Article
Engineering, Biomedical
Bradley S. Henderson, Katelyn F. Cudworth, Estefania Pena, Trevor J. Lujan
Summary: This study demonstrates the feasibility of using a visco-hyperelastic damage model to simulate low- and high-cycle fatigue failure in soft fibrous tissue. The model successfully simulated cyclic creep behavior and predicted tissue rupture. It also suggests that solid viscoelasticity plays a crucial role in fatigue failure of soft tissue.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Prakhar Bandil, Franck J. Vernerey
Summary: Mechanical forces play a crucial role in the morphogenesis and growth of biological tissues, and understanding the interaction between mechanical forces and biological processes is of great importance. This study presents a continuum-scale model that describes the active mechanics and evolution of a cell population, which can capture the complex cross-talk between mechanical forces and biological processes.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Article
Multidisciplinary Sciences
D. Mistry, N. A. Traugutt, B. Sanborn, R. H. Volpe, L. S. Chatham, R. Zhou, B. Song, K. Yu, K. N. Long, C. M. Yakacki
Summary: The study investigates the soft-elasticity characteristics of monodomain liquid crystal elastomers (LCEs) and their potential for impact absorption. Through the use of direct-ink writing technology, sufficiently large monodomain LCE devices were successfully fabricated. The research found that monodomain soft-elastic LCE performed well at different strain rates and excelled in reducing the severity of impacts.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Aldo Tecse, Stefano E. Romero, Roozbeh Naemi, Benjamin Castaneda
Summary: This study aimed to develop a validated method for characterizing the viscoelastic properties of soft tissues based on ultrasound elastography data. The viscoelastic parameters were estimated and compared to mechanical test results. The results showed that the fractional-derivative models, especially the FD-KV and FD-Maxwell models, were more effective in simulating the viscoelastic behavior of plantar soft tissue. This study has important implications for assessing the function of soft tissue and can be used as markers for diagnosis or prognosis.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Robotics
Maria Guix, Rafael Mestre, Tania Patino, Marco De Corato, Judith Fuentes, Giulia Zarpellon, Samuel Sanchez
Summary: Bioinspired hybrid soft robots, which combine living and synthetic components, utilize unique characteristics not found in artificial materials, such as adaptability and response to external stimuli. By optimizing 3D-printed skeleton designs and electrically activating muscle tissue, these robots are able to achieve both swimming and gliding motion mechanisms.
Article
Biotechnology & Applied Microbiology
Sai Naga Sri Harsha Chittajallu, Ashutosh Richhariya, Kwong Ming Tse, Viswanath Chinthapenta
Summary: Computational modelling of damage and rupture of non-connective and connective soft tissues is crucial for understanding failures. Recent advancements in damage models have applications in developing artificial tissues, medical devices/implants, and surgical intervention. This article reviews the recently developed models that consider tissue microstructure, providing key conceptual ideas, advantages, limitations, and challenges for damage and rupture models in soft tissues.
BIOENGINEERING-BASEL
(2022)
Article
Engineering, Biomedical
David Nordsletten, Adela Capilnasiu, Will Zhang, Anna Wittgenstein, Myrianthi Hadjicharalambous, Gerhard Sommer, Ralph Sinkus, Gerhard A. Holzapfel
Summary: Understanding the biomechanics of the heart is crucial for diagnosing and treating heart failure. A new viscoelastic constitutive model for cardiac muscle has been developed, showing improved accuracy compared to traditional hyperelastic models. The model demonstrates high sensitivity, fidelity, and parameter uniqueness, and is versatile in simulating various loading phenomena.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Multidisciplinary
Will Zhang, Adela Capilnasiu, David Nordsletten
Summary: This study systematically examines classical and fractional nonlinear isotropic viscoelastic models, considering different testing paradigms and model behaviors. It introduces similarity metrics for model comparison and parameter analysis, providing key insights for deciding on the appropriate viscoelastic modeling formulations.
