Article
Reproductive Biology
Ryosuke Suzuki, Mai Okada, Hiroki Nagai, Junichi Kobayashi, Satoshi Sugimura
Summary: This study for the first time visualized pronuclei (PN) in delipidated bovine zygotes using time-lapse cinematography (TLC), showing that abnormalities in PN morphokinetics are associated with subsequent embryonic development. Observations suggest that PN morphokinetic abnormalities are linked to developmental competence, highlighting the potential of non-invasive visible light TLC by delipidation as a powerful tool for studying the relationship between PN morphokinetics and embryonic development.
Article
Medicine, General & Internal
Lisa Boucret, Lea Tramon, Patrick Saulnier, Veronique Ferre-L'Hotellier, Pierre-Emmanuel Bouet, Pascale May-Panloup
Summary: The study evaluated how TLS and the KIDScore algorithm changed embryo selection practices and improved clinical pregnancy rates compared to conventional morphological evaluation. Findings showed that the TLS group in 2020 had significantly higher CPR compared to the conventional group in 2019, indicating that TLS is useful in identifying embryos with the highest potential for pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Carla Gimenez, Laura Conversa, Lucia Murria, Marcos Meseguer
Summary: Time-lapse imaging is a non-invasive method that allows continuous monitoring of embryo development. It has provided new markers for embryo selection and can be used to create predictive models of in vitro fertilization outcomes. The review of 47 articles shows that morphokinetics of the embryo during in vitro development can predict the ability to reach blastocyst stage, implantation and pregnancy rates, live birth outcome, and embryo ploidy.
FERTILITY AND STERILITY
(2023)
Article
Multidisciplinary Sciences
Shabana Sayed, Marte Myhre Reigstad, Bjorn Molt Petersen, Arne Schwennicke, Jon Wegner Hausken, Ritsa Storeng
Summary: The primary purpose of this study was to investigate the association between nucleation status of preimplantation embryos on Day 2 and live births following IVF. The analysis was based on 2769 transferred embryos and revealed that the frequency of nucleation errors was 23.8%. Embryos with nucleation errors at the two-cell stage had significantly lower live birth rates. Furthermore, increased age, delayed cell divisions, and insemination with surgically retrieved spermatozoa were identified as factors associated with higher incidences of nucleation errors.
Article
Agriculture, Dairy & Animal Science
Joanna Kochan, Agnieszka Nowak, Barbara Kij, Sylwia Prochowska, Wojciech Nizanski
Summary: The study identified that the timing of the first and second cleavage divisions, the timing of blastocyst cavity formation, and morphological anomalies are early and non-invasive indicators of cat embryo development in vitro.
Article
Computer Science, Interdisciplinary Applications
Mikkel F. Kragh, Jens Rimestad, Jacob T. Lassen, Jorgen Berntsen, Henrik Karstoft
Summary: This paper introduces a method for analyzing time-lapse videos of developing embryos using self-supervised learning, and demonstrates its superiority in predicting pregnancy likelihood. Additionally, the paper explores how transfer learning and semi-supervised learning can improve model performance when labeled data is limited.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Review
Endocrinology & Metabolism
Xue Wang, YaLing Xiao, ZhengYi Sun, JingRan Zhen, Qi Yu
Summary: There is no consensus on the timing intervals within ICSI cycles, leading to inconsistent and contradictory results. Further research is needed to determine the optimal time intervals for better laboratory and reproductive outcomes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Mehdi Benchaib, Elsa Labrune, Sandrine Giscard D'Estaing, Bruno Salle, Jacqueline Lornage
Summary: This study aimed to construct shallow neural networks using time-lapse technology and morphokinetic parameters coupled to assisted reproductive technology parameters. The predictive power of the networks was measured using performance scores, with all networks showing efficiency in predicting the probability of achieving a live birth.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2022)
Article
Genetics & Heredity
Lee-Sarose Orevich, Kate Watson, Kee Ong, Irving Korman, Ross Turner, David Shaker, Yanhe Liu
Summary: This study examined the morphometric and morphokinetic features of male and female pronuclei (PN) in human zygotes. The results showed that male and female zygotes had different time intervals and size differences in PN appearance. Male zygotes also had a higher rate of central PN juxtaposition compared to female zygotes. These findings suggest that embryo selection based on these parameters may result in an unbalanced sex ratio in offspring.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Review
Obstetrics & Gynecology
Romualdo Sciorio, Marcos Meseguer
Summary: The main aim of assisted reproductive technology is to achieve a healthy singleton live birth, and the introduction of time-lapse monitoring technology has enabled embryologists to more accurately assess embryo status and implantation potential.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Multidisciplinary Sciences
Carmen Huayhua, Misael Rodriguez, Jhorjhi Vega, Mario Briones, Lleretny Rodriguez-Alvarez, Edwin Mellisho
Summary: The objective of this study was to evaluate the time of blastulation monitored by time-lapse technology to predict in vitro viability of bovine blastocysts. The study found that early blastulation is associated with higher quality and post-hatching development in bovine blastocysts, and selecting blastocysts based on blastulation time and blastocyst diameter maximizes in vitro viability.
Article
Obstetrics & Gynecology
Xavier Ferraretto, Karima Hammas, Marie-Astrid Llabador, Solenne Gricourt, Julie Labrosse, Johanna Lousqui, Sylvie Epelboin, Sarah Tubiana, Catherine Patrat
Summary: The study observed a high prevalence of ACL in embryos, with certain embryo characteristics being related to the patients' reproductive origin. However, no factors related to IVF cycles were found to be statistically associated with ACL occurrence.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Health Care Sciences & Services
Adham Fawarseh, Yuval Atzmon, Nardin Aslih, Asaf Bilgory, Einat Shalom-Paz
Summary: This study examined the impact of maternal BMI on embryo morphokinetics and the outcomes of frozen embryo transfer cycles. The findings showed that embryos from normal-weight patients had slower cleavage rates compared to obese patients, but the quality of the embryos was similar between the BMI groups. There were no significant differences in pregnancy rate, clinical pregnancy rate, or miscarriage rate among the groups.
Article
Obstetrics & Gynecology
Saskia-Laureen Herbert, Claudia Staib, Theresa Wallner, Sanja Loeb, Carolin Curtaz, Michael Schwab, Achim Woeckel, Sebastian Haeusler
Summary: Our retrospective study analyzed 237 embryos from 128 IVF and/or ICSI transfer cycles to investigate the impact of complete resection of endometriosis on embryo quality. The results showed that complete resection significantly improved embryo quality and we recommend surgery for patients with endometriosis prior to assisted reproduction.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Qingxia Meng, Yunyu Xu, Aiyan Zheng, Hong Li, Jie Ding, Yongle Xu, Yan Pu, Wei Wang, Huihua Wu
Summary: This prospective randomized controlled trial aimed to compare the effectiveness of time-lapse monitoring (TLM) and conventional morphological assessment (CMA) for embryo selection. The results showed that the clinical pregnancy rate (CPR) and live birth rate (LBR) were significantly lower in the TLM group compared to the CMA group. However, there was no significant difference in CPR between the TLM and CMA groups for fresh embryo transfer or FET.
FERTILITY AND STERILITY
(2022)