Article
Immunology
Piet Nuijten, Natalie Cleton, Jeroen van der Loop, Birgit Makoschey, Wilco Pulskens, Geert Vertenten
Summary: Intranasal vaccination with live attenuated BRSV and BPIV3 virus strains can provide early protection against bovine respiratory disease in young calves. Vaccination induced gene expression profiles reflecting an antiviral state, early activation of innate immune and antiviral responses, and specific cellular immune pathways. The vaccinated animals were protected against nasal shedding of the challenge virus and clinical symptoms, and gene expression levels returned to values before vaccination.
Article
Fisheries
K. P. Madushani, K. A. S. N. Shanaka, H. M. S. M. Wijerathna, Chaehyeon Lim, Taehyug Jeong, Sumi Jung, Jehee Lee
Summary: In this study, Bcl2 in Amphiprion clarkii was identified as an anti-apoptotic protein with the highest expression level in blood, potentially facilitating the propagation of viral infections.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Carter Gottlieb, Mason Henrich, Philip T. Liu, Vahe Yacoubian, Jeffery Wang, Rene Chun, John S. Adams
Summary: Vitamin D modulates human immune responses and deficiency increases susceptibility to infection. However, there is debate over what constitutes sufficient levels and whether it is useful as a therapeutic adjuvant, largely due to inadequate understanding of its immune modulatory function.
Article
Fisheries
Xiaohao Li, Yanyun Liu, Jianxin Cheng, Yuqing Xia, Kunpeng Fan, Ying Liu, Peng-fei Liu
Summary: This study cloned a fibrinogen alpha chain-like gene from Atlantic salmon, analyzed its expression pattern after infection by the bacterium Aeromonas salmonicida, and found that it may play important roles in the innate immune responses to bacterial invasion in Atlantic salmon. The study highlighted the significance of Ss-FGA in the immune system of Atlantic salmon.
AQUACULTURE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Livio Ruzzante, Romain Feron, Maarten J. M. F. Reijnders, Antonin Thiebaut, Robert M. Waterhouse
Summary: The study explores the roles of constraints in shaping evolutionary outcomes in the contexts of developmental biology, population genetics, and comparative genomics. It suggests that gene roles in immune responses limit the range of possible evolutionary scenarios they exhibit.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Veterinary Sciences
Elisabetta Razzuoli, Chiara Grazia De Ciucis, Barbara Chirullo, Katia Varello, Roberto Zoccola, Lisa Guardone, Paola Petrucci, Danja Rubini, Elena Bozzetta, Maria Goria, Floriana Fruscione, Paola Modesto
Summary: Canine mammary cancer shares many similarities with human breast cancer in terms of risk factors, behavior, and clinical course. These breast tumors are resistant to conventional therapies, making the study of alternative treatments necessary. The CF33 cell line can serve as an in vitro model for evaluating innovative therapeutic approaches involving bacteria.
VETERINARY SCIENCES
(2022)
Article
Genetics & Heredity
Xiaofei Zhu, Kang Mu, Yi Wan, Linlin Zhang
Summary: NOD-like receptor (NLR) genes are critical innate immune receptors in animals and plants. However, the systematic study of NLRs in lophotrochozoans, one of the most species-rich superphyla, is lacking. In this study, we annotated 185 NLRs in 29 lophotrochozoan genomes and analyzed their domain organization, phylogenetic distribution, molecular evolution, and gene expression patterns. Our findings reveal that molluscs have a limited number of NLRs and some show developmental stage-specific expression patterns.
Article
Oncology
Kit Tong, Sharon Yoon, Keren Isaev, Mehran Bakhtiari, Tracy Lackraj, Michael Y. He, Jesse Joynt, Anjali Silva, Maria C. Xu, Gilbert G. Prive, Housheng Hansen He, Rodger E. Tiedemann, Elizabeth A. Chavez, Lauren C. Chong, Merrill Boyle, David W. Scott, Christian Steidl, Robert Kridel
Summary: The study focuses on uncovering the genetic and pharmacologic opportunities to enhance the clinical efficacy of EZH2 inhibitors in DLBCL, specifically through the sensitizing effect of IKZF1 loss and combination treatment with lenalidomide. Transcriptomic and epigenetic analyses shed light on the synergistic modulation of epigenetic changes and enhancement of antitumor effects in DLBCL with the combination treatment.
CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Aiten Ismailova, Reyhaneh Salehi-Tabar, Vassil Dimitrov, Babak Memari, Camille Barbier, John H. White
Summary: This study identified a transcription network in neutrophils that is induced in response to inflammatory stimuli, which is regulated by FOXP4 transcription factor. The network consists of genes encoding proinflammatory cytokines and transcription factors involved in stress, survival, and inflammation responses. The findings highlight the importance of the FOXP4 transcription network in neutrophil response to inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Adrienne R. Kambouris, Jerod A. Brammer, Holly Roussey, Chixiang Chen, Alan S. Cross
Summary: The combination of burn state and infection affects gene expression in both the host and pathogen, increasing the propensity for infection. Inhibiting IL-10 signaling or co-administering arginine can improve survival rates in a burn and infection model.
Article
Multidisciplinary Sciences
Hongzhen Li, Vijender Chaitankar, Lena Cui, Weiping Chen, Kyung Chin, Jianqiong Zhu, Wenli Liu, Griffin P. Rodgers
Summary: In this study, the distribution of Olfm4/eGFP-expressing cells in the mouse prostate and urethral tube was investigated. Olfm4+ cells were found to play important roles in the growth and development of the epithelium.
SCIENTIFIC REPORTS
(2023)
Article
Fisheries
Lei Zhu, Gaoliang Yuan, Xinyu Jiang, Jie Zhang, Xianliang Zhao, Chao Pei, Li Li, Xianghui Kong
Summary: The Rab5 and Rab6 genes from crayfish Procambarus clarkii were cloned, and their involvement in bacterial and viral infections in the immune response of P. clarkii was revealed. The genes showed wide tissue distribution and increased expression levels after infection with pathogens. Silencing of PcRab5 and PcRab6 affected the mortality rate of crayfish challenged by pathogens, indicating their significant roles in the immune response.
Article
Engineering, Multidisciplinary
Jian Yang, Lili Zhao, Sheng Yi, Fei Ding, Yumin Yang, Yan Liu, Yongjun Wang, Mei Liu, Chengbin Xue, Lian Xu, Leilei Gong, Xinghui Wang, Yu Zhang, Bin Yu, Guo-li Ming, Xiaosong Gu
Summary: The molecular network features of spinal cord development, including fluctuating RNA expression levels, microRNAs and transcriptional factors exhibiting mosaic profiles, and differential alternative splicing events, play crucial roles in initiating spinal cord patterning and development. Furthermore, there is a negative correlation between innate immunity and intrinsic growth capacity, with epigenetic modifications and G protein-coupled receptors contributing to the regulatory functions and pleiotropic roles in axonal growth. This study provides valuable insights for investigating spinal cord development and developing novel tissue engineering strategies.
Article
Immunology
Fumie Horiuchi, Yuta Yoshino, Hiroshi Kumon, Rie Hosokawa, Kiwamu Nakachi, Kentaro Kawabe, Jun-ichi Iga, Shu-ichi Ueno
Summary: This study identified significant gene expression changes in the blood of adults with ASD, particularly in genes related to the immune system. The replication cohort confirmed these findings, suggesting a potential link between dysregulated gene expressions and the pathogenesis of ASD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Veterinary Sciences
Carlos Neila-Ibanez, Louise Brogaard, Lola Pailler-Garcia, Jorge Martinez, Joaquim Segales, Mariela Segura, Peter M. H. Heegaard, Virginia Aragon
Summary: Streptococcus suis is a common pathogen in swine that can cause arthritis, polyserositis, and meningitis. Colonization by S. suis often occurs early in the life of piglets, and the outcome of infection is influenced by both the virulence of the strains and the immunity of the animals. In this study, the innate immune response to S. suis was investigated in piglets, showing differences in gene transcription and local inflammatory responses between virulent and non-virulent strains of the pathogen.
VETERINARY RESEARCH
(2021)
Article
Fisheries
Rosana A. Estevez, Miriam G. Contreras Mostazo, Eduardo Rodriguez, Juan Carlos Espinoz, Juan Kuznar, Zophonias O. Jorisson, Gudmundur H. Gudmundsson, Valerie H. Maier
FISH & SHELLFISH IMMUNOLOGY
(2018)
Article
Materials Science, Biomaterials
Jacob Odeberg, Anders Wirsen, Ake Norberg, Jakob Frie, Gordana Printz, Hugo Lagercrantz, Gudmundur H. Gudmundsson, Birgitta Agerberth, Baldvin Jonsson
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Multidisciplinary Sciences
Iwona T. Myszor, Zahida Parveen, Hakan Ottosson, Peter Bergman, Birgitta Agerberth, Roger Stromberg, Gudmundur H. Gudmundsson
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Rokeya Sultana Rekha, Harpa Karadottir, Sultan Ahmed, Gudmundur H. Gudmundsson, Birgitta Agerberth, Peter Bergman
INFECTION AND IMMUNITY
(2020)
Review
Immunology
Peter Bergman, Rubhana Raqib, Rokeya Sultana Rekha, Birgitta Agerberth, Gudmundur H. Gudmundsson
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Xinmeng Liao, Yawen Lan, Rui Shao, Jiayu Liu, Shufei Liang, Zhan Yin, Gudmundur H. Gudmundsson, Peter Bergman, Min Wan
Summary: Vitamin D has a significant impact on the generation and function of neutrophils in zebrafish, promoting granulopoiesis and enhancing neutrophil activity. VD also reduces bacterial counts and mortality in zebrafish infected with pathogens, in a neutrophil-dependent manner.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Immunology
Iwona T. Myszor, Snaevar Sigurdsson, Alexia Ros Viktorsdottir, Birgitta Agerberth, Eeva-Liisa Eskelinen, Margret Helga Ogmundsdottir, Gudmundur H. Gudmundsson
Summary: This study found that APD HO53 induces autophagy through a complex mechanism involving multiple pathways and epigenetic events. The induction of autophagy is associated with activation of AMPK, nuclear translocation of TFEB, and changes in expression of autophagy-related genes.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Marjorie Laurence Barrier, Iwona Teresa Myszor, Priyanka Sahariah, Snaevar Sigurdsson, Miguel Carmena-Bargueno, Horacio Perez-Sanchez, Gudmundur Hrafn Gudmundsson
Summary: In the context of antibiotic resistance, the urgent need for alternative treatment strategies is addressed in this study. The researchers investigated the use of synthetized compounds called aroylated phenylenediamines (APDs) to induce the expression of a gene called cathelicidin antimicrobial peptide gene (CAMP) as a means to reduce the use of antibiotics during infection. The compound HO53 showed promising results in inducing CAMP expression in bronchial epithelium cells, and further analysis revealed its potential as a histone deacetylase (HDAC) inhibitor, which affects the acetylation status of cells and influences the expression of CAMP and other genes related to innate immunity and metabolism.
MOLECULAR IMMUNOLOGY
(2023)
Review
Immunology
Iwona T. Myszor, Gudmundur Hrafn Gudmundsson
Summary: The innate immune system of the airway epithelium consists of multiple components that work together to protect the host from invading pathogens. Modulating innate immune responses in the airway epithelium to boost host defenses and enhance immune responses is an alternative approach to standard antibiotics. This review discusses the possibilities of such modulation for host-directed therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Xinmeng Liao, Yawen Lan, Wentao Wang, Jinjin Zhang, Rui Shao, Zhan Yin, Gudmundur H. Gudmundsson, Peter Bergman, Kangsen Mai, Qinghui Ai, Min Wan
Summary: This study used cyp2r1 mutant zebrafish and zebrafish fed a VD-deficient diet as VD-deficient animal models to investigate the role of VD in intestinal immunity against bacterial infection. The results showed that VD deficiency decreased the expression of antimicrobial peptides and IL-22, and increased susceptibility to bacterial infection in zebrafish. VD regulated gut microbiota composition and short-chain fatty acid production in the zebrafish intestine, leading to enhanced immunity.
Article
Medicine, Research & Experimental
Jon P. Joelsson, Iwona T. Myszor, Snaevar Sigurdsson, Fredrik Lehmann, Clive P. Page, Gudmundur H. Gudmundsson, Thorarinn Gudjonsson, Sigurbergur Karason
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2020)
Review
Infectious Diseases
Sultan Ahmed, Rubhana Raqib, Gudmundur Hrafn Gudmundsson, Peter Bergman, Birgitta Agerberth, Rokeya Sultana Rekha
Article
Medicine, Research & Experimental
Jon P. Joelsson, Iwona T. Myszor, Ari J. Arason, Saevar Ingthorsson, Paulina Cherek, Gabriel S. Windels, Kristjan Leosson, Gudmundur H. Gudmundsson, Thorarinn Gudjonsson, Sigurbergur Karason
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2019)
Article
Respiratory System
Ari Jon Arason, Jon Petur Joelsson, Bryndis Valdimarsdottir, Snaevar Sigurdsson, Alexander Gudjonsson, Skarphedinn Halldorsson, Freyr Johannsson, Ottar Rolfsson, Fredrik Lehmann, Saevar Ingthorsson, Paulina Cherek, Gudmundur H. Gudmundsson, Fridrik R. Gardarsson, Clive P. Page, Olafur Baldursson, Thorarinn Gudjonsson, Jennifer A. Kricker
RESPIRATORY RESEARCH
(2019)
Article
Immunology
Shakir Hasan, Nikhil Nitin Kulkarni, Arni Asbjarnarson, Irena Linhartova, Radim Osicka, Peter Sebo, Gudmundur H. Gudmundsson
INFECTION AND IMMUNITY
(2018)