JOURNAL OF ELASTICITY
(2021)
Article
Engineering, Biomedical
Will Zhang, Majid Jadidi, Sayed Ahmadreza Razian, Gerhard A. Holzapfel, Alexey Kamenskiy, David A. Nordsletten
Summary: This study introduces a new viscoelastic constitutive model for the human femoropopliteal artery, which accurately describes its mechanical characteristics and time-dependent behavior. The model improves the accuracy of computational simulations and expands our knowledge of arterial mechanophysiology.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Andrea Acuna, Julian M. Jimenez, Naomi Deneke, Sean M. Rothenberger, Sarah Libring, Luis Solorio, Vitaliy L. Rayz, Chelsea S. Davis, Sarah Calve
Summary: Characterizing the mechanical properties of tissues is crucial for biomaterials and regenerative therapies; understanding microenvironments can promote growth and remodeling; a micromanipulator and spring system was developed to mechanically test small, soft materials under tension.
ACTA BIOMATERIALIA
(2021)
Article
Physics, Multidisciplinary
Thomas Fuhs, Franziska Wetzel, Anatol W. Fritsch, Xinzhi Li, Roland Stange, Steve Pawlizak, Tobias R. Kiessling, Erik Morawetz, Steffen Grosser, Frank Sauer, Juergen Lippoldt, Frederic Renner, Sabrina Friebe, Mareike Zink, Klaus Bendrat, Juergen Braun, Maja H. Oktay, John Condeelis, Susanne Briest, Benjamin Wolf, Lars-Christian Horn, Michael Hoeckel, Bahriye Aktas, M. Cristina Marchetti, M. Lisa Manning, Axel Niendorf, Dapeng Bi, Josef A. Kaes
Summary: Cancer cells within tumors tend to become softer, and primary tumors exhibit high mechanical heterogeneity across scales, providing stability and room for cell motility.
Article
Engineering, Biomedical
Manuel Rausch, William D. D. Meador, John Toaquiza-Tubon, Omar Moreno-Flores, Adrian Buganza Tepole
Summary: Understanding the response of skin to superphysiological temperatures is crucial for the diagnosis, prognosis, and development of thermal therapies. This study explores the complex interdependence of time, temperature, direction, and load in skin's response to superphysiological temperatures. Two models are proposed to explain the observations, both based on the denaturation of the collagen microstructure. The success of these models provides guidance for future experiments and the engineering design of heat treatment therapies.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Yulia Malkova, Sijie Ran, Dmitri Vainchtein, Gary Friedman
Summary: This paper investigates the reaction forces of spherical solids in soft tissues through experiments and mathematical modeling. The proposed model, which considers the history-dependent nature of the reaction forces, accurately describes the experimental results. The experiments involve using magnetic forces to drag a permanent magnet sphere in agarose gel and accurately tracking its motion through video tracking.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Vahidullah Tac, Manuel K. Rausch, Francisco Sahli Costabal, Adrian Buganza Tepole
Summary: We develop a fully data-driven model of anisotropic finite viscoelasticity using neural ordinary differential equations. The model replaces the Helmholtz free energy function and the dissipation potential with data-driven functions that satisfy physics-based constraints. This approach allows modeling of viscoelastic behavior under arbitrary loads in three-dimensions and large deviations from thermodynamic equilibrium. The data-driven nature of the model provides flexibility in modeling a wide class of materials and outperforms traditional models of viscoelasticity.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
A. J. McGhee, E. O. McGhee, J. E. Famiglietti, K. D. Schulze
Summary: Researchers have developed a method using contemporary 3D printing techniques to acquire real-time full-field deformation of a hydrogel subsurface, successfully observing the mechanical response in the bulk of a hydrogel. This method has the potential to answer fundamental questions regarding biological material mechanical behaviors.
