Article
Andrology
Manesh Kumar Panner Selvam, Ashok Agarwal
Summary: This study compared the seminal plasma proteome of healthy fertile men with varicocele patients, identifying differentially expressed proteins associated with processes such as acrosome binding, protein folding, and oxidative stress. Validation confirmed abnormal expression levels of key proteins in varicocele patients. These findings suggest that aberrant seminal plasma protein expression could serve as an indicator of sperm pathology in varicocele patients.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Cell Biology
Jasmine Nayak, Soumya Ranjan Jena, Sugandh Kumar, Sujata Kar, Anshuman Dixit, Luna Samanta
Summary: This study aims to explore the correlation between seminal polyaromatic hydrocarbon (PAH) exposome and sperm function in idiopathic male infertility (IMI) patients through a proteomic approach. Results showed that 13 out of 16 toxic PAHs were detected in semen. The spermatozoa proteome was analyzed and validated, revealing the impact of PAHs on male infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Federica Barbagallo, Sandro La Vignera, Rossella Cannarella, Andrea Crafa, Aldo E. Calogero, Rosita A. Condorelli
Summary: The study found that patients with high seminal fluid viscosity show significant impairment of antioxidant systems and increased oxidative stress, indicating that a careful assessment of oxidative stress may be beneficial in clinical practice. Treatment with antioxidants could potentially benefit infertile patients with seminal fluid hyperviscosity by protecting sperm cells from oxidative damage and enhancing their functional properties.
Article
Cell Biology
Ewa Janiszewska, Izabela Kokot, Agnieszka Kmieciak, Iwona Gilowska, Ricardo Faundez, Ewa Maria Kratz
Summary: Oxidative stress is a contributing factor to male infertility. This study found that seminal plasma advanced oxidation protein products (AOPP) concentrations were associated with selected biochemical parameters and may affect sperm disorders. Total protein levels may be related to asthenozoospermia, and insufficient iron levels may reflect a decrease in sperm count.
Article
Biochemistry & Molecular Biology
Matteo Becatti, Gianmartin Cito, Flavia Rita Argento, Eleonora Fini, Alessandra Bettiol, Serena Borghi, Amanda Mannucci, Rossella Fucci, Claudia Giachini, Rita Picone, Giacomo Emmi, Niccolo Taddei, Maria Elisabetta Coccia, Claudia Fiorillo
Summary: A significant number of infertile men are classified as idiopathic or unexplained cases due to the lack of clear diagnosis based on standard semen parameters. This study investigates the role of oxidative stress in male infertility and suggests that blood redox markers can be used as an additional tool for assessing sperm quality and providing specific information in preconception care.
Article
Biology
Feda Aljaser, Hajera Tabassum, Sabiha Fatima, Manal Abudawood, Naheed Banu
Summary: The study found that oxidative stress and trace elements have a significant impact on male infertility, with increased oxidation and lipid peroxidation in infertile men's semen, decreased antioxidant capacity, and lower levels of trace elements like zinc and magnesium. There was a significant correlation between trace elements and oxidative markers with sperm motility.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Andrology
Manesh Kumar Panner Selvam, Ashok Agarwal, Rakesh Sharma, Luna Samanta, Sajal Gupta, Tania R. Dias, Ana Dias Martins
Summary: This study identified differentially expressed proteins in seminal plasma of unilateral varicocele patients compared to fertile donors, with significant upregulation of ANXA2 and downregulation of KIF5B. The main upstream regulators of these proteins in unilateral varicocele group were androgen receptor, YB1, and NRF2. KIF5B and ANXA2 could potentially serve as biomarkers for infertility in unilateral varicocele patients.
WORLD JOURNAL OF MENS HEALTH
(2021)
Review
Andrology
Manesh Kumar Panner Selvam, Renata Finelli, Ashok Agarwal, Ralf Henkel
Summary: ORP as a new oxidative stress marker plays an important role in evaluating semen quality and male fertility status, but further research is needed to establish its use in assisted reproductive techniques practice.
