Article
Acoustics
U. Nowacka, I Papastefanou, A. Bouariu, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study investigates the additional value of second-trimester placental growth factor (PlGF) in predicting small-for-gestational-age (SGA) neonates and examines second-trimester contingent screening strategies. The results show that the combination of maternal risk factors, estimated fetal weight (EFW), uterine artery pulsatility index (UtA-PI), and PlGF significantly improves the prediction of SGA compared to maternal risk factors alone. However, the incremental improvement decreases when PlGF is added to screening with a combination of maternal risk factors, EFW, and UtA-PI. By reserving measurements of UtA-PI and PlGF for a certain percentage of the population, similar detection rates and false-positive rates can be achieved. The study concludes that the combination of maternal risk factors, EFW, UtA-PI, and PlGF provides an effective prediction of SGA in the second trimester.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Nutrition & Dietetics
Iskander LC. Shadid, Nicklas Brustad, Mengdi Lu, Bo L. Chawes, Hans Bisgaard, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Henk-Jan Guchelaar, Augusto A. Litonjua, Scott T. Weiss, Hooman Mirzakhani
Summary: Prenatal vitamin D deficiency is associated with offspring asthma or recurrent wheezing. However, evidence on the efficacy of vitamin D supplementation is inconclusive. This study aimed to examine the efficacy of prenatal vitamin D supplementation based on maternal baseline vitamin D status and timing of supplementation, and found that supplementation was beneficial regardless of baseline vitamin D levels, with the greatest reduction in asthma or wheezing observed in severely vitamin D-deficient women.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Medicine, General & Internal
Olga Buerger, Tania Elger, Antonia Varthaliti, Argyro Syngelaki, Alan Wright, Kypros H. Nicolaides
Summary: In this study, we found that maternal characteristics and medical history can be used to predict the risk of Gestational Diabetes Mellitus (GDM), with a higher risk in twin pregnancies. Factors such as maternal age, weight, family history, racial background, and conception method all influence the risk of GDM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ilona Hromadnikova, Katerina Kotlabova, Ladislav Krofta
Summary: The study aimed to determine the diagnostic potential of cardiovascular disease-associated microRNAs for the early detection of SGA and FGR without PE. The findings suggest that these microRNAs could serve as promising biomarkers and improve the detection rate of these conditions.
Article
Multidisciplinary Sciences
Mefkure Eraslan Sahin, Erdem Sahin, Mehmet Mete Kirlangic
Summary: The current study aimed to investigate the relationship between third-trimester persistent maternal hypotension and small for gestational age (SGA) neonates as well as other adverse perinatal outcomes. A large retrospective cohort study was conducted, enrolling 6560 pregnant women who were divided into two groups based on maternal blood pressure: a normotensive group (n: 6290) and a persistent maternal hypotension group (n: 270). The study found no significant association between persistent maternal hypotension and SGA neonates or other adverse perinatal outcomes.
Article
Nutrition & Dietetics
Shuting Si, Zhicheng Peng, Haoyue Cheng, Yan Zhuang, Peihan Chi, Xialidan Alifu, Haibo Zhou, Minjia Mo, Yunxian Yu
Summary: The study found a positive association between plasma vitamin D levels and hemoglobin concentration in pregnant women. This association was more significant among women who received iron supplementation during pregnancy.
Article
Environmental Sciences
Anne Marie Z. Jukic, Stephani S. Kim, John D. Meeker, Scott T. Weiss, David E. Cantonwine, Thomas F. McElrath, Kelly K. Ferguson
Summary: The study found that low 25OHD in the first trimester of pregnancy was associated with increased lead and tin levels, as well as higher odds of detectable tungsten in the late second trimester. Women who reported their race as Black or other races had higher thallium levels and increased likelihood of detectable beryllium and tungsten with low 25OHD. However, there was no significant association between metal levels and low 25OHD in women who identified as White.
