Article
Biophysics
Ahmed El-Fiqi, Joong-Hyun Kim, Hae-Won Kim
Summary: The study successfully prepared highly bioactive bone cement microspheres, which have the potential to serve as bone defect fillers to promote bone regeneration. These microspheres have a large specific surface area, sustained release of soluble silicate ions, and high protein adsorption capacity. The experimental results demonstrate that these cement microspheres exhibit excellent bioactivity both in vitro and in vivo, accelerating new bone formation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Multidisciplinary
QuanZhe Liu, Jung Hun Kim, MinJoon Cho, Su Hyeon Kim, Bin Xu, Sivashanmugam Amirthalingam, Nathaniel S. Hwang, Jae Hyup Lee
Summary: In this study, a new functional bone cement was synthesized by incorporating tetracalcium phosphate and whitlockite with PMMA cement, and its characteristics were evaluated based on ISO standards. The results showed that this functional bone cement has the potential to promote new bone formation, support bone tissue, and treat osteoporotic vertebral compression fractures (OVCF).
MATERIALS & DESIGN
(2023)
Article
Engineering, Mechanical
Guogao Zhang, Tenghao Yin, Guodong Nian, Zhigang Suo
Summary: This study introduces a fatigue-resistant PU fiber-matrix composite, utilizing Spandex fibers and PU elastomer matrix to enhance toughness and fatigue threshold. The pullout test demonstrates high adhesion toughness, with the composite showing advantages in stress deconcentration solutions.
EXTREME MECHANICS LETTERS
(2021)
Article
Chemistry, Physical
Shaochun Lv, Tianyu Qu, Hisham Al-Ward, Liting Mu, Hongbin Qiu, Yunlong Zhang
Summary: Bone defects can cause deformities and dysfunctions in the human body. The use of bioactive bone cement for bone regeneration is essential. In this study, bioactive magnesium phosphate bone cement (BMPC) was fabricated and its properties were discussed. The results showed that BMPC had good biocompatibility and degradability, making it a promising orthopedic material.
Article
Engineering, Biomedical
Victor P. Galvan-Chacon, Laura Costa, David Barata, Pamela Habibovic
Summary: Affordable and effective biomaterials are needed for successful treatment of orthopaedic bone defects. Calcium phosphate ceramics are commonly used for bone repair, but further optimization is necessary. A microfluidic strategy for producing CaP microparticles with controlled properties was developed in this study, showing potential for bioactive ceramics synthesis.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Environmental
Xiaoming Zhao, Jun Gao, Hao Han, Xiaoxiao Lou, Hongyun Ma, Xiaochen Su, Liuyang Zhang, Jing Tian, Bo Len, Yingang Zhang
Summary: In this study, a multifunctional bioactive bone cement reinforced with poly(citrate-silicon) nanospheres was developed to overcome the limitations of traditional polymethyl methacrylate (PMMA) bone cement. The reinforced cement showed improved properties such as increased injectability, extended setting time, increased hydrophilicity, reduced polymerization heat, and good degradability. It also exhibited antioxidant, antibacterial, and biomineralization properties. Cellular experiments showed enhanced osteogenic differentiation, mineral deposition, anti-inflammatory, and pro-angiogenic properties. In a rat model, the reinforced bone cement significantly promoted new bone formation and bone ingrowth, through improved osteogenic proteins and angiogenesis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Engineering, Biomedical
Oznur Demir-Oguz, Aldo R. Boccaccini, Dagnija Loca
Summary: Calcium phosphate bone cements (CPCs) have valuable properties such as bioactivity, osteoconductivity, injectability, and moldability, but their low mechanical performance limits their clinical application. Adding bioactive glasses (BGs) as a secondary powder phase can improve the injectable properties of CPCs and enhance the degradation rate, in vitro osteogenic differentiation, cell response, and tissue-material interaction.
BIOACTIVE MATERIALS
(2023)
Article
Construction & Building Technology
Zhongli Wang, Tian Xia, Jianhui Xu, Youbing Li, Min Wang
Summary: This study investigated the effect of polyurethane (PU) addition on the dynamic mechanical properties of cement emulsified asphalt (CA) used in railway construction. The results showed that 5% and 10% PU loading could enhance both the dynamic stiffness and damping capacity of CA, while the variation of 0-20% PU loading resulted in a nonmonotonic change in dynamic stiffness. The fatigue life of CA was prolonged by the addition of PU, with the most prominent effect observed at 10% PU loading. Scanning electron microscope (SEM) and Fourier Transform Infrared Spectrometer (FTIR) analysis revealed a core-shell structure composed of anionic PU covering the surface of cationic emulsified asphalt, indicating the important role of the inorganic-organic transition layer in enhancing the dynamic mechanical properties of CA.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Engineering, Biomedical
Jiawen Wang, Ziqing Cheng, Duanjing Chen, Guangyue Li, Jie Chen, Kai Wang, Ling Xu, Jiao Huang
Summary: Magnesium phosphate cement (MPC) has been modified to be porous by using calcium carbonate and citric acid as foaming agents. The resulting MPC with 3% CaCO3/CA showed improved physicochemical properties and enhanced biocompatibility. In animal experiments, 3%CaCO3/CA-MPC exhibited better bone regeneration compared to the blank group, and slightly lower regeneration compared to the Bio-Oss(R) group. This study suggests that porous MPC foamed with calcium carbonate and CA is a promising material for bone regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Microbiology
Peng Zhou, Brittny L. Garcia, Georgios A. Kotsakis
Summary: This study evaluated the antibacterial and antibiofilm effects of the parent compound 45S5 and S53P4 against various anaerobic and aerobic bacteria associated with osteomyelitis. The results showed that 45S5 was as effective as S53P4, and possibly even more capable of limiting bacterial infections.
