Article
Engineering, Environmental
Zilin Zhou, Leigh R. Crilley, Jenna C. Ditto, Trevor C. Vandenboer, Jonathan P. D. Abbatt
Summary: Unsaturated triglycerides found in food and skin oils are reactive in ambient air, but their chemical fate in genuine indoor environments is not well understood. This study monitored the aging of oil coatings on glass surfaces and found that ozonolysis is the dominant degradation pathway for oil films in both commercial and office settings. Indoor photooxidation was found to accelerate radical formation on surfaces. The reactive oxygen species (ROS) observed may induce oxidative stress in human bodies and further investigation of their toxicological properties is warranted.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Food Science & Technology
Yuxuan Peng, Shen Dai, Yan Lu, Ligui Xiong, Jianan Huang, Zhonghua Liu, Yushun Gong
Summary: (-English Summary:)
The main active ingredient in green tea, Epigallocatechin-3-gallate (EGCG), has been shown to extend the lifespan of Caenorhabditis elegans. The combination of EGCG with theanine, rather than caffeine, can alleviate the adverse effects induced by high doses of EGCG. These findings will contribute to further research on the health benefits of tea active components and their interactions.
Article
Fisheries
Morteza Yousefi, Hamed Ghafarifarsani, Seyyed Morteza Hoseini, Seyed Hossein Hoseinifar, Behrooz Abtahi, Yury Anatolyevich Vatnikov, Evgeny Vladimirovich Kulikov, Hien Van Doan
Summary: The combination of thyme essential oil and Immunogen has positive effects on the growth performance, hematological parameters, immunity, and oxidative status of rainbow trout, enhancing their growth performance and immune capabilities.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Zhao, Yu-Cai Guo, Ming-Yan Huai, Lily Li, Chi Man, Wolf Pelletier, Han-Lin Wei, Rong Yao, Jin Niu
Summary: The effects of dietary astaxanthin from different sources on growth, pigmentation, and physiological function in Oncorhynchus mykiss were studied. Astaxanthin supplementation improved pigmentation, growth, intestinal morphology, crude protein content in dorsal muscle, and decreased cholesterol levels and enzyme activity in plasma. Astaxanthin also enhanced antioxidant capacity and stimulated innate immune responses in fish.
Article
Biochemistry & Molecular Biology
Nathan Favalier, Vincent Veron, Michael Marchand, Anne Surget, Patrick Maunas, Nicolas Turonnet, Stephane Panserat, Lucie Marandel
Summary: The study found that glucose and lipid metabolism in rainbow trout were regulated by nutritional status in all sexes, regardless of carbohydrate intake. Short-term carbohydrate intake at low temperature did not induce specific metabolic changes in broodstock. Additionally, sex differences were demonstrated for the first time regarding the consequences of two days of feeding on glucose and lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Morteza Yousefi, Mehdi Naderi Farsani, Hamed Ghafarifarsani, Seyed Hossein Hoseinifar, Hien Van Doan
Summary: The study demonstrated that mistletoe extract supplementation improved the growth performance, immune and antioxidant systems, and bactericidal activity of rainbow trout. The optimal dietary mistletoe extract level ranged from 1.78% to 1.94%.
Article
Fisheries
Esmaeil Pirali Kheirabadi, Pezhman Hosseini Shekarabi, Foroud Yadollahi, Mehdi Soltani, Esfandeyar Najafi, Juhani von Hellens, Carlos Luna Flores, Kheibar Salehi, Caterina Faggio
Summary: This study investigated the effects of red yeast (Phaffia rhodozyma) as an additive in rainbow trout feed on performance, carcass composition, antioxidant activity, and fillet pigmentation. The results showed that the addition of red yeast can improve the growth performance, antioxidant activity, and pigmentation of rainbow trout fillets.
AQUACULTURE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Giuliana Cardozo, Mauricio Mastrogiovanni, Ari Zeida, Nicolas Viera, Rafael Radi, Anibal M. Reyes, Madia Trujillo
Summary: Human peroxiredoxin 3 (HsPrx3) is oxidized and hyperoxidized by (f)FA-OOHs, including arachidonic acid and eicosapentaenoic acid peroxidation products. Biophysical methods and molecular dynamic simulations suggest that HsPrx3 can bind hydrophobic structures and interact with the hydroperoxide group of (f)FA-OOHs. Kinetic simulation analysis supports that mitochondrial (f)FA-OOHs can lead to HsPrx3 hyperoxidation.