ENVIRONMENTAL RESEARCH
(2021)
Article
Medicine, General & Internal
Bo Chen, Yongquan Chen, Yuanhong Xu
Summary: The study found that the majority of pregnant women were deficient in vitamin D, influenced by factors such as gestational age, season, education level, time spent outdoors, and supplement of vitamin D and trace elements during pregnancy. Low levels of vitamin D may increase the risk of spontaneous abortion and small-for-gestational-age newborns.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasuyuki Kojita, Hidetoshi Matsuo, Tomonori Kanda, Mizuho Nishio, Keitaro Sofue, Munenobu Nogami, Atsushi K. Kono, Masatoshi Hori, Takamichi Murakami
Summary: The study found that a deep learning model can accurately predict gestational age from fetal brain MRI images acquired after the first trimester.
EUROPEAN RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Otilia Perichart-Perera, Valeria Avila-Sosa, Juan Mario Solis-Paredes, Araceli Montoya-Estrada, Enrique Reyes-Munoz, Ameyalli M. Rodriguez-Cano, Carla P. Gonzalez-Leyva, Maribel Sanchez-Martinez, Guadalupe Estrada-Gutierrez, Claudine Irles
Summary: This study developed an artificial neural network model to predict small for gestational age (SGA) newborns in pregnancies with or without obesity, using first-trimester maternal body fat composition, biochemical and oxidative stress biomarkers, and gestational weight gain. The model showed good performance and identified protein and lipid oxidation biomarkers, gestational weight gain, vitamin D, and total antioxidant capacity as the top predictors. Excessive gestational weight gain, redox imbalance, and vitamin D deficiency all predicted SGA newborns.
Article
Acoustics
R. L. Deter, W. Lee, P. Dicker, E. C. Tully, F. Cody, F. D. Malone, K. M. Flood
Summary: This study found that there are seven growth restriction patterns in small fetuses with delayed growth in the third trimester. 37% of fetuses without evidence of growth restriction had vascular abnormalities. The distribution and types of normal growth and growth restriction patterns in the AGA cohort were different compared to the SGA cohort.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Ali Abbara, Maya Al-Memar, Maria Phylactou, Christopher Kyriacou, Pei Chia Eng, Rans Nadir, Chioma Izzi-Engbeaya, Sophie A. Clarke, Edouard G. Mills, Elisabeth Daniels, Lechun Huo, Ewa Pacuszka, Lisa Yang, Bijal Patel, Tricia An, Paul Bech, Alexander N. Comninos, Hanine Fourie, Tom W. Kelsey, Tom Bourne, Waljit S. Dhillo
Summary: This study compared the performance of Kisspeptin and beta hCG as biomarkers for miscarriage in the first trimester, finding that Kisspeptin showed better performance, especially in later gestational weeks. The conclusion suggests that Kisspeptin is a promising biomarker for miscarriage, and combining it with beta hCG improves prediction accuracy.
FERTILITY AND STERILITY
(2021)
Article
Nutrition & Dietetics
Rosalyn J. Singleton, Gretchen M. Day, Timothy K. Thomas, Joseph A. Klejka, Christine A. Desnoyers, Melanie N. P. McIntyre, David M. Compton, Kenneth E. Thummel, Robert J. Schroth, Leanne M. Ward, Dane C. Lenaker, Rachel K. Lescher, Joseph B. McLaughlin
Summary: The study found that prenatal vitamin D supplementation in high-risk populations can improve childhood outcomes regarding rickets and dental caries.
Article
Multidisciplinary Sciences
Andres Diaz-Lopez, Sandra Diaz-Torres, Francisco Martin-Lujan, Josep Basora, Victoria Arija
Summary: This study examined the relationship between adherence to a Mediterranean diet during pregnancy and foetal growth. The results showed that pregnant women who followed the Mediterranean diet had a lower risk of delivering a small-for-gestational-age baby, but there was no association with birth weight, length, and head circumference.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Joseph Phillipos, Thao Vi Luong, Deborah Chang, Suresh Varadarajan, Paul Howat, Lauren Hodgson, Deb Colville, Judy Savige
Summary: The study compared the effects of gestational diabetes, pregnancy-associated hypertension, and small-for-gestational age babies on systemic small vessel calibre examined in the retina. Results showed that women with gestational diabetes, pregnancy-associated hypertension, or small-for-gestational age babies had reduced mean retinal arterial calibre, with the greatest reduction seen in pregnancy-associated hypertension and small-for-gestational age babies.
