Article
Acoustics
Noa Gilad, Alina Weissmann-Brenner, Yinon Gilboa, Benjamin Dekel, Reuven Achiron, Sharon Perlman
Summary: The normal kidney contralateral to an MCDK exhibits a unique linear growth pattern during intrauterine life, with significantly higher growth during the third trimester compared to the second trimester. Compared to a solitary kidney, there is a significant compensatory trend in growth observed in the normal kidney contralateral to an MCDK during the third trimester. This study provides valuable information for prenatal counseling regarding future renal outcomes.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Meiying Cai, Chong Guo, Xinrui Wang, Min Lin, Shiyi Xu, Hailong Huang, Na Lin, Liangpu Xu
Summary: Genetic tests using chromosome microarray analysis (CMA) and whole-exome sequencing (WES) helped identify the genetic etiology of multicystic dysplastic kidney (MCDK) fetuses, providing a basis for prenatal diagnosis and prognosis evaluation. Abnormal copy number variations (CNVs), including pathogenic CNVs and a variant of unknown significance (VUS) CNVs, were detected by CMA, and two MCDK fetuses were identified with Bardet-Biedl syndrome (BBS) using WES.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Urology & Nephrology
Samuel M. Pettit, William J. Devan, David J. Chalmers, Allison Zanno
Summary: Multicystic Dysplastic Kidney is a developmental disease that usually involutes over time with conservative management. It can cause palpable abdominal mass and respiratory distress in neonates, though such cases are rare.
Article
Pediatrics
Douglas G. Matsell, Carol Bao, Teagan Po White, Ella Chan, Eli Matsell, Dan Cojocaru, Marisa Catapang
Summary: The study revealed that in patients with solitary functioning kidney, unilateral renal agenesis (URA) is more commonly associated with syndromes or anomalies, and has worse outcomes over time compared to multicystic dysplastic kidney (MCDK). Patients with URA are more likely to experience hypertension, proteinuria, and chronic kidney injury.
PEDIATRIC NEPHROLOGY
(2021)
Article
Urology & Nephrology
Keisuke Sugimoto, Takuji Enya, Kensuke Joh, Kohei Miyazaki, Tomoki Miyazawa, Rina Ohshima, Satoshi Marutani, Takemura Tsukasa, Mitsuru Okada
Summary: This case report discusses an infant who underwent nephrectomy for hypertension due to congenital renal hypoplasia. The examination of the renal specimen revealed abnormal vascular structure and irregular renin localizations, which may be the cause of hypertension. Serum renin and aldosterone levels gradually decreased post-surgery, reaching normal levels on the 90th postoperative day, indicating a successful outcome.
Article
Pathology
Mahmut Akgul, Sean R. Williamson, Dilek Ertoy, Pedram Argani, Sounak Gupta, Anna Calio, Victor Reuter, Satish Tickoo, Hikmat A. Al-Ahmadie, George J. Netto, Ondrej Hes, Michelle S. Hirsch, Brett Delahunt, Rohit Mehra, Stephanie Skala, Adeboye O. Osunkoya, Lara Harik, Priya Rao, Ankur R. Sangoi, Maya Nourieh, Debra L. Zynger, Steven Cristopher Smith, Tipu Nazeer, Berrak Gumuskaya, Ibrahim Kulac, Francesca Khani, Maria S. Tretiakova, Funda Vakar-Lopez, Guliz Barkan, Vincent Molinie, Virginie Verkarre, Qiu Rao, Lorand Kis, Angel Panizo, Ted Farzaneh, Martin J. Magers, Joseph Sanfrancesco, Carmen Perrino, Dibson Gondim, Ronald Araneta, Jeffrey S. So, Jae Y. Ro, Matthew Wasco, Omar Hameed, Antonio Lopez-Beltran, Hemamali Samaratunga, Sara E. Wobker, Jonathan Melamed, Liang Cheng, Muhammad T. Idrees
Summary: TFE3-rearranged renal cell carcinoma (TFE3-RCC) presents with heterogenous morphologic and IHC features, with pathologists primarily focusing on cytologic characteristics and TFE3 IHC expression in the diagnostic work-up. Variability and preferences exist among participants in the use of additional IHC assays, positive cut-off for TFE3 FISH, and the need for further molecular studies in confirming TFE3-RCC diagnosis.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Medicine, General & Internal
Jin-Hee Yu, Sa-Ra Lee, Heayeon Choi, Kun-Suk Kim, Byung-Moon Kang
Summary: This study presented a new case of congenital Herlyn-Werner-Wunderlich syndrome and reviewed the related literature. The patient was accurately diagnosed through magnetic resonance imaging and surgical examination, and underwent appropriate surgical treatment.