Review
Biochemistry & Molecular Biology
Irina Tyuryaeva, Olga Lyublinskaya
Summary: In this review, the bioactivity of antioxidants (N-acetylcysteine, polyphenols, vitamin C) traditionally used in experimental biology and clinic was collected. The data presented indicate that while these substances have the capacity to scavenge peroxides and free radicals in cell-free systems, their ability to exhibit these properties in vivo has not been confirmed. Their cytoprotective activity is mainly explained by the activation of multiple redox pathways, leading to biphasic hormetic responses and pleiotropic effects in cells. The activity of antioxidants also strongly depends on the biological context and mode of application, which can explain conflicting results in research and guide their usage strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Hye-Jung Shin, Jin-Hee Chang, Jung-Ah Han
Summary: In order to develop a convenient food formulation for supplying antioxidants, HA-based ODFs containing Vit C and CAT with different molar ratios were prepared and analyzed. The results showed that CAT content affected the thickness, texture, and antioxidant effects of the ODFs. The most suitable molar ratio of Vit C:CAT was found to be 1:0.4. The optimized ODF exhibited rapid release of both Vit C and CAT in simulated body fluids, making it a suitable delivery formulation for fast-acting antioxidants.
Article
Biochemistry & Molecular Biology
Etsuo Niki
Summary: Vitamin E plays a crucial role in inhibiting unregulated lipid peroxidation by scavenging lipid peroxyl radicals, although it is not efficient in scavenging certain types of free radicals. Free radical-mediated lipid peroxidation is the major pathway of lipid oxidation in humans. Together with other antioxidants like vitamin C, vitamin E helps maintain human health and prevent diseases by inhibiting detrimental oxidation of biological molecules.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Iwona Zwolak
Summary: This review focuses on the effects of epigallocatechin gallate (EGCG) on toxicities induced by heavy metals (HMs), highlighting both the protective mechanisms and potential adverse impacts of EGCG. Challenges related to EGCG's low bioavailability and proper dosing in HM intoxication therapy are also discussed, offering insights into the design of new therapeutics for HM poisoning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Mahdi Banaee, Federica Impellitteri, Cristiana Roberta Multisanti, Antoni Sureda, Francesca Arfuso, Giuseppe Piccione, Caterina Faggio
Summary: This study investigated the effects of diazinon on fish and explored the potential protective effects of silymarin supplementation. Diazinon exposure caused liver damage in fish, but silymarin showed potential in reducing oxidative stress and restoring enzyme activities. However, the effectiveness of silymarin on creatine phosphokinase, glutathione reductase, and ammonia may be limited.
Article
Biotechnology & Applied Microbiology
Bernat Morro, Richard Broughton, Pablo Balseiro, Sigurd O. Handeland, Simon Mackenzie, Mary K. Doherty, Phillip D. Whitfield, Munetaka Shimizu, Marnix Gorissen, Harald Sveier, Amaya Albalat
Summary: The study found that growth stunting in seawater-transferred rainbow trout is mainly caused by a significant downregulation in plasma IGF-I and liver igf1 transcription, while changes in the liver proteome suggest reactive-oxygen-species-mediated endoplasmic reticulum stress as a key mechanism underlying the phenotype. Lipidomic analysis revealed a reduction in triacylglycerols and elevated amounts of cardiolipins, a characteristic lipid class associated with oxidative stress, in the growth stunting phenotype.
Article
Environmental Sciences
Jana Bohackova, Lucie Havlickova, Jaroslav Semerad, Ivan Titov, Olga Trhlikova, Hynek Benes, Tomas Cajthaml
Summary: The toxicity of polyethylene terephthalate (PET) and two forms of polyvinyl chloride (PVC) was assessed using cell lines derived from rainbow trout. The study showed that PVC dry blend powder and processed PVC microplastics had different toxic effects on the cells, with the dry blend powder causing higher ROS generation. PET did not induce any toxicity. The importance of choosing realistic extraction procedures for microplastic toxicity experiments was emphasized.