FRONTIERS IN MEDICINE
(2023)
Review
Obstetrics & Gynecology
Kypros H. Nicolaides, Manoel Sarno, Alan Wright
Summary: The ophthalmic artery Doppler provides a useful biomarker for the prediction of preeclampsia, as it can provide information on the intracranial circulation. Studies have shown that there is a decrease in impedance to flow and an increase in velocities in the flow velocity waveforms from the ophthalmic arteries in women with preeclampsia. The peak systolic velocity ratio in ophthalmic artery Doppler has been found to be superior to other biomarkers in predicting preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Anna Kajdy, Dorota Sys, Artur Pokropek, Steven W. Shaw, Tung-Yao Chang, Pavel Calda, Ganesh Acharya, Maya Ben-Zion, Tal Biron-Shental, Dariusz Borowski, Bartosz Czuba, Adolfo Etchegaray, Stepan Feduniw, Rosario Garcia-Mandujano, Monica Garcia Santacruz, Maria M. Gil, Sonia Hassan, Sebastian Kwiatkowski, Arancha Martin-Arias, Raigam Jafet Martinez-Portilla, Federico Prefumo, Michal Rabijewski, Laurent J. Salomon, Heidi Tiller, Stefan Verlohren, Hian Yan Voon, Omar Fernando Yanque-Robles, Soon Leong Yong, Liona C. Poon
Summary: This study examines risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic. The results indicate that pregnant women in high-income economies experience higher levels of anxiety and depression. Factors such as the need for psychiatric treatment before pregnancy, restrictions in social distancing and access to leisure activities, pregnancy-related complications, fear of adverse outcomes in children related to COVID-19, and financial burden are associated with increased risk of anxiety and depression during pregnancy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Gordon Rukundo, Fouzia Farooq, Kacey Ferguson, Sasha Baumann, Kristina Maria Adams Waldorf, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Elisa Bevilacqua, Nabal Bracero, Justin S. Brandt, Natalie Broutet, Jorge Carrillo, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Maria del Mar Gil, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Irene Fernandez Buhigas, Valerie Flaherman, Christopher Gale, Christine L. Godwin, Sami Gottlieb, Eduard Gratacos, Siran He, Olivia Hernandez, Stephanie Jones, Sheetal Joshi, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen L. Kotloff, Antonio Lanzone, Valentina Laurita Longo, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Torri D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Olof Stephansson, Marleen Temmerman, Anna Thorson, Soe Soe Thwin, Beth A. Tippett Barr, Jorge E. Tolosa, Niyazi Tug, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Clare Whitehead, Mollie Wood, Huixia Yang, Rebecca Zavala, James M. Tielsch
Summary: This sequential, prospective meta-analysis aimed to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to disease severity, maternal morbidities, neonatal mortality and morbidity, and adverse birth outcomes. Data from 21 participating studies were included, and risk factors and outcomes were analyzed. The study found that women with comorbidities, HIV infection, prepregnancy underweight, and anemia were at increased risk for severe COVID-19-related outcomes and adverse birth outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Acoustics
A. Arechvo, D. A. Nikolaidi, M. M. Gil, V. Rolle, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study aimed to examine the relationship between the English index of multiple deprivation (IMD) and the incidence of stillbirth and evaluate whether IMD contributes to the prediction of stillbirth provided by maternal demographic characteristics and elements of medical history. The study found that women living in the most deprived areas in South East England had higher rates of stillbirth, particularly placental dysfunction-related stillbirth. However, including IMD in stillbirth screening did not improve the prediction provided by race, other maternal characteristics, and elements of medical history.