Article
Oncology
Maria Dans, Jean S. Kutner, Rajiv Agarwal, Justin N. Baker, Jessica R. Bauman, Anna C. Beck, Toby C. Campbell, Elise C. Carey, Amy A. Case, Shalini Dalal, Danielle J. Doberman, Andrew S. Epstein, Leslie Fecher, Joshua Jones, Jennifer Kapo, Richard T. Lee, Elizabeth T. Loggers, Susan McCammon, William Mitchell, Adeboye B. Ogunseitan, Diane G. Portman, Kavitha Ramchandran, Linda Sutton, Jennifer Temel, Melissa L. Teply, Stephanie Y. Terauchi, Jane Thomas, Anne M. Walling, Finly Zachariah, Mary Anne Bergman, Ndiya Ogba, Mallory Campbell
Summary: Palliative care is increasingly recognized as an integral part of comprehensive cancer care, aiming to improve patient quality of life and outcomes through early intervention. The NCCN Guidelines provide recommendations to help oncology teams promote the best quality of life possible for cancer patients throughout their illness trajectory.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Oncology
Tara Sanft, Andrew Day, Shannon Ansbaugh, Saro Armenian, K. Scott Baker, Tara Ballinger, Wendy Demark-Wahnefried, Kristin Dickinson, Nathan Paul Fairman, Josephine Felciano, Tessa Faye Flores, Debra L. Friedman, Nicolette M. Gabel, Mindy Goldman, Norah Lynn Henry, Christine Hill-Kayser, Melissa Hudson, Divya Koura, Kimberly Lee, Allison L. Mcdonough, Michelle Melisko, Kathi Mooney, Halle C. F. Moore, Natalie Moryl, Heather Neuman, Tracey O'Connor, Linda Overholser, Electra D. Paskett, Chirayu Patel, Lindsay Peterson, William Pirl, Andrea Porpiglia, M. Alma Rodriguez, Lidia Schapira, Anna L. Schwartz, Sophia Smith, Amye Tevaarwerk, Eric Yang, Phyllis Zee, Nicole R. McMillian, Deborah A. Freedman-Cass
Summary: The NCCN Guidelines for Survivorship assist healthcare professionals in addressing the diverse needs of cancer survivors. These guidelines offer recommendations for screening, evaluation, and treatment of psychosocial and physical issues resulting from cancer and its treatment, as well as promoting healthy behaviors and immunizations. The guidelines also provide a framework for care coordination.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Oncology
Amye Tevaarwerk, Crystal S. Denlinger, Tara Sanft, Shannon M. Ansbaugh, Saro Armenian, K. Scott Baker, Gregory Broderick, Andrew Day, Wendy Demark-Wahnefried, Kristin Dickinson, Debra L. Friedman, Patricia Ganz, Mindy Goldman, Norah Lynn Henry, Christine Hill-Kayser, Melissa Hudson, Nazanin Khakpour, Divya Koura, Allison L. McDonough, Michelle Melisko, Kathi Mooney, Halle C. F. Moore, Natalie Moryl, Javid J. Moslehi, Tracey O'Connor, Linda Overholser, Electra D. Paskett, Chirayu Patel, Lindsay Peterson, William Pirl, M. Alma Rodriguez, Kathryn J. Ruddy, Lidia Schapira, Lillie Shockney, Sophia Smith, Karen L. Syrjala, Phyllis Zee, Nicole R. McMillian, Deborah A. Freedman-Cass
Summary: The NCCN Guidelines for Survivorship aim to assist healthcare professionals in meeting the complex needs of cancer survivors, including recommendations for employment and return to work.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Oncology
Tara Sanft, Andrew Day, Lindsay Peterson, M. Alma Rodriguez, Shannon Ansbaugh, Saro Armenian, K. Scott Baker, Tarah Ballinger, Gregory Broderick, Wendy Demark-Wahnefried, Kristin Dickinson, Nathan Paul Fairman, Debra L. Friedman, Mindy Goldman, Norah Lynn Henry, Christine Hill-Kayser, Melissa Hudson, Nazanin Khakpour, Divya Koura, Allison L. McDonough, Michelle Melisko, Kathi Mooney, Halle C. F. Moore, Natalie Moryl, Heather Neuman, Tracey O'Connor, Linda Overholser, Electra D. Paskett, Chirayu Patel, William Pirl, Andrea Porpiglia, Kathryn J. Ruddy, Lidia Schapira, Lillie Shockney, Sophia Smith, Karen L. Syrjala, Amye Tevaarwerk, Eric H. Yang, Phyllis Zee, Nicole R. McMillian, Deborah A. Freedman-Cass
