion of inflammatory cytokines and regulating the proportion of T cells. Moreover, DF blocks the JAK/STAT signaling pathway to suppress the development of arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Organic
Nicolas Fay, Remi Blieck, Cyrille Kouklovsky, Aurelien de la Torre
Summary: This paper reviews the synthetic approaches to access grayanane natural products. By surveying the literature, the completed total syntheses are mainly focused on, with mention of ongoing synthetic efforts. The paper aims to provide a critical perspective on grayanane synthesis, highlighting the advantages, downsides, and remaining challenges of each strategy.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Ningyawen Liu, Lu Zhang, Yanli Zhou, Mengling Tu, Zhenzhen Wu, Daping Gui, Yongpeng Ma, Jihua Wang, Chengjun Zhang
Summary: The Rhododendron Plant Genome Database (RPGD) is a comprehensive platform for Rhododendron researchers, providing a wide range of omics data, tools, and resources. It is expected to become an indispensable hub for Rhododendron research.
Review
Plant Sciences
Jian Yang, Jingyi Zhao, Jiquan Zhang
Summary: This review investigated the notable anti-nociception, toxicity, and probable mechanisms of grayanoids, in addition to the analysis of binding sites on voltage-gated sodium channels (VSGCs). Over 50 compounds in grayanoids showed significant anti-nociception, with VSGCs playing a key role in both analgesic action and toxicity mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Horticulture
Jie Qiu, Chao Gao, Hongli Wei, Biao Wang, Yang Hu, Zhiyan Guo, Li Long, Lu Yang, Huie Li
Summary: The flowering biology of Rhododendron pulchrum was studied using various methods, revealing high pollen viability, a facultative outcrossing breeding system, and partial self-compatibility.
Article
Agronomy
Zbigniew Jarosz, Zenia Michalojc, Karolina Pitura, Katarzyna Dzida, Michal Koter
Summary: The study revealed that mycorrhization positively impacted the nutritional status of large-flowered azaleas, especially in the second and third years of cultivation.
Review
Biochemistry & Molecular Biology
Yi-Wen Nie, Yuan Li, Lan Luo, Chun-Yan Zhang, Wei Fan, Wei-Ying Gu, Kou-Rong Shi, Xiao-Xiang Zhai, Jian-Yong Zhu
Summary: Plants of the genus Daphne contain abundant natural diterpenoids with various bioactivities such as anticancer, anti-inflammatory, and anti-HIV effects. Studies have also summarized the structure-activity relationship to facilitate the synthesis and optimization of drugs.
Article
Chemistry, Organic
Xusheng Xu, Zhiqian Liu, Wenhao Shao, Ji Ye, Qingyan Sun, Weiwei He, Weidong Zhang
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2015)
Article
Chemistry, Organic
Chunting Liu, Kaijian Bi, Wanlin Chang, Ji Ye, Weidong Zhang, Qingyan Sun
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2015)
Article
Clinical Neurology
Jiao-Ning Shen, Liu-Xin Xu, Lei Shan, Wei-Dong Zhang, Hong-Lin Li, Rui Wang
CURRENT ALZHEIMER RESEARCH
(2015)
Review
Plant Sciences
Jian-Ping Zhang, Guo-Wei Wang, Xin-Hui Tian, Yong-Xun Yang, Qing-Xin Liu, Li-Ping Chen, Hui-Liang Li, Wei-Dong Zhang
JOURNAL OF ETHNOPHARMACOLOGY
(2015)
Article
Plant Sciences
Sabine Montaut, Wei-Dong Zhang, Jean-Marc Nuzillard, Gina R. De Nicola, Patrick Rollin
JOURNAL OF NATURAL PRODUCTS
(2015)
Article
Chemistry, Organic
Xi-ke Xu, Ji Ye, Li-ping Chen, Wei-dong Zhang, Yong-xun Yang, Hui-liang Li
TETRAHEDRON LETTERS
(2015)
Article
Oncology
Jiang-Jiang Qin, Wei Wang, Sukesh Voruganti, Hui Wang, Wei-Dong Zhang, Ruiwen Zhang
Article
Oncology
Jiang-Jiang Qin, Wei Wang, Sukesh Voruganti, Hui Wang, Wei-Dong Zhang, Ruiwen Zhang
Article
Chemistry, Multidisciplinary
Zhu-zhen Han, Ji Ye, Qing-Xin Liu, Yun-heng Shen, Rong-Cai Yue, Hui-Liang Li, Wei-Dong Zhang
Article
Multidisciplinary Sciences
Miao Jiang, Qinglin Zha, Chi Zhang, Cheng Lu, Xiaoping Yan, Wanhua Zhu, Wei Liu, Shenghao Tu, Liping Hou, Chengwu Wang, Wandong Zhang, Qinghua Liang, Bing Fan, Jiangping Yu, Weidong Zhang, Xinru Liu, Jing Yang, Xiaojuan He, Li Li, Xuyan Niu, Yan Liu, Hongtao Guo, Bing He, Ge Zhang, Zhaoxiang Bian, Aiping Lu
SCIENTIFIC REPORTS
(2015)
Article
Plant Sciences
Yan-Ping Gao, Qiang Wu, Yun-Heng Shen, Wei-Dong Zhang
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2016)
Article
Biochemical Research Methods
Yufen Wei, Na Gao, Zhongxiao Zhang, Xianpeng Zu, Zhenlin Hu, Weidong Zhang, Jun Yin, Xinru Liu
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2016)
Article
Biochemical Research Methods
Chengcheng Peng, Yongge Yang, Chao Lv, Huizi Jin, Jianfei Tao, Xing Yuan, Huimei Huang, Lin Han, Wanlin Chang, Runhui Liu, Weidong Zhang
BIOMEDICAL CHROMATOGRAPHY
(2015)
Article
Biochemical Research Methods
Mahmoud A. ElSohly, Waseem Gul, Candice Tolbert, Kareem M. ElSohly, Timothy P. Murphy, Bharathi Avula, Amar G. Chittiboyina, Mei Wang, Ikhlas A. Khan, Min Yang, Dean Guo, Wei-Dong Zhang, Juan Su
DRUG TESTING AND ANALYSIS
(2015)
Article
Integrative & Complementary Medicine
Yan Shi-Kai, Liu Run-Hui, Jin Hui-Zi, Liu Xin-Ru, Ye Ji, Shan Lei, Zhang Wei-Dong
CHINESE JOURNAL OF NATURAL MEDICINES
(2015)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