Editorial Material
Urology & Nephrology
Kurt Willis, Dawn L. MacLellan, Rodrigo L. P. Romao, Daniel T. Keefe
Summary: Congenital anomalies of the kidney and urinary tract (CAKUT) are a group of urologic conditions affecting the kidneys, ureter, bladder, and urethra. Ureteroceles and posterior urethral valves, both classified under CAKUT, do not have a known common pathophysiologic mechanism. This report presents the only documented case of CAKUT related to posterior urethral valves, ureterocele, and multicystic dysplastic kidney.
Article
Pediatrics
Matthew J. Harmer, Douglas J. Stewart, Pallavi Prasad, Faidra Veligratli, Charles Pickles, Ji Soo Kim, Maduri Raja
Summary: Follow-up is necessary for unilateral multicystic dysplastic kidneys (MCDK) due to the risks of contralateral kidney abnormalities and chronic kidney disease. A survey of senior UK pediatricians revealed significant variability in management, with 62% confirming diagnosis through a dimercaptosuccinic acid scan, 8% investigating contralateral vesicoureteric reflux through a cystogram, and 62% measuring renal function routinely. Concerns were raised about overcautiousness, but national guidance could offer consensus, safe variation, and choice for families. The estimated cost of follow-up ranged from £258 to £3854.
CLINICAL PEDIATRICS
(2023)
Article
Urology & Nephrology
Francesco Vasuri, Anthony P. Lisi, Carmen Ciavarella, Alessio Degiovanni, Benedetta Fabbrizio, Sabrina Valente, Gisella Vischini, Gaetano La Manna, Antonia D'Errico, Gianandrea Pasquinelli
Summary: This study evaluates the ultrastructural progression of thrombotic microangiopathy kidney disease and finds that Caveolin-1 can serve as a marker for early endothelial damage and correlate with disease severity.
JOURNAL OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Mehtap Akbalik Kara, Aysel Taktak, Caner Alparslan
Summary: This retrospective study evaluated the clinical features of 111 unilateral multicystic dysplastic kidney (MCDK) patients, finding that the majority of patients were diagnosed prenatally, with some also having other urological anomalies. Complications such as urinary tract infections, renal failure, and scarring were relatively common among the patients.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Review
Pediatrics
Samuel Pettit, David Chalmers
Summary: This systematic review examines neonatal cases of Multicystic Dysplastic Kidney (MCDK) complicated by external compression, highlighting the successful outcomes following neonatal nephrectomy. Encouraging communication about exceptional cases like these is emphasized for informing future management strategies.
JOURNAL OF PEDIATRIC UROLOGY
(2021)
Article
Anatomy & Morphology
Milorad Antic, Marija Dakovic Bjelakovic, Aleksandar Petrovic, Marko Bjelakovic, Goran Radenkovic, Nikola Zivkovic, Miljan Krstic, Vladimir Antic
Summary: This study examined the development of glomeruli and tubules in the kidney cortex of human foetuses at different gestational ages. The expression of proliferation marker Ki-67 and apoptosis-related markers Bcl-2 and Bax during nephrogenesis was also investigated. The results showed a spatiotemporal gradient of nephron differentiation and the morphological characteristics of definitive nephrons in the inner cortex. The size and density of glomeruli and tubules changed with gestational age, and the expression patterns of Ki-67, Bcl-2, and Bax varied throughout nephron development.
CELLS TISSUES ORGANS
(2023)
Article
Pediatrics
Yuri Nishiya, Kohei Kawaguchi, Kosuke Kudo, Takuya Kawaguchi, Juma Obayashi, Kunihide Tanaka, Kei Ohyama, Shigeyuki Furuta, Yasuji Seki, Junki Koike, Kevin C. Pringle, Hiroaki Kitagawa
Summary: Creating obstructive uropathy (OU) during glomerulogenesis in fetal lambs leads to the formation of multicystic dysplastic kidney (MCDK). Through immunohistochemical techniques, we found that the expression of PAX2 and CD10 is associated with renal development. In the OU model, CD10 and PAX2 were expressed in the cystic epithelial cells, suggesting that cyst formation may be related to abnormal regulation of PAX2 in the nephrogenic zone epithelial cells.