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Kacey Ferguson, Fouzia Farooq, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Beth A. Tippett Barr, Elisa Bevilacqua, Justin S. Brandt, Nathalie Broutet, Irene Fernandez Buhigas, Jorge Carrillo, Rebecca Clifton, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Valerie J. Flaherman, Chris Gale, Maria M. Gil, Sami L. Gottlieb, Eduard Gratacos, Olivia Hernandez, Stephanie Jones, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen Kotloff, Antonio Lanzone, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Valentina Laurita Longo, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Elizabeth M. McClure, Tori D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Gordon Rukundo, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Jonas Soderling, Olof Stephansson, Marleen Temmerman, Anna Thorson, Jorge E. Tolosa, Julia Townson, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Kristina Adams Waldorf, Clare Whitehead, Murat Yassa, Jim M. Tielsch
Summary: Despite heterogeneity in study design and quality, a sequential, prospective meta-analysis found that SARS-CoV-2 infection during pregnancy increases the risk of maternal mortality, severe maternal morbidity, and neonatal morbidity. However, there is no association with stillbirth or intrauterine growth restriction. The findings highlight the importance of preventing and managing SARS-CoV-2 infection in pregnant women. Overall, the study is rated 8 out of 10 in terms of importance.
Article
Obstetrics & Gynecology
Marcos Javier Cuerva, Elena Rodriguez, Marta Perez De Aguado, Maria del Mar Gil, Valeria Rolle, Francisco Lopez, Jose Luis Bartha
Summary: The aim of this study was to assess whether intrapartum ultrasound (ITU) measurements in maternal lateral posture are comparable to ITU measurements in semi-recumbent position. The results showed that the angle of progression (AOP) and head-perineum distance (HPD) were lower in the lateral posture compared to semi-recumbent position, while they were higher with contractions. Therefore, monitoring the second stage of labor with ITU in lateral maternal posture is feasible.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Oncology
Ignacio Zapardiel, Myriam Gracia Segovia, Ronalds Macuks, Rosanna Mancari, Patriciu Achimas-Cadariu, Giacomo Corrado, Arnoldas Bartusevicius, Vladyslav Sukhin, Juan C. Muruzabal, Pluvio J. Coronado Martin, Barbara Gardella, Jurgen M. Piek, Nicole Concin, Clemente Arab, Dimitrios Papatheodorou, Stephan Polterauer, Sara Iacoponi, Teresa Nieto, Martha C. Lopez-Sanclemente, Hanna Trukhan, Maria M. Gil, Irina Bakinovskaya, Alena Dalamanava, Marc Cucurull, Dzmitry Rovski, Laura Baquedano, Luis Chiva, Marcin Mardas, Siarhei Anatolievich Mavrichev, Jaroslav Klat, Carlos A. Lopez de la Manzanara, Yusuf Yildirim, SARCUT Study Grp
Summary: This retrospective study analyzed 683 patients with uterine sarcoma to identify and evaluate the impact of different prognostic factors on overall survival and disease-free survival. The results showed variations in 5-year overall survival and disease-free survival rates among different subtypes of uterine sarcoma. The presence of residual disease after surgery was identified as the most significant factor affecting overall survival.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Obstetrics & Gynecology
Irene Fernandez-Buhigas, Aranzazu Martin Arias, Marina Vargas-Terrones, Maia Brik, Valeria Rolle, Ruben Barakat, Maria D. Munoz-Gonzalez, Ignacio Refoyo, Maria M. Gil, Belen Santacruz
Summary: This study aimed to analyze the longitudinal effect of a supervised moderate physical exercise program during pregnancy on uteroplacental and fetal Doppler parameters. The results showed that a regular supervised moderate exercise program during pregnancy does not deteriorate fetal or maternal ultrasound Doppler parameters.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Ana M. Fidalgo, Raquel Miguel, Irene Fernandez-Buhigas, Asuncion Aguado, Marcos J. Cuerva, Elisa Corrales, Valeria Rolle, Belen Santacruz, Maria M. Gil, Liona C. Poon
