Article
Medicine, General & Internal
Changqing Ma, Chad E. Storer, Uma Chandran, William A. LaFramboise, Patricia Petrosko, Madison Frank, Douglas J. Hartman, Liron Pantanowitz, Talin Haritunians, Richard D. Head, Ta-Chiang Liu
Summary: Individuals with the ATG16L1 T300A genotype in gastric carcinoma show suppressed EGFR and PPAR pathways, increased tumor apoptosis, and improved overall survival. Genotyping gastric cancer patients may offer additional insights for clinical stratification.
Article
Oncology
Jarlath C. Bolger, Mohammed Al Azzawi, Jack Whooley, Eamonn M. Bolger, Luke Trench, Jack Allen, Michael E. Kelly, Conor Brosnan, Mayilone Arumugasamy, William B. Robb
Summary: Textbook outcomes (TBOs) are associated with improved overall survival in oesophagogastric malignancy patients. Minimally invasive surgery (MIA) has a positive impact on achieving TBO and overall survival. The completion of MIA should be considered as a parameter in predicting long-term survival.
Article
Biochemistry & Molecular Biology
Rina Fujiwara-Tani, Ayaka Okamoto, Hiroyuki Katsuragawa, Hitoshi Ohmori, Kiyomu Fujii, Shiori Mori, Shingo Kishi, Takamitsu Sasaki, Chie Nakashima, Isao Kawahara, Yudai Hojo, Yukiko Nishiguchi, Takuya Mori, Takeshi Mizumoto, Kenta Nagai, Yi Luo, Hiroki Kuniyasu
Summary: Analysis of samples from 102 GHP patients revealed that atypia in GHP increased with age and polyp size, especially in polyps larger than 1 cm, which were associated with higher grade dysplasia and cancer. Atypia was correlated with enhanced proliferative ability and nuclear 8-hydroxy-2'-deoxyguanosine levels. In cases of HPAGC, those with a BRAF mutation may represent a novel subtype that does not involve H. pylori infection, showing high stemness and p53 protein accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sarah R. Kaslow, Zhongyang Ma, Leena Hani, Katherine Prendergast, Gerardo Vitiello, Ann Y. Lee, Russell S. Berman, Judith D. Goldberg, Camilo Correa-Gallego
Summary: Adherence to evidence-based guidelines for gastric cancer is low, and guideline-adherent treatment is strongly associated with longer overall survival. The study highlights the importance of using guideline adherence as a benchmark for quality improvement for physicians and institutions caring for patients with gastric cancer.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Arun J. Sanyal, Quentin M. Anstee, Michael Trauner, Eric J. Lawitz, Manal F. Abdelmalek, Dora Ding, Ling Han, Catherine Jia, Ryan S. Huss, Chuhan Chung, Vincent Wai-Sun Wong, Takeshi Okanoue, Manuel Romero-Gomez, Andrew J. Muir, Nezam H. Afdhal, Jaime Bosch, Zachary Goodman, Stephen A. Harrison, Zobair M. Younossi, Robert P. Myers
Summary: The study aimed to assess the association between histologic and noninvasive tests with liver-related complications in NASH cirrhosis patients. The results showed that regression of fibrosis is associated with a reduction in liver-related complications.
Article
Oncology
Daniel W. Kim, Grace Lee, Theodore S. Hong, Guichao Li, Nora K. Horick, Eric Roeland, Florence K. Keane, Christine Eyler, Lorraine C. Drapek, David P. Ryan, Jill N. Allen, David Berger, Aparna R. Parikh, John T. Mullen, Sam J. Klempner, Jeffrey W. Clark, Jennifer Y. Wo
Summary: This study compared the survival outcomes between neoadjuvant and postoperative chemoradiotherapy for patients with gastric and gastroesophageal junction cancer, and found that neoadjuvant CRT was associated with longer overall survival, higher rate of R0 resection, and lower treatment-related toxicity compared to postoperative CRT.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Candan cetinkaya-Hosgoer, Philippa Seika, Jonas Raakow, Dino Kroell, Eva Maria Dobrindt, Max Magnus Maurer, Friederike Martin, Ramin Raul Ossami Saidy, Peter Thuss-Patience, Johann Pratschke, Matthias Biebl, Christian Denecke, H. Christian Weber
Summary: This study examined the impact of surgical outcomes on long-term survival in gastric cancer patients. The achievement of textbook outcome (TO) was found to be significantly associated with improved long-term survival. Factors such as surgical approach and incomplete neoadjuvant chemotherapy influenced the attainment of TO. The findings highlight the importance of surgical quality improvement for long-term survival in gastric cancer patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Dandan Yu, Jinru Yang, Min Jin, Bin Zhou, Linli Shi, Lei Zhao, Jieying Zhang, Zhenyu Lin, Jinghua Ren, Li Liu, Tao Zhang, Hongli Liu
Summary: The gut microbiome plays a critical role in predicting gastric cancer and liver metastasis, with Streptococcus potentially serving as a biomarker.