PEDIATRIC SURGERY INTERNATIONAL
(2022)
Article
Polymer Science
Ernesto Oyervides-Munoz, Luc Averous, Gerardo de Jesus Sosa-Santillan, Eric Pollet, Nancy Veronica Perez-Aguilar, Claudia Maribel Rojas-Caldera, Jose Guadalupe Fuentes-Aviles, Clara Garcia-Astrain
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2019)
Article
Environmental Sciences
Enzo Leiva-Aravena, Eduardo Leiva, Vasty Zamorano, Claudia Rojas, John M. Regan, Ignacio T. Vargas
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Fisheries
Camila Fernandez, Angel Rain-Franco, Claudia Rojas, Veronica Molina
AQUACULTURE RESEARCH
(2020)
Article
Pediatrics
Mohammed Farhan Ali, Sunil Kumar Bathally Venkatarayappa, Merline Benny, Claudia Rojas, Keyvan Yousefi, Lina A. Shehadeh, Shathiyah Kulandavelu, Mayank Sharma, Naimeh Da Silva, Michael Freundlich, Carolyn L. Abitbol, Marissa J. DeFreitas, Karen C. Young
PEDIATRIC RESEARCH
(2020)
Article
Behavioral Sciences
Alfredo Catalan, Claudia A. Rojas, Gonzalo A. Chavez
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH
(2020)
Article
Chemistry, Physical
Claudia I. Viquez Rojas, Lyudmila V. Slipchenko
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2020)
Article
Pediatrics
Kori B. Flower, Samuel Wurzelmann, Christine Tucker, Claudia Rojas, Maria E. Diaz-Gonzalez de Ferris, Francisco Sylvester
Summary: The study found that children of Spanish-speaking caregivers in academic medical centers face multiple barriers to care, including both language-specific and non-language-specific barriers. Providing bilingual staff, interpreters, and written materials in Spanish can help facilitate healthcare for these children.
ACADEMIC PEDIATRICS
(2021)
Article
Medical Laboratory Technology
Domenika Ortiz Requena, Claudia Rojas, Monica Garcia-Buitrago
Summary: Brunner's gland adenoma (hyperplasia) is a benign gastrointestinal lesion that is usually asymptomatic and often detected incidentally. Diagnosis is typically based on typical cytological morphology and immunohistochemical features, with clinical and pathological features being essential for an accurate diagnosis.
DIAGNOSTIC CYTOPATHOLOGY
(2021)
Review
Entomology
Renate Krause-Sakate, Luis Fernando Maranho Watanabe, Eduardo Silva Gorayeb, Felipe Barreto da Silva, Daniel de Lima Alvarez, Vinicius Henrique Bello, Angelica Maria Nogueira, Bruno Rossitto de Marchi, Eduardo Vicentin, Marcos Roberto Ribeiro-Junior, Julio Massaharu Marubayashi, Claudia Andrea Rojas-Bertini, Cristiane Muller, Regiane Cristina Oliveira de Freitas Bueno, Marlene Rosales, Murad Ghanim, Marcelo Agenor Pavan
Article
Environmental Sciences
Humberto Aponte, Pedro Mondaca, Christian Santander, Sebastian Meier, Jorge Paolini, Benjamin Butler, Claudia Rojas, Maria Cristina Diez, Pablo Cornejo
Summary: The study found that enzyme activities decreased in highly metal(loid) contaminated soils, which also had low organic carbon and clay contents, reflecting long term processes of soil degradation. Additionally, positive relationships between enzyme activities and total organic carbon were observed.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Environmental Sciences
Jesus Rodrigo-Comino, Manuel Lopez-Vicente, Vinod Kumar, Andres Rodriguez-Seijo, Orsolya Valko, Claudia Rojas, Hamid Reza Pourghasemi, Luca Salvati, Noura Bakr, Emmanuelle Vaudour, Eric C. Brevik, Maja Radziemska, Manuel Pulido, Simone Di Prima, Marta Dondini, Wim de Vries, Erika S. Santos, Maria de Lourdes Mendonca-Santos, Yang Yu, Panos Panagos
AIR SOIL AND WATER RESEARCH
(2020)
Article
Environmental Studies
Claudia Lucia Rojas Bernal, Kelly Shannon, Bruno De Meulder
LANDSCAPE RESEARCH
(2020)
Article
Health Policy & Services
Kori B. Flower, Samuel Wurzelmann, Claudia Rojas, Kristina Morris Heredia, Myriam Peereboom, Francisco Sylvester, Kellei Agostinelli, Victor Silva Ritter, Jason Fine, Michael J. Steiner
JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
(2020)
Article
Geography
Claudia Marcela Orduz Rojas, Doralice Barros Pereira, Janise Bruno Dias
CYBERGEO-EUROPEAN JOURNAL OF GEOGRAPHY
(2019)
Article
Emergency Medicine
Felix R. Montes, Skarlet Marcell Vasquez, Claudia Marcela Camargo-Rojas, Myriam V. Rueda, Lina Goez-Mogollon, Paula A. Alvarado, Danny J. Novoa, Juan Carlos Villar
BMC EMERGENCY MEDICINE
(2019)