Article
Biotechnology & Applied Microbiology
Angelico Madaro, Ole Torrissen, Paul Whatmore, Santosh P. Lall, Jerome Schmeisser, Viviane Verlhac Trichet, Rolf Erik Olsen
MARINE BIOTECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Chris J. Hulatt, Irina Smolina, Adam Dowle, Martina Kopp, Ghana K. Vasanth, Galice G. Hoarau, Rene H. Wijffels, Viswanath Kiron
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Youngjin Park, Qirui Zhang, Geert F. Wiegertjes, Jorge M. O. Fernandes, Viswanath Kiron
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Serena Lima, Peter S. C. Schulze, Lisa M. Schuler, Ralf Rautenberger, Daniela Morales-Sanchez, Tamara F. Santos, Hugo Pereira, Joao C. S. Varela, Francesca Scargiali, Rene H. Wijffels, Viswanath Kiron
Summary: The periodic emission of light pulses by LEDs can stimulate growth or induce high value biocompounds in microalgae. Low-frequency flashing light can increase the productivity of proteins, polyunsaturated fatty acids, and pigments in algae biomass.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Immunology
Viswanath Kiron, Youngjin Park, Prabhugouda Siriyappagouder, Dalia Dahle, Ghana K. Vasanth, Jorge Dias, Jorge M. O. Fernandes, Mette Sorensen, Viviane Verlhac Trichet
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Environmental Sciences
Isabel S. Abihssira-Garcia, Youngjin Park, Viswanath Kiron, Pal A. Olsvik
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2020)
Article
Biotechnology & Applied Microbiology
Jerome Schmeisser, Viviane Verlhac-Trichet, Angelico Madaro, Santosh P. Lall, Ole Torrissen, Rolf Erik Olsen
Summary: The transcriptomic analysis revealed that pyloric caeca in post-smolt Atlantic salmon is more sensitive to dietary astaxanthin supplementation compared to hepatic and muscular tissues. Key genes sensitive to astaxanthin supplementation were identified in pylorus, liver, and muscle. The modulation of genes in pylorus was related to absorption and metabolism of astaxanthin, while liver showed a potential link to the ferroptosis process. Dietary astaxanthin had a lesser impact on muscle except for genes related to actin remodelling and glucose homeostasis.
MARINE BIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Giacomo Zaccone, Gioele Capillo, Jorge Manuel Oliveira Fernandes, Viswanath Kiron, Eugenia Rita Lauriano, Alessio Alesci, Patrizia Lo Cascio, Maria Cristina Guerrera, Michal Kuciel, Krystyna Zuwala, Jose Manuel Icardo, Atsushi Ishimatsu, Ryosuke Murata, Takafumi Amagai, Antonino Germana, Marialuisa Aragona
Summary: Antimicrobial peptides (AMPs) are multifunctional peptides with antimicrobial and immunomodulatory activities. This review focuses on the molecular characterization of the fish-specific AMP piscidin1 and its role in the immune response against pathogens. The discovery of piscidins in the gill and skin and their potential as drug targets for antimicrobial barrier function and aquaculture therapy is important for future research.
Article
Biochemical Research Methods
Viswanath Kiron, Purushothaman Kathiresan, Jorge M. O. Fernandes, Mette Sorensen, Ghana K. Vasanth, Qingsong Lin, Qifeng Lin, Teck Kwang Lim, Dalia Dahle, Jorge Dias, Viviane Verlhac Trichet
Summary: The study investigates the effects of a dietary health additive on intestinal inflammation in Atlantic salmon by profiling the intestine mucus proteome. The results indicate that the dietary additive reduces the severity of inflammation and the number of altered proteins. This study provides insights into the limited understanding of the inflammation-associated proteome in fish and suggests the potential of dietary approaches in preventing organ dysfunction.
