Characterization of retinal architecture in Parkinson's disease

Background: Parkinson's disease (PD) is a neurodegenerative disorder associated with dopaminergic cell loss and a-synuclein aggregation in Lewy bodies, which has been demonstrated in the retina. Methods: We performed a spectral-domain optical coherence tomography (OCT) study in patients with PD and healthy controls to measure the peripapillary retinal nerve fiber layer thickness and macular volume. Intra-retinal segmentation was performed to measure the volume of the retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL), and outer nuclear (ONL) layers. Analysis was carried out blinded to the clinical status of study participants. Results: 101 PD and 46 healthy control eyes were included in the study. In PD patients, peripapillary retinal nerve fiber layer was not significantly thinner (96.95 mu m vs 94.42 mu m, p = 0.08) but macular volume was (8.58 mm3 vs 833 mm3, p = 0.0002). Intra-retinal segmentation showed that PD subjects have reduced GCL, IPL, INL and ONL volumes. In contrast the OPL volume was significantly increased (0.81 mm3 vs 0.78 mm3 p = 0.0214). Conclusions: Thickening of the OPL is a novel finding which may correspond to the localization of alpha-synuclein in the OPL of PD patients. We hypothesize that the enlargement of the OPL may represent a potential biomarker of a-synuclein aggregation in PD. This may have significant clinical implications. (C) 2015 Published by Elsevier B.V.