Summary: After appropriate training, attending midwives and obstetricians have a level of agreement in ultrasound measurements to evaluate fetal head position and progress of labor.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Katarzyna Kosinska-Kaczynska, Beata Rebizant, Hanna Czeszko-Paprocka, Agata Bojdo, Maciej Przybylski, Katarzyna Chaberek, Agnieszka Lewandowska, Iwona Szymusik, Robert Brawura-Biskupski-Samaha
Summary: Pregnant women infected with SARS-CoV-2 at delivery have increased umbilical cord blood IL-6 concentration, indicating the possibility of IL-6 passage through the placenta. Maternal SARS-CoV-2 infection at delivery carries a risk of impacting the health of infants, even in asymptomatic cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Francisca Sonia Molina, Laura Pardo, Maria D. Munoz, Amaia Aiartzaguena, Amelia Valladolid, Jose E. Blanco, Jorge Burgos, MariaMar Gil
Summary: This study evaluated the reproducibility and usability of a novel medical device, the Fine Birth, for accurately diagnosing threatened preterm labor through objective quantification of cervical consistency in pregnant women. The results showed good intraobserver reproducibility and excellent interobserver reproducibility after adding a lateral microcamera and providing training.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Raquel Gonzalez, Anna Gonce, M. del Mar Gil, Edurne Mazarico, Elena Ferriols-Perez, Paloma Toro, Elisa Llurba, Elisa Saez, Miguel angel Rodriguez-Zambrano, Laura Garcia-Otero, Marta Lopez, Belen Santacruz, M. angeles Roman, Antoni Paya, Sofia Alonso, Monica Cruz-Lemini, Clara Pons-Duran, Luis Bernardo Herrera, Haily Chen, Azucena Bardaji, Llorenc Quinto, Clara Menendez
Summary: This study aimed to evaluate the safety and efficacy of hydroxychloroquine (HCQ) in pregnant and postpartum women with SARS-CoV-2 infection. The results showed that although the prevalence of infection was lower in the HCQ group, there were no significant differences between the two groups in terms of COVID-19 progression, adverse events, and electrocardiogram changes.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Obstetrics & Gynecology
Piya Chaemsaithong, Maria M. Gil, Noppadol Chaiyasit, Diana Cuenca-Gomez, Walter Plasencia, Valeria Rolle, Liona C. Poon
Summary: This study aimed to assess the diagnostic accuracy of placental growth factor and placental growth factor-based models in predicting the development of preeclampsia in asymptomatic women. The findings suggest that placental growth factor combined with maternal factors has the highest predictive performance for early preeclampsia, while placental growth factor-based models perform similarly to soluble fms-like tyrosine kinase-1-placental growth factor ratio for any-onset preeclampsia in the third trimester. Standardized research using consistent models is needed to accurately predict preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Biology
Szymon Plotka, Michal K. Grzeszczyk, Robert Brawura-Biskupski-Samaha, Pawel Gutaj, Michal Lipa, Tomasz Trzcinski, Ivana Isgum, Clara I. Sanchez, Arkadiusz Sitek
Summary: Accurate prediction of fetal birth weight is important for perinatal care, but current methods have challenges and inherent errors. This paper proposes a method that uses fetal ultrasound video scans and clinical data to automatically predict fetal birth weight. The method outperforms other automatic methods and can serve as an aid for less experienced clinicians.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Raquel Martin-Alonso, Valeria Rolle, Ranjit Akolekar, Catalina de Paco Matallana, Irene Fernandez-Buhigas, Maria Isabel Sanchez-Camps, Tara Giacchino, Miguel Rodriguez-Fernandez, Jose Eliseo Blanco-Carnero, Belen Santacruz, Maria M. Gil
Summary: In late-term uncomplicated singleton pregnancies, the cerebroplacental ratio (CPR) has shown poor predictive capacity for adverse perinatal outcomes.
MEDICINA-LITHUANIA
(2023)