Summary: The NCCN Guidelines for Survivorship provide recommendations for addressing the complex needs of cancer survivors, including screening, evaluation, and treatment. They also promote physical activity, weight management, and immunizations, as well as care coordination.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Oncology
Edward M. Schaeffer, Sandy Srinivas, Nabil Adra, Yi An, Daniel Barocas, Rhonda Bitting, Alan Bryce, Brian Chapin, Heather H. Cheng, Anthony Victor D'Amico, Neil Desai, Tanya Dorff, James A. Eastham, Thomas A. Farrington, Xin Gao, Shilpa Gupta, Thomas Guzzo, Joseph E. Ippolito, Michael R. Kuettel, Joshua M. Lang, Tamara Lotan, Rana R. McKay, Todd Morgan, George Netto, Julio M. Pow-Sang, Robert Reiter, Mack Roach, Tyler Robin, Stan Rosenfeld, Ahmad Shabsigh, Daniel Spratt, Benjamin A. Teply, Jonathan Tward, Richard Valicenti, Jessica Karen Wong, Ryan A. Berardi, Dorothy A. Shead, Deborah A. Freedman-Cass
Summary: The NCCN Guidelines for Prostate Cancer discuss staging and risk assessment after a prostate cancer diagnosis and provide treatment options for different stages of the disease. The guidelines are updated annually based on new clinical data and input from various sources. This article summarizes the discussions regarding systemic therapy for metastatic prostate cancer.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Oncology
Peter L. Greenberg, Richard M. Stone, Aref Al-Kali, John M. Bennett, Uma Borate, Andrew M. Brunner, Wanxing Chai-Ho, Peter Curtin, Carlos M. de Castro, H. Joachim Deeg, Amy E. DeZern, Shira Dinner, Charles Foucar, Karin Gaensler, Guillermo Garcia-Manero, Elizabeth A. Griffiths, David Head, Brian A. Jonas, Sioban Keel, Yazan Madanat, Lori J. Maness, James Mangan, Shannon McCurdy, Christine McMahon, Bhumika Patel, Vishnu V. Reddy, David A. Sallman, Rory Shallis, Paul J. Shami, Swapna Thota, Asya Nina Varshavsky-Yanovsky, Peter Westervelt, Elizabeth Hollinger, Dorothy A. Shead, Cindy Hochstetler
Summary: The NCCN Guidelines for Myelodysplastic Syndromes (MDS) provide recommendations for the evaluation, diagnosis, and management of patients with MDS based on clinical evidence. The 2022 updates include treatment recommendations for both lower-risk and higher-risk MDS, emerging therapies, supportive care recommendations, and genetic assessment for hereditary myeloid malignancy predisposition syndromes.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Oncology
Natalie S. Callander, Muhamed Baljevic, Kehinde Adekola, Larry D. Anderson, Erica Campagnaro, Jorge J. Castillo, Caitlin Costello, Srinivas Devarakonda, Noura Elsedawy, Matthew Faiman, Alfred Garfall, Kelly Godby, Jens Hillengass, Leona Holmberg, Myo Htut, Carol Ann Huff, Malin Hultcrantz, Yubin Kang, Sarah Larson, Michaela Liedtke, Thomas Martin, James Omel, Douglas Sborov, Kenneth Shain, Keith Stockerl-Goldstein, Donna Weber, Ryan A. Berardi, Rashmi Kumar, Shaji K. Kumar
Summary: The NCCN Guidelines for Multiple Myeloma offer recommendations for various aspects of diagnosis, initial workup, treatment, follow-up, and supportive care for patients. The 2022 version of the guidelines highlights important updates/changes specifically related to the treatment of multiple myeloma patients.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Oncology
