Article
Obstetrics & Gynecology
Xavier Ferraretto, Karima Hammas, Marie-Astrid Llabador, Solenne Gricourt, Julie Labrosse, Johanna Lousqui, Sylvie Epelboin, Sarah Tubiana, Catherine Patrat
Summary: The study observed a high prevalence of ACL in embryos, with certain embryo characteristics being related to the patients' reproductive origin. However, no factors related to IVF cycles were found to be statistically associated with ACL occurrence.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Multidisciplinary Sciences
Carmen Huayhua, Misael Rodriguez, Jhorjhi Vega, Mario Briones, Lleretny Rodriguez-Alvarez, Edwin Mellisho
Summary: The objective of this study was to evaluate the time of blastulation monitored by time-lapse technology to predict in vitro viability of bovine blastocysts. The study found that early blastulation is associated with higher quality and post-hatching development in bovine blastocysts, and selecting blastocysts based on blastulation time and blastocyst diameter maximizes in vitro viability.
Article
Obstetrics & Gynecology
Yaoyu Zou, Yingxia Pan, Naidong Ge, Yan Xu, Ruihuan Gu, Zhichao Li, Jing Fu, Junhui Gao, Xiaoxi Sun, Yijuan Sun
Summary: This study investigated the use of artificial intelligence models to predict the ploidy status and implantation potential of embryos. The addition of clinical features improved the predictive performance of the algorithms. However, the ploidy prediction models were not highly predictive and cannot replace preimplantation genetic testing currently.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Xiao-Dong Zhang, Qi Zhang, Wei Han, Wei -Wei Liu, Xiao- Li Shen, Gui-Dong Yao, Sen-Lin Shi, Lin -Li Hu, Shan -Shan Wang, Jun-Xia Wang, Jian-Jun Zhou, Wei -Wei Kang, Heng-De Zhang, Chen Luo, Qi Yu, Rui-Zhi Liu, Ying-Pu Sun, Hai-Xiang Sun, Xiao-Hong Wang, Song Quan, Guo-Ning Huang
Summary: The study found that using a time-lapse incubator for embryo culture and assessment led to a significantly higher number of successfully implanted embryos in the first transfer cycle and a higher implantation rate compared to using a standard incubator with static assessment. This suggests that time-lapse technology may have potential clinical benefits in assisted reproduction.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Agriculture, Dairy & Animal Science
Fumie Magata
Summary: In vitro fertilization (IVF) has been increasingly used in bovine embryo production to select cows with high genetic values. Time-lapse monitoring (TLM) has emerged as a new technique that allows frequent and non-invasive imaging of developing embryos. This review outlines the potential application of TLM technology to improve the fertility of bovine IVF embryos and discusses the association between morphokinetic data obtained using TLM and the implantation potential of embryos.
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2023)
Article
Reproductive Biology
Ryosuke Suzuki, Mai Okada, Hiroki Nagai, Junichi Kobayashi, Satoshi Sugimura
Summary: This study for the first time visualized pronuclei (PN) in delipidated bovine zygotes using time-lapse cinematography (TLC), showing that abnormalities in PN morphokinetics are associated with subsequent embryonic development. Observations suggest that PN morphokinetic abnormalities are linked to developmental competence, highlighting the potential of non-invasive visible light TLC by delipidation as a powerful tool for studying the relationship between PN morphokinetics and embryonic development.
Article
Obstetrics & Gynecology
Shirly Lahav-Baratz, Idit Blais, Mara Koifman, Martha Dirnfeld, Galia Oron
Summary: The aim of this study was to examine the implantation potential of fragmented embryos that underwent morphokinetic evaluation in a time-lapse incubator. A retrospective study analyzed 4210 Day 5 embryos incubated between 2013 and 2019. Results showed that embryo fragmentation and morphokinetics were independent variables for clinical pregnancy achievements. Fragmented embryos had a potential to implant and should be considered for transfer.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Computer Science, Interdisciplinary Applications
Mikkel F. Kragh, Jens Rimestad, Jacob T. Lassen, Jorgen Berntsen, Henrik Karstoft
Summary: This paper introduces a method for analyzing time-lapse videos of developing embryos using self-supervised learning, and demonstrates its superiority in predicting pregnancy likelihood. Additionally, the paper explores how transfer learning and semi-supervised learning can improve model performance when labeled data is limited.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Obstetrics & Gynecology
Chandra C. C. Shenoy, Alexandra Bader, David L. L. Walker, Jolene R. R. Fredrickson, Amy L. L. Weaver, Yulian Zhao
Summary: This study examined blastomere exclusion during embryo development and its association with aneuploidy. Results showed that embryos with blastomere exclusion had a higher rate of aneuploidy compared to those without exclusion. Late blastomere exclusion or a combination of early and late exclusion was particularly associated with an increased risk of aneuploid embryo genetics. These findings should be considered in embryo selection using time-lapse culture systems.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Aisling Ahlstrom, Kersti Lundin, Anna-Karin Lind, Kristina Gunnarsson, Goran Westlander, Hannah Park, Anna Thurin-Kjellberg, Steinunn A. Thorsteinsdottir, Snorri Einarsson, Mari Astrom, Kristina Lofdahl, Judith Menezes, Susanne Callender, Cina Nyberg, Jens Winerdal, Camilla Stenfelt, Brit-Randi Jonassen, Nan Oldereid, Lisa Nolte, Malin Sundler, Thorir Hardarson
Summary: The use of a commercially available time-lapse algorithm for Day 5 blastocyst selection did not improve ongoing pregnancy rates compared with morphology alone.
HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Ko-Tung Chang, Yu-Ting Su, Yi-Ru Tsai, Kuo-Chung Lan, Yan-Der Hsuuw, Hong-Yo Kang, Wen-Hsiung Chan, Fu-Jen Huang
Summary: High levels of estradiol directly impact blastocysts during implantation, impairing their implantation and early development.
BIOMEDICAL JOURNAL
(2022)
Article
Obstetrics & Gynecology
Troels Eliasen, Anette Gabrielsen, Bjorn Bay, Lea Iversen, Ulla Knudsen
Summary: This retrospective cohort study aimed to identify monochorionic twin pregnancies before blastocyst transfer based on maternal or embryo characteristics registered by time lapse. The study found that inner cell mass grade A and s3 division timing may be associated with an increased risk of monochorionic twinning. Further investigation is needed to determine if these factors reflect a biological background for monochorionic twinning.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Genetics & Heredity
Roberto Matorras, Alberto Vendrell, Marcos Ferrando, Zaloa Larreategui
Summary: Monozygotic twins (MZT) are more common in ART compared to natural conceptions, and various mechanisms related to ART may be associated with MZT. Retrospective studies analyzing time-lapse records have suggested that certain morphokinetic traits of the inner cell mass and trophectoderm could potentially predict MZT, although results are conflicting. We present a case of MZT where the embryos split at the moment of division, with one cell extruding through a hole in the zona pellucida (ZP), and both embryos developing normally and being vitrified.
TWIN RESEARCH AND HUMAN GENETICS
(2023)
Article
Endocrinology & Metabolism
Yuqiong Wang, Sheng Wang, Xilin Qian, Yanrong Kuai, Yang Xu
Summary: A single-center, large-cohort, retrospective study compared embryonic development in group culture systems with or without G4 embryos, revealing that multiple G4 embryos have a negative impact on neighboring embryos, while polypronuclear embryos contribute positively. LC-MS/MS analysis of G1-G4 embryo secretome showed that certain proteins secreted by G4 embryos may harm nearby embryos, emphasizing the importance of limiting the number of G4 embryos in group culture settings.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Harunobu Kagawa, Alok Javali, Heidar Heidari Khoei, Theresa Maria Sommer, Giovanni Sestini, Maria Novatchkova, Yvonne Scholte Op Reimer, Gael Castel, Alexandre Bruneau, Nina Maenhoudt, Jenna Lammers, Sophie Loubersac, Thomas Freour, Hugo Vankelecom, Laurent David, Nicolas Rivron
Summary: Human pluripotent stem cells cultured in specific conditions can efficiently form blastoids resembling blastocyst-stage analogues, providing a faithful model for investigating human implantation and development.