Article
Medicine, General & Internal
Valeria Masciullo, Tommaso Susini, Giacomo Corrado, Marina Stepanova, Alessandro Baroni, Irene Renda, Francesca Castiglione, Corrado Minimo, Alfonso Bellacosa, Benito Chiofalo, Enrico Vizza, Giovanni Scambia
Summary: This study evaluated the expression pattern and prognostic value of beta-catenin in endometrial carcinoma patients. The results showed that nuclear expression of beta-catenin was associated with a better prognosis, while membranous expression of beta-catenin was associated with a poorer prognosis. The five-year disease-related survival rate was higher for patients expressing nuclear beta-catenin compared to those expressing membranous beta-catenin.
Article
Nutrition & Dietetics
Sara Mustafa, Jane Harding, Clare Wall, Caroline Crowther
Summary: Adherence to dietary recommendations among women with gestational diabetes mellitus in New Zealand is generally low and could be improved. Factors such as primiparity, underweight, and smoking may influence dietary adherence. Further research is needed to identify ways to improve adherence to dietary recommendations for women with gestational diabetes mellitus.
Article
Pharmacology & Pharmacy
Luyun Xu, Yan Ye, Yuqin Sun, Wenting Zhong, Liangjie Chi, Youyu Lin, Hongxia Liu, ShengZhao Li, Hui Chen, Chengcheng Li, Yuxuan Lin, Qingshui Wang, Fangqin Xue, Yao Lin
Summary: This study found that FNDC5 is expressed at a low level in gastric cancer tissues, and lower FNDC5 expression is associated with better prognosis. Overexpression of FNDC5 inhibits migration and invasion of gastric cancer cells. Additionally, a risk score model based on FNDC5-related genes can predict the clinical outcome of gastric cancer patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Xuechun Li, Zhao Sun, Gongxin Peng, Yi Xiao, Junchao Guo, Bin Wu, Xiaoyi Li, Weixun Zhou, Jiarui Li, Zhe Li, Chunmei Bai, Lin Zhao, Qin Han, Robert Chunhua Zhao, Xiaoyue Wang
Summary: This study reveals the characteristics of different CAF subsets in gastric cancer (GC) and their interactions with the tumor microenvironment (TME) using single-cell RNA sequencing and multistaining registration techniques. The results demonstrate that iCAFs and eCAFs not only exhibit enhanced protumor activities, but also mobilize surrounding immune cells to construct a tumor-favorable microenvironment.
Article
Gastroenterology & Hepatology
Monika Laszkowska, Laura Tang, Elvira Vos, Stephanie King, Erin Salo-Mullen, Patrick T. Magahis, Miseker Abate, Amanda Catchings, Ann G. Zauber, Anne I. Hahn, Mark Schattner, Daniel Coit, Zsofia K. Stadler, Vivian E. Strong, Arnold J. Markowitz
Summary: This study aimed to identify endoscopic findings and biopsy practices associated with the detection of signet ring cell carcinoma (SRCC) in individuals with germline pathogenic CDH1 variants. The results showed that targeted biopsy sampling of gastric pale mucosal areas and increasing the number of biopsy samples taken can improve the detection of SRCC. The findings support updated endoscopic surveillance guidelines and further studies are needed to refine endoscopic protocols for detecting SRCC in this high-risk population.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Emanuele Dilaghi, Francesca Baldaro, Emanuela Pilozzi, Laura Conti, Antonio Palumbo, Gianluca Esposito, Bruno Annibale, Edith Lahner
Summary: In patients with CAG, the presence of corpus PPM without corpus IM at baseline was not associated with the development of GC or GD at follow-up, as these lesions were consistently linked to corpus IM. Corpus PPM without corpus IM was associated with younger age, lack of pernicious anemia, and less severe corpus atrophy, suggesting a less advanced stage of disease progression.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Cell Biology
Yi Lu, Dan Li, Yixin Cao, Leqian Ying, Qing Tao, Fen Xiong, Zhangmin Hu, Yufei Yang, Xuehan Qiao, Chen Peng, Dongqin Zhu, Deqiang Wang, Xiaoqin Li
Summary: The study showed that evaluating CAF infiltration in tumors using FAMscore can independently predict prognosis and immunotherapy outcomes. High FAMscore is associated with immune-related genomic biomarkers, immune cell infiltration, and abnormal immune signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)