William J. Gradishar, Meena S. Moran, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H. Allison, Sarah L. Blair, Harold J. Burstein, Chau Dang, Anthony D. Elias, Sharon H. Giordano, Matthew P. Goetz, Lori J. Goldstein, Sara A. Hurvitz, Steven J. Isakoff, Rachel C. Jankowitz, Sara H. Javid, Jairam Krishnamurthy, Marilyn Leitch, Janice Lyons, Jennifer Matro, Ingrid A. Mayer, Joanne Mortimer, Ruth M. O'Regan, Sameer A. Patel, Lori J. Pierce, Hope S. Rugo, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, Erica M. Stringer-Reasor, Melinda L. Telli, John H. Ward, Kari B. Wisinski, Jessica S. Young, Jennifer L. Burns, Rashmi Kumar
Summary: The NCCN Guidelines for Breast Cancer cover various types of breast cancer and are developed by a multidisciplinary panel of experts. The recent updates focus on recommendations for adjuvant systemic therapy in patients with early-stage, hormone receptor-positive, HER2-negative breast cancer.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Oncology
Thomas W. Flaig, Philippe E. Spiess, Michael Abern, Neeraj Agarwal, Rick Bangs, Stephen A. Boorjian, Mark K. Buyyounouski, Kevin Chan, Sam Chang, Terence Friedlander, Richard E. Greenberg, Khurshid A. Guru, Harry W. Herr, Jean Hoffman-Censits, Amar Kishan, Shilajit Kundu, Subodh M. Lele, Ronac Mamtani, Vitaly Margulis, Omar Y. Mian, Jeff Michalski, Jeffrey S. Montgomery, Lakshminarayanan Nandagopal, Lance C. Pagliaro, Mamta Parikh, Anthony Patterson, Elizabeth R. Plimack, Kamal S. Pohar, Mark A. Preston, Kyle Richards, Wade J. Sexton, Arlene O. Siefker-Radtke, Matthew Tollefson, Jonathan Tward, Jonathan L. Wright, Mary A. Dwyer, Carly J. Cassara, Lisa A. Gurski
Summary: This article discusses the importance of the NCCN Guidelines for Bladder Cancer, as well as recent updates and panel discussions regarding the treatment of non-muscle-invasive bladder cancer.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Oncology
Edward Schaeffer, Sandy Srinivas, Emmanuel S. Antonarakis, Andrew J. Armstrong, Justin E. Bekelman, Heather Cheng, Anthony Victor D'Amico, Brian J. Davis, Neil Desai, Tanya Dorff, James A. Eastham, Thomas A. Farrington, Xin Gao, Eric Mark Horwitz, Joseph E. Ippolito, Michael R. Kuettel, Joshua M. Lang, Rana Mckay, Jesse McKenney, George Netto, David F. Penson, Julio M. Pow-Sang, Robert Reiter, Sylvia Richey, Mack Roach, Stan Rosenfeld, Ahmad Shabsigh, Daniel E. Spratt, Benjamin A. Teply, Jonathan Tward, Dorothy A. Shead, Deborah A. Freedman-Cass
Summary: The NCCN Guidelines for Prostate Cancer provide recommendations for staging and risk assessment post-diagnosis, with management options for localized, regional, and metastatic disease. The guidelines also cover disease monitoring and treatment of recurrent disease. The NCCN Prostate Cancer Panel meets annually to update recommendations based on new clinical data, aiming to provide the most effective care for patients.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Oncology
Susan M. Swetter, John A. Thompson, Mark R. Albertini, Christopher A. Barker, Joel Baumgartner, Genevieve Boland, Bartosz Chmielowski, Dominick DiMaio, Alison Durham, Ryan C. Fields, Martin D. Fleming, Anjela Galan, Brian Gastman, Kenneth Grossmann, Samantha Guild, Ashley Holder, Douglas Johnson, Richard W. Joseph, Giorgos Karakousis, Kari Kendra, Julie R. Lange, Ryan Lanning, Kim Margolin, Anthony J. Olszanski, Patrick A. Ott, Merrick Ross, April K. Salama, Rohit Sharma, Joseph Skitzki, Jeffrey Sosman, Evan Wuthrick, Nicole R. McMillian, Anita M. Engh
