Article
Psychology, Clinical
Alan J. Thomas, Calum A. Hamilton, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, Louise M. Allan, John O'Brien, John-Paul Taylor, Paul C. Donaghy
Summary: Impaired olfaction may serve as a potential biomarker for early Lewy body disease, particularly in cases of mild cognitive impairment with Lewy bodies (MCI-LB). Olfactory function was significantly worse in individuals with probable MCI-LB compared to those with MCI-AD and healthy controls. A lower cutoff score of ≤ 7 on the SS-16 is recommended for identifying early LB disease in memory services.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Clinical
Calum A. Hamilton, Fiona E. Matthews, Paul C. Donaghy, John-Paul Taylor, John T. O'Brien, Nicola Barnett, Kirsty Olsen, Ian G. McKeith, Alan J. Thomas
Summary: The study identified three distinct cognitive trajectories in individuals with MCI: slow/stable progression, intermediate progressive decline, and a small group with rapid decline. The presence of LB symptoms, particularly visual hallucinations, predicted decline in cognitive function. Identifying individuals with rapid decline is important for early intervention, although further research with larger cohorts is needed.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Hiroyuki Watanabe, Sakura Hikida, Manabu Ikeda, Etsuro Mori
Summary: This study aimed to determine the characteristics of aphasic mild cognitive impairment (aphasic MCI), which is characterized by a progressive and relatively prominent language impairment compared with other cognitive impairments, in the prodromal phase of dementia with Lewy bodies (DLB). The clinical diagnosis of probable prodromal DLB accounted for more than 30% of cases in the aphasic MCI cohort, and language impairment was not very uncommon in prodromal DLB. Patients with cholinesterase inhibitor therapy showed improvement in general cognitive function, including language function.
FRONTIERS IN NEUROLOGY
(2023)
Article
Psychology, Clinical
Paul C. Donaghy, Joanna Ciafone, Rory Durcan, Calum A. Hamilton, Sally Barker, Jim Lloyd, Michael Firbank, Louise M. Allan, John T. O'Brien, John-Paul Taylor, Alan J. Thomas
Summary: MCI-LB is characterized by more neuropsychiatric symptoms compared to MCI-AD. The presence of two or more neuropsychiatric supportive symptoms as defined by MCI-LB diagnostic criteria is highly specific and moderately sensitive for a diagnosis of MCI-LB. The cognitive profile of MCI-LB differs from MCI-AD.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neurosciences
Manon Querry, Frederic Blanc, Olivier Bousiges, Nathalie Philippi, Benjamin Cretin, Catherine Demuynck, Candice Muller, Anne Botzung
Summary: The aim of this study was to describe the characteristics and evolution of the long-term memory profile of patients with prodromal and mild DLB and AD. The study found that DLB patients performed better than AD patients in terms of total recall, delayed total recall, recognition, and loss of information over time. The memory performance of DLB patients remained stable over 48 months, unlike that of AD patients. Four indicators were relevant to distinguish between DLB and AD patients in terms of memory performance.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Calum A. Hamilton, James Frith, Paul C. Donaghy, Sally A. H. Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, John-Paul Taylor, Louise M. Allan, John O'Brien, Alison J. Yarnall, Alan J. Thomas
Summary: The study aimed to compare the blood pressure and heart rate responses of probable MCI-LB and MCI-AD patients to orthostatic challenge and Valsalva manoeuvre. The findings indicate that abnormal blood pressure response to Valsalva may be more common in probable MCI-LB, while orthostatic hypotension is not a clear distinguishing feature between MCI-AD and MCI-LB.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Paul C. Donaghy, Claudia Carrarini, Daniel Ferreira, Annegret Habich, Dag Aarsland, Claudio Babiloni, Ece Bayram, Joseph P. M. Kane, Simon J. G. Lewis, Andrea Pilotto, Alan J. Thomas, Laura Bonanni
Summary: This study conducted a systematic review and meta-analysis of the diagnostic clinical features and biomarkers in MCI-LB, supporting the inclusion of current clinical features in the diagnostic criteria and finding promise in FDG-PET and quantitative EEG as diagnostic biomarkers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kobra Etminani, Amira Soliman, Anette Davidsson, Jose R. Chang, Begona Martinez-Sanchis, Stefan Byttner, Valle Camacho, Matteo Bauckneht, Roxana Stegeran, Marcus Ressner, Marc Agudelo-Cifuentes, Andrea Chincarini, Matthias Brendel, Axel Rominger, Rose Bruffaerts, Rik Vandenberghe, Milica G. Kramberger, Maja Trost, Nicolas Nicastro, Giovanni B. Frisoni, Afina W. Lemstra, Bart N. M. van Berckel, Andrea Pilotto, Alessandro Padovani, Silvia Morbelli, Dag Aarsland, Flavio Nobili, Valentina Garibotto, Miguel Ochoa-Figueroa
Summary: This study developed and validated a 3D deep learning model to predict the final clinical diagnosis of common neurodegenerative disorders using 18F-FDG PET scans of the brain. The model's performance was competitive compared to human readers and showed superior results in ROC space.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Geriatrics & Gerontology
Andrea M. Weinstein, Swathi Gujral, Meryl A. Butters, Christopher R. Bowie, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, James L. Kennedy, Linda Mah, Shima Ovaysikia, Bruce G. Pollock, Tarek K. Rajji, Benoit H. Mulsant
Summary: This study compared diagnostic rates and clinical predictors between NIA-AA criteria and DSM-5 criteria, finding that discrepancies were more likely in individuals with a history of MDD or carrying at least one ApoE4 allele. Detailed neuropsychological testing and NIA-AA criteria identified a greater prevalence of cognitive impairment compared to DSM-5 criteria and the Montreal Cognitive Assessment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Neurosciences
Sarah Payne, Jane B. Shofer, Andrew Shutes-David, Ge Li, Adrienne Jankowski, Pamela Dean, Debby Tsuang
Summary: This study aims to identify baseline characteristics in individuals with mild cognitive impairment (MCI) that correlate with eventual conversion to DLB or AD. The strongest predictors of conversion to DLB were nonamnestic MCI, multidomain MCI, male sex, and presence of nighttime behaviors.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Andre Janse, Ondine van de Rest, Lisette C. P. G. M. de Groot, Renger F. Witkamp
Summary: This study investigated the association between 25(OH)D levels and different types of dementia in a geriatric outpatient population in the Netherlands. The results showed that both AD and VaD patients had lower levels of 25(OH)D compared to individuals without dementia, while there were no significant differences in 25(OH)D levels between MCI and other types of dementia patients and individuals without dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
James E. Galvin, Stephanie Chrisphonte, Iris Cohen, Keri K. Greenfield, Michael J. Kleiman, Claudia Moore, Mary Lou Riccio, Amie Rosenfeld, Niurka Shkolnik, Marcia Walker, Lun-Ching Chang, Magdalena I. Tolea
Summary: The study tested the performance of the LBD-MOD module in characterizing Lewy body dementia (DLB) and distinguishing it from Alzheimer's disease (AD). Results showed differences between DLB and AD in various symptoms, as well as differences between MCI-DLB and MCI-AD. The LBD-MOD module provided excellent characterization of core features and supportive features to differentiate DLB from AD and also characterize features of MCI-DLB.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Alan J. Thomas, Calum A. Hamilton, Amanda Heslegrave, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Debbie Lett, Michael Firbank, Gemma Roberts, John-Paul Taylor, Paul C. Donaghy, Henrik Zetterberg, John O'Brien
Summary: The study found that plasma pTau181 can serve as a blood-based biomarker for AD co-pathology and is associated with cognitive decline in patients with dementia with Lewy bodies and MCI with AD. pTau181 partially discriminated probable MCI-LB from controls and MCI-AD from controls, but was not useful in distinguishing probable MCI-LB from MCI-AD.
MOVEMENT DISORDERS
(2022)
Letter
Clinical Neurology
Min Seung Kim, Don Gueu Park, Jung Han Yoon
ACTA NEUROLOGICA BELGICA
(2023)
Letter
Neurosciences
Don Gueu Park, Min Seung Kim, Jung Han Yoon
Article
Neurosciences
Don Gueu Park, Juhee Kang, Young-Sil An, Jaerak Chang, Jung Han Yoon
Summary: In early Parkinson's disease patients, plasma alpha-synuclein levels were found to correlate with cardiac sympathetic denervation but not with nigrostriatal degeneration. This suggests that plasma alpha-synuclein levels may more readily reflect the peripheral deposition of Lewy bodies rather than their central deposition.
NEUROSCIENCE LETTERS
(2022)
Article
Clinical Neurology
Don Gueu Park, Suk Yun Kang, Jin Yong Hong, Mun Kyung Sunwoo, Jung Han Yoon
Summary: In a study investigating determinants of motor severity in vascular parkinsonism (VaP), it was found that regional white matter intensity (WMH) burden and comorbidities such as periventricular hyperintensities (PVH) and diabetes were significantly associated with motor severity in patients with normal dopamine transporter (DAT) imaging. These results suggest that diabetes and white matter hyperintensities may play a significant role in the development of motor symptoms in VaP.
PARKINSONISM & RELATED DISORDERS
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Keun Lee, Dong Gueu Park, Min Seung Kim, Young Sil An, Jung Han Yoon
CLINICAL NUCLEAR MEDICINE
(2022)
Letter
Clinical Neurology
Min Seung Kim, InJa Shin, Don Gueu Park, Jung Han Yoon
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Min Seung Kim, Don Gueu Park, Young-Sil An, Jung Han Yoon
Summary: This study compared the specific patterns of cortical hypoperfusion, dopamine transporter uptake, and cardiac MIBG uptake between glucocerebrosidase gene mutation Parkinson's disease (GBA-PD) and sporadic Parkinson's disease (sPD). The findings showed decreased regional perfusion in the bilateral posterior parietal and occipital cortex in GBA-PD patients and a higher prevalence of cardiac sympathetic denervation and non-motor symptoms in GBA-PD compared to sPD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Ji Man Hong, Jin Soo Lee, Yeong-Bae Lee, Dong Hoon Shin, Dong-Ick Shin, Yang-Ha Hwang, Seong Hwan Ahn, Jae Guk Kim, Sung-Il Sohn, Sun U. Kwon, Ji Sung Lee, Byoung Joo Gwag, Angel Chamorro, Dennis W. Choi
Summary: This study evaluated the safety and efficacy of nelonemdaz in patients with acute ischemic stroke. While there was no significant difference in the proportion of patients achieving modified Rankin Scale scores of 0-2 at 12 weeks among the groups, patients treated with nelonemdaz showed a favorable tendency towards achieving these scores without serious adverse effects. A large-scale phase III trial is warranted for further validation.
Article
Clinical Neurology
Yoon Seob Kim, Don Gueu Park, Min Seung Kim, Jung Han Yoon
Summary: This case report presents a 53-year-old patient with Parkinson's disease and a VCP mutation who developed motor complications. The patient underwent subthalamic nucleus deep brain stimulation at 56 years old, but myopathy emerged 1.5 years after the surgery. The variability of VCP phenotype should be taken into consideration when evaluating the long-term outcomes of deep brain stimulation.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Don Gueu Park, Ju Yeong Kim, Min Seung Kim, Mi Hee Kim, Young-Sil An, Jaerak Chang, Jung Han Yoon
Summary: This study found that plasma neurofilament light chain (NfL) and cardiac metaiodobenzylguanidine (MIBG) uptake may be useful biomarkers in predicting phenoconversion of isolated rapid-eye-movement sleep behavior disorder (iRBD) patients. Elevated plasma NfL levels may suggest imminent phenoconversion to multiple system atrophy (MSA), whereas low cardiac MIBG uptake suggests phenoconversion to Lewy body disease (LBD).
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Min Seung Kim, Don Gueu Park, Young Eun Gil, In Ja Shin, Jung Han Yoon
Summary: It has been found that 1-year levodopa treatment may have adverse effects on vascular endothelial function in de novo PD patients. Further studies are needed to clarify the exact pathogenesis and clinical implication of levodopa-induced endothelial dysfunction in PD.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Don Gueu Park, Min Seung Kim, In Ja Shin, Jung Han Yoon
Summary: This study suggests that STN-DBS can improve vascular endothelial function in PD patients. Age is a key factor influencing the change in vascular endothelial function.
PARKINSONISM & RELATED DISORDERS
(2023)
Letter
Clinical Neurology
In Ja Shin, Tae Joon Kim, Min Seung Kim, Don Gueu Park, Jung Han Yoon
PARKINSONISM & RELATED DISORDERS
(2023)
Letter
Clinical Neurology
Min Seung Kim, Don Gueu Park, Jung Han Yoon
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Min Kim, Seong-Joon Lee, So Young Park, Ji Man Hong, Jin Soo Lee
Summary: In this study, a new classification system for intracranial large vessel occlusion (LVO) patients undergoing endovascular treatment (EVT) was proposed. The system differentiated between extracranial and intracranial atherosclerosis, classified cryptogenic embolism, and identified other determined etiologies. The ICAS group had a longer median onset-to-puncture time and a lower rate of complete recanalization after EVT.
PRECISION AND FUTURE MEDICINE
(2023)