Article
Materials Science, Ceramics
Manqi Yan, Yanan Zhao, Yue Dai, Xiaokang Yao, Honglian Dai
Summary: In this study, modified calcium magnesium phosphate bone cement (MCPC) composites were constructed by introducing gelatin solutions. The modified MCPC composites exhibited improved microenvironment, enhanced osteogenic differentiation and biomineralization. When incorporated with 1% and 5% of gelatin, the MCPC composites showed higher mechanical properties and osteogenic ability of BMSCs.
CERAMICS INTERNATIONAL
(2022)
Article
Construction & Building Technology
Hu Feng, Shihao Shen, Yuyang Pang, Danying Gao, Zhenyu Wang, M. Neaz Sheikh
Summary: This study investigated the mechanical properties of magnesium phosphate cement (MPC) enhanced by adding fiber and nano-Al2O3, showing improvements in workability and mechanical properties. Increasing fiber content decreased workability while increasing compressive and tensile strength. The addition of micro-steel fiber had the most significant effect on improving flexural toughness. Empirical formulae for predicting strength properties of the fiber and nano-Al2O3 reinforced MPC composite were proposed. The modification mechanisms of nano-Al2O3 on the MPC were revealed through microscopic phase tests.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Engineering, Biomedical
Zoe M. Wright, Avanti M. Pandit, Michelle M. Karpinsky, Brian D. Holt, Edward P. Zovinka, Stefanie A. Sydlik
Summary: Graphene oxide and functionalized graphenic materials show promise in enhancing bioactivity of PMMA-based bone cement. By combining bioactive FGM fillers with a custom cement formulation, higher loading levels of graphenic fillers can be achieved without compromising cement strength, leading to enhanced biological activity and controlled release of osteogenic calcium ions. Design criteria are provided for future bone cements utilizing FGMs to achieve dynamic biological activity.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Hao Zhang, Yinglin Cui, Xianglong Zhuo, Jua Kim, Honglong Li, Shuaijie Li, Hongsheng Yang, Kun Su, Chunyu Liu, Pengfei Tian, Xian Li, Li Li, Deping Wang, Limin Zhao, Jianyun Wang, Bing Li, Xu Cui, Haobo Pan
Summary: PMMA bone cement used in vertebroplasty lacks proper biological response, resulting in a fragile interface with the host bone. This study modified PMMA by incorporating borosilicate glass, which provided an alkaline microenvironment and enhanced osteogenesis. Clinical case observation showed that the modified cement formed a biological interface, making it a promising biomaterial for vertebroplasty.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Zhibo Zheng, Siyu Chen, Xudong Liu, Yingjie Wang, Yanyan Bian, Bin Feng, Rui Zhao, Zhiye Qiu, Yulong Sun, Hongyu Zhang, Fuzhai Cui, Xiao Yang, Xisheng Weng
Summary: In this study, mineralized collagen (MC) was incorporated into polymethylmethacrylate (PMMA) bone cement to enhance osteointegration ability, showing improved wettability and mechanical performance of PMMA-MC in vitro. In animal models, the PMMA-MC group demonstrated more new bone formation and higher fixation force compared to the PMMA group. Moreover, in torsion tests on cadaveric femurs, the PMMA-MC group required more torque for the same rotation degree, indicating the potential of MC to induce efficient fixation in osteoporotic bone.