Summary: In recent years, the NCCN Guidelines for Melanoma: Cutaneous have expanded to include pathways for microscopic satellitosis, molecular testing, systemic therapy considerations, and brain metastases management. The latest update in v1.2021 includes additional modifications to pathology, surgical margins, lymph node biopsy, lymph node dissection, and radiation therapy recommendations.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Oncology
Richard T. Hoppe, Ranjana H. Advani, Weiyun Z. Ai, Richard F. Ambinder, Philippe Armand, Celeste M. Bello, Cecil M. Benitez, Weina Chen, Bouthaina Dabaja, Megan E. Daly, Leo I. Gordon, Neil Hansen, Alex F. Herrera, Ephraim P. Hochberg, Patrick B. Johnston, Mark S. Kaminski, Christopher R. Kelsey, Vaishalee P. Kenkre, Nadia Khan, Ryan C. Lynch, Kami Maddocks, Jonathan McConathy, Monika Metzger, David Morgan, Carolyn Mulroney, Sheeja T. Pullarkat, Rachel Rabinovitch, Karen C. Rosenspire, Stuart Seropian, Randa Tao, Pallawi Torka, Jane N. Winter, Joachim Yahalom, Joanna C. Yang, Jennifer L. Burns, Mallory Campbell, Hema Sundar
Summary: This article discusses the classification and treatment options for Hodgkin lymphoma, focusing on radiation therapy dose constraints and the management of advanced-stage and relapsed or refractory Hodgkin lymphoma.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Oncology
Al B. Benson, Michael I. D'Angelica, Thomas Abrams, Daniel E. Abbott, Aijaz Ahmed, Daniel A. Anaya, Robert Anders, Chandrakanth Are, Melinda Bachini, David Binder, Mitesh Borad, Christopher Bowlus, Daniel Brown, Adam Burgoyne, Jason Castellanos, Prabhleen Chahal, Jordan Cloyd, Anne M. Covey, Evan S. Glazer, William G. Hawkins, Renuka Iyer, Rojymon Jacob, Lawrence Jennings, R. Kate Kelley, Robin Kim, Matthew Levine, Manisha Palta, James O. Park, Steven Raman, Sanjay Reddy, Sean Ronnekleiv-Kelly, Vaibhav Sahai, Gagandeep Singh, Stacey Stein, Anita Turk, Jean-Nicolas Vauthey, Alan P. Venook, Adam Yopp, Nicole McMillian, Ryan Schonfeld, Cindy Hochstetler
Summary: In 2023, the NCCN Guidelines for Hepatobiliary Cancers were divided into two separate guidelines: Hepatocellular Carcinoma and Biliary Tract Cancers. The Biliary Tract Cancers guidelines provide recommendations for the evaluation and comprehensive care of patients with gallbladder cancer, intrahepatic cholangiocarcinoma, and extrahepatic cholangiocarcinoma. A multidisciplinary panel of experts meets regularly to review new data and therapies.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Oncology
Andrew D. Zelenetz, Leo I. Gordon, Julie E. Chang, Beth Christian, Jeremy S. Abramson, Ranjana H. Advani, Nancy L. Bartlett, L. Elizabeth Budde, Paolo F. Caimi, Sven De Vos, Bhagirathbhai Dholaria, Bita Fakhri, Luis E. Fayad, Martha J. Glenn, Thomas M. Habermann, Francisco Hernandez-Ilizaliturri, Eric Hsi, Boyu Hu, Mark S. Kaminski, Christopher R. Kelsey, Nadia Khan, Susan Krivacic, Ann S. LaCasce, Megan Lim, Mayur Narkhede, Rachel Rabinovitch, Praveen Ramakrishnan, Erin Reid, Kenneth B. Roberts, Hayder Saeed, Stephen D. Smith, Jakub Svoboda, Lode J. Swinnen, Joseph Tuscano, Julie M. Vose, Mary A. Dwyer, Hema Sundar