EXPERIMENTAL MECHANICS
(2021)
Article
Urology & Nephrology
Sarah J. Welsh, Nicola Thompson, Anne Warren, Andrew N. Priest, Tristan Barrett, Stephan Ursprung, Ferdia A. Gallagher, Fulvio Zaccagna, Grant D. Stewart, Kate M. Fife, Athena Matakidou, Andrea J. Machin, Wendi Qian, Victoria Ingleson, Jean Mullin, Antony C. P. Riddick, James N. Armitage, Stephen Connolly, Timothy G. Q. Eisen
Summary: This study aimed to explore translational biological and imaging biomarkers for sunitinib treatment before and after debulking nephrectomy. The results showed that pre-surgical sunitinib significantly increased necrosis of tumors and reduced certain biomarkers, leading to improved overall survival and progression-free survival in patients with metastatic renal cell carcinoma.
Article
Urology & Nephrology
Hannah Harrison, Lisa Pennells, Angela Wood, Sabrina H. Rossi, Grant D. Stewart, Simon J. Griffin, Juliet A. Usher-Smith
Summary: This study validated 30 risk prediction models for kidney cancer in the UK Biobank cohort, with 10 models showing reasonable discrimination. The best models performed better in identifying high-risk individuals compared to age and sex-based screening, but had lower performance in women than in men.
Review
Urology & Nephrology
Jordan G. Flitcroft, Jeroen Verheyen, Tarun Vemulkar, Emma N. Welbourne, Sabrina H. Rossi, Sarah J. Welsh, Russell P. Cowburn, Grant D. Stewart
Summary: Several urinary protein biomarkers are being validated for RCC diagnostics, but none have been approved for clinical use yet due to low sensitivity or specificity, inconsistencies in study design, or lack of external validation. Evaluation of feasibility, sample preparation, biomarker validation, and novel technologies may maximize the potential for a truly non-invasive biomarker in early RCC diagnostics.
Article
Oncology
Helen Mossop, Michael J. Grayling, Ferdia A. Gallagher, Sarah J. Welsh, Grant D. Stewart, James M. S. Wason
Summary: Efficient trial designs are crucial for prioritizing promising drugs in Phase II trials. Three trial approaches were compared in a simulation study, with the MASTER design showing extra efficiency in cases of endpoint delay or rapid recruitment. The study recommends the MASTER design as an efficient way to test multiple promising cancer treatments in non-comparative Phase II trials.
BRITISH JOURNAL OF CANCER
(2022)
Editorial Material
Urology & Nephrology
Juliet A. Usher-Smith, Grant D. Stewart
Summary: Prognostic models play a crucial role in the management of post-surgery RCC patients. Existing clinico-pathological models to predict cancer outcomes in these patients seem to have reached their performance limit. Future research should focus on identifying new prognostic markers and determining the implementation of RCC prognostic models in practice.
NATURE REVIEWS UROLOGY
(2022)
Review
Urology & Nephrology
Hannah Harrison, Nicole Li, Catherine L. Saunders, Sabrina H. Rossi, Joe Dennis, Simon J. Griffin, Grant D. Stewart, Juliet A. Usher-Smith
Summary: This study reviewed the current state of genetic risk models for predicting the development of kidney cancer. By identifying and comparing published models, it was found that the performance of these models is poorer compared to genetic risk models for other cancers. Further research is needed to identify more genetic variants associated with kidney cancer in order to improve the genetic risk models for this disease.
Article
Health Care Sciences & Services
Rebecca A. Dennison, Rachel A. Boscott, Rae Thomas, Simon J. Griffin, Hannah Harrison, Stephen D. John, Sowmiya A. Moorthie, Stephen Morris, Sabrina H. Rossi, Grant D. Stewart, Chloe Thomas, Juliet A. Usher-Smith
Summary: Using risk stratification to determine eligibility for cancer screening is generally acceptable to the public, especially when the risk factors are perceived as fair and the communication is transparent.