MATERIALS & DESIGN
(2021)
Article
Biophysics
Gregory B. Lowen, Katherine A. Garrett, Stephanie N. Moore-Lotridge, Sasidhar Uppuganti, Scott A. Guelcher, Jonathan G. Schoenecker, Jeffry S. Nyman
Summary: Delayed long bone fracture healing and nonunion are significant socioeconomic burdens. Mechanical stimulation plays a crucial role in bone repair process. Understanding the impact of interfragmentary strain (IFS) in terms of its magnitude, mode, and commencement on fracture healing can guide the development of new therapeutic strategies. This proof-of-concept finite element analysis study focuses on identifying the design parameters of intramedullary nails (IMNs) that have the largest impact on IFS in a murine transverse femoral osteotomy model. Results show that the nail material, distance between interlocking screws, and clearance between the nail and endosteal surface are important factors affecting IFS. Therefore, low modulus IMNs, such as PEEK, can be used alongside commercially available SS nails to investigate the effect of initial IFS or stability on fracture healing in different biological repair conditions.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Endocrinology & Metabolism
M. Saito, S. N. Moore-Lotridge, S. Uppuganti, S. Egawa, T. Yoshii, J. P. Robinette, S. L. Posey, B. H. Y. Gibson, H. A. Cole, G. D. Hawley, S. A. Guelcher, S. B. Tanner, J. R. McCarthy, J. S. Nyman, J. G. Schoenecker
Summary: This study found that bisphosphonates can prevent severe injury-induced bone loss and soft tissue calcification if administered early after injury, without interfering with bone repair or remodeling.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
J. Ethan Joll Ii, Matthew R. Bersi, Jeffry S. Nyman, W. David Merryman
Summary: Postmenopausal women with severe osteoporosis tend to have worse cardiovascular outcomes. This study evaluated the left ventricle and aortic valve phenotype of ovariectomized mice on a Western diet. The results showed that ovariectomized mice had increased left ventricle mass compared to control mice, but no fibrosis. This model provides a novel method for studying left ventricle hypertrophy in female populations.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Instruments & Instrumentation
Donald H. Lee, Kaitlyn Reasoner, Sasidhar Uppuganti, Mihir J. Desai, Jeffry S. Nyman
Summary: This study investigated the safety and utility of impact microindentation technique in measuring bone quality during surgical procedures. The results showed that there were no significant differences in bone material strength index (BMSi) between patients with different fracture histories, indicating that BMSi may not be sensitive to osteoporosis. The study demonstrated the feasibility of intraoperative impact microindentation but called for further research to determine its ability to identify patients with inferior bone matrix quality.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2022)
Article
Endocrinology & Metabolism
Sasidhar Uppuganti, Thammathida Ketsiri, Yumeng Zhang, Mark D. Does, Jeffry S. Nyman
Summary: This study found that HR-pQCT parameters are capable of predicting the bending strength of cortical bone, with cortical area and estimated failure load showing the strongest correlation with ultimate moment. However, there was no significant correlation between HR-pQCT parameters and post-yield displacement, an indicator of bone brittleness.
Article
Computer Science, Interdisciplinary Applications
Thammathida Ketsiri, Sasidhar Uppuganti, Kevin D. Harkins, Daniel F. Gochberg, Jeffry S. Nyman, Mark D. Does
Summary: Ultrashort echo time (UTE) MRI techniques can be used to assess the concentration of water in bones, which have the potential to serve as biomarkers for bone fracture risk. This study demonstrates that MRI-derived measures of collagen-bound water concentration (C-bw) and pore water concentration (C-pw) improve the prediction of bone mechanical properties and have the potential to assess patient-specific bone fragility risk.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Thammathida Ketsiri, Sasidhar Uppuganti, Kevin D. D. Harkins, Daniel F. F. Gochberg, Jeffry S. S. Nyman, Mark D. D. Does
Summary: MRI measurements of bound and pore water concentration in cortical bone can be used as potential diagnostic tools for bone fracture risk. This study provides a detailed understanding of the T-1 relaxation characteristics of both bound and pore water using spectroscopic relaxometry measurements. The results show a wide range and substantial variation in the T-1 spectra of pore water. Neglecting this variation can lead to significant errors in MRI measurements of both bound and pore water concentrations, particularly in adiabatic inversion recovery (AIR) based measurements.
NMR IN BIOMEDICINE
(2023)
Article
Engineering, Biomedical
Mustafa Unal, Sasidhar Uppuganti, Daniel Y. Dapaah, Rafay Ahmed, Jacquelyn S. Pennings, Thomas L. Willett, Paul Voziyan, Jeffry S. Nyman
Summary: Raman spectroscopy (RS) can detect the accumulation of advanced glycation end-products (AGEs) and measure matrix-sensitive properties related to the fracture toughness of human cortical bone. However, it is unclear if the sugar-mediated accumulation of AGEs affects the fracture toughness of human cortical bone as indicated by the negative correlations between amide I sub-peak ratios.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Spectroscopy
Rekha Gautam, Rafay Ahmed, Ezekiel Haugen, Mustafa Unal, Sean Fitzgerald, Sasidhar Uppuganti, Anita Mahadevan-Jansen, Jeffry S. Nyman
Summary: This study investigated the feasibility of using spatially offset Raman spectroscopy (SORS) to acquire Raman bands related to bone fracture resistance. The results showed that autoclaving of femur mid-shafts reduced the yield stress of cortical beams. Autoclaving also affected the Raman characteristics of the organic matrix, but changes in Raman properties related to bone strength could still be detected with SORS.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Rafay Ahmed, Mustafa Unal, Rekha Gautam, Sasidhar Uppuganti, Shrey Derasari, Anita Mahadevan-Jansen, Jeffry S. Nyman
Summary: The fracture resistance of bone is determined by the hierarchical arrangement of minerals, collagen fibrils, non-collagenous proteins, and water. Raman spectroscopy can detect changes in the protein structure and composition, making it a valuable tool for studying bone properties.
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)