Summary: In the past decade, advancements in understanding the molecular pathogenesis of B-cell non-Hodgkin lymphomas have led to the development of novel targeted therapies, including small molecule inhibitors of select kinases, antibody-drug conjugates, and small molecules targeting various proteins. These therapies, such as anti-CD19 CAR T-cell therapy, have been approved for the treatment of relapsed/refractory diffuse large B-cell lymphoma, and also show promise for follicular lymphoma and mantle cell lymphoma. These developments are highlighted in the NCCN Guidelines for B-Cell Lymphomas.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Oncology
Daniel A. Pollyea, Dale Bixby, Alexander Perl, Vijaya Raj Bhatt, Jessica K. Altman, Frederick R. Appelbaum, Marcos de Lima, Amir T. Fathi, James M. Foran, Ivana Gojo, Aric C. Hall, Meagan Jacoby, Jeffrey Lancet, Gabriel Mannis, Guido Marcucci, Michael G. Martin, Alice Mims, Jadee Neff, Reza Nejati, Rebecca Olin, Mary-Elizabeth Percival, Thomas Prebet, Amanda Przespolewski, Dinesh Rao, Farhad Ravandi-Kashani, Paul J. Shami, Richard M. Stone, Stephen A. Strickland, Kendra Sweet, Pankit Vachhani, Matthew Wieduwilt, Kristina M. Gregory, Ndiya Ogba, Martin S. Tallman
Summary: The NCCN Guidelines for Acute Myeloid Leukemia provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment. Recent updates focus on familial genetic alterations, treatment strategies for low-risk and favorable-risk AML, venetoclax-based therapies, and considerations for patients who prefer not to receive blood transfusions.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Review
Oncology
Nicole Birrer, Carolina Chinchilla, Marcela Del Carmen, Don S. Dizon
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2018)
Article
Obstetrics & Gynecology
Kathleen R. Cho, Kumarasen Cooper, Sabrina Croce, Bojana Djordevic, Simon Herrington, Brooke Howitt, Pei Hui, Philip Ip, Martin Koebel, Sigurd Lax, Bradley J. Quade, Patricia Shaw, August Vidal, Anna Yemelyanova, Blaise Clarke, Lora Hedrick Ellenson, Teri A. Longacre, Ie-Ming Shih, W. Glenn McCluggage, Anais Malpica, Esther Oliva, Vinita Parkash, Xavier Matias-Guiu
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2019)
Meeting Abstract
Oncology
Jeffrey M. Peppercorn, Katharine M. Quain, Karen Sepucha, Don S. Dizon, Beverly Moy, Laura Spring, Therese Marie Mulvey, Jennifer Adrienne Shin, Giselle Katiria Perez
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Meeting Abstract
Oncology
Emeline Aviki, Marina Stasenko, Sarah E. Dilley, William P. Tew, Don S. Dizon, Peter Bach, Carol L. Brown
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Review
Oncology
Wui-Jin Koh, Nadeem R. Abu-Rustum, Sarah Bean, Kristin Bradley, Susana M. Campos, Kathleen R. Cho, Hye Sook Chon, Christina Chu, Rachel Clark, David Cohn, Marta Ann Crispens, Shari Damast, Oliver Dorigo, Patricia J. Eifel, Christine M. Fisher, Peter Frederick, David K. Gaffney, Ernest Han, Warner K. Huh, John R. Lurain, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Todd Tillmanns, Stefanie Ueda, Emily Wyse, Catheryn M. Yashar, Nicole R. McMillian, Jillian L. Scavone
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2019)
Article
Oncology
Lorena Lazo de la Vega, Mia C. Samaha, Kevin Hu, Nolan R. Bick, Javed Siddiqui, Daniel H. Hovelson, Chia-Jen Liu, Cody S. Carter, Kathleen R. Cho, Andrew P. Sciallis, Scott A. Tomlins
MOLECULAR CANCER RESEARCH
(2019)
Article
Oncology
Yisheng Wang, Michael S. Sessine, Yali Zhai, Courtney Tipton, Kevin McCool, Rork Kuick, Denise C. Connolly, Eric R. Fearon, Kathleen R. Cho