HEALTH EXPECTATIONS
(2022)
Article
Oncology
Bhavna Oza, Tim Eisen, Eleni Frangou, Grant D. Stewart, Axel Bex, Alastair W. S. Ritchie, Rick Kaplan, Benjamin Smith, Ian D. Davis, Martin R. Stockler, Laurence Albiges, Bernard Escudier, James Larkin, Steven Joniau, Barry Hancock, Gregers G. Hermann, Joaquim Bellmunt, Mahesh K. B. Parmar, Patrick Royston, Angela Meade
Summary: This study provides a robust external validation of the 2003 Leibovich score using contemporary data, demonstrating its discriminative accuracy and calibration in predicting risk for patients with locally advanced renal cell carcinoma (RCC). The score can be used to guide risk stratification in adjuvant clinical trials for RCC patients.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Grant D. Stewart, Sarah J. Welsh, Stephan Ursprung, Ferdia A. Gallagher, James O. Jones, Jacqui Shields, Christopher G. Smith, Thomas J. Mitchell, Anne Y. Warren, Axel Bex, Ekaterini Boleti, Jade Carruthers, Tim Eisen, Kate Fife, Abdel Hamid, Alexander Laird, Steve Leung, Jahangeer Malik, Iosif A. Mendichovszky, Faiz Mumtaz, Grenville Oades, Andrew N. Priest, Antony C. P. Riddick, Balaji Venugopal, Michelle Welsh, Kathleen Riddle, Lisa E. M. Hopcroft, Robert J. Jones
Summary: The study demonstrates that axitinib can reduce the level of VTT in patients, leading to a reduction in the extent of surgery for a significant proportion of patients. However, some patients show poor response to axitinib.
BRITISH JOURNAL OF CANCER
(2022)
Letter
Oncology
Bhavna Oza, Tim Eisen, Grant D. Stewart, Axel Bex, Patrick Royston, Angela Meade
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Urology & Nephrology
Tobias Klatte, Sarah J. J. Welsh, Antony C. P. Riddick, Jose A. Karam, Grant D. D. Stewart
Article
Urology & Nephrology
Hannah Harrison, Grant D. Stewart, Juliet A. Usher-Smith
Summary: The objective of this study was to explore the patient experience of follow-up care after kidney cancer surgery and develop recommendations for best practice. Two focus groups were conducted with 14 participants who had experience with kidney cancer follow-up care after surgery. Thematic analysis identified six themes describing the patient experience, including feelings of abandonment, uncertainty about the plan, anxiety about appointments, variation in care, a need for information, and a need for emotional support. Based on the results, a set of recommendations was developed to address these challenges.
Review
Oncology
Evie Papavasiliou, Valerie A. Sills, Natalia Calanzani, Hannah Harrison, Claudia Snudden, Erica di Martino, Andy Cowan, Dawnya Behiyat, Rachel Boscott, Sapphire Tan, Jennifer Bovaird, Grant D. Stewart, Fiona M. Walter, Yin Zhou
Summary: Bladder cancer is a common cancer worldwide and early diagnosis is crucial for better survival rates. Urinary biomarkers have been developed but their diagnostic performance in the general population is limited. This study systematically reviewed evidence on biomarkers suitable for use in community and primary care settings, identifying three biomarkers with similar diagnostic performance and some promising novel biomarkers. Further validation studies in the general population are needed.
Article
Chemistry, Multidisciplinary
Selma Leulmi Pichot, Tarun Vemulkar, Jeroen Verheyen, Lauren Wallis, James O. Jones, Andrew P. Stewart, Sarah J. Welsh, Grant D. Stewart, Russell P. Cowburn
Summary: This study describes a newly developed non-invasive urine-based assay for the early detection of renal cell carcinoma (RCC). The study shows that magnetic heterostructures have precise magnetic control and efficient code readout capabilities, making them suitable for screening RCC biomarkers.
NANOSCALE ADVANCES
(2023)
Review
Oncology
James O. Jones, William H. J. Ince, Sarah J. Welsh, Grant D. Stewart
Summary: ICPI treatment has shown efficacy in metastatic renal cell carcinoma, but there is limited evidence on the long-term survival benefit of ICPI therapy in localized disease in both neoadjuvant and adjuvant settings.
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