JOURNAL OF PROTEOMICS
(2022)
Article
Food Science & Technology
Viswanath Kiron, Maria Hayes, Dorit Avni
Summary: Inflammatory bowel disease (IBD) was originally associated with industrialized nations but has now spread globally due to the popularity of ultra-processed food and lack of proper strategies to avoid foodborne microbes. Imbalance in bacteria, intestinal permeability, and dysbiosis are key factors in IBD. Using probiotics, prebiotics from algae, and a synbiotic strategy could help combat IBD by controlling pathogen proliferation and promoting beneficial bacteria growth.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Fisheries
S. Rider, V. Verlhac-Trichet, D. Constant, E. Chenal, S. Etheve, B. Riond, H. Schmidt-Posthaus, R. Schoop
Summary: The vitamin D endocrine system is essential for regulating the expression of various genes in vertebrates, including those related to bone health, growth, nutrient metabolism, and immunity. Salmonids have high requirements for vitamin D compared to other aquaculture species. However, factors such as aquafeed composition, growth in seawater, and production challenges may lead to suboptimal activation of vitamin D hormone in fish.
Article
Fisheries
Ester Santigosa, Rolf Erik Olsen, Angelico Madaro, Viviane Verlhac Trichet, Ian Carr
Summary: This study confirms the effects of partially or fully replacing fish oil (FO) with microalgal oil (AO) on growth, muscle fatty acid profiles, and muscle quality of farmed Atlantic salmon, contributing to the sustainable growth of aquaculture. EPA and DHA digestibility was greater than 96% when the lipid source in the diet was changed. Sensory characteristics of raw fish fillets were similar among treatments, indicating no impact on consumers. Overall, the results suggest that the tested AO enables sustainable growth of Atlantic salmon aquaculture by maintaining EPA and DHA levels in fish fillets while reducing the marine footprint of aquafeeds.
JOURNAL OF THE WORLD AQUACULTURE SOCIETY
(2023)
Article
Food Science & Technology
Yousri Abdelhafiz, Adnan Hussain Gora, Saima Rehman, Soumitra Chowdhury, Youngjin Park, Saraswathy Bisa, Viviane Verlhac Trichet, Jorge M. O. Fernandes, Mette S. orensen, Viswanath Kiron
Summary: Dietary polyphenols improve gut health through direct effects on the host's intestinal barrier, antioxidant and immune systems, as well as through the action of metabolites produced by the microbiota. Specific polyphenols like gallic acid, curcumin, resveratrol, quercetin, daidzein, and anthocyanins have been found to prevent or treat intestinal inflammation and brain disorders by chelating metals and scavenging free radicals. However, only a small fraction of polyphenol catabolites are bioavailable, with the majority being metabolized by the gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Fisheries
Giacomo Zaccone, Alessio Alesci, Doaa M. M. Mokhtar, Marialuisa Aragona, Maria Cristina Guerrera, Gioele Capillo, Marco Albano, Jorge de Oliveira Fernandes, Viswanath Kiron, Ramy K. A. Sayed, Marwa M. M. Hussein, Patrizia Lo Cascio, Michal Kuciel, Krystyna Zuwala, Antonino Germana, Jose Manuel Icardo, Eugenia Rita Lauriano
Summary: The recognition and elimination of invading pathogens are essential for host survival. Macrophages, which function similarly to vertebrate macrophages, play a crucial role in host protection in all multicellular organisms. CD14 is a pattern responsible for bacterial recognition found on the surface of macrophages. These cells store antimicrobial molecules and display polarization states similar to mammalian macrophages. The present study reports the presence of various cell markers, including CD14, in the intestinal macrophages of catfish and bonytongue, providing insights into the in vivo function of macrophages in fish.
Article
Fisheries
Solveig Lysfjord Sorensen, Ateshm Ghirmay, Yangyang Gong, Dalia Dahle, Ghana Vasanth, Mette Sorensen, Viswanath Kiron
Summary: The study found that the fish meal-based diet showed the best growth performance, followed by the pre-extruded Nannochloropsis diet. Feeding of unprocessed Nannochloropsis and Tetraselmis resulted in reduced enterocyte vacuolization. There was a significant effect of processing on fillet fatty acid content, intestine and liver structure, and the expression of selected genes in the liver.