JOURNAL OF PATHOLOGY
(2019)
Article
Medicine, Research & Experimental
Jinyu Tang, Ying Feng, Rork Kuick, Megan Green, Maranne Green, Naoya Sakamoto, Yuki Kurosu, Jeffry Lin, Kathleen R. Cho, Eric R. Fearon
LABORATORY INVESTIGATION
(2019)
Article
Obstetrics & Gynecology
Monica Hagan Vetter, Blair Smith, Jason Benedict, Erinn M. Hade, Kristin Bixel, Larry J. Copeland, David E. Cohn, Jeffrey M. Fowler, David O'Malley, Ritu Salani, Floor J. Backes
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Article
Oncology
David S. Miller, Virginia L. Filiaci, Robert S. Mannel, David E. Cohn, Takashi Matsumoto, Krishnansu S. Tewari, Paul DiSilvestro, Michael L. Pearl, Peter A. Argenta, Matthew A. Powell, Susan L. Zweizig, David P. Warshal, Parviz Hanjani, Michael E. Carney, Helen Huang, David Cella, Richard Zaino, Gini F. Fleming
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Minh Tung Phung, Alice W. Lee, Anna H. Wu, Andrew Berchuck, Kathleen R. Cho, Daniel W. Cramer, Jennifer Anne Doherty, Marc T. Goodman, Gillian E. Hanley, Holly R. Harris, Karen McLean, Francesmary Modugno, Kirsten B. Moysich, Bhramar Mukherjee, Joellen M. Schildkraut, Kathryn L. Terry, Linda J. Titus, Susan J. Jordan, Penelope M. Webb, Malcolm C. Pike, Celeste Leigh Pearce
Summary: The use of combined oral contraceptives and progestin-only contraceptives is associated with a decreased risk of ovarian cancer. Specifically, the injectable progestin-only contraceptive depot-medroxyprogesterone acetate (DMPA) was found to be associated with a 35% decreased risk of ovarian cancer, with a significant trend of decreasing risk with increasing duration of use. Some studies showed an inverse association between DMPA use and ovarian cancer risk, while others showed increased risk, indicating a need for further investigation into the mechanism of this association.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Lixing Chen, Yali Zhai, Yisheng Wang, Eric R. Fearon, Gabriel Nunez, Naohiro Inohara, Kathleen R. Cho
Summary: Bacteria play a role in the pathogenesis of ovarian cancer, with evidence from an in vivo mouse model. Altering the microbiome with antibiotics may enhance the response of HGSC to immunotherapy, as demonstrated in this study.
Article
Oncology
Monica D. Levine, Rachel Pearlman, Heather Hampel, Casey Cosgrove, David Cohn, Alexis Chassen, Adrian Suarez, David A. Barrington, Joseph P. McElroy, Steven Waggoner, John Nakayama, Caroline Billingsley, Kim Resnick, Stephen Andrews, Sareena Singh, Eric Jenison, Aine Clements, Robert Neff, Paul J. Goodfellow
Summary: This prospective multicenter study revealed actionable germline variants in 10% of unselected women with newly diagnosed EC, supporting the use of up-front MGPT for all EC patients. The discovery that BRCA1 or BRCA2 heterozygotes frequently had type II cancers points to therapeutic opportunities for women with aggressive histologic EC subtypes.
JCO PRECISION ONCOLOGY
(2021)
Article
Oncology
Jhalak Dholakia, David E. Cohn, J. Michael Straughn, Sarah E. Dilley
Summary: The study assessed the potential cost-effectiveness of prehabilitation in medically frail patients undergoing surgery for EOC, finding that prehabilitation was not only more effective but also cost-saving, by reducing complication rates and decreasing care facility requirements to save healthcare costs.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
Review
Surgery
Mary Lopresti, Tina Rizack, Don S. Dizon
