Article
Oncology
Joao Boavida Ferreira, Rafael Cabrera, Filipa Santos, Andreia Relva, Hugo Vasques, Antonio Gomes, Antonio Guimaraes, Antonio Moreira
Summary: Benign metastasizing leiomyomatosis is a rare disease that primarily affects women with a history of uterine leiomyomatosis. It can occur in various organs and tissues, with the lungs being the most commonly affected. Treatment for this condition is individualized based on the patient's hormonal status and desires.
Review
Medicine, General & Internal
Jia-Wen Yang, Yu Hua, Hua Xu, Liu He, Hai-Zhong Huo, Chen-Fang Zhu
Summary: LPD is a rare disease with challenging diagnosis and treatment. Surgical excision is the mainstay, but hormone blockade therapy, particularly with goserelin acetate, has shown to be effective. Long-term use of goserelin acetate is considered safe and can replace repeated surgical excision in recurrent patients.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Surgery
Shih-Feng Huang, Chen-Yueh Wen, Cheng- Liao, Jung-Chia Lin, Cheng-Chung Tsai
Summary: LPD is a rare clinical condition that can be challenging to diagnose due to its resemblance to other conditions. This case report highlights the importance of learning from rare cases like LPD and provides valuable clinical information for further studies on the condition.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Medicine, General & Internal
Zhongxue Ye, Lu Chen
Summary: We present a case of LPD in a 43-year-old female who developed a lump in her abdomen after laparoscopic surgeries. Surgery was performed and endocrine therapy was chosen postoperatively, with no recurrence observed during follow-up.
Article
Medicine, General & Internal
Syed Tirmazy, Muhammad Farooq Latif, Goran Nadir Salih, Badr Ahmed, Wafa Talib Erabia
Summary: Benign metastasising leiomyomatosis (BML) is a rare disease that mainly affects premenopausal women and can be difficult to diagnose, often misdiagnosed as malignancy. This case study describes a 41-year-old woman with a history of hysterectomy for multiple fibroids who presented with respiratory symptoms and chest discomfort. Despite initial diagnosis of sarcoidosis and treatment with steroids, further investigations failed to confirm the diagnosis. Video-assisted thoracoscopic surgery revealed leiomyomatosis, and tamoxifen treatment led to significant improvement. BML should be considered in women with previous hysterectomy and multiple lung nodules on imaging.
Article
Obstetrics & Gynecology
Yixuan Liu, Dong Li, Xueqing Li, Jingnan Wang, Jigang Wang
Summary: Benign metastasizing leiomyoma (BML) is a rare condition primarily affecting women with a history of uterine leiomyoma. This study aimed to investigate its clinical characteristics and outcomes by reviewing 385 cases from previous reports. The common sites for metastasis were the lung, abdomen/pelvis/retroperitoneum, bone, lymph nodes, and heart. Hormone deprivation treatment, such as oophorectomy and hormone drugs, was found to be the most effective strategy for managing unresectable tumors. This study may serve as a valuable resource for diagnosing and managing BMLs.
REPRODUCTIVE SCIENCES
(2023)
Article
Surgery
Xin Chen, Haiyuan Liu, Honghui Shi, Qingbo Fan, Dawei Sun, Jinghe Lang
Summary: Iatrogenic leiomyomatosis peritonealis disseminata (LPD) is a relatively rare condition with patients usually exhibiting no hormonal stimulation factors. Surgery is the main treatment method, with hormone suppressive therapy rarely used. The nodules of LPD are usually large, less numerous, and mainly involve the pelvis, with a good prognosis for iatrogenic LPD.
FRONTIERS IN SURGERY
(2021)
Article
Oncology
Yue Wu, Liwen Fan, Yuxu Niu, Yun Wu, Wen Gao
Summary: Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease that mainly occurs in reproductive-age women and is closely related to sex hormone levels. When faced with female patients with lung lesions resembling metastatic tumors, regardless of a history of uterine fibroids surgery, the possibility of PBML should be considered, and sequential surgical treatment can be arranged.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Xiaoli Xiao, Cong Wang, Yuyuan Zhang, Fang Li, Huan Zhang, Ruiqing Ma
Summary: Leiomyomatosis peritonealis disseminata (LPD) is a rare and benign disease with non-specific clinical and imaging findings. This study reports a case of recurrent LPD with endometriosis in a patient who underwent multiple myomectomies and hysterectomy. The patient was treated with a combination of cytoreductive surgery, peritonectomy, ovarian ablation, and hyperthermic intraperitoneal chemotherapy, and achieved a tumor-free survival of 13 months.
Article
Medicine, General & Internal
Nguyen Manh Thang, Dang Hong Thien, Nguyen Thi Huyen Anh, Tran Danh Cuong
Summary: Leiomyomatosis peritonealis disseminata (LPD) is a rare disease that can be challenging to diagnose. The use of a power morcellator without in-bag containment system may contribute to the pathogenesis of LPD. Diagnosis relies on medical history, clinical presentation, imaging studies, and histopathological examination. Preventative measures such as using containment bags during power morcellation should be considered to reduce the risk of LPD.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Oncology
Lukas Krasny, Chris P. Wilding, Emma Perkins, Amani Arthur, Nafia Guljar, Andrew D. Jenks, Cyril Fisher, Ian Judson, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Intravenous leiomyomatosis is a distinct disease from other smooth muscle tumors due to its enrichment of components of the spliceosome machinery. Co-regulated expression of splicing factors in intravenous leiomyomatosis suggests a possible role for alternative splicing in disease initiation and progression.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Simin Wu, Jiayu Cai, Qi Chen, Jing Wu, Haojun Chen
Summary: In this case report, a 37-year-old woman with a history of uterine leiomyomas presented with benign metastasizing leiomyomas (BMLs) in the lung and pelvis after hysterectomy. F-18-FDG PET/CT showed faint uptake in the metastatic lesions, while Ga-68-FAPI PET/CT demonstrated elevated activity, indicating low glucose metabolism but excessive accumulation of activated fibroblasts in the BMLs. This case suggests that Ga-68-FAPI PET/CT may be potentially useful in the evaluation of BMLs.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Obstetrics & Gynecology
Kota Aoki, Takuro Yamamoto, Ryu Terauchi, Taisuke Mori, Toshiharu Shirai, Jo Kitawaki
Summary: BML is a rare disease characterized by well-differentiated smooth muscle tumors occurring extrauterine site in women with a history of uterine leiomyoma, with the lung being the most common metastatic site. It should be considered when multiple soft tissue tumors are found in women with a history of leiomyomas.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Obstetrics & Gynecology
Youngsin Han, Youn-Jee Chung, Inhye Shin, Jung Yoon Park, Suhyun Shim, Ayah Hijazi, Jae-Yen Song, Hyun Hee Cho, Mee-Ran Kim
Summary: This study highlights the importance of accurate diagnosis and comprehensive preoperative evaluation in intravenous leiomyomatosis, emphasizing the necessity of a multidisciplinary approach for successful treatment outcomes.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Tamar Perri, Daphna Amitai Komem, Sara Apter, Yael Inbar, Daniela Dick-Necula, Gabriel Levin, Jacob Korach
Summary: This retrospective cohort study compared characteristics, disease course, and prognosis of iatrogenic and spontaneous benign metastasizing leiomyoma (BML), showing that while both generally have favorable prognosis, spontaneous BML may have a less favorable course.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