Article
Biochemistry & Molecular Biology
Manesh Kumar Panner Selvam, Saradha Baskaran, Samantha O'Connell, Wael Almajed, Wayne J. G. Hellstrom, Suresh C. Sikka
Summary: This study conducted a systematic review and meta-analysis to evaluate the relationship between seminal ORP and SDF. The results showed a significant positive correlation between ORP and SDF, indicating the role of oxidative stress in sperm DNA damage. Further exploration of the clinical value of these sperm function tests is warranted.
Article
Biochemistry & Molecular Biology
Jaime Catalan, Ivan Yanez-Ortiz, Asta Tvarijonaviciute, Luis Guillermo Gonzalez-Arostegui, Camila P. Rubio, Isabel Barranco, Marc Yeste, Jordi Miro
Summary: This study examined the relationship between enzymatic and non-enzymatic antioxidants in seminal plasma and horse sperm's ability to withstand freeze-thawing. The results showed that enzymatic antioxidants PON1 and SOD, as well as non-enzymatic antioxidant TEAC, were positively correlated with sperm motility and plasma membrane integrity. On the other hand, the oxidative stress index (OSI) was negatively correlated with these parameters and positively correlated with plasma membrane lipid disorder. Further investigation is needed to explore the potential use of these antioxidants and OSI in predicting sperm cryotolerance in horses.
Article
Urology & Nephrology
Ozge Senem Yucel Cicek, Gozde Kaya, Begum Alyuruk, Emek Doger, Tugba Girisen, Serdar Filiz
Summary: Understanding the effects of high oxidation reduction potential (ORP) levels on sperm parameters revealed a significant decrease in total sperm count, sperm concentration, and total motile sperm count in samples with sORP values >1.36mV/10(6)sperm/mL. This study suggests that seminal oxidative stress, as indicated by sORP cutoff, is associated with oligozoospermia, reduced progressive motility, and low total motile sperm count in semen analysis.
INTERNATIONAL BRAZ J UROL
(2021)
Article
Cell Biology
Tanja Turunen, Martina Magris, Marjo Malinen, Jukka Kekalainen
Summary: This study investigates the effects of seminal plasma (SP) identity and protein composition on human sperm function. The results show that SP identity and its protein composition play a role in sperm swimming velocity, viability, and hyperactivation. The interaction between sperm and SP donor also affects sperm performance. Additionally, specific SP proteins, such as DPP4 and NEP, are positively associated with sperm swimming velocity and hyperactivation.
Article
Cell Biology
Sergio Garcia-Segura, Javier del Rey, Laia Closa, Iris Garcia-Martinez, Carlos Hobeich, Ana Belen Castel, Francisco Vidal, Jordi Benet, Jordi Ribas-Maynou, Maria Oliver-Bonet
Summary: The development of new biomarkers for male infertility is crucial. This study found a relationship between seminal microbiota and sperm quality parameters, chromatin integrity, and oxidative stress. Specific genera were associated with different sperm quality defects, suggesting the potential use of microbial profiles as biomarkers for male fertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vittore Verratti, Simona Mrakic-Sposta, Jonathan Fusi, Iva Sabovic, Ferdinando Franzoni, Tiziana Pietrangelo, Danilo Bondi, Stefano Dall'Acqua, Simona Daniele, Giorgia Scarfo, Camillo Di Giulio, Andrea Garolla
Summary: This study evaluated the effects of high-altitude exposure on sperm parameters and health status in travellers. The results showed that high-altitude trekking led to a decrease in sperm concentration and seminal volume, and an increase in oxidative stress. The study also suggested that uncontrolled ROS production may be the cause of impaired sperm quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Gemma Gaitskell-Phillips, Francisco E. Martin-Cano, Jose M. Ortiz-Rodriguez, Eva Da Silva-Alvarez, Javier Masot, Eloy Redondo, Maria C. Gil, Cristina Ortega-Ferrusola, Fernando J. Pena
Summary: Seminal plasma proteins play crucial roles in sperm functionality, and their abundance in samples correlates with the quality of ejaculates from different stallions. Identifying specific proteins in seminal plasma could potentially help improve the quality of stallion ejaculates and enhance breeding strategies.
Article
Oncology
Branka Radic-Sarikas, Kalliopi P. Tsafou, Kristina B. Emdal, Theodore Papamarkou, Kilian V. M. Huber, Cornelia Mutz, Jeffrey A. Toretsky, Keiryn L. Bennett, Jesper V. Olsen, Soren Brunak, Heinrich Kovar, Giulio Superti-Furga
MOLECULAR CANCER THERAPEUTICS
(2017)
Article
Biochemical Research Methods
Fernando J. Sialana, Peter Gulyassy, Peter Majek, Evelina Sjostedt, Viktor Kis, Andre C. Muller, Elena L. Rudashevskaya, Jan Mulder, Keiryn L. Bennett, Gert Lubec
Article
Hematology
Iris Z. Uras, Ruth M. Scheicher, Karoline Kollmann, Martin Gloesmann, Michaela Prchal-Murphy, Anca S. Tigan, Daniela A. Fux, Sandro Altamura, Joana Neves, Martina U. Muckenthaler, Keiryn L. Bennett, Stefan Kubicek, Philip W. Hinds, Marieke von Lindern, Veronika Sexl
Article
Gastroenterology & Hepatology
Clara Jana-Lui Busch, Tim Hendrikx, David Weismann, Sven Jaeckel, Sofie M. A. Walenbergh, Andre F. Rendeiro, Juliane Weisser, Florian Puhm, Anastasiya Hladik, Laura Goederle, Nikolina Papac-Milicevic, Gerald Haas, Vincent Millischer, Saravanan Subramaniam, Sylvia Knapp, Keiryn L. Bennett, Christoph Bock, Christoph Reinhardt, Ronit Shiri-Sverdlov, Christoph J. Binder
Article
Cell Biology
Przemyslaw A. Filipek, Mariana E. G. de Araujo, Georg F. Vogel, Cedric H. De Smet, Daniela Eberharter, Manuele Rebsamen, Elena L. Rudashevskaya, Leopold Kremser, Teodor Yordanov, Philipp Tschaikner, Barbara G. Fuernrohr, Stefan Lechner, Theresia Dunzendorfer-Matt, Klaus Scheffzek, Keiryn L. Bennett, Giulio Superti-Furga, Herbert H. Lindner, Taras Stasyk, Lukas A. Huber
JOURNAL OF CELL BIOLOGY
(2017)
Article
Urology & Nephrology
Maria Bartosova, Betti Schaefer, Justo Lorenzo Bermejo, Silvia Tarantino, Felix Lasitschka, Stephan Macher-Goeppinger, Peter Sinn, Bradley A. Warady, Ariane Zaloszyc, Katja Parapatics, Peter Majek, Keiryn L. Bennett, Jun Oh, Christoph Aufricht, Franz Schaefer, Klaus Kratochwill, Claus Peter Schmitt
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Article
Biochemical Research Methods
Rebecca Herzog, Michael Boehm, Markus Unterwurzacher, Anja Wagner, Katja Parapatics, Peter Majek, Andre C. Mueller, Anton Lichtenauer, Keiryn L. Bennett, Seth L. Alper, Andreas Vychytil, Christoph Aufricht, Klaus Kratochwill
MOLECULAR & CELLULAR PROTEOMICS
(2018)
Article
Biochemistry & Molecular Biology
Marco P. Licciardello, Anna Ringler, Patrick Markt, Freya Klepsch, Charles-Hugues Lardeau, Sara Sdelci, Erika Schirghuber, Andre C. Mueller, Michael Caldera, Anja Wagner, Rebecca Herzog, Thomas Penz, Michael Schuster, Bernd Boidol, Gerhard Duernberger, Yasin Folkvaljon, Par Stattin, Vladimir Ivanov, Jacques Colinge, Christoph Bock, Klaus Kratochwill, Joerg Menche, Keiryn L. Bennett, Stefan Kubicek
NATURE CHEMICAL BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Rajasekharan Somasundaram, Gao Zhang, Mizuho Fukunaga-Kalabis, Michela Perego, Clemens Krepler, Xiaowei Xu, Christine Wagner, Denitsa Hristova, Jie Zhang, Tian Tian, Zhi Wei, Qin Liu, Kanika Garg, Johannes Griss, Rufus Hards, Margarita Maurer, Christine Hafner, Marius Mayerhoefer, Georgios Karanikas, Ahmad Jalili, Verena Bauer-Pohl, Felix Weihsengruber, Klemens Rappersberger, Josef Koller, Roland Lang, Courtney Hudgens, Guo Chen, Michael Tetzlaff, Lawrence Wu, Dennie Tompers Frederick, Richard A. Scolyer, Georgina V. Long, Manashree Damle, Courtney Ellingsworth, Leon Grinman, Harry Choi, Brian J. Gavin, Margaret Dunagin, Arjun Raj, Nathalie Scholler, Laura Gross, Marilda Beqiri, Keiryn Bennett, Ian Watson, Helmut Schaider, Michael A. Davies, Jennifer Wargo, Brian J. Czerniecki, Lynn Schuchter, Dorothee Herlyn, Keith Flaherty, Meenhard Herlyn, Stephan N. Wagner
NATURE COMMUNICATIONS
(2017)
Article
Microbiology
Kseniya Khamina, Alexander Lercher, Michael Caldera, Christopher Schliehe, Bojan Vilagos, Mehmet Sahin, Lindsay Kosack, Anannya Bhattacharya, Peter Majek, Alexey Stukalov, Roberto Sacco, Leo C. James, Daniel D. Pinschewer, Keiryn L. Bennett, Jorg Menche, Andreas Bergthaler
Article
Hematology
Iris Z. Uras, Ruth M. Scheicher, Karoline Kollmann, Martin Gloesmann, Michaela Prchal-Murphy, Anca S. Tigan, Daniela A. Fux, Sandro Altamura, Joana Neves, Martina U. Muckenthaler, Keiryn L. Bennett, Stefan Kubicek, Philip W. Hinds, Marieke von Lindern, Veronika Sexl
Article
Biochemistry & Molecular Biology
Mette Ishoey, Someth Chorn, Natesh Singh, Martin G. Jaeger, Matthias Brand, Joshiawa Paulk, Sophie Bauer, Michael A. Erb, Katja Parapatics, Andre C. Mueller, Keiryn L. Bennett, Gerhard F. Ecker, James E. Bradner, Georg E. Winter
ACS CHEMICAL BIOLOGY
(2018)
Meeting Abstract
Hematology
A. Skucha, J. Ebner, J. Schmoellerl, A. Cesar Razquin, T. Eder, A. Stukalov, S. Vittori, M. Muhar, M. Roth, B. Gyoerffy, P. Valent, K. Bennett, J. Zuber, G. Superti-Furga, F. Grebien
Article
Chemistry, Analytical
Juliane Weisser, Claudia Ctortecka, Clara J. Busch, Shane R. Austin, Karin Nowikovsky, Koji Uchida, Christoph J. Binder, Keiryn L. Bennett
ANALYTICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Jin Li, Tamara Casteels, Thomas Frogne, Camilla Ingvorsen, Christian Honore, Monica Courtney, Kilian V. M. Huber, Nicole Schmitner, Robin A. Kimmel, Roman A. Romanov, Caterina Sturtzel, Charles-Hugues Lardeau, Johanna Klughammer, Matthias Farlik, Sara Sdelci, Andhira Vieira, Fabio Avolio, Francois Briand, Igor Baburin, Peter Majek, Florian M. Pauler, Thomas Penz, Alexey Stukalov, Manuela Gridling, Katja Parapatics, Charlotte Barbieux, Ekaterine Berishvili, Andreas Spittler, Jacques Colinge, Keiryn L. Bennett, Steffen Hering, Thierry Sulpice, Christoph Bock, Martin Distel, Tibor Harkany, Dirk Meyer, Giulio Superti-Furga, Patrick Collombat, Jacob Hecksher-Sorensen, Stefan Kubicek