Article
Obstetrics & Gynecology
Yanhe Liu, Katie Feenan, Vincent Chapple, Peter Roberts, Phillip Matson
Article
Obstetrics & Gynecology
Yanhe Liu, Katie Feenan, Vincent Chapple, Phillip Matson
Editorial Material
Obstetrics & Gynecology
Yanhe Liu, Denny Sakkas, Masoud Afnan, Phillip Matson
Review
Genetics & Heredity
Yanhe Liu, Fang Qi, Phillip Matson, Dean E. Morbeck, Ben W. Mol, Sai Zhao, Masoud Afnan
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Article
Genetics & Heredity
Kate Watson, Irving Korman, Yanhe Liu, Deirdre Zander-Fox
Summary: Live birth can be achieved in patients with zona production deficiency. Adjustments in ovarian stimulation and subsequent embryo culture strategies may have contributed to the success of the third cycle.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Obstetrics & Gynecology
James M. Kemper, Yanhe Liu, Masoud Afnan, Elizabeth R. Hammond, Dean E. Morbeck, Ben W. J. Mol
Summary: Embryo quality is crucial for the success of IVF, with low-grade blastocysts (LGB) not receiving enough attention in existing scoring systems. Studies show that LGB have similar euploidy and pregnancy success rates after implantation, with no adverse effects on pregnancy or perinatal outcomes. Evidence for pregnancy outcomes is lacking for different grades of LGB, with most studies comparing all LGB as one category with optimal blastocysts.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Genetics & Heredity
Lee-Sarose Orevich, Kate Watson, Kee Ong, Irving Korman, Ross Turner, David Shaker, Yanhe Liu
Summary: This study examined the morphometric and morphokinetic features of male and female pronuclei (PN) in human zygotes. The results showed that male and female zygotes had different time intervals and size differences in PN appearance. Male zygotes also had a higher rate of central PN juxtaposition compared to female zygotes. These findings suggest that embryo selection based on these parameters may result in an unbalanced sex ratio in offspring.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Editorial Material
Obstetrics & Gynecology
Masoud Afnan, Michael Anis Mihdi Afnan, Yanhe Liu, Julian Savulescu, Abhishek Mishra, Vincent Conitzer, Cynthia Rudin
Summary: The past decade has witnessed a rapid growth of machine learning applications in healthcare, but the premature implementation of these algorithms has led to mixed and sometimes negative outcomes. This paper emphasizes the critical need for "data solidarity" in machine learning for embryo selection, which involves ensuring individual rights, promoting data justice and equity, and utilizing data for the public good.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Haowen Zou, James M. Kemper, Elizabeth R. Hammond, Fengqin Xu, Gensheng Liu, Lintao Xue, Xiaohong Bai, Hongqing Liao, Songguo Xue, Shuqin Zhao, Lan Xia, Jean Scott, Vincent Chapple, Masoud Afnan, Dean E. Morbeck, Ben W. J. Mol, Yanhe Liu, Rui Wang
Summary: The transfer of single low-grade blastocysts resulted in a reduced live birth rate compared to single good-grade blastocysts, but did not lead to more adverse perinatal outcomes.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Kate Bickendorf, Fang Qi, Kelli Peirce, Jay Natalwala, Vincent Chapple, Yanhe Liu
Summary: Spontaneous collapse (SC) of human blastocysts is associated with reduced euploid embryo and pregnancy rates in IVF treatment.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
James M. Kemper, Yanhe Liu, Masoud Afnan, Ben W. J. Mol, Dean E. Morbeck
Summary: There is a lack of evidence on embryos derived from oocytes without two pronuclei (2PN) or 'normal fertilization'. A significant difference exists between the development potential of oocytes with abnormal pronuclei and those with 2PN. Most recent studies focus on outcomes of blastocysts derived from non-2PN oocytes, suggesting that they have lower blastocyst rates and slightly reduced implantation potential compared to 2PN oocytes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Obstetrics & Gynecology
Tammy Lee, Jay Natalwala, Vincent Chapple, Yanhe Liu
Summary: With the advancement in computing power and accumulation of embryo image data, artificial intelligence (AI) has been applied in embryo selection in IVF. Machine learning (ML) has the potential to reduce subjectivity and save time, but the lack of interpretability in modern deep learning (DL) techniques has raised concerns. The effectiveness of black-box models lacks confirmation from randomized controlled trials, and recent evidence suggests underperformance compared to interpretable ML models. Interpretable AI is gaining support due to its ethical advantages and technical feasibility. A novel classification system for embryo selection models is proposed, focusing on subjectivity, interpretability, and explainability.
HUMAN REPRODUCTION
(2023)
Meeting Abstract
Obstetrics & Gynecology
B. W. Mol, M. Afnan, J. M. Kemper, F. Xu, G. Liu, L. Xue, X. Bai, H. Liao, S. Xue, S. Zhao, L. Xia, J. Scott, D. Morbeck, Y. Liu
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Yanh Liu, Kee Ong, Irving Korman, Ross Turner, David Shaker, Deirdre Zander-Fox, Luk Rombauts
Summary: This study found that the timing of assessment on day 5 is a confounding factor in predicting live birth using snapshot blastocyst morphology. A numerical algorithm incorporating day 5 assessment HPI, blastocyst morphology, and maternal age can be developed for live birth prediction.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Michael Anis Mihdi Afnan, Yanhe Liu, Vincent Conitzer, Cynthia Rudin, Abhishek Mishra, Julian Savulescu, Masoud Afnan
Summary: The potential of using artificial intelligence in the field of in vitro fertilization is significant, but challenges remain in terms of ethical implementation, algorithm interpretability, and clinical accuracy. Current studies show that algorithms can differentiate well between high-quality and poor-quality embryos, but struggle with embryos of similar quality, leading to various epistemic and ethical concerns.
HUMAN REPRODUCTION OPEN
(2021)