Article
Immunology
Justin T. H. Chan, Amparo Picard-Sanchez, Jovana Majstorovic, Alexander Rebl, Dirk Koczan, Filip Dycka, Astrid S. Holzer, Tomas Korytar
Summary: The presence of pathogen antibodies on red blood cells of infected rainbow trout indicates that red blood cells play a larger role in host immunity than previously appreciated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Jinho Bae, Seunghyung Lee, Mohammad Moniruzzaman, Ali Hamidoghli, Wonsuk Choi, Seunghan Lee, Taesun Min, Shin-Kwon Kim, Sungchul C. Bai
Summary: The study investigated the effects of different diets containing fish meal and fish meal analog on juvenile Japanese eel, determined the optimum level of fish meal analog as a substitute for fish meal protein, and evaluated the immunostimulant effects of natural feed additives. The results showed that fish meal analog could replace up to 10% of fish meal protein without compromising growth and health of the fish, and the additives could improve the replacing rate of fish meal analog without affecting the fish's growth and health.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Fisheries
Qiang Fu, Jie Hu, Pei Zhang, Yuqing Li, Shoucong Zhao, Min Cao, Ning Yang, Chao Li
Summary: Seventeen CC and CXC chemokine genes were identified in the turbot genome, making it a valuable resource for comparative immunological studies and functional characterization of chemokines in teleost.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Xing Lv, Qiang Luo, Shiying Xin, Weiwei Zheng, Tianjun Xu, Yuena Sun
Summary: In recent years, there has been an increasing focus on the study of circular RNAs (circRNAs) in noncoding RNAs. While circRNAs are abundant in mammalian studies, research in lower vertebrates has been lacking. In this study, a circRNA called circPlce1 was found to be related to the innate immune response in Miichthys miiuy (miiuy croaker). Experimental results showed that circPlce1 could promote the production of antiviral genes and inflammatory response. It was also observed that circPlce1 can promote cell proliferation and improve cell viability. The study provides a foundation for understanding the biological function of circRNAs in the innate immune response in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Nora Albaladejo-Riad, Alberto Cuesta, M. Angeles Esteban
Summary: The aim of this study was to induce and characterize extracellular traps (ETs) produced by gilthead seabream (Sparus aurata L.) head-kidney leucocytes. After stimulating the leucocytes with various substances, ETs structures were observed and quantified, revealing different morphological properties depending on the stimulant used. This research provides important insights into the immune response of fish and its potential application in mitigating microbial infections in fish farms.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Lisen Li, Joao C. R. Cardoso, Rute C. Felix, Ana Patricia Mateus, Adelino V. M. Canario, Deborah M. Power
Summary: The evolution and function of lysozymes in fish show lineage and species-specific adaptations, suggesting differences in maternal innate immune protection among different species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Fisheries
Yina Shao, Chengyang Wang, Tianyu Lu, Jianyang Jiang, Chenghua Li, Xuelei Wang
Summary: This study found that feeding Bacillus cereus LS2 could significantly improve the growth performance and immune parameters of sea cucumbers by activating specific pathways. Furthermore, LS2 diet could also influence the intestinal microbial composition of sea cucumbers by increasing the abundance of Actinobacteria and Bacteroidetes.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Nguyen Bao Trung, Fan-Hua Nan, Meng-Chou Lee, Jiun-Yan Loh, Hong-Yi Gong, Ming-Wei Lu, Ho Thi Hang, Yu-Lin Lin, Po-Tsang Lee
Summary: TLR18 is expressed in all tissues, with the highest levels in the intestine and the lowest in the liver. It is up-regulated in immune-related organs after bacterial and poly I:C challenges, and in THK cells after LPS stimulation. TLR18 localizes in the intracellular compartment, and interacts with MyD88 and TRIF as adaptors. Constitutively active TLR18 induces the production of various effectors like cytokines and antimicrobial peptides in THK cells.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Yanhong Song, Weiwei Zheng, Shiying Xin, Jiajia Pan, Liyuan Yang, Yuena Sun, Tianjun Xu
Summary: This study identified a novel long noncoding RNA (lncRNA) called LTCONS6801 in Miichthys miiuy, which contributes to the TANK-binding kinase 1 (TBK1) pathway and promotes the host immune function. The overexpression of lncRNA LTCONS6801 was found to enhance cell activity and increase the expression of antiviral genes and TBK1. Furthermore, lncRNA LTCONS6801 was found to regulate the NF-kappa B and IRF3 signaling pathways by modulating TBK1 expression. In conclusion, lncRNA LTCONS6801 positively regulates the host innate immune response by controlling TBK1 expression, highlighting its important role in antiviral immunity of teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Tan Phat Nguyen, Bao Trung Nguyen, Fan-Hua Nan, Meng-Chou Lee, Po-Tsang Lee
Summary: Nile tilapia (Oreochromis niloticus) is an important food fish species mainly cultivated in tropical and subtropical countries. This study focuses on Toll-like receptors (TLRs) and the clonation of OnTLR23 in fish cells. The study also explores the interaction of OnTLR23 with other molecules and its potential role in immune responses.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Mahaut Beghin, Melodie Schmitz, Stephane Betoulle, Olivier Palluel, Sebastien Baekelandt, Syaghalirwa N. M. Mandiki, Erin Gillet, Katherine Nott, Jean-Marc Porcher, Christelle Robert, Sebastien Ronkart, Patrick Kestemont
Summary: This study found that subchronic waterborne exposure to a common pharmaceutical mixture in freshwater ecosystems may affect the neuroendocrine and immune systems of juvenile rainbow trout.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biochemistry & Molecular Biology
Smruti Mahapatra, Bristy Ganguly, Saswati Pani, Ashis Saha, Mrinal Samanta
Summary: This article provides an overview of various aspects of Toll-like receptors (TLRs) in fish, including their history, classification, structure, function, signaling pathways, and expression patterns. The article highlights the specific contribution of TLRs to the immune response in fish and identifies gaps in research in this area.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Ning-Xia Xiong, Sheng-Wei Luo, Zhuang-Wen Mao, Lan-Fen Fan, Kai-Kun Luo, Shi Wang, Fang-Zhou Hu, Ming Wen, Qing-Feng Liu, Shao-Jun Liu
Summary: The study revealed that Ferritin H in hybrid fish plays an important role in regulating fish immunity, with its fusion proteins exhibiting direct binding activity to A. hydrophila and reducing inflammation. These findings suggest that Ferritin H in hybrid fish elicits a similar immune response to A. hydrophila-induced inflammation compared to its parental species.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Editorial Material
Hematology
Dorian O. Haskard
Summary: The article by Obermayer et al in this issue of Blood presents a new perspective by discovering an anticoagulant role for innate immunity, linking circulating microvesicles with natural immunoglobulin M antibodies. This intriguing story carries high clinical significance.
Article
Chemistry, Medicinal
Bruno Reis, Lourenco Ramos-Pinto, Sara A. Cunha, Manuela Pintado, Joana Laranjeira da Silva, Jorge Dias, Luis Conceicao, Elisabete Matos, Benjamin Costas
Summary: This study evaluated the effects of different feed formulations containing Chlorella vulgaris on the health status and inflammatory response of gilthead seabream. The results showed that Chlorella vulgaris supplementation had an impact on the circulating neutrophils in the fish, but had mild effects on the innate immune and antioxidant functions. In the inflammatory response, the soluble peptide-enriched extract of Chlorella vulgaris seemed to have a protective, anti-stress effect in the gut.
Article
Fisheries
Janet Velazquez, Jannel Acosta, Naylin Herrera, Antonio Morales, Osmany Gonzalez, Fidel Herrera, Mario Pablo Estrada, Yamila Carpio
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Immunology
Rebeca Martinez, Liz Hernandez, Lazaro Gil, Yamila Carpio, Antonio Morales, Fidel Herrera, Anna Rodriguez-Mallon, Yeny Leal, Aracelys Blanco, Mario Pablo Estrada
Article
Immunology
Marisela Suarez, Yusmel Sordo, Yanet Prieto, Maria P. Rodriguez, Lidice Mendez, Elsa M. Rodriguez, Alina Rodriguez-Mallon, Elianet Lorenzo, Elaine Santana, Nemecio Gonzalez, Paula Naranjo, Maria Teresa Frias, Yamila Carpio, Mario Pablo Estrada
Article
Fisheries
Janet Velazquez, Jannel Acosta, Juana Maria Lugo, Eduardo Reyes, Fidel Herrera, Osmany Gonzalez, Antonio Morales, Yamila Carpio, Mario Pablo Estrada
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2018)
Article
Immunology
Shawna L. Semple, Tania Rodriguez-Ramos, Yamila Carpio, John S. Lumsden, Mario P. Estrada, Brian Dixon
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Fisheries
Yeny Leal, Janet Velazquez, Liz Hernandez, Jaya Kumari Swain, Alianet Rodriguez Rodriguez, Rebeca Martinez, Claudia Garcia, Yassel Ramos, Mario Pablo Estrada, Yamila Carpio
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Fisheries
Yehfang Hu, Yamila Carpio, Callum Scott, Ayham Alnabulsi, Abdo Alnabulsi, Tingyu Wang, Fuguo Liu, Milena Monte, Tiehui Wang, Christopher J. Secombes
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2019)
Article
Fisheries
Mayte Gonzalez, Jesus Luis Betancourt, Tania Rodriguez-Ramos, Mario Pablo Estrada, Yamila Carpio, Laida Ramos
AQUACULTURE RESEARCH
(2020)
Article
Fisheries
Janet Velazquez, Geysi Perez, Shawna L. Semple, Tania Rodriguez-Ramos, Patricia Diaz-Rosales, Maria del Camino Ordas, Juana Maria Lugo, Brian Dixon, Carolina Tafalla, Mario Pablo Estrada, Yamila Carpio
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Jaya Kumari Swain, Yamila Carpio, Lill-Heidi Johansen, Janet Velazquez, Liz Hernandez, Yeny Leal, Ajey Kumar, Mario Pablo Estrada
Article
Fisheries
Janet Velazquez, Alianet Rodriguez, Hasel Aragon, Arlette Haidar, Marcos Gonzalez, Rodolfo Valdes, Hilda Elsa Garay, David Diago Abreu, Yassel Ramos, Ania Cabrales, Antonio Morales, Osmany Gonzalez, Fidel Herrera, Mario Pablo Estrada, Yamila Carpio
Summary: In this study, a monoclonal antibody against tilapia IgM heavy chain was successfully produced and characterized using a peptide-based strategy. The antibody showed specificity and efficacy in studying the humoral immune response in fish species, demonstrating its utility as a molecular tool for fish immunology research.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Alianet Rodriguez, Janet Velazquez, Luis Gonzalez, Tania Rodriguez-Ramos, Brian Dixon, Fidel Herrera Miyares, Antonio Morales, Osmany Gonzalez, Mario Pablo Estrada, Yamila Carpio
Summary: PACAP-38 from African catfish enhances antibacterial activity and modulates gene expression of immune-related molecules, suggesting its potential as an antimicrobial agent in aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Fidel Herrera, Janet Velazquez, Juana Maria Lugo, Paola Orellana, Joceline Ruiz, Matias Vega, Alex Romero, Nestor Santos, Gerardo Ramses, Tania Rodriguez-Ramos, Brian Dixon, Mario Pablo Estrada, Patricio Dantagnan, Yamila Carpio
Summary: This study demonstrated that dietary supplementation with synthetic PACAP-38 can improve PUFA content in muscle, increase the number of caliciform cells within intestinal villi, and modulate the transcription of cytokines in head kidney of rainbow trout fingerlings. These findings suggest potential benefits of using small peptides as feed additives to enhance the quality of cultured fish fingerlings.
AQUACULTURE REPORTS
(2021)
Article
Immunology
Ileanet Avalos, Thailin Lao, Elsa Maria Rodriguez, Yasser Zamora, Alianet Rodriguez, Ailyn Ramon, Gilda Lemos, Ania Cabrales, Monica Bequet-Romero, Dionne Casillas, Ivan Andujar, Luis Ariel Espinosa, Luis Javier Gonzalez, Yanitza Alvarez, Yamila Carpio, Mario Pablo Estrada
Summary: COVID-19 is a highly contagious respiratory viral disease caused by the novel coronavirus SARS-CoV-2. Researchers have developed a recombinant protein by fusing the receptor-binding domain (RBD) of the viral protein spike (S) with the extracellular domain of CD154, an immune system modulator molecule. This recombinant protein has shown promising immunogenicity in mice and non-human primates, inducing a specific and high IgG response and neutralizing the virus. It has the potential to enhance the current vaccines against COVID-19.
Article
Fisheries
Janet Velazquez, Lynn Cruz, Maylin Perez-Bernal, Onel Valdivia, Arlette Haidar, Alianet Rodriguez, Fidel Herrera, Osmany Gonzalez, Antonio Morales, Lisbet Ulloa, Reinaldo Blanco, Joel Perez, Dayami Dorta, Yaramis Luna, Hilda Elisa Garay, David Diago Abreu, Yassel Ramos, Vladimir Besada, Yeosvany Cabrera, Mario Pablo Estrada, Yamila Carpio
Summary: In this study, a monoclonal antibody (mAb) specific to Nile tilapia IgT was generated and confirmed for its specificity. The mAb showed immunoreactivity against recombinant IgT fragment and native IgT in skin mucus. The percentage of IgT+ B cell populations differed between juveniles and adults and after immunostimulation. This mAb serves as an important immunological tool for studying the biological function and structural characteristics of tilapia IgT.
FISH AND SHELLFISH IMMUNOLOGY REPORTS
(2023)