Review
Environmental Sciences
Ines Klein, Helmar C. Lehmann
Summary: Peripheral neuropathy is a common side effect of chemotherapy, affecting up to 60% of cancer patients. Paclitaxel induces neuropathy in gynecological and urological cancer patients, leading to cell death and affecting both central and peripheral nervous system cells. Symptoms include pain and numbness in hands and feet, with pathomechanisms involving axonal damage and disrupted axonal transport.
Article
Multidisciplinary Sciences
Grace Ji-eun Shin, Maria Elena Pero, Luke A. Hammond, Anita Burgos, Atul Kumar, Samantha E. Galindo, Tanguy Lucas, Francesca Bartolini, Wesley B. Grueber
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect from cancer treatment with no known prevention or cure. Studying a genetically tractable Drosophila model and mouse sensory neurons, researchers have identified potential protective pathways against CIPN, shedding light on the mechanisms underlying this condition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Martial Caillaud, Nipa H. Patel, Alyssa White, Mackinsey Wood, Katherine M. Contreras, Wisam Toma, Yasmin Alkhlaif, Jane L. Roberts, Tammy H. Tran, Asti B. Jackson, Justin Poklis, David A. Gewirtz, M. Imad Damaj
Summary: The study demonstrated the therapeutic potential of fibrates, specifically fenofibrate and choline fenofibrate, in reversing and preventing pain sensitivity in peripheral neuropathies associated with paclitaxel treatment. Additionally, these fibrates did not diminish the antitumoral effects of paclitaxel, suggesting a potential for their pharmacological repurposing in PIPN.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Oncology
Martial Caillaud, Nipa H. Patel, Wisam Toma, Alyssa White, Danielle Thompson, Jared Mann, Tammy H. Tran, Jane L. Roberts, Justin L. Poklis, John W. Bigbee, Xianjun Fang, David A. Gewirtz, M. Imad Damaj
Summary: The study demonstrates the therapeutic potential of fenofibrate in preventing paclitaxel-induced peripheral neuropathy by reducing pain symptoms through modulation of PPAR-alpha expression and decreasing neuroinflammation. This suggests a possible repurposing of fenofibrate in the clinic for preventing paclitaxel-induced neuropathy.
Article
Medicine, General & Internal
David Mizrahi, Susanna B. Park, Tiffany Li, Hannah C. Timmins, Terry Trinh, Kimberley Au, Eva Battaglini, David Wyld, Robert D. Henderson, Peter Grimison, Helen Ke, Peter Geelan-Small, Julie Marker, Brian Wall, David Goldstein
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating adverse effect of neurotoxic cancer treatments, and this study suggests that participants with low pretreatment hemoglobin, higher body mass index, older age, and female sex were more likely to develop CIPN posttreatment after receiving paclitaxel or oxaliplatin chemotherapy. Future research should explore whether these risk factors are associated with a higher incidence of CIPN development.
Review
Biochemistry & Molecular Biology
Takehiro Kawashiri, Mizuki Inoue, Kohei Mori, Daisuke Kobayashi, Keisuke Mine, Soichiro Ushio, Hibiki Kudamatsu, Mayako Uchida, Nobuaki Egashira, Takao Shimazoe
Summary: Paclitaxel is essential in chemotherapy for various cancers, but its frequent side effect of peripheral neuropathy poses challenges. While many drugs have shown neuroprotective effects in animal models, few have demonstrated efficacy in clinical trials. Therefore, enhancing translational research is crucial for bridging the gap between preclinical and clinical studies in addressing paclitaxel-induced peripheral neuropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Su-Hyun Kim, Ki Hoon Kim, Jae-Won Hyun, Ji Hyun Kim, Sang-Soo Seo, Ho Jin Kim, Sang-Yoon Park, Myong Cheol Lim
Summary: This study evaluated the potential of sNfL and sBDNF as reliable biomarkers for PIPN. The study found that sNfL levels were associated with the severity of PIPN and may indicate PIPN progression. Additionally, low sBDNF levels within 6 months after chemotherapy may affect PIPN recovery.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Kosar Hooshmand, David Goldstein, Hannah C. Timmins, Tiffany Li, Michelle Harrison, Michael L. Friedlander, Craig R. Lewis, Justin G. Lees, Gila Moalem-Taylor, Boris Guennewig, Susanna B. Park, John B. Kwok
Summary: This study identified genetic loci associated with paclitaxel-induced chemotherapy-induced peripheral neuropathy (CIPN) through a genome-wide association study. Further analysis revealed the potential involvement of axon development and regeneration pathways in CIPN.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Nathan P. Staff, Sybil C. Hrstka, Surendra Dasari, Enrico Capobianco, Sandra Rieger
Summary: This study investigated the effects of paclitaxel therapy on the skin of breast cancer patients with chemotherapy-induced peripheral neuropathy (CIPN). Neurological examinations, quality of life questionnaires, and skin punch biopsies were conducted, revealing no significant difference in intraepidermal nerve fiber (IENF) density between control and CIPN patients. However, RNA sequencing and immunostaining showed upregulated MMP-13 expression and ultrastructural changes in collagen and basement membrane structures.
Article
Endocrinology & Metabolism
Chao Yu, Lei Zhuang, Feng Xu, Li-hua Zhao, Xiao-hua Wang, Chun-hua Wang, Li-yan Ning, Xiu-lin Zhang, Dong-mei Zhang, Xue-qin Wang, Jian-bin Su
Summary: Increased serum ADA levels may be a potential risk factor for diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2D).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Pavel Adamek, Mario Heles, Anirban Bhattacharyya, Monica Pontearso, Jakub Slepicka, Jiri Palecek
Summary: The novel FDA-approved PI3K delta/gamma isoform-specific inhibitor duvelisib shows promising ability in preventing paclitaxel-induced peripheral neuropathy, indicating its potential for use in human medicine.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Oncology
Alisha Joan Leen, Dominic Wei Ting Yap, Chong Boon Teo, Benjamin Kye Jyn Tan, Alex Molassiotis, Hiroshi Ishiguro, Sarah Wei Xian Fan, Raghav Sundar, Yu Yang Soon, Aishwarya Bandla
Summary: The study found that non-pharmacological neuroprotective interventions are more effective than pharmacological methods in preventing PIPN, leading to a significant reduction in the incidence of PIPN.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Martina Catalano, Monica Ramello, Raffaele Conca, Giuseppe Aprile, Roberto Petrioli, Giandomenico Roviello
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse event in cancer patients receiving taxane-based chemotherapy. This study identified age and the number of chemotherapy cycles as key risk factors for CIPN development. Identifying and validating different risk factors could help in preventing and optimizing management of CIPN.
Article
Cell Biology
Shanshan Zhong, Fangxi Liu, Rashid Giniatullin, Jukka Jolkkonen, Yong Li, Zhike Zhou, Xinyu Lin, Chang Liu, Xiuchun Zhang, Zhouyang Liu, Cheng Lv, Qianqian Guo, Chuansheng Zhao
Summary: This study analyzed the microbiome and metabolome of feces and serum from breast cancer patients receiving paclitaxel treatment. The results showed that increased levels of deoxycholic acid (DCA) due to the growth of Clostridium species were associated with severe neuropathy. DCA further induced overexpression of CCR5 in dorsal root ganglion (DRG) through the TGR5 receptor, leading to neuronal hyperexcitability. Inhibition of CCR5 suppressed the development of neuropathic nociception.
Article
Biochemistry & Molecular Biology
Haizhu Xing, Shubo Zhang, Min You, Ming Yan, Jie Zhang, Jiayi Chen, Yang Chen, Xiaoli Liu, Jing Zhu
Summary: In this study, the neuroprotective effects and mechanisms of thymoquinone (TQ) in paclitaxel-induced peripheral neuropathy (PIPN) were investigated. The results demonstrated that TQ significantly alleviated pain behavior, modulated pathological changes, and reduced inflammatory factors induced by PIPN. Further experiments revealed that TQ exerts neuroprotective effects by regulating the TLR4/MyD88 and its downstream NF-kappa B and MAPKs inflammatory pathways. Molecular docking and cellular thermal shift assay confirmed the interaction between TQ and TLR4.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Hematology
Carlos Bravo-Perez, Maria Eugenia de la Morena-Barrio, Belen de la Morena-Barrio, Antonia Minano, Jose Padilla, Rosa Cifuentes, Pedro Garrido, Vicente Vicente, Javier Corral
Summary: This study reveals a molecular defect in a significant proportion of cases with transient antithrombin deficiency, changing the paradigm of thrombophilia as the pathogenic effect of some mutations may depend on external factors and only be present at certain time points. Antithrombin deficiency is underestimated, and molecular screening may be appropriate in cases with fluctuating laboratory findings.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Correction
Oncology
E. Perez-Navarro, V. Conteduca, A. Gonzalez-del-Alba, B. Mellado, P. Cremaschi, O. Fernandez-Calvo, M. J. Mendez-Vidal, M. A. Climent, I. Duran, A. Font, M. P. Fernandez-Perez, A. Martinez, M. J. Lopez-Andreo, G. Attard, D. Castellano, E. Grande, U. de Giorgi, J. A. Botia, J. T. Palma Mendez, E. Gonzalez-Billalabeitia
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
M. A. Vicente Conesa, M. Zafra Poves, A. Carmona-Bayonas, I Ballester Navarro, P. de la Morena Barrio, A. Ivars Rubio, S. Montenegro Luis, E. Garcia Garre, V. Vicente, F. Ayala de la Pena
Summary: In this study, a simple and validated model was developed to provide individualized predictions of survival for oncological patients after hospitalization.
Article
Biochemistry & Molecular Biology
David Zaragoza-Huesca, Pedro Garrido-Rodriguez, Paula Jimenez-Fonseca, Eva Martinez de Castro, Manuel Sanchez-Canovas, Laura Visa, Ana Custodio, Ana Fernandez-Montes, Julia Penas-Martinez, Patricia Morales del Burgo, Javier Gallego, Gines Luengo-Gil, Vicente Vicente, Irene Martinez-Martinez, Alberto Carmona-Bayonas
Summary: The study aimed to identify genes associated with thrombosis in advanced gastric cancer patients, in order to improve the prediction of thrombotic risk. Using a national registry, the researchers identified several genes related to thrombosis and found that these genes were associated with both the intestinal and diffuse subtypes of gastric cancer.
Article
Oncology
Esther Navarro-Manzano, Gines Luengo-Gil, Rocio Gonzalez-Conejero, Elisa Garcia-Garre, Elena Garcia-Martinez, Esmeralda Garcia-Torralba, Asuncion Chaves-Benito, Vicente Vicente, Francisco Ayala de la Pena
Summary: miR-200c-3p may play an important prognostic and predictive role in breast cancer and can be used as a marker for breast cancer.
Article
Oncology
David Zaragoza-Huesca, Andres Nieto-Olivares, Francisco Garcia-Molina, Guillermo Ricote, Sofia Montenegro, Manuel Sanchez-Canovas, Pedro Garrido-Rodriguez, Julia Penas-Martinez, Vicente Vicente, Francisco Martinez, Maria Luisa Lozano, Alberto Carmona-Bayonas, Irene Martinez-Martinez
Summary: This study investigated the role of hepsin in colorectal cancer and found that it is an independent prognostic factor for metastasis and thrombosis in patients with localized disease. Low levels of hepsin were associated with higher tumor dedifferentiation and spread to distant organs in metastatic patients. These findings suggest that hepsin could be a potential biomarker for complications in colorectal cancer patients.
Article
Multidisciplinary Sciences
Alejandro Cisterna-Garcia, Antonio Guillen-Teruel, Marcos Caracena, Enrique Perez, Fernando Jimenez, Francisco J. Francisco-Verdu, Gabriel Reina, Enrique Gonzalez-Billalabeitia, Jose Palma, Alvaro Sanchez-Ferrer, Juan A. Botia
Summary: This study develops a machine learning model using electronic medical records to predict mortality and hospitalization risk of COVID-19 patients. The model achieves high accuracy in predicting patient's final status and moderate accuracy in predicting hospitalization risk.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Natalia Jimenez, Oscar Reig, Mercedes Marin-Aguilera, Caterina Aversa, Laura Ferrer-Mileo, Albert Font, Alejo Rodriguez-Vida, Miguel Angel Climent, Sara Cros, Isabel Chirivella, Montserrat Domenech, Mariona Figols, Enrique Gonzalez-Billalabeitia, Daniel Jimenez Peralta, Leonardo Rodriguez-Carunchio, Samuel Garcia-Esteve, Marta Garcia de Herreros, Maria J. Ribal, Aleix Prat, Begona Mellado
Summary: In this study, transcriptomic analysis was used to investigate the predictive value of gene expression in the clinical outcomes of mHSPC patients treated with ADT+DX. The results showed that high expression of AR and ESR signatures and low expression of TSG are associated with better prognosis. These molecular alterations may serve as potential biomarkers for personalized treatment selection.
Article
Endocrinology & Metabolism
Maria P. Fernandez-Perez, Enrique Perez-Navarro, Teresa Alonso-Gordoa, Vicenza Conteduca, Albert Font, Sergio Vazquez-Estevez, Aranzazu Gonzalez-del-Alba, Daniel Wetterskog, Emmanuel S. Antonarakis, Begona Mellado, Ovidio Fernandez-Calvo, Maria J. Mendez-Vidal, Miguel A. Climent, Ignacio Duran, Enrique Gallardo, Angel Rodriguez Sanchez, Carmen Santander, Maria Saez, Javier Puente, Julian Tudela, Alberto Martinez, Maria J. Lopez-Andreo, Jose Padilla, Rebeca Lozano, David Hervas, Jun Luo, Ugo de Giorgi, Daniel Castellano, Gerhardt Attard, Enrique Grande, Enrique Gonzalez-Billalabeitia
Summary: This study investigated the prognostic value of multiple biomarkers in the treatment response and survival outcomes of castration-resistant prostate cancer patients. The study found that circulating tumor cells and plasma androgen receptor gain were the most relevant biomarkers.
Article
Oncology
Manuel Valladares-Ayerbes, Pilar Garcia-Alfonso, Jorge Munoz Luengo, Paola Patricia Pimentel Caceres, Oscar Alfredo Castillo Trujillo, Rosario Vidal-Tocino, Marta Llanos, Beatriz Llorente Ayala, Maria Luisa Limon Miron, Antonieta Salud, Luis Cirera Nogueras, Rocio Garcia-Carbonero, Maria Jose Safont, Esther Falco Ferrer, Jorge Aparicio, Maria Angeles Vicente Conesa, Carmen Guillen-Ponce, Paula Garcia-Teijido, Maria Begona Medina Magan, Isabel Busquier, Mercedes Salgado, Ariadna Lloansi Vila
Summary: Monitoring cell-free DNA RAS mutations is important for selecting eligible patients for anti-EGFR treatment and disease molecular characterization in metastatic colorectal cancer (mCRC). This study evaluated the role of different mutant allele fraction thresholds in monitoring RAS mutations and found that continuous evaluation of RAS mutations can provide valuable insights into tumor molecular dynamics.
Article
Biochemistry & Molecular Biology
Rosa Cifuentes, Jose Padilla, Maria Eugenia de la Morena-Barrio, Belen de la Morena-Barrio, Carlos Bravo-Perez, Pedro Garrido-Rodriguez, Maria Llamas, Antonia Minano, Vicente Vicente, Maria Luisa Lozano, Javier Corral
Summary: Multiplex ligation-dependent probe amplification (MLPA) is effective in identifying genetic structural variants in SERPINC1 in 5% of antithrombin deficiency (ATD) cases. However, MLPA has limitations in detecting intronic structural variants, and can produce imprecise and false-positive results for genetic defects affecting MLPA probes. Validation of MLPA results is encouraged based on our study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Esmeralda Garcia-Torralba, Miguel Perez Ramos, Alejandra Ivars Rubio, Esther Navarro-Manzano, Noel Blaya Boluda, Pilar de la Morena Barrio, Elisa Garcia-Garre, Francisco Martinez Diaz, Asuncion Chaves-Benito, Elena Garcia-Martinez, Francisco Ayala de la Pena
Summary: This study aimed to investigate the predictive and prognostic value of stromal lymphocytic infiltration (sTIL) in early luminal breast cancer (BC). The results showed that sTIL can predict pathologic complete response after neoadjuvant chemotherapy and has an independent prognostic impact on the relapse-free interval. The prognostic impact of sTIL is mainly observed in luminal B BC.
Article
Oncology
Francisco Ayala de la Pena, Silvia Antolin Novoa, Joaquin Gavila Gregori, Lucia Gonzalez Cortijo, Fernando Henao Carrasco, Maria Teresa Martinez Martinez, Cristina Morales Estevez, Agostina Stradella, Maria Jesus Vidal Losada, Eva Ciruelos
Summary: Breast cancer is the main cause of cancer in women in Spain, with a rapidly increasing annual incidence. Despite the potential impact of the COVID-19 pandemic on screening programs (not yet quantified), almost 90% of breast cancer cases are detected early and can be potentially cured. New diagnostic tools have improved the balance between toxicity and clinical benefit in locoregional and systemic therapies, and new therapeutic strategies such as immunotherapy, targeted drugs, and antibody-drug conjugates have improved outcomes in certain patient subgroups.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Ruth Vera, Oscar Juan-Vidal, Maria Jose Safont-Aguilera, Francisco Ayala de la Pena, Aranzazu Gonzalez del Alba
Summary: Precision medicine in oncology aims to provide personalized treatment based on individual features, but disparities in cancer care based on sex exist. Genetic and environmental factors contribute to these differences, highlighting the importance of increasing awareness among healthcare